Depigmentation TreatmentEffect of CoeNCT07677826
Effect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation
A study testing surgical depigmentation, Coenzyme Q10 and Vitamin C in people with Depigmentation Treatment and Depigmentation, run by Al-Azhar University at 1 site in Egypt.
Trial summary
This study aims to assess the clinical effectiveness of Co-enzyme Q10 and Vitamin C, applied individually or in combination after surgical gingival depigmentation. Read more about this study
- Who is it for?
- Ages 18 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Depigmentation Treatment, Depigmentation
- What is being tested?
- surgical depigmentation, Coenzyme Q10 and Vitamin C
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteEgypt
- Study dates
- 2 Mar 2026to 20 Dec 2026
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Systemically healthy patient of both genders aged from 18-45 years.
- Presence of bilateral physiologic gingival pigmentation in the anterior maxillary or mandibular region DOPI grades III-IV only.
- Good oral hygiene.
- Thick gingival phenotype.
Who cannot join
- Patient clinically diagnosed with periodontitis.
- Pregnant or lactating females.
- Patient with previous treatment of gingival hyperpigmentation.
- History of hypersensitivity to any study material.
- Patients who are active or previous smokers.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
nora abdelgawad abdelgawad, phd contact
Egypt1 site, 1 recruiting
- Recruiting
Faculty of dental medicine for girls? ALAZHAR University, Cairo, egypt
Nāşir
Nora Abdelgawad Associate professor, Phd, +×01019407891, Noramohamed.26@azhar.edu.eg
About this study
Official title: Ffect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation a Randomized Clinical Study
This study aims to assess the clinical effectiveness of Co-enzyme Q10 and Vitamin C, applied individually or in combination after surgical gingival depigmentation.
- Conditions
- Depigmentation Treatment, Depigmentation
- Being tested
- surgical depigmentation, Coenzyme Q10, Vitamin C, Surgical Gingival Depigmentation Coenzyme Q10 Vitamin C
- Medical subject headings
- Vitiligo
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
surgical depigmentationProcedure or surgery
Surgical gingival depigmentation performed using the conventional scalpel technique. The pigmented gingival epithelium is surgically removed under local anesthesia to eliminate melanin pigmentation and improve gingival esthetics.
Coenzyme Q10Dietary supplement
Coenzyme Q10 administered according to the study protocol following surgical gingival depigmentation to evaluate its effect on wound healing and gingival depigmentation.
Vitamin CDietary supplement
Vitamin C administered according to the study protocol following surgical gingival depigmentation to evaluate its effect on wound healing and gingival depigmentation.
Surgical Gingival Depigmentation Coenzyme Q10 Vitamin CDietary supplement
Coenzyme Q10 and vitamin c administered according to the study protocol following surgical gingival depigmentation to evaluate its effect on wound healing and gingival repigmentation.
| Study group | Role | What they receive |
|---|---|---|
| control | Active comparator | Surgical Depigmentation Alone Receives: Procedure: surgical depigmentation |
| test I | Experimental | Surgical Depigmentation + CoQ10 Receives: Procedure: surgical depigmentation; Dietary Supplement: Coenzyme Q10 |
| Test II | Experimental | Surgical Depigmentation + Vitamin C Receives: Procedure: surgical depigmentation; Dietary Supplement: Vitamin C |
| Test III | Experimental | Surgical Depigmentation + CoQ10 + Vitamin C Receives: Procedure: surgical depigmentation; Dietary Supplement: Surgical Gingival Depigmentation Coenzyme Q10 Vitamin C |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in gingival pigmentation intensity using the Dummett Oral Pigmentation Index (DOPI). The DOPI scale from 0 to 3, where:0 = No clinical pigmentation ,1 = Mild pigmentation , 2 = Moderate pigmentation 3 = Heavy pigmentation
Change in gingival pigmentation intensity that measured by using a standardized gingival pigmentation index (DOPI)
Measured: 1 week, 1 month and 3 months. ,6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Jul 2026
- Study start2 Mar 2026
- Primary completion1 Dec 2026 (estimated)
- Study completion20 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Depigmentation TreatmentStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Surgical gingival depigmentation performed using the conventional scalpel technique under local anesthesia. The pigmented gingival epithelium is surgically removed to eliminate physiologic melanin pigmentation and improve gingival esthetics. The procedure is performed as the standard treatment for gingival hyperpigmentation in all study participants.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Al-Azhar University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Nora Abdelgawad Mohamed, Al-Azhar University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07677826
- Sponsor's protocol ID
- P-ME-26-1
- Acronym
- Effect of Coe
- Status last verified
- Jun 2026
- First submitted
- 24 Jun 2026
- Last updated
- 1 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No