Clinical trials: Depigmentation Treatment
Vitiligo, Non-segmental Vitiligo
Comparison of Needling and Microneedling Plus Phototherapy in Localized Vitiligo Patients
This randomized controlled trial aims to compare the efficacy of needling versus microneedling, both followed by narrowband UVB therapy, in achieving repigmentation in patients with localized stable non-segmental vitiligo.
- Trial name
- NCT06991972
- Testing
- Needling + NBUVB, Microneedling + NBUVB
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Khyber Teaching Hospital
Vitiligo
The Investigation on the Expression of High Mobility Group Protein Box-1 (HMGB1) in Peripheral Blood of Vitiligo Patients and Healthy Controls According to Clinical Features, Treatment and Disease Activity
Vitiligo is an acquired depigmented disorder that causes white spots on the skin due to the loss of melanocytes. It is a common disease which accounts for 0.5-1% of the whole population.
- Trial name
- NCT03741738
- Where
- South Korea
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Vitiligo
The Value of Adding Mini-oral Pulse Steroid Therapy in Preventing Peri-lesional Halo Post Non-cultured Epidermal Cell Suspension (NCES) in Cases With Stable Segmental and Non-acral Vitiligo.
The goal of this clinical trial is to learn if adding mini-oral pulse steroid therapy improves the results of non-cultured epidermal cell suspension (NCES) surgery in patients with stable vitiligo.
- Trial name
- NCT07472816
- Testing
- Non-cultured epidermal cell suspension (NCES) surgery, Oral mini pulse, Excimer Sessions
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Vitiligo
Comparative Study of Techniques in Melanocyte-Keratinocyte Transplantation for the Treatment of Vitiligo
Previous studies have evaluated the transplantation of pigment cells (melanocytes)and skin cells (keratinocytes) for the treatment of vitiligo. This procedure is known as MKTP (Melanocyte Keratinocyte Transplantation Procedure).
- Trial name
- NCT01822379
- Testing
- Melanocyte Keratinocyte transplantation
- Where
- United States
- Sponsor
- Henry Ford Health System
Gingival Pigmentation, Depigmentation
Gingival Hyperpigmentation Treatment
It is a clinical study conducted to evaluate the effect of vitamin C and Glucathonine injection of pigmented gingival tissue versus surgical removal by scalpel
- Conditions
- Gingival Pigmentation, Depigmentation, Vitamin C, Glutathione
- Trial name
- NCT07595705
- Testing
- Vitamin c and glutathione, Surgical depigmentation
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Indolent Systemic Mastocytosis
Masitinib in Severe Indolent or Smoldering Systemic Mastocytosis
The objective of this study is to compare the safety and efficacy of masitinib (AB1010) to placebo in patients with mastocytosis with handicap.
- Trial name
- AB06006 (NCT00814073)
- Testing
- Masitinib, Best Supportive Care
- Where
- 24 sites in United States, France
- Volunteers
- 135 people
- Sponsor
- AB Science
Psoriasis, Atopic Dermatitis
LANDSCAPE: Demographics and Treatment Patterns of Patients With Immune-Mediated Inflammatory Skin Diseases in Italian Clinical Practice
This multicenter retrospective observational registry study will collect existing clinical data from Italian centers to describe epidemiology, treatment patterns, clinical evolution, safety, and comorbidities in patients aged 12…
- Conditions
- Psoriasis, Atopic Dermatitis, Vitiligo, Alopecia Areata
- Trial name
- LANDSCAPE (NCT07336641)
- Testing
- Conventional Systemic Therapies, Biologic Therapies
- Where
- Italy
- Volunteers
- 20,000 people
- Sponsor
- Fondazione ISIDE
Vitiligo
Evaluation of Efficacy of Microneedling and Topical Methotrexate Versus Microneedling and Topical 5-flourouracil in Treatment of Vitillgo Patients
Vitiligo is a depigmenting skin disorder, characterized by the selective loss of melanocytes, which in turn leads to loss of pigment in the affected areas of the skin It considerd as autoimmune disease, associated with genetic…
- Trial name
- NCT05467839
- Testing
- derma pen
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Upper Cross Syndrome
Effectiveness of Exercise in the Treatment of Upper Cross Syndrome
Upper cross syndrome (UCS) is a common postural deformity characterized by a change in neck, torso and shoulder muscle activity and shoulder movement.
- Trial name
- NCT06185322
- Testing
- Physical therapy program with upper cross syndrome specific exercises, Physical therapy program with conventional neck strengthening exercises
- Volunteers
- 30 people
- Sponsor
- Baskent University
Vitiligo
Effectiveness of Narrow-band Ultraviolet B Combined With Topical Tacrolimus 0.03% in Treatment of Patients With Vitiligo
The study will compare the effectiveness of combined treatment with NB-UVB and tacrolimus versus NB-UVB alone . Patients will be treated for 6 months and followed up after 3 months .All types of vitiligo will be included except…
- Trial name
- NCT03199664
- Testing
- NB-UVB, NB-UVB & Tacrolimus 0.03%
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- South Valley University
Vitiligo
The Value of Using Mini-oral Pulse Steroid Therapy Along With Non Cultured Epidermal Cell Suspension (NCES) in Stable Resistant Vitiligo
Assessing the additive value of mini-oral pulse steroid therapy in surgical treatment of acral and difficult to treat sites of vitiligo
- Trial name
- NCES (NCT06974669)
- Testing
- oral steroid-dexamethasone, non cultured epidermal suspension
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Vitiligo
Vitiligo Treated With TL01 Combined With Tacrolimus Ointment Versus Placebo
BACKGROUND Vitiligo is a common, often distressing condition. Many of the patients do not achieve sufficient effect from what is regarded as the treatment of choice at present, narrow band(NB)UVB(Tl01).
- Trial name
- NCT00807690
- Testing
- Tacrolimus ointment
- Sponsor
- Oslo University Hospital
Vitiligo
Efficacy of 311-nm Ti:Sapphire Laser Versus 308-nm Excimer Laser Treatment in Vitiligo
A randomized controlled non-inferiority trial based on split-body was planned to compare the efficacy of 308-nm excimer laser and 311-nm Ti:Sapphire laser in patients with vitiligo.
- Trial name
- NCT02925767
- Testing
- 311-nm Ti:Sapphire laser, 308-nm excimer laser
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Scars, Hypopigmented Scar
Treatment of Hypopigmented Scars With Bimatoprost
Patients who have hypo-pigmented burn scar will have two scars chosen and randomized to treated scar and control scar. The subject will then have both scars treated with fractional ablative CO2 laser (FLSR).
- Conditions
- Scars, Hypopigmented Scar, Hypopigmented Skin, Burn Scar
- Trial name
- NCT06122090
- Testing
- Bimatoprost, Saline
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Medstar Health Research Institute
Vitiligo
Comparison of Efficacy and Safety of 0.1% Tacrolimus and 0.1% Mometasone Furoate for Adult Vitiligo
Vitiligo has remained a difficult disease to treat. Previous available therapies are often ineffective. It usually takes several months or years for complete repigmentation and some areas of the body get at best only partial…
- Trial name
- NCT01333410
- Testing
- tacrolimus ointment, Mometasone furoate
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Mahidol University
Vitiligo, Halo Nevus
Nevus Removal vs. Conservative Treatment in Halo Nevus With Vitiligo: A Randomized Study
This clinical trial aims to compare the efficacy and safety of central nevus removal versus conservative treatment in patients with halo nevus accompanied by non-segmental vitiligo.
- Trial name
- NCT07307534
- Testing
- Central Nevus Excision, The Standardized Medication Regimen
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Vitiligo
Combination Approach With Ritlecitinib and nbUVB Compared to Ritlecitinib Alone for Treating Vitiligo
Vitiligo affects approximately 1 to 2% of the global population and significantly impacts people's quality of life. areas of high stress.
- Trial name
- COMBIVIT (NCT07152626)
- Testing
- LITFULO, LITFULO and UVB
- Where
- 5 sites in France
- Volunteers
- 56 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Vitiligo
Treatment of Acral Vitiligo : Narrowband Ultraviolet-B and Microneedling With and Without Platelet Rich Plasma
Vitiligo is a relatively common acquired chronic disorder of pigmentation characterized by the development of white macules on the skin due to loss of epidermal melanocytes .Affecting approximately 0.5%-2% of general population…
- Trial name
- NCT03155698
- Testing
- microneedling and Platelet rich plasma, NB-UVB phototherapy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Neck Pain
Upper Cross Syndrome Rehabilitation Strengthening of the Dorsal Erector Muscles
The purpose of this study is to determine which treatment is more effective for chronic neck pain associated with Upper Cross Syndrome.
- Trial name
- NCT04540614
- Testing
- Strengthening exercises programme
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Martín, Carlos García
Vitiligo Vulgaris
The Effect of Fractional Co2 Laser Either With Tacrolimus, Calcipotriol or NB-UVB in Stable Generalized Vitiligo
Vitiligo is an acquired disorder of the skin and mucous membranes characterized by well circumscribed depigmented macules and patches that occur secondary to selective destruction of melanocytes (Zhang et al., 2009).
- Trial name
- NCT03234673
- Testing
- Tacrolimus ointment, calcipotriol ointment, NB-UVB
- Volunteers
- 30 people
- Sponsor
- Assiut University