Muscle FatigueMAMFNCT07665008
MULTİDİMENSİONAL ASSESSMENT OF MUSCLE FATİGUE İN SOCCER PLAYERS
An observational study of Muscle Fatigue, run by Giresun University at 1 site in Turkey (Türkiye).
Trial summary
Muscle fatigue is a multifactorial physiological phenomenon characterized by a reduction in the ability of a muscle to generate force during sustained or repetitive contractions. Read more about this study
- Who is it for?
- Ages 18 to 30 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Muscle Fatigue
- What is being tested?
- Neuromuscular Assessment Devices
- Type of treatment
- Medical device
- How many people
- 30 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Nov 2024to 15 Mar 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- Men only
- Healthy volunteers accepted
- Adult
Study population: Healthy male soccer players aged 18 to 30 years who were actively participating in regular football training and competition. Participants were recruited from football teams and underwent assessments of muscle thickness, surface electromyography (sEMG), accelerometer-derived mechanical vibration parameters, and isometric strength during laboratory-based testing sessions. Only individuals meeting all eligibility criteria and providing informed consent were included in the study.
Who may be able to join
- Healthy male soccer players aged 18-30 years
- No lower extremity injury within the previous six months
- No condition limiting lower extremity exercise performance
- No caffeine or stimulant consumption on the testing day
- Non-smoker
- Provided written informed consent
Who cannot join
- Female athletes
- Serious injury to the dominant leg within the previous year
- Intense exercise within the previous 24 hours
- Use of pain relievers or muscle relaxants on the testing day
- Inability to complete testing procedures
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Ordu University Faculty of Sports Sciences
Ordu, Merkez, 52100
About this study
Official title: MULTIDIMENSIONAL ASSESSMENT OF MUSCLE FATIGUE USING ACCELEROMETER, ELECTROMYOGRAPHY AND MUSCLE THICKNESS DATA
Muscle fatigue is a multifactorial physiological phenomenon characterized by a reduction in the ability of a muscle to generate force during sustained or repetitive contractions. This cross-sectional observational study aimed to investigate the relationships among muscle thickness, surface electromyography (sEMG) median frequency, accelerometer-derived mechanical vibration parameters, and isometric force characteristics in healthy male soccer players. Thirty participants aged 18-30 years underwent ultrasonographic muscle thickness assessment, synchronized sEMG and accelerometer recordings, and isometric strength testing at different knee flexion angles (90°, 60°, and 30°). The study evaluated the interaction between morphological, electrical, and mechanical indicators of muscle fatigue to support the development of multidimensional fatigue monitoring approaches.
Read the detailed description
Muscle fatigue is commonly assessed using surface electromyography (sEMG), particularly through frequency-domain parameters such as median frequency. However, fatigue-related changes are not limited to electrical activity and may also involve alterations in muscle mechanical behavior and morphological characteristics. Accelerometer-derived signals provide information regarding muscle vibrations and mechanical oscillations, while ultrasonographic measurements of muscle thickness provide information about muscle morphology and force-generating capacity.
The purpose of this study was to examine the relationships among muscle thickness, sEMG median frequency, accelerometer-derived mechanical vibration parameters, and isometric force variables during maximal voluntary isometric contractions performed at different knee flexion angles. Healthy male soccer players participated in a laboratory-based assessment protocol including ultrasonography, synchronized sEMG recordings, triaxial accelerometry, and isokinetic dynamometry.
Muscle thickness of the vastus lateralis obliquus (VLO), vastus medialis obliquus (VMO), and rectus femoris obliquus (RFO) muscles was measured using ultrasonography. Participants subsequently performed maximal voluntary isometric contractions at 90°, 60°, and 30° knee flexion angles. Surface electromyography, accelerometer signals, and force-related variables were recorded simultaneously. Median frequency values, acceleration-based root mean square (RMS) parameters, peak torque, mean torque, and time-to-peak torque variables were analyzed.
The study aimed to provide a multidimensional framework for muscle fatigue assessment by integrating morphological, electrical, and mechanical indicators and to explore their associations in healthy athletic populations.
- Conditions
- Muscle Fatigue
- Being tested
- Neuromuscular Assessment Devices
- Keywords
- Muscle Fatigue, Surface Electromyography, Accelerometry, Muscle Thickness, Mechanomyography
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Neuromuscular Assessment DevicesDevice
Participants underwent non-invasive neuromuscular assessment procedures using surface electromyography (sEMG), triaxial accelerometers, ultrasonography, and an isokinetic dynamometer. Measurements were performed during maximal voluntary isometric contractions at 30°, 60°, and 90° knee flexion angles. The devices were used exclusively for data collection and assessment purposes. No therapeutic, pharmacological, behavioral, or rehabilitative intervention was administered.
| Study group | Role | What they receive |
|---|---|---|
| Healthy Male Soccer Players | Healthy male soccer players aged 18-30 years who participated in a cross-sectional observational study. Participants underwent ultrasonographic muscle thickness assessment, surface electromyography (sEMG), accelerometer-based mechanical vibration measurements, and isometric strength testing during maximal voluntary isometric contractions performed at different knee flexion angles (30°, 60°, and 90°). Receives: Device: Neuromuscular Assessment Devices |
What is being measured
The primary outcome is the main question the study is designed to answer.
Surface Electromyography (sEMG) Median Frequency
Median frequency (Hz) obtained from the vastus lateralis obliquus (VLO), vastus medialis obliquus (VMO), and rectus femoris obliquus (RFO) muscles during maximal voluntary isometric contractions performed at 30°, 60°, and 90° knee flexion angles.
Measured: Day 1
Secondary outcomes (3)
Muscle Thickness
Ultrasonographic muscle thickness measurements of the VLO, VMO, and RFO muscles (mm).
Measured: Day 1
Accelerometer-Derived Mechanical Vibration Parameters
Root mean square (RMS) acceleration values obtained from thigh and shank triaxial accelerometers during isometric contractions.
Measured: Day 1
Isometric Strength Parameters
Peak torque, mean torque, and time-to-peak torque measured using an isokinetic dynamometer during maximal voluntary isometric contractions.
Measured: Day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Jun 2026
- Study start1 Nov 2024
- Primary completion20 Feb 2025
- Study completion15 Mar 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Muscle FatigueStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Giresun University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Tugce Namazci, Giresun University
- Investigators
- Tuğçe Namazcı, PhD, Principal investigator, Giresun Üniversitesi
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07665008
- Sponsor's protocol ID
- TN-2024-127
- Acronym
- MAMF
- Status last verified
- Jun 2026
- First submitted
- 12 Jun 2026
- Last updated
- 24 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be publicly shared. The study was conducted as part of a doctoral thesis, and no formal data-sharing plan has been established. Aggregate study results are reported in publications, while access to underlying data may be considered by the corresponding author on a reasonable request basis and in accordance with applicable ethical and institutional requirements.
Publications
Karthick PA, Venugopal G, Ramakrishnan S. Analysis of Muscle Fatigue Progression using Cyclostationary Property of Surface Electromyography Signals. J Med Syst. 2016 Jan;40(1):28. doi: 10.1007/s10916-015-0394-0. Epub 2015 Nov 7.
PubMed 26547848
Study at a glance
From the registry record, last updated by the sponsor on 24 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- MULTIDIMENSIONAL ASSESSMENT OF MUSCLE FATIGUE USING ACCELEROMETER, ELECTROMYOGRAPHY AND MUSCLE THICKNESS DATA
- ClinicalTrials.gov ID
- NCT07665008
- Acronym / sponsor ID
- MAMF / TN-2024-127
- Conditions
- Muscle Fatigue
- Keywords
- Muscle Fatigue, Surface Electromyography, Accelerometry, Muscle Thickness, Mechanomyography
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Giresun UniversityUniversity, hospital or other
- Study start
- 1 Nov 2024 (actual)
- Primary completion
- 20 Feb 2025 (actual)
- Study completion
- 15 Mar 2025 (actual)
- First posted
- 24 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Muscle fatigue is a multifactorial physiological phenomenon characterized by a reduction in the ability of a muscle to generate force during sustained or repetitive contractions. This cross-sectional observational study aimed to investigate the relationships among muscle thickness, surface electromyography (sEMG) median frequency, accelerometer-derived mechanical vibration parameters, and isometric force characteristics in healthy male soccer players. Thirty participants aged 18-30 years underwent ultrasonographic muscle thickness assessment, synchronized sEMG and accelerometer recordings, and isometric strength testing at different knee flexion angles (90°, 60°, and 30°). The study evaluated the interaction between morphological, electrical, and mechanical indicators of muscle fatigue to support the development of multidimensional fatigue monitoring approaches.
Detailed description
Muscle fatigue is commonly assessed using surface electromyography (sEMG), particularly through frequency-domain parameters such as median frequency. However, fatigue-related changes are not limited to electrical activity and may also involve alterations in muscle mechanical behavior and morphological characteristics. Accelerometer-derived signals provide information regarding muscle vibrations and mechanical oscillations, while ultrasonographic measurements of muscle thickness provide information about muscle morphology and force-generating capacity.
The purpose of this study was to examine the relationships among muscle thickness, sEMG median frequency, accelerometer-derived mechanical vibration parameters, and isometric force variables during maximal voluntary isometric contractions performed at different knee flexion angles. Healthy male soccer players participated in a laboratory-based assessment protocol including ultrasonography, synchronized sEMG recordings, triaxial accelerometry, and isokinetic dynamometry.
Muscle thickness of the vastus lateralis obliquus (VLO), vastus medialis obliquus (VMO), and rectus femoris obliquus (RFO) muscles was measured using ultrasonography. Participants subsequently performed maximal voluntary isometric contractions at 90°, 60°, and 30° knee flexion angles. Surface electromyography, accelerometer signals, and force-related variables were recorded simultaneously. Median frequency values, acceleration-based root mean square (RMS) parameters, peak torque, mean torque, and time-to-peak torque variables were analyzed.
The study aimed to provide a multidimensional framework for muscle fatigue assessment by integrating morphological, electrical, and mechanical indicators and to explore their associations in healthy athletic populations.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Healthy Male Soccer Players | – | Device: Neuromuscular Assessment DevicesHealthy male soccer players aged 18-30 years who participated in a cross-sectional observational study. Participants underwent ultrasonographic muscle thickness assessment, surface electromyography (sEMG), accelerometer-based mechanical vibration measurements, and isometric strength testing during maximal voluntary isometric contractions performed at different knee flexion angles (30°, 60°, and 90°). |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- Healthy male soccer players aged 18 to 30 years who were actively participating in regular football training and competition. Participants were recruited from football teams and underwent assessments of muscle thickness, surface electromyography (sEMG), accelerometer-derived mechanical vibration parameters, and isometric strength during laboratory-based testing sessions. Only individuals meeting all eligibility criteria and providing informed consent were included in the study.
Key inclusion criteria (6 listed)
- Healthy male soccer players aged 18-30 years
- No lower extremity injury within the previous six months
- No condition limiting lower extremity exercise performance
- No caffeine or stimulant consumption on the testing day
- Non-smoker
Key exclusion criteria (5 listed)
- Female athletes
- Serious injury to the dominant leg within the previous year
- Intense exercise within the previous 24 hours
- Use of pain relievers or muscle relaxants on the testing day
- Inability to complete testing procedures
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Neuromuscular Assessment DevicesParticipants underwent non-invasive neuromuscular assessment procedures using surface electromyography (sEMG), triaxial accelerometers, ultrasonography, and an isokinetic dynamometer. Measurements were performed during maximal voluntary isometric contractions at 30°, 60°, and 90° knee flexion angles. The devices were used exclusively for data collection and assessment purposes. No therapeutic, pharmacological, behavioral, or rehabilitative intervention was administered. | Device | Healthy Male Soccer Players |
Primary outcome
Surface Electromyography (sEMG) Median Frequency
Time frame: Day 1
Median frequency (Hz) obtained from the vastus lateralis obliquus (VLO), vastus medialis obliquus (VMO), and rectus femoris obliquus (RFO) muscles during maximal voluntary isometric contractions performed at 30°, 60°, and 90° knee flexion angles.
3 secondary outcomes
Muscle Thickness
Time frame: Day 1
Accelerometer-Derived Mechanical Vibration Parameters
Time frame: Day 1
Isometric Strength Parameters
Time frame: Day 1
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Jun 2026.
- Background: PubMed 26547848Karthick PA, Venugopal G, Ramakrishnan S. Analysis of Muscle Fatigue Progression using Cyclostationary Property of Surface Electromyography Signals. J Med Syst. 2016 Jan;40(1):28. doi: 10.1007/s10916-015-0394-0. Epub 2015 Nov 7.
- Published article related to muscle fatigue assessment using surface electromyographyLink provided by the sponsor.
- Individual participant dataSharing planned: No. Individual participant data will not be publicly shared. The study was conducted as part of a doctoral thesis, and no formal data-sharing plan has been established. Aggregate study results are reported in publications, while access to underlying data may be considered by the corresponding author on a reasonable request basis and in accordance with applicable ethical and institutional requirements.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Tuğçe Namazcı, PhD principal investigator
Giresun Üniversitesi
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Muscle Fatigue, run by Giresun University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Surface Electromyography (sEMG) Median Frequency (time frame: Day 1). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07665008, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Jun 2026.