Heart FailureNCT07662876
Moderate Intensity vs High Intensity Interval Training in Women With Heart Failure
A study testing moderate-intensity aerobic training and High-intensity interval training in people with Heart Failure, run by Riphah International University at 1 site in Pakistan.
Trial summary
To determine the effects of moderate intensity exercise vs high intensity interval training on functional capacity in women with heart failure To determine the effects of moderate intensity exercise vs high intensity interval training on quality of life in women with heart failure Read more about this study
- Who is it for?
- Ages 40 to 70 years, women only
- Conditions the study is for
- Heart Failure
- What is being tested?
- moderate-intensity aerobic training and High-intensity interval training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 64 participants
- Where
- 1 sitePakistan
- Study dates
- Jul 2026to Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 70 years
- Women only
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Women aged 40-70 years, diagnosed with Stable Heart Failure (NYHA class II or III).
- Clinically stable patients referred for exercise-based cardiac rehabilitation by the physician.
- Able to perform exercise testing (able to walk 150 meters on the six-minute walk test) before starting the program.
- Women willing to participate and provide informed consent.
Who cannot join
- Unstable Heart failure or myocardial infarction (< 4 weeks).
- Severe arrhythmias, uncontrolled hypertension, or ongoing chest pain during exercise.
- Orthopedic, neurological, or cognitive limitations preventing safe exercise participation.
- Any medical contraindication to exercise testing.
- Refusal or inability to provide informed consent or comply with the rehabilitation program.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site
Riphah International University
Islamabad, Fedral, 44000
Dua Yasin, MSPT*, +92 318 5084334, duayasin7@gmail.com
Dua Yasin, MSPT*
About this study
Official title: Effects of Moderate Intensity Exercise vs High Intensity Interval Training on Functional Capacity and Quality of Life in Women With Heart Failure
- To determine the effects of moderate intensity exercise vs high intensity interval training on functional capacity in women with heart failure
- To determine the effects of moderate intensity exercise vs high intensity interval training on quality of life in women with heart failure
- Conditions
- Heart Failure
- Being tested
- moderate-intensity aerobic training, High-intensity interval training
- Keywords
- Heart failure, Moderate Intensity, High Intensity Interval Training
- Medical subject headings
- Heart Failure
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
moderate-intensity aerobic trainingOther
Group A will undergo a moderate-intensity aerobic training program as part of a structured cardiac rehabilitation protocol. The program will be supervised sessions, conducted three times per week for 12 weeks. Each session will include approximately 30 minutes of aerobic exercise performed on a bicycle ergometer at an intensity of 60% of heart rate reserve (HRR)
High-intensity interval trainingOther
Group B will perform a high-intensity interval training (HIIT) program designed according to established cardiac rehabilitation protocols. Bicycle ergometer will be used, in which each session will begin with a 10-minute warm-up (lower limb large muscle stretches), followed by intervals performed at 80% of heart rate reserve (HRR) for 3 min, alternating with recovery periods at low intensity 40% of HRR for 3 min. The total exercise duration will be approximately 30 minutes per session, conducted three times weekly for 12 weeks under supervision. Participants will be encouraged to maintain self-directed exercise after the intervention period
| Study group | Role | What they receive |
|---|---|---|
| moderate-intensity aerobic training | Active comparator | Not described Receives: Other: moderate-intensity aerobic training |
| High-intensity interval training | Experimental | Not described Receives: Other: High-intensity interval training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Six-minute walk test
The Six-Minute Walk Test (6MWT) is a simple, submaximal test that evaluates functional capacity and exercise capacity in patients with chronic heart failure by measuring the distance walked and estimating peak VO2. It will be performed in a 30-meter corridor, where participants will walk as far as possible in six minutes, with heart rate and oxygen saturation monitored before and after the test. This study tested the validity and reliability of the six-minute walk test (6MWT) in cardiac rehabilitation patients, including those with heart failure.
Measured: Baseline and 12 Week
EuroQol 5-Dimension Questionnaire
EuroQol 5-Dimension Questionnaire (EQ-5D): The EuroQol-5 Dimension (EQ-5D) is a questionnaire used to measure quality of life (QoL). It evaluates five key areas: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Each area has one question, and responses together describe a person's overall health status. For the 5L, scores range from 5 to 25. A lower score indicates better health, while a higher score indicates greater health problems. Patients rate their overall health TODAY on a vertical scale from 0 (worst imaginable health) to 100 (best imaginable health)
Measured: Baseline and 12 week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Jun 2026
- Study startJul 2026 (estimated)
- Primary completionDec 2026 (estimated)
- Study completionDec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Heart FailureStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 64 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Muhammad iqbal Tariq, PhD*, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07662876
- Sponsor's protocol ID
- Dua Yasin
- Status last verified
- Jun 2026
- First submitted
- 17 Jun 2026
- Last updated
- 23 Jun 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 23 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Moderate Intensity Exercise vs High Intensity Interval Training on Functional Capacity and Quality of Life in Women With Heart Failure
- ClinicalTrials.gov ID
- NCT07662876
- Acronym / sponsor ID
- Dua Yasin
- Conditions
- Heart Failure
- Keywords
- Heart failure, Moderate Intensity, High Intensity Interval Training
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 64 participants (estimated)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- Jul 2026 (estimated)
- Primary completion
- Dec 2026 (estimated)
- Study completion
- Dec 2026 (estimated)
- First posted
- 23 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
- To determine the effects of moderate intensity exercise vs high intensity interval training on functional capacity in women with heart failure
- To determine the effects of moderate intensity exercise vs high intensity interval training on quality of life in women with heart failure
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| moderate-intensity aerobic training | Active comparator | Other: moderate-intensity aerobic training |
| High-intensity interval training | Experimental | Other: High-intensity interval training |
Who may qualify
- Ages
- 40 to 70 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Women aged 40-70 years, diagnosed with Stable Heart Failure (NYHA class II or III).
- Clinically stable patients referred for exercise-based cardiac rehabilitation by the physician.
- Able to perform exercise testing (able to walk 150 meters on the six-minute walk test) before starting the program.
- Women willing to participate and provide informed consent.
Key exclusion criteria (5 listed)
- Unstable Heart failure or myocardial infarction (< 4 weeks).
- Severe arrhythmias, uncontrolled hypertension, or ongoing chest pain during exercise.
- Orthopedic, neurological, or cognitive limitations preventing safe exercise participation.
- Any medical contraindication to exercise testing.
- Refusal or inability to provide informed consent or comply with the rehabilitation program.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| moderate-intensity aerobic trainingGroup A will undergo a moderate-intensity aerobic training program as part of a structured cardiac rehabilitation protocol. The program will be supervised sessions, conducted three times per week for 12 weeks. Each session will include approximately 30 minutes of aerobic exercise performed on a bicycle ergometer at an intensity of 60% of heart rate reserve (HRR) | Other | moderate-intensity aerobic training |
| High-intensity interval trainingGroup B will perform a high-intensity interval training (HIIT) program designed according to established cardiac rehabilitation protocols. Bicycle ergometer will be used, in which each session will begin with a 10-minute warm-up (lower limb large muscle stretches), followed by intervals performed at 80% of heart rate reserve (HRR) for 3 min, alternating with recovery periods at low intensity 40% of HRR for 3 min. The total exercise duration will be approximately 30 minutes per session, conducted three times weekly for 12 weeks under supervision. Participants will be encouraged to maintain self-directed exercise after the intervention period | Other | High-intensity interval training |
Primary outcome
Six-minute walk test
Time frame: Baseline and 12 Week
The Six-Minute Walk Test (6MWT) is a simple, submaximal test that evaluates functional capacity and exercise capacity in patients with chronic heart failure by measuring the distance walked and estimating peak VO2. It will be performed in a 30-meter corridor, where participants will walk as far as possible in six minutes, with heart rate and oxygen saturation monitored before and after the test. This study tested the validity and reliability of the six-minute walk test (6MWT) in cardiac rehabilitation patients, including those with heart failure.
EuroQol 5-Dimension Questionnaire
Time frame: Baseline and 12 week
EuroQol 5-Dimension Questionnaire (EQ-5D): The EuroQol-5 Dimension (EQ-5D) is a questionnaire used to measure quality of life (QoL). It evaluates five key areas: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Each area has one question, and responses together describe a person's overall health status. For the 5L, scores range from 5 to 25. A lower score indicates better health, while a higher score indicates greater health problems. Patients rate their overall health TODAY on a vertical scale from 0 (worst imaginable health) to 100 (best imaginable health)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Jun 2026.
- Individual participant dataSharing planned: No
Related trials for Heart Failure
RecruitingPhase 4
The Effects of Ferric Derisomaltose in Patients With Acute Heart Failure and Iron Deficiency on Exercise Capacity and Quality of Life(COREVIVE-HFrEF)
Heart Failure With Reduced Ejection Fraction, Iron Deficiency
Not yet recruitingPhase 2
A Study of Bimagrumab in Participants With HFpEF
Heart Failure, Diastolic, Diastolic Heart Failure
Recruiting
Evaluation of a French Hospital Discharge Therapeutic Education Program by Nurses for Heart Failure Patient (EduSor)
Heart Failure
Active, not recruiting
Assessment of Combined CCM and ICD Device in HFrEF
Heart Failure, Heart Failure With Reduced Ejection Fraction
Not yet recruiting
RELIEVE-HFrEF TRIAL: REducing Lung congestIon Symptoms Using the v-wavE Shunt in adVancEd Heart Failure With Reduced EF
Heart Failure and Reduced Ejection Fraction, Heart Failure Chronic
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Muhammad iqbal Tariq, PhD* principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing moderate-intensity aerobic training and High-intensity interval training in people with Heart Failure, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 23 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Muhammad Iqbal Tariq (333826752, iqbal.tariq@riphah.edu.pk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Six-minute walk test (time frame: Baseline and 12 Week). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jun 2026.