Clinical trials: Lung Collapse
Pneumothorax, Atelectasis
Digital Air Leak Monitoring for Patients Undergoing Lung Resection
Often the decision for chest tube removal or trial of chest tube clamping is based on subjective assessment. This can lead to delay in chest tube removal.
- Trial name
- NCT01810172
- Testing
- Digital pleural drainage system, Dry suction pleura drainage device
- Where
- Canada
- Volunteers
- 216 people
- Sponsor
- Nova Scotia Health Authority
Atelectasis, Lung Cancer
Study of the Application of CPAP to Reduce Complications and Improve Lung Cancer Ablation Radiofrequency Treatment
The project aims to study whether the application of a continuous positive airway pressure (CPAP) of 4 cm water vapor is a safe method in pulmonary radiofrequency intervention (PRF) lung cancer under conscious sedation compared…
- Trial name
- CPAP-RFP (NCT02117908)
- Testing
- RESMED AUTOSET S9
- Where
- Spain
- Volunteers
- 47 people
- Sponsor
- Sara Varea
Septic Shock, Hemodynamic Instability
Whether a Minimal Volume Could Predict Fluid Responsiveness Using Thermodilution by PAC in Septic Shock Patients
Assessment of fluid responsiveness (FR) is to detect whether patient could benefit from fluid therapy. Mini fluid challenge has been widely used in clinical practice to prevent patients from volume overload.
- Conditions
- Septic Shock, Hemodynamic Instability, Fluid Therapy
- Trial name
- NCT04515511
- Testing
- 4% gelatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
RDS of Prematurity, Surfactant Deficiency Syndrome Neonatal
Surfactant Administration by Insure or Thin Catheter
This trial evaluates the efficacy and safety of surfactant administration with thin catheter technique together with analgesic premedication in comparison with the established INSURE-strategy.
- Conditions
- RDS of Prematurity, Surfactant Deficiency Syndrome Neonatal, Analgesia
- Trial name
- SAINT (NCT04445571)
- Testing
- Thin catheter technique or standard ET-tube for surfactant administration
- Where
- Sweden
- Volunteers
- 160 people
- Sponsor
- Karolinska Institutet
Complication, Postoperative
Perioperative Fluid Management: Goal-directed Versus Restrictive Strategy
There is no ideal "cookbook recipe" for fluid prescription that would fit every surgical patient. In this study, the investigators working hypothesis is that the adoption of an integrative algorithm for perioperative fluid and…
- Trial name
- NCT02625701
- Testing
- Goal-directed therapy, Restrictive fluid therapy
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital, Geneva
Pulmonary Complication, Dyspnea
Incentive Spirometry in Non-critically Ill Hospitalized Patients With Acute Respiratory Failure
To evaluate the use of Incentive Spirometry in Non-critically Ill Hospitalized Patients With Shortness of Breath.
- Conditions
- Pulmonary Complication, Dyspnea, Pneumonia, COPD
- Trial name
- NCT02873000
- Testing
- Incentive Spirometry
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Jewish Hospital, Cincinnati, Ohio
Bariatric Surgery Candidate
Effects of Alveolar Recruitment Strategies on Arterial Oxygenation and Postoperative Inflammatory Response During Laparoscopic Bariatric Surgery: A Randomised Control Trial.
even though the advancement of ambulatory bariatric surgeries, yet the precise spot of recruitment manoeuvres as a secure and efficient approach to enhance the respiratory efficacy of obese patients is still obscured.
- Trial name
- NCT05960071
- Testing
- protective lung strategy with recruitment manoeuvre (RM) - steady PEEP, protective lung strategy with recruitment manoeuvre (RM) - decreasing PEEP
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
SARS-CoV-2, Coronavirus
Personalized Health Education Against the Health Damage of Novel Coronavirus (COVID-19) Outbreak in Hungary
The additional effect of personalized health education compared to general education following the internationally accepted principles will be evaluated in the prevention of the serious course of the novel coronavirus infection.
- Conditions
- SARS-CoV-2, Coronavirus, COVID-19, 2019-nCoV
- Trial name
- PROACTIVE-19 (NCT04321928)
- Testing
- Personalized health education, General health education
- Where
- Hungary
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- University of Pecs
COVID-19, Cytokine Storm
Intercellular Adhesion Molecule-1 and TNF-α in Patients With COVID-19
This study aimed to assess the cytokine profile in COVID 19 patients and its relation with disease progression \& severity using COVID reporting and data system (CORADS) score.
- Trial name
- NCT05408325
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Segmental Lung Atelectasis
Segmental Lung Recruitment: a Randomized Controlled Trial
This study compares two ways of reopening collapsed parts of the lung in patients on a ventilator. In one group, doctors use a small camera (bronchoscope) to guide air pressure directly to the blocked part of the lung.
- Trial name
- NCT07442708
- Testing
- Segmental lung recruitment, Conventional lung recruitment
- Volunteers
- 20 people
- Sponsor
- Clinical Hospital Center Rijeka
Respiration, Artificial, Lung Diseases
Impact of Lung Recruitment Maneuvers on Driving Pressure in Cardiac Surgery
In anesthesia the incidence of postoperative pulmonary complications is frequent, especially in cardiac surgery where the incidence can reach 10%.
- Conditions
- Respiration, Artificial, Lung Diseases, Atelectasis, Cardiac Surgical Procedures
- Trial name
- IMPREMO (NCT03976947)
- Where
- France
- Volunteers
- 217 people
- Sponsor
- University Hospital, Caen
Atelectasis
Minimizing Lung Injury During Laparoscopy in Steep Trendelenburg Position
The investigators hypothesize that the level of PEEP is often suboptimally applied in certain operative conditions, such as in laparoscopy with head down (Trendelenburg) positioning.
- Trial name
- optiPEEP (NCT04900714)
- Testing
- Decremental PEEP, Lung ultrasound score, Blood gas analysis
- Where
- Belgium
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Coronavirus Infection, COVID
Cytokine Adsorption in Patients With Severe COVID-19 Pneumonia Requiring Extracorporeal Membrane Oxygenation
In December 2019 in the city of Wuhan in China, a series of patients with unclear pneumonia was noticed, some of whom have died of it.
- Conditions
- Coronavirus Infection, COVID, SARS-CoV 2, Respiratory Failure
- Trial name
- CYCOV-II (NCT04385771)
- Testing
- vv-ECMO + cytokine adsorption (Cytosorb adsorber), vv-ECMO only (no cytokine adsorption)
- Where
- 3 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Dr. Alexander Supady
Patients With Respiratory Failure and Shocked
Effect of Arterio-venous ECMO on Severe Sepsis and ARDS
To evaluate and compare the effect of immunoadsorption effect of A-V ECMO on course of sepsis weaning from inotropes, weaning from the ventilator, duration of ICU stays and effect on mortality rate in patients with septic shock…
- Trial name
- NCT04555798
- Testing
- Meropenem Injection, A-V ECMO
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- Mohamed Gaber Allam
AIDS Pneumonia, Septic Shock
Clinical Application of Cytokine Adsorption Technique in AIDS Patients With Severe Pneumonia and/or Septic Shock
Observing the Real-World Application Effectiveness of Cytokine Immune Adsorption Technology in AIDS Patients with Severe Pneumonia or septic shock.
- Trial name
- NCT06145828
- Testing
- Cytokine Adsorption
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangzhou 8th People's Hospital
Circulatory Failure
Volume Expansion With Albumin vs. Crystalloid and Expiratory Lung Impedance
Acute circulatory failure reduces oxygen delivery below cellular requirements, potentially leading to organ failure. Intravenous fluids are generally administered with the aim of increasing cardiac output and restore organ…
- Trial name
- EXHALE (NCT04037644)
- Testing
- Fluid loading with Albumin, Fluid loading with Ringer Lactate
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- University of Milan
Chronic Bronchitis
Comparison Of Blow Bottle Positive Expiratory Pressure (BBPEP) Versus Acapella Among Patient With Chronic Bronchitis
Comparison of Blow Bottle Positive Expiratory pressure(BBPEP)versus acapella on Oxygenation ,peak Expiratory Flow Rate(PEFR)among patient with chronic bronchitis.
- Trial name
- NCT06086730
- Testing
- blow bottle positive expiratory pressure, acapella
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Severe Sepsis, Septic Shock
Studying Complement Inhibition in Early, Newly Developing Septic Organ Dysfunction
The trial enrolls patients with early severe sepsis or septic shock displaying at least one newly developed organ dysfunction and showing clinical evidence of pulmonary or abdominal infection.
- Trial name
- SCIENS (NCT02246595)
- Testing
- CaCP29
- Where
- 11 sites in Germany
- Volunteers
- 72 people
- Sponsor
- InflaRx GmbH
Thoracic Surgery, One-lung Ventilation
Intraoperative Neuromuscular Blockade and Postoperative Atelectasis
During one-lung ventilation in thoracic surgery, the intensity of neuromuscular blockade may change the compliance and resistance of ventilated lung, thereby affecting postoperative atelectasis.
- Trial name
- NCT03503565
- Testing
- intraoperative neuromuscular blockade
- Where
- South Korea
- Volunteers
- 118 people
- Sponsor
- Kyung Hee University Hospital at Gangdong
COVID-19, Fatigue
Differential Diagnosis of Persistent COVID-19 by Artificial Intelligence
The pandemic caused by SARS-CoV-2 infection has resulted, in addition to the well-known acute symptoms, in the emergence of persistent, diffuse and heterogeneous symptoms referred to as persistent COVID.
- Conditions
- COVID-19, Fatigue, Distress Respiratory Syndrome, Cognitive Dysfunction
- Trial name
- DICOPERIA (NCT05629793)
- Testing
- Experimental tests
- Where
- 7 sites in Spain
- Volunteers
- 136 people
- Sponsor
- Fundacin Biomedica Galicia Sur