Lung CollapseNCT07660588
Brief Bronchial Suction for Lung Collapse During Uniportal VATS
A study testing bronchial suction in people with Lung Collapse and One-lung Ventilation, run by Mahidol University at 1 site in Thailand.
Trial summary
The goal of this clinical trial is to learn whether a brief suction of the airway going to the surgical lung (bronchus) can help the lung collapse faster and more completely during uniportal video-assisted thoracoscopic surgery (UVATS). Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Lung Collapse, One-lung Ventilation, Thoracic Anesthesia
- What is being tested?
- bronchial suction
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 100 participants
- Where
- 1 siteThailand
- Study dates
- Nov 2026to Jul 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age ≥ 18 years old
- BMI ≤ 35 kg/m2
- American Society of Anesthesiologists (ASA) physical status I to III
- Scheduled for elective single-port video-assisted thoracoscopic surgery (VATS) at Siriraj Hospital
- Requirement for one-lung ventilation using a double-lumen tube (DLT)
- Surgery performed in the lateral decubitus position
- Ability to provide written informed consent
Who cannot join
- Previous thoracic surgery
- Known or suspected severe pleural adhesions based on preoperative imaging or clinical history
- Tracheobronchial anatomical abnormalities
- Pulmonary bullae identified on chest radiography or computed tomography, or a history of recurrent pneumothorax
- Forced vital capacity (FVC) < 50% of predicted
- Pregnancy
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Effect of Brief Bronchial Suction on the Quality of Non-Ventilated Lung Collapse and Time to Adequate Surgical Exposure During Uniportal Video-Assisted Thoracoscopic Surgery: a Randomized Patient- and Surgeon-Blinded Trial
The goal of this clinical trial is to learn whether a brief suction of the airway going to the surgical lung (bronchus) can help the lung collapse faster and more completely during uniportal video-assisted thoracoscopic surgery (UVATS). This type of surgery is performed through a small incision in the chest, and good lung collapse helps the surgeon see and work safely. The main questions it aims to answer are
- Does brief bronchial suction improve the quality of lung collapse 1 minute after chest cavity is opened?
- Does brief bronchial suction help reach satisfactory lung collapse faster?
Read more
Researchers will compare patients who receive brief bronchial suction and those who do not. This is to see if suction improves and fastens lung collapse, reduce the need for additional steps if lung is not adequately collapsed, affect inflammation, oxygenation, postoperative pulmonary complications, operative time, and the duration of one-lung ventilation. Participants will
- Undergo UVATS under general anesthesia
- Have a double-lumen breathing tube placed as part of the standard anesthetic care
- Be randomly assigned to either receive bronchial suction for one minute or receive no bronchial suction
- Have the surgical team assess the quality of lung collapse at different time points
- Have information collected from the routine anesthesia and surgical records such as oxygen levels during surgery, length of surgery and lung-related complications within 7 days after surgery
Read the detailed description
Uniportal video-assisted lung surgery (UVATS) is increasingly being performed in many centers. Due to a short interval between the skin incision and pleural opening, a rapid and adequate surgical lung collapse is important for optimal surgical exposure and operative efficiency. Delayed or inadequate lung collapse may interfere with the operative field, increase the need for manual lung manipulation by surgeons and possibly a resultant increase in lung inflammation. Brief bronchial suction through a double lumen tube has been used to facilitate lung collapse although its effectiveness is questionable in three-port VATS. This study aims to investigate if a brief bronchial suction helps achieve a better and faster lung collapse in UVATS.
Study objectives This randomized controlled trial aims to evaluate whether a brief suction through a tube in the non-ventilated lung leads to a better quality of lung collapse at one minute after the surgeon enters the chest. The study will compare the results between patients who receive a brief bronchial suction and those who do not.
Study design This is a randomized controlled trial conducted at a single university hospital in Thailand. Adult patients undergoing UVATS will be enrolled. A double-lumen endotracheal tube will be placed under general anesthesia as part of a standard anesthetic care. Patients will be randomly assigned to either receive a bronchial suction for one minute or no bronchial suction. The intervention group will undergo bronchial suction on two occasions: before pleural opening and immediately after pleural opening. Each suction period will last for 60 seconds.
The quality of lung collapse will be assessed by the surgical team at different time points during the surgery, including one minute after chest opening. Time to satisfactory lung collapse will also be evaluated.
Other perioperative data and outcome including requirement for additional steps in case of inadequate lung collapse, duration of one-lung ventilation, duration of surgery, incidence of intraoperative hypoxemia and postoperative pulmonary complications will also be collected.
Potential significance The findings from this study may help to optimize anesthetic management for patients undergoing VATS, particularly UVATS, and provide evidence on the effectiveness of bronchial suction on the quality and speed of lung collapse. The information may contribute to evidence-based recommendations on intraoperative strategies to improve lung collapse during minimally invasive lung surgery.
- Conditions
- Lung Collapse, One-lung Ventilation, Thoracic Anesthesia, Thoracic Surgery, Video-assisted, Double-lumen Tube, Uniportal Video Assisted Thoracic Surgery (U-VATS)
- Being tested
- bronchial suction, Sham Control
- Keywords
- uniportal VATS, UVATS, bronchial suction, lung collapse, one-lung ventilation, double-lumen tube, thoracic anesthesia
- Medical subject headings
- Pulmonary Atelectasis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
bronchial suctionOther
Participants will receive bronchial suction at -30 cmH₂O through the bronchoscopy port of the operative lumen of the double-lumen endotracheal tube on two occasions: (1) during a 60-second apnea period immediately before initiation of one-lung ventilation and (2) during a 60-second apnea period immediately after pleural opening. Following the first suction period, the bronchoscopy port of the operative lumen will be closed. The bronchoscopy port of the operative lumen will be opened to ambient air following the second suction period after pleural entry.
Sham ControlOther
Participants will undergo the same 60-second apnea periods as the bronchial suction group immediately before initiation of one-lung ventilation and immediately after pleural opening. The suction device will be activated for 60 seconds to produce sham suction noise but will not be connected to the patient.
| Study group | Role | What they receive |
|---|---|---|
| Bronchial suction | Experimental | Participants will receive bronchial suction through the bronchoscopy port of the operative lumen of the double-lumen endotracheal tube Receives: Other: bronchial suction |
| No bronchial suction | Sham comparator | Participants will undergo one-lung ventilation without bronchial suction Receives: Other: Sham Control |
What is being measured
The primary outcome is the main question the study is designed to answer.
Quality of lung collapse at 1 minute after pleural opening
Surgical team to assess quality of lung collapse at 1 minute after pleural opening by using lung collapse score (LCS). The higher the LCS, the better the lung collapse.
Measured: At 1 minute after pleural opening
Secondary outcomes (7)
Quality of lung collapse at pleural opening, 5 minutes and 10 minutes after pleural opening
Quality of lung collapse assessed by the surgical team using the Lung Collapse Score (LCS) immediately after pleural opening, and at 5 minutes and 10 minutes after pleural opening.
Measured: At pleural opening, and at 5 and 10 minutes after pleural opening
Time to satisfactory lung collapse
Time from pleural opening to the first Lung Collapse Score (LCS) of 8 or greater
Measured: From pleural opening until the first LCS of 8 or greater, assessed up to 10 minutes after pleural opening
Requirement for rescue maneuvers for inadequate lung collapse
Need for additional intraoperative maneuvers to improve lung collapse due to inadequate surgical exposure
Measured: From pleural opening until the end of one-lung ventilation during the index surgery up to 6 hours
Incidence of intraoperative hypoxemia
Occurrence of intraoperative hypoxemia during one-lung ventilation, defined as SpO2 < 90%
Measured: From initiation of one-lung ventilation until resumption of two-lung ventilation during the index surgery up to 6 hours
Incidence of postoperative pulmonary complications
Occurrence of postoperative pulmonary complications within 7 days after surgery or until hospital discharge, whichever occurs first. These include, but are not limited to, atelectasis, pneumonia, pulmonary aspiration, respiratory infection, pleural effusion, pneumothorax, bronchospasm, pulmonary edema, and respiratory failure.
Measured: From end of surgery through postoperative day 7 or hospital discharge, whichever occurs first
Total operative duration
Duration of surgery measured from surgical incision to completion of surgery.
Measured: From surgical incision to completion of surgery during the index operation, up to 6 hours
Duration of one-lung ventilation
Total duration of one-lung ventilation during surgery
Measured: From initiation of one-lung ventilation until resumption of two-lung ventilation during the index operation, up to 6 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Jun 2026
- Study startNov 2026 (estimated)
- Primary completionJul 2028 (estimated)
- Study completionJul 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (16)Papers the sponsor has linked to this study.
- Other trials for Lung CollapseStudies of the same condition, open and under way.
- More trials run by Mahidol UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomly assigned in a 1:1 ratio to either a bronchial suction group or a control group. Outcomes will be compared between the two parallel groups.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mahidol University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Nattaya Raykateeraroj, MD, Principal investigator, Siriraj Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07660588
- Sponsor's protocol ID
- SIRIRAJ-SUCTION-UVATS-2026
- Status last verified
- Jun 2026
- First submitted
- 8 Jun 2026
- Last updated
- 7 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: There is no current plan to share individual participant data outside the study team
Publications
Miskovic A, Lumb AB. Postoperative pulmonary complications. Br J Anaesth. 2017 Mar 1;118(3):317-334. doi: 10.1093/bja/aex002.
PubMed 28186222Abbott TEF, Fowler AJ, Pelosi P, Gama de Abreu M, Moller AM, Canet J, Creagh-Brown B, Mythen M, Gin T, Lalu MM, Futier E, Grocott MP, Schultz MJ, Pearse RM; StEP-COMPAC Group. A systematic review and consensus definitions for standardised end-points in perioperative medicine: pulmonary complications. Br J Anaesth. 2018 May;120(5):1066-1079. doi: 10.1016/j.bja.2018.02.007. Epub 2018 Mar 27.
PubMed 29661384Brassard CL, Lohser J, Donati F, Bussieres JS. Step-by-step clinical management of one-lung ventilation: continuing professional development. Can J Anaesth. 2014 Dec;61(12):1103-21. doi: 10.1007/s12630-014-0246-2. Epub 2014 Nov 12. English, French.
PubMed 25389025Engels GE, van Oeveren W. Biomarkers of lung injury in cardiothoracic surgery. Dis Markers. 2015;2015:472360. doi: 10.1155/2015/472360. Epub 2015 Mar 17.
PubMed 25866435Reinersman JM, Passera E, Rocco G. Overview of uniportal video-assisted thoracic surgery (VATS): past and present. Ann Cardiothorac Surg. 2016 Mar;5(2):112-7. doi: 10.21037/acs.2016.03.08.
PubMed 27134837Xiang YY, Chen Q, Tang XX, Cao L. Comparison of the effect of double-lumen endotracheal tubes and bronchial blockers on lung collapse in video-assisted thoracoscopic surgery: a systematic review and meta-analysis. BMC Anesthesiol. 2022 Oct 29;22(1):330. doi: 10.1186/s12871-022-01876-2.
PubMed 36309646Quan X, Yi J, Huang Y, Zhang X, Shen L, Li S. Bronchial suction does not facilitate lung collapse when using a double-lumen tube during video-assisted thoracoscopic surgery: a randomized controlled trial. J Thorac Dis. 2017 Dec;9(12):5244-5248. doi: 10.21037/jtd.2017.11.63.
PubMed 29312732Zhang Y, Yan W, Fan Z, Kang X, Tan H, Fu H, Li Z, Chen KN, Chen J. Preemptive one lung ventilation enhances lung collapse during thoracoscopic surgery: A randomized controlled trial. Thorac Cancer. 2019 Jun;10(6):1448-1452. doi: 10.1111/1759-7714.13091. Epub 2019 May 21.
PubMed 31115153Yoshimura T, Ueda K, Kakinuma A, Sawai J, Nakata Y. Bronchial blocker lung collapse technique: nitrous oxide for facilitating lung collapse during one-lung ventilation with a bronchial blocker. Anesth Analg. 2014 Mar;118(3):666-70. doi: 10.1213/ANE.0000000000000106.
PubMed 24557112Somma J, Couture EJ, Pelletier S, Provencher S, Moreault O, Lohser J, Ugalde PA, Vigneault L, Lemieux J, Somma A, Guay SE, Bussieres JS. Non-ventilated lung deflation during one-lung ventilation with a double-lumen endotracheal tube: a randomized-controlled trial of occluding the non-ventilated endobronchial lumen before pleural opening. Can J Anaesth. 2021 Jun;68(6):801-811. doi: 10.1007/s12630-021-01957-9. Epub 2021 Apr 2.
PubMed 33797018Li Q, Zhang X, Wu J, Xu M. Two-minute disconnection technique with a double-lumen tube to speed the collapse of the non-ventilated lung for one-lung ventilation in thoracoscopic surgery. BMC Anesthesiol. 2017 Jun 15;17(1):80. doi: 10.1186/s12871-017-0371-x.
PubMed 28619111Pfitzner J. Facilitating lung collapse during one lung ventilation can be rational. Anesth Analg. 2014 Oct;119(4):1002-1003. doi: 10.1213/ANE.0000000000000336. No abstract available.
PubMed 25232695Pfitzner J, Peacock MJ, Harris RJ. Speed of collapse of the non-ventilated lung during single-lung ventilation for thoracoscopic surgery: the effect of transient increases in pleural pressure on the venting of gas from the non-ventilated lung. Anaesthesia. 2001 Oct;56(10):940-6. doi: 10.1046/j.1365-2044.2001.02211.x.
PubMed 11576095Li Y, Huang H, Hang L. Comparison of efficacy and safety of different suction pressure for speeding non-ventilated lung collapse in uniport video-assisted thoracoscopic surgery: a randomized-controlled trial. BMC Surg. 2024 Sep 3;24(1):247. doi: 10.1186/s12893-024-02539-4.
PubMed 39227846Hang L, Ju J, Li Y, He M. The impact of suction duration on lung collapse during one-lung ventilation. Front Surg. 2025 Mar 31;12:1532176. doi: 10.3389/fsurg.2025.1532176. eCollection 2025.
PubMed 40230709
Study at a glance
From the registry record, last updated by the sponsor on 7 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Brief Bronchial Suction on the Quality of Non-Ventilated Lung Collapse and Time to Adequate Surgical Exposure During Uniportal Video-Assisted Thoracoscopic Surgery: a Randomized Patient- and Surgeon-Blinded Trial
- ClinicalTrials.gov ID
- NCT07660588
- Acronym / sponsor ID
- SIRIRAJ-SUCTION-UVATS-2026
- Conditions
- Lung Collapse, One-lung Ventilation, Thoracic Anesthesia, Thoracic Surgery, Video-assisted, Double-lumen Tube, Uniportal Video Assisted Thoracic Surgery (U-VATS)
- Keywords
- uniportal VATS, UVATS, bronchial suction, lung collapse, one-lung ventilation, double-lumen tube, thoracic anesthesia
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Mahidol UniversityUniversity, hospital or other
- Study start
- Nov 2026 (estimated)
- Primary completion
- Jul 2028 (estimated)
- Study completion
- Jul 2028 (estimated)
- First posted
- 22 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn whether a brief suction of the airway going to the surgical lung (bronchus) can help the lung collapse faster and more completely during uniportal video-assisted thoracoscopic surgery (UVATS). This type of surgery is performed through a small incision in the chest, and good lung collapse helps the surgeon see and work safely. The main questions it aims to answer are
- Does brief bronchial suction improve the quality of lung collapse 1 minute after chest cavity is opened?
- Does brief bronchial suction help reach satisfactory lung collapse faster?
Researchers will compare patients who receive brief bronchial suction and those who do not. This is to see if suction improves and fastens lung collapse, reduce the need for additional steps if lung is not adequately collapsed, affect inflammation, oxygenation, postoperative pulmonary complications, operative time, and the duration of one-lung ventilation. Participants will
- Undergo UVATS under general anesthesia
- Have a double-lumen breathing tube placed as part of the standard anesthetic care
- Be randomly assigned to either receive bronchial suction for one minute or receive no bronchial suction
- Have the surgical team assess the quality of lung collapse at different time points
- Have information collected from the routine anesthesia and surgical records such as oxygen levels during surgery, length of surgery and lung-related complications within 7 days after surgery
Detailed description
Uniportal video-assisted lung surgery (UVATS) is increasingly being performed in many centers. Due to a short interval between the skin incision and pleural opening, a rapid and adequate surgical lung collapse is important for optimal surgical exposure and operative efficiency. Delayed or inadequate lung collapse may interfere with the operative field, increase the need for manual lung manipulation by surgeons and possibly a resultant increase in lung inflammation. Brief bronchial suction through a double lumen tube has been used to facilitate lung collapse although its effectiveness is questionable in three-port VATS. This study aims to investigate if a brief bronchial suction helps achieve a better and faster lung collapse in UVATS.
Study objectives This randomized controlled trial aims to evaluate whether a brief suction through a tube in the non-ventilated lung leads to a better quality of lung collapse at one minute after the surgeon enters the chest. The study will compare the results between patients who receive a brief bronchial suction and those who do not.
Study design This is a randomized controlled trial conducted at a single university hospital in Thailand. Adult patients undergoing UVATS will be enrolled. A double-lumen endotracheal tube will be placed under general anesthesia as part of a standard anesthetic care. Patients will be randomly assigned to either receive a bronchial suction for one minute or no bronchial suction. The intervention group will undergo bronchial suction on two occasions: before pleural opening and immediately after pleural opening. Each suction period will last for 60 seconds.
The quality of lung collapse will be assessed by the surgical team at different time points during the surgery, including one minute after chest opening. Time to satisfactory lung collapse will also be evaluated.
Other perioperative data and outcome including requirement for additional steps in case of inadequate lung collapse, duration of one-lung ventilation, duration of surgery, incidence of intraoperative hypoxemia and postoperative pulmonary complications will also be collected.
Potential significance The findings from this study may help to optimize anesthetic management for patients undergoing VATS, particularly UVATS, and provide evidence on the effectiveness of bronchial suction on the quality and speed of lung collapse. The information may contribute to evidence-based recommendations on intraoperative strategies to improve lung collapse during minimally invasive lung surgery.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
- Model description
- Participants will be randomly assigned in a 1:1 ratio to either a bronchial suction group or a control group. Outcomes will be compared between the two parallel groups.
| Arm | Type | Receives |
|---|---|---|
| Bronchial suction | Experimental | Other: bronchial suctionParticipants will receive bronchial suction through the bronchoscopy port of the operative lumen of the double-lumen endotracheal tube |
| No bronchial suction | Sham comparator | Other: Sham ControlParticipants will undergo one-lung ventilation without bronchial suction |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Age ≥ 18 years old
- BMI ≤ 35 kg/m2
- American Society of Anesthesiologists (ASA) physical status I to III
- Scheduled for elective single-port video-assisted thoracoscopic surgery (VATS) at Siriraj Hospital
- Requirement for one-lung ventilation using a double-lumen tube (DLT)
Key exclusion criteria (6 listed)
- Previous thoracic surgery
- Known or suspected severe pleural adhesions based on preoperative imaging or clinical history
- Tracheobronchial anatomical abnormalities
- Pulmonary bullae identified on chest radiography or computed tomography, or a history of recurrent pneumothorax
- Forced vital capacity (FVC) < 50% of predicted
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| bronchial suctionParticipants will receive bronchial suction at -30 cmH₂O through the bronchoscopy port of the operative lumen of the double-lumen endotracheal tube on two occasions: (1) during a 60-second apnea period immediately before initiation of one-lung ventilation and (2) during a 60-second apnea period immediately after pleural opening. Following the first suction period, the bronchoscopy port of the operative lumen will be closed. The bronchoscopy port of the operative lumen will be opened to ambient air following the second suction period after pleural entry. | Other | Bronchial suction |
| Sham ControlParticipants will undergo the same 60-second apnea periods as the bronchial suction group immediately before initiation of one-lung ventilation and immediately after pleural opening. The suction device will be activated for 60 seconds to produce sham suction noise but will not be connected to the patient. | Other | No bronchial suction |
Primary outcome
Quality of lung collapse at 1 minute after pleural opening
Time frame: At 1 minute after pleural opening
Surgical team to assess quality of lung collapse at 1 minute after pleural opening by using lung collapse score (LCS). The higher the LCS, the better the lung collapse.
7 secondary outcomes
Quality of lung collapse at pleural opening, 5 minutes and 10 minutes after pleural opening
Time frame: At pleural opening, and at 5 and 10 minutes after pleural opening
Time to satisfactory lung collapse
Time frame: From pleural opening until the first LCS of 8 or greater, assessed up to 10 minutes after pleural opening
Requirement for rescue maneuvers for inadequate lung collapse
Time frame: From pleural opening until the end of one-lung ventilation during the index surgery up to 6 hours
Incidence of intraoperative hypoxemia
Time frame: From initiation of one-lung ventilation until resumption of two-lung ventilation during the index surgery up to 6 hours
Incidence of postoperative pulmonary complications
Time frame: From end of surgery through postoperative day 7 or hospital discharge, whichever occurs first
Total operative duration
Time frame: From surgical incision to completion of surgery during the index operation, up to 6 hours
Duration of one-lung ventilation
Time frame: From initiation of one-lung ventilation until resumption of two-lung ventilation during the index operation, up to 6 hours
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Oct 2026.
- Background: PubMed 28186222Miskovic A, Lumb AB. Postoperative pulmonary complications. Br J Anaesth. 2017 Mar 1;118(3):317-334. doi: 10.1093/bja/aex002.
- Background: PubMed 29661384Abbott TEF, Fowler AJ, Pelosi P, Gama de Abreu M, Moller AM, Canet J, Creagh-Brown B, Mythen M, Gin T, Lalu MM, Futier E, Grocott MP, Schultz MJ, Pearse RM; StEP-COMPAC Group. A systematic review and consensus definitions for standardised end-points in perioperative medicine: pulmonary complications. Br J Anaesth. 2018 May;120(5):1066-1079. doi: 10.1016/j.bja.2018.02.007. Epub 2018 Mar 27.
- Background: PubMed 25389025Brassard CL, Lohser J, Donati F, Bussieres JS. Step-by-step clinical management of one-lung ventilation: continuing professional development. Can J Anaesth. 2014 Dec;61(12):1103-21. doi: 10.1007/s12630-014-0246-2. Epub 2014 Nov 12. English, French.
- Background: PubMed 25866435Engels GE, van Oeveren W. Biomarkers of lung injury in cardiothoracic surgery. Dis Markers. 2015;2015:472360. doi: 10.1155/2015/472360. Epub 2015 Mar 17.
- Background: PubMed 27134837Reinersman JM, Passera E, Rocco G. Overview of uniportal video-assisted thoracic surgery (VATS): past and present. Ann Cardiothorac Surg. 2016 Mar;5(2):112-7. doi: 10.21037/acs.2016.03.08.
- Background: PubMed 36309646Xiang YY, Chen Q, Tang XX, Cao L. Comparison of the effect of double-lumen endotracheal tubes and bronchial blockers on lung collapse in video-assisted thoracoscopic surgery: a systematic review and meta-analysis. BMC Anesthesiol. 2022 Oct 29;22(1):330. doi: 10.1186/s12871-022-01876-2.
- Background: PubMed 29312732Quan X, Yi J, Huang Y, Zhang X, Shen L, Li S. Bronchial suction does not facilitate lung collapse when using a double-lumen tube during video-assisted thoracoscopic surgery: a randomized controlled trial. J Thorac Dis. 2017 Dec;9(12):5244-5248. doi: 10.21037/jtd.2017.11.63.
- Background: PubMed 31115153Zhang Y, Yan W, Fan Z, Kang X, Tan H, Fu H, Li Z, Chen KN, Chen J. Preemptive one lung ventilation enhances lung collapse during thoracoscopic surgery: A randomized controlled trial. Thorac Cancer. 2019 Jun;10(6):1448-1452. doi: 10.1111/1759-7714.13091. Epub 2019 May 21.
- Background: PubMed 24557112Yoshimura T, Ueda K, Kakinuma A, Sawai J, Nakata Y. Bronchial blocker lung collapse technique: nitrous oxide for facilitating lung collapse during one-lung ventilation with a bronchial blocker. Anesth Analg. 2014 Mar;118(3):666-70. doi: 10.1213/ANE.0000000000000106.
- Background: PubMed 33797018Somma J, Couture EJ, Pelletier S, Provencher S, Moreault O, Lohser J, Ugalde PA, Vigneault L, Lemieux J, Somma A, Guay SE, Bussieres JS. Non-ventilated lung deflation during one-lung ventilation with a double-lumen endotracheal tube: a randomized-controlled trial of occluding the non-ventilated endobronchial lumen before pleural opening. Can J Anaesth. 2021 Jun;68(6):801-811. doi: 10.1007/s12630-021-01957-9. Epub 2021 Apr 2.
- Background: PubMed 28619111Li Q, Zhang X, Wu J, Xu M. Two-minute disconnection technique with a double-lumen tube to speed the collapse of the non-ventilated lung for one-lung ventilation in thoracoscopic surgery. BMC Anesthesiol. 2017 Jun 15;17(1):80. doi: 10.1186/s12871-017-0371-x.
- Background: PubMed 25232695Pfitzner J. Facilitating lung collapse during one lung ventilation can be rational. Anesth Analg. 2014 Oct;119(4):1002-1003. doi: 10.1213/ANE.0000000000000336. No abstract available.
- Individual participant dataSharing planned: No. There is no current plan to share individual participant data outside the study team
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Nattaya Raykateeraroj, MD principal investigator
Siriraj Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing bronchial suction in people with Lung Collapse and One-lung Ventilation, run by Mahidol University at 1 site in Thailand.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 7 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Thailand. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Nattaya Raykateeraroj, MD (+66993519963, raykageeraroj@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Quality of lung collapse at 1 minute after pleural opening (time frame: At 1 minute after pleural opening). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07660588, which also lists 16 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Oct 2026.