Facial AgingFRANCT07664280
Effect of Single Facial Acupuncture on Dermal Structure and Appearance Satisfaction
A study testing Facial Rejuvenation Acupuncture (FRA) in people with Facial Aging and Wrinkles, run by Far Eastern Memorial Hospital at 1 site in Taiwan.
Trial summary
This study aims to investigate the effects of a single session of facial rejuvenation acupuncture on skin structure and personal satisfaction with facial appearance. As facial aging involves complex changes in muscles, skin, and soft tissues, facial acupuncture is considered a potential minimally invasive treatment to… Read more about this study
- Who is it for?
- Ages 30 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Facial Aging, Wrinkles, Skin Aging
- What is being tested?
- Facial Rejuvenation Acupuncture (FRA)
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteTaiwan
- Study dates
- 11 Jun 2026to 31 Aug 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Adults aged 30 to 60 years old. Individuals concerned about facial aging issues.
- Individuals without severe chronic diseases.
Who cannot join
- Pregnant women.
- Individuals with coagulation disorders.
- Individuals with a keloid constitution or tendency for abnormal scarring.
- Individuals with acute or chronic facial hemiplegia/paralysis of any cause.
- Individuals who have undergone facial cosmetic surgery or cosmetic injections within the past 6 months.
- Individuals currently taking anticoagulant medications.
Show all 9Show fewer
- Individuals with active skin infections.
- Individuals with a history of severe allergies.
- Individuals otherwise deemed unsuitable for facial acupuncture by the investigators.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Taiwan1 site, 1 recruiting
- Recruiting
Neihu Lixin TCM Clinic
Taipei, 114
Jui-Pin Shen, physician, +886-2-2633-1255, bingosjp@gmail.com
About this study
Official title: Effects of Single-Session Facial Acupuncture on Dermal Structure and Aesthetic Satisfaction: A Randomized Controlled Trial Combining High-Frequency Ultrasound and Patient-Reported Outcomes
This study aims to investigate the effects of a single session of facial rejuvenation acupuncture on skin structure and personal satisfaction with facial appearance. As facial aging involves complex changes in muscles, skin, and soft tissues, facial acupuncture is considered a potential minimally invasive treatment to help restore balance and promote tissue repair.
Researchers will enroll 60 healthy adults aged 30 to 60 who are concerned about facial aging. Participants will be randomly assigned to either an immediate intervention group or a waitlist control group. The intervention group will receive one session of facial acupuncture at the start of the study. The control group will continue their normal daily skincare routine for 6 weeks, after which they will receive the same single acupuncture treatment.
All participants will be monitored weekly for 6 weeks. The research team will use non-invasive tools, including high-frequency skin ultrasound, 3D facial scanning, and a digital complexion analysis system, to objectively measure changes in skin thickness, facial volume, and wrinkles. Participants will also complete questionnaires at various time points to share their satisfaction with their appearance, self-confidence, and quality of life.
Read the detailed description
Facial aging is a complex, multi-layered process involving cranial bone resorption, fat pad redistribution, and biomechanical imbalances within the superficial musculo-aponeurotic system (SMAS) and facial expression muscles. While conventional aesthetic treatments like botulinum toxin, dermal fillers, and surgical facelifts are effective, they are associated with potential limitations such as expression stiffness, vascular risks, high costs, and extended recovery times. Consequently, Facial Rejuvenation Acupuncture (FRA) has emerged as a minimally invasive alternative designed to promote endogenous tissue repair with minimal downtime.
The potential physiological mechanisms of FRA include: regulating myofascial tension by targeting specific expression muscles to restore biomechanical balance; initiating a wound-healing cascade via micro-trauma to stimulate collagen synthesis; and enhancing local microcirculation through axon reflexes. Despite its growing clinical popularity, most existing research focuses on the cumulative effects of 5 to 10 sessions, leaving a significant gap in understanding the temporal dynamics of a single intervention. It remains unclear whether a single FRA session produces only a short-term "Cinderella effect" or initiates a sustained tissue remodeling process. Furthermore, previous studies have heavily relied on subjective assessments rather than objective quantification.
To address these gaps, this single-blind, randomized, waitlist-controlled trial aims to systematically evaluate the short-to-mid-term biological effects of a single FRA session over a 6-week period. Sixty eligible adults (aged 30-60) will be randomly allocated via sealed envelopes to an intervention group or a waitlist control group. The intervention group receives a single comprehensive FRA treatment at Week 0, targeting 20 specific anatomical structures across the neck, jaw, perioral, cheek, periorbital, and fascial regions to release ligament adhesions and adjust muscle tension. The control group maintains routine non-invasive skincare for 6 weeks before receiving a compensatory FRA treatment. To establish robust evidence, objective multi-modal imaging and assessments will be conducted weekly for all participants.
These tools include:
1.High-Frequency Skin Ultrasound (DUB Cutis): To measure changes in dermal thickness and assess collagen density via echogenicity.
2.3D Facial Scanning (Morpheus 3D): To quantify mid-to-lower face soft tissue volume changes and evaluate lifting effects via curved length measurements. 3.Digital Skin Analysis (VISIA): To objectively assess wrinkle depth, quantity, and overall skin surface texture.
In parallel with objective imaging, Patient-Reported Outcome Measures (PROMs) will track subjective changes in appearance satisfaction, self-confidence, and quality of life. Data collected across the 7 time points (Baseline to Week 6) will be analyzed using Linear Mixed Models (LMM) to evaluate the dynamic trends and interactions of the treatment effects over time.
- Conditions
- Facial Aging, Wrinkles, Skin Aging
- Being tested
- Facial Rejuvenation Acupuncture (FRA)
- Keywords
- Facial Rejuvenation Acupuncture, Acupuncture Therapy, Dermal Thickness, Skin Rejuvenation, High-Frequency Ultrasound, 3D Facial Scanning, Facial Contouring, Patient Satisfaction
- Medical subject headings
- Patient Satisfaction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Facial Rejuvenation Acupuncture (FRA)Procedure or surgery
Also called Single-Session Facial Acupuncture, Cosmetic Acupuncture, Facial Rejuvenation Acupuncture, FRA
This intervention consists of a single, comprehensive session of Facial Rejuvenation Acupuncture (FRA). The procedure targets 20 specific anatomical structures across the neck, jaw, perioral, cheek, periorbital, and upper face regions. The acupuncturist uses specific needling techniques (e.g., flat, oblique, and deep insertions) to balance myofascial tension-relaxing hypertonic muscles (such as the corrugator and masseter) and stimulating hypotonic muscles (such as the zygomaticus major/minor). Additionally, ligament release techniques are applied to vertical and horizontal retaining ligaments to stimulate tissue remodeling. The intervention is administered once at Week 0 for the experimental arm, and once at Week 6 for the waitlist control arm.
| Study group | Role | What they receive |
|---|---|---|
| Single FRA | Experimental | Participants randomized to this arm will receive a single, comprehensive Facial Rejuvenation Acupuncture (FRA) session at Week 0. The treatment targets 20 key anatomical structures, including facial and neck muscles, as well as specific ligaments, to balance myofascial tension and stimulate tissue repair. Following the single intervention, participants will use only routine non-invasive skincare (moisturizer/lotion) and undergo weekly assessments using ultrasound, 3D scanning, and digital complexion analysis for 6 weeks. Receives: Procedure: Facial Rejuvenation Acupuncture (FRA) |
| Waitlist Control Group | No intervention | Participants randomized to this arm will not receive any active treatment during the primary 6-week study period. They are instructed to maintain their routine non-invasive daily skincare (using only basic moisturizer or lotion). During these 6 weeks, they will undergo the same weekly assessments as the experimental group. After the Week 6 assessments are completed, participants in this waitlist group will receive a compensatory single session of the same Facial Rejuvenation Acupuncture (FRA) provided to the experimental arm. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Dermal Thickness
Measured as the change in thickness (in µm) from the sub-epidermis to the upper margin of the subcutaneous fat layer using high-frequency skin ultrasound (DUB Cutis). This objective metric reflects the microstructural changes and extracellular matrix remodeling stimulated by the intervention.
Measured: Baseline (Week 0) to Week 6
Secondary outcomes (7)
Change in Facial Volume and Contour
Measured as the difference in mid-to-lower face soft tissue volume (in cc) and changes in lifting curved length (e.g., from tragus to the corner of the mouth) using 3D facial scanning (Morpheus 3D Scanner).
Measured: Baseline (Week 0) to Week 6
Change in Skin Density
Assessed by analyzing the change in dermal echogenicity using a high-frequency skin ultrasound (DUB Cutis). Echogenicity is measured quantitatively as the pixel density, reported in percentage (%)
Measured: Baseline (Week 0) to Week 6
Change in Wrinkle Depth
Quantified measurement of wrinkle depth using a digital complexion analysis system (VISIA). Reported in millimeters (mm).
Measured: Baseline (Week 0) to Week 6
Change in Wrinkle Quantity
Quantified measurement of the absolute number of wrinkles using a digital complexion analysis system (VISIA). Reported as a count.
Measured: Baseline (Week 0) to Week 6
Change in Patient-Reported Appearance Satisfaction
Assessed using standardized questionnaires to evaluate the patient's subjective changes in appearance satisfaction, self-confidence, and quality of life/social function scores.
Measured: Assessed using the FACE-Q Satisfaction with Appearance Scale. Higher scores indicate a better outcome (greater satisfaction with appearance).
Change in Skin Surface Smoothness
Quantified measurement of overall skin surface smoothness using a digital complexion analysis system (VISIA). Reported in Absolute Score where a higher value indicates smoother skin.
Measured: Baseline (Week 0) to Week 6
Change in Quality of Life
Description: Assessed using the Dermatology Life Quality Index. Higher scores indicate a worse outcome (greater negative impact on quality of life).
Measured: Baseline (Week 0) to Week 6
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Jun 2026
- Study start11 Jun 2026
- Primary completion31 Aug 2027 (estimated)
- Study completion31 Aug 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Facial AgingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This is a single-blind, randomized, waitlist-controlled trial. Participants are randomized into two parallel groups. The intervention group receives a single session of facial rejuvenation acupuncture at Week 0. The waitlist control group receives no intervention (maintains routine skincare) for the first 6 weeks, and then receives a compensatory single session of facial acupuncture at Week 6.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Far Eastern Memorial Hospital
- Sponsor type
- University, hospital or other
- Collaborators
- Neihu Lixin TCM Clinic
- Responsible party
- Principal investigator, Jen-Tang Sun, Far Eastern Memorial Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07664280
- Sponsor's protocol ID
- 115070-F
- Acronym
- FRA
- Status last verified
- Jun 2026
- First submitted
- 11 Jun 2026
- Last updated
- 24 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: We do not plan to share Individual Participant Data (IPD) with other researchers. According to the approved Institutional Review Board (IRB) protocol and informed consent form, all participant data will be strictly de-identified and managed under the principle of minimum necessary use. The data will be securely stored on encrypted drives accessible only to authorized research team members. To protect participant privacy and strictly comply with data protection regulations, individual-level data will not be made publicly available, nor will it be shared for secondary research purposes outside the scope of this specific trial.
Publications
Haghir H, Yazdanpanah MJ, Khadem-Rezaiyan M, Bidouei F, Azizi H. Effects of Face and Body Acupuncture on Glabellar Frown Lines in Women Aged 30-59: a Study Protocol for a Double-Arm Randomized Waitlist-Controlled Trial. J Acupunct Meridian Stud. 2024 Dec 31;17(6):221-228. doi: 10.51507/j.jams.2024.17.6.221.
PubMed 39722645Haghir H, Yazdanpanah MJ, Farahmand SK, Khadem-Rezaiyan M, Azizi H. Is Acupuncture Effective in Diminishing Frown Lines? Evidence From a Randomized Controlled Trial. J Cosmet Dermatol. 2025 Apr;24(4):e70144. doi: 10.1111/jocd.70144.
PubMed 40193060Rerksuppaphol L, Charoenpong T, Rerksuppaphol S. Randomized clinical trial of facial acupuncture with or without body acupuncture for treatment of melasma. Complement Ther Clin Pract. 2016 Feb;22:1-7. doi: 10.1016/j.ctcp.2015.10.004. Epub 2015 Oct 30.
PubMed 26850796Yun Y, Choi I. Effect of thread embedding acupuncture for facial wrinkles and laxity: a single-arm, prospective, open-label study. Integr Med Res. 2017 Dec;6(4):418-426. doi: 10.1016/j.imr.2017.09.002. Epub 2017 Sep 19.
PubMed 29296569
Study at a glance
From the registry record, last updated by the sponsor on 24 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Single-Session Facial Acupuncture on Dermal Structure and Aesthetic Satisfaction: A Randomized Controlled Trial Combining High-Frequency Ultrasound and Patient-Reported Outcomes
- ClinicalTrials.gov ID
- NCT07664280
- Acronym / sponsor ID
- FRA / 115070-F
- Conditions
- Facial Aging, Wrinkles, Skin Aging
- Keywords
- Facial Rejuvenation Acupuncture, Acupuncture Therapy, Dermal Thickness, Skin Rejuvenation, High-Frequency Ultrasound, 3D Facial Scanning, Facial Contouring, Patient Satisfaction
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Far Eastern Memorial HospitalUniversity, hospital or other
- Collaborators
- Neihu Lixin TCM Clinic
- Study start
- 11 Jun 2026 (actual)
- Primary completion
- 31 Aug 2027 (estimated)
- Study completion
- 31 Aug 2027 (estimated)
- First posted
- 24 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to investigate the effects of a single session of facial rejuvenation acupuncture on skin structure and personal satisfaction with facial appearance. As facial aging involves complex changes in muscles, skin, and soft tissues, facial acupuncture is considered a potential minimally invasive treatment to help restore balance and promote tissue repair.
Researchers will enroll 60 healthy adults aged 30 to 60 who are concerned about facial aging. Participants will be randomly assigned to either an immediate intervention group or a waitlist control group. The intervention group will receive one session of facial acupuncture at the start of the study. The control group will continue their normal daily skincare routine for 6 weeks, after which they will receive the same single acupuncture treatment.
All participants will be monitored weekly for 6 weeks. The research team will use non-invasive tools, including high-frequency skin ultrasound, 3D facial scanning, and a digital complexion analysis system, to objectively measure changes in skin thickness, facial volume, and wrinkles. Participants will also complete questionnaires at various time points to share their satisfaction with their appearance, self-confidence, and quality of life.
Detailed description
Facial aging is a complex, multi-layered process involving cranial bone resorption, fat pad redistribution, and biomechanical imbalances within the superficial musculo-aponeurotic system (SMAS) and facial expression muscles. While conventional aesthetic treatments like botulinum toxin, dermal fillers, and surgical facelifts are effective, they are associated with potential limitations such as expression stiffness, vascular risks, high costs, and extended recovery times. Consequently, Facial Rejuvenation Acupuncture (FRA) has emerged as a minimally invasive alternative designed to promote endogenous tissue repair with minimal downtime.
The potential physiological mechanisms of FRA include: regulating myofascial tension by targeting specific expression muscles to restore biomechanical balance; initiating a wound-healing cascade via micro-trauma to stimulate collagen synthesis; and enhancing local microcirculation through axon reflexes. Despite its growing clinical popularity, most existing research focuses on the cumulative effects of 5 to 10 sessions, leaving a significant gap in understanding the temporal dynamics of a single intervention. It remains unclear whether a single FRA session produces only a short-term "Cinderella effect" or initiates a sustained tissue remodeling process. Furthermore, previous studies have heavily relied on subjective assessments rather than objective quantification.
To address these gaps, this single-blind, randomized, waitlist-controlled trial aims to systematically evaluate the short-to-mid-term biological effects of a single FRA session over a 6-week period. Sixty eligible adults (aged 30-60) will be randomly allocated via sealed envelopes to an intervention group or a waitlist control group. The intervention group receives a single comprehensive FRA treatment at Week 0, targeting 20 specific anatomical structures across the neck, jaw, perioral, cheek, periorbital, and fascial regions to release ligament adhesions and adjust muscle tension. The control group maintains routine non-invasive skincare for 6 weeks before receiving a compensatory FRA treatment. To establish robust evidence, objective multi-modal imaging and assessments will be conducted weekly for all participants.
These tools include:
1.High-Frequency Skin Ultrasound (DUB Cutis): To measure changes in dermal thickness and assess collagen density via echogenicity.
2.3D Facial Scanning (Morpheus 3D): To quantify mid-to-lower face soft tissue volume changes and evaluate lifting effects via curved length measurements. 3.Digital Skin Analysis (VISIA): To objectively assess wrinkle depth, quantity, and overall skin surface texture.
In parallel with objective imaging, Patient-Reported Outcome Measures (PROMs) will track subjective changes in appearance satisfaction, self-confidence, and quality of life. Data collected across the 7 time points (Baseline to Week 6) will be analyzed using Linear Mixed Models (LMM) to evaluate the dynamic trends and interactions of the treatment effects over time.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- This is a single-blind, randomized, waitlist-controlled trial. Participants are randomized into two parallel groups. The intervention group receives a single session of facial rejuvenation acupuncture at Week 0. The waitlist control group receives no intervention (maintains routine skincare) for the first 6 weeks, and then receives a compensatory single session of facial acupuncture at Week 6.
| Arm | Type | Receives |
|---|---|---|
| Single FRA | Experimental | Procedure: Facial Rejuvenation Acupuncture (FRA)Participants randomized to this arm will receive a single, comprehensive Facial Rejuvenation Acupuncture (FRA) session at Week 0. The treatment targets 20 key anatomical structures, including facial and neck muscles, as well as specific ligaments, to balance myofascial tension and stimulate tissue repair. Following the single intervention, participants will use only routine non-invasive skincare (moisturizer/lotion) and undergo weekly assessments using ultrasound, 3D scanning, and digital complexion analysis for 6 weeks. |
| Waitlist Control Group | No intervention | –Participants randomized to this arm will not receive any active treatment during the primary 6-week study period. They are instructed to maintain their routine non-invasive daily skincare (using only basic moisturizer or lotion). During these 6 weeks, they will undergo the same weekly assessments as the experimental group. After the Week 6 assessments are completed, participants in this waitlist group will receive a compensatory single session of the same Facial Rejuvenation Acupuncture (FRA) provided to the experimental arm. |
Who may qualify
- Ages
- 30 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Adults aged 30 to 60 years old. Individuals concerned about facial aging issues.
- Individuals without severe chronic diseases.
Key exclusion criteria (9 listed)
- Pregnant women.
- Individuals with coagulation disorders.
- Individuals with a keloid constitution or tendency for abnormal scarring.
- Individuals with acute or chronic facial hemiplegia/paralysis of any cause.
- Individuals who have undergone facial cosmetic surgery or cosmetic injections within the past 6 months.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Facial Rejuvenation Acupuncture (FRA)Also: Single-Session Facial Acupuncture, Cosmetic Acupuncture, Facial Rejuvenation Acupuncture, FRAThis intervention consists of a single, comprehensive session of Facial Rejuvenation Acupuncture (FRA). The procedure targets 20 specific anatomical structures across the neck, jaw, perioral, cheek, periorbital, and upper face regions. The acupuncturist uses specific needling techniques (e.g., flat, oblique, and deep insertions) to balance myofascial tension-relaxing hypertonic muscles (such as the corrugator and masseter) and stimulating hypotonic muscles (such as the zygomaticus major/minor). Additionally, ligament release techniques are applied to vertical and horizontal retaining ligaments to stimulate tissue remodeling. The intervention is administered once at Week 0 for the experimental arm, and once at Week 6 for the waitlist control arm. | Procedure or surgery | Single FRA |
Primary outcome
Change in Dermal Thickness
Time frame: Baseline (Week 0) to Week 6
Measured as the change in thickness (in µm) from the sub-epidermis to the upper margin of the subcutaneous fat layer using high-frequency skin ultrasound (DUB Cutis). This objective metric reflects the microstructural changes and extracellular matrix remodeling stimulated by the intervention.
7 secondary outcomes
Change in Facial Volume and Contour
Time frame: Baseline (Week 0) to Week 6
Change in Skin Density
Time frame: Baseline (Week 0) to Week 6
Change in Wrinkle Depth
Time frame: Baseline (Week 0) to Week 6
Change in Wrinkle Quantity
Time frame: Baseline (Week 0) to Week 6
Change in Patient-Reported Appearance Satisfaction
Time frame: Assessed using the FACE-Q Satisfaction with Appearance Scale. Higher scores indicate a better outcome (greater satisfaction with appearance).
Change in Skin Surface Smoothness
Time frame: Baseline (Week 0) to Week 6
Change in Quality of Life
Time frame: Baseline (Week 0) to Week 6
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Jun 2026.
- Results publication: PubMed 39722645Haghir H, Yazdanpanah MJ, Khadem-Rezaiyan M, Bidouei F, Azizi H. Effects of Face and Body Acupuncture on Glabellar Frown Lines in Women Aged 30-59: a Study Protocol for a Double-Arm Randomized Waitlist-Controlled Trial. J Acupunct Meridian Stud. 2024 Dec 31;17(6):221-228. doi: 10.51507/j.jams.2024.17.6.221.
- Results publication: PubMed 40193060Haghir H, Yazdanpanah MJ, Farahmand SK, Khadem-Rezaiyan M, Azizi H. Is Acupuncture Effective in Diminishing Frown Lines? Evidence From a Randomized Controlled Trial. J Cosmet Dermatol. 2025 Apr;24(4):e70144. doi: 10.1111/jocd.70144.
- Results publication: PubMed 26850796Rerksuppaphol L, Charoenpong T, Rerksuppaphol S. Randomized clinical trial of facial acupuncture with or without body acupuncture for treatment of melasma. Complement Ther Clin Pract. 2016 Feb;22:1-7. doi: 10.1016/j.ctcp.2015.10.004. Epub 2015 Oct 30.
- Results publication: PubMed 29296569Yun Y, Choi I. Effect of thread embedding acupuncture for facial wrinkles and laxity: a single-arm, prospective, open-label study. Integr Med Res. 2017 Dec;6(4):418-426. doi: 10.1016/j.imr.2017.09.002. Epub 2017 Sep 19.
- Individual participant dataSharing planned: No. We do not plan to share Individual Participant Data (IPD) with other researchers. According to the approved Institutional Review Board (IRB) protocol and informed consent form, all participant data will be strictly de-identified and managed under the principle of minimum necessary use. The data will be securely stored on encrypted drives accessible only to authorized research team members. To protect participant privacy and strictly comply with data protection regulations, individual-level data will not be made publicly available, nor will it be shared for secondary research purposes outside the scope of this specific trial.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Facial Rejuvenation Acupuncture (FRA) in people with Facial Aging and Wrinkles, run by Far Eastern Memorial Hospital at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 24 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Jen-Tang Sun, physician (+88677281843, tangtang05231980@hotmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Dermal Thickness (time frame: Baseline (Week 0) to Week 6). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07664280, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Jun 2026.