Out of Hospital Cardiac ArrestCHEER4TTENCT07679737
The CPR, Pre-hospital ECPR and Early Reperfusion Study: A Target Trial Emulation
An observational study of Out of Hospital Cardiac Arrest and Extracorporeal Cardiopulmonary Resuscitation, run by Australian and New Zealand Intensive Care Research Centre at 1 site in Australia.
Trial summary
CHEER4TTE is a target trial emulation, designed to simulate a randomised controlled trial by utilising data from pre-existing data sources. The aim is to determine whether prehospital ECPR for refractory out-of-hospital cardiac arrest improves the rate of survival to hospital discharge when compared to conventional… Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Out of Hospital Cardiac Arrest, Extracorporeal Cardiopulmonary Resuscitation
- What is being tested?
- Extracorporeal cardiopulmonary resuscitation
- How many people
- 250 participants
- Where
- 1 siteAustralia
- Study dates
- 1 Jan 2025to Oct 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients with refractory out-of-hospital cardiac arrest in the metropolitan regions of Sydney and Melbourne.
Who may be able to join
- Witnessed cardiac arrest
- Bystander CPR
- Refractory cardiac arrest (failure to achieve sustained ROSC >20 minutes)
- Initial cardiac rhythm VF, VT or PEA
- Within the hours of prehospital ECPR service operation
Who cannot join
- Initial cardiac rhythm asystole
- ROSC with sustained recovery
- Unable to reach the patient and commence cannulation within 45 minutes of onset of arrest
- Evidence of/suspected end-stage disease:
- severe disability impairing activities of daily living
- end-stage organ disease - cardiac, liver, lung, renal
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- other life-limiting diseases, e.g. malignancy, terminal illness
- advance health care directive
- Time periods of advanced public health restrictions in Victoria and NSW due to COVID-19
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The CPR, Pre-hospital ECPR and Early Reperfusion Study: A Target Trial Emulation (CHEER4TTE)
CHEER4TTE is a target trial emulation, designed to simulate a randomised controlled trial by utilising data from pre-existing data sources. The aim is to determine whether prehospital ECPR for refractory out-of-hospital cardiac arrest improves the rate of survival to hospital discharge when compared to conventional cardiac arrest care.
- Being tested
- Extracorporeal cardiopulmonary resuscitation
- Keywords
- ECMO, ECPR, Extracorporeal membrane oxygenation, ECMO CPR, at the scene, scene based, OHCA
- Medical subject headings
- Out-of-Hospital Cardiac Arrest
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Extracorporeal cardiopulmonary resuscitationOther
Also called Extracorporeal Cardiopulmonary Resuscitation (ECPR), Prehospital ECPR, Scene based ECPR
The Intervention being evaluated is the initiation of extracorporeal cardiopulmonary resuscitation (ECPR) at the scene, in addition to conventional cardiac arrest care.
| Study group | Role | What they receive |
|---|---|---|
| Prehospital Extracorporeal Cardiopulmonary Resuscitation (ECPR) Strategy | Patients with refractory OHCA treated with scene-based, pre-hospital ECPR (Intervention) will be identified within two studies testing feasibility of prehospital ECPR for refractory OHCA in the metropolitan regions of Melbourne and Sydney. All intra-arrest and post-arrest care follow guidelines based on the Australian and New Zealand Council of Resuscitation recommendations supplemented by the Victorian ECMO Service (VECMOS) guidelines within Victoria and Agency for Clinical Innovation ECMO Clinical Practice Guidelines in NSW. Receives: Other: Extracorporeal cardiopulmonary resuscitation | |
| Conventional Cardiac Arrest Strategy | Patients with refractory OHCA treated with conventional cardiac arrest strategy (standard care) will be identified within NSW and Victorian Ambulance OHCA Registries. All intra-arrest and post-arrest care for patients in this group follow guidelines based on the Australian and New Zealand Council of Resuscitation recommendations. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Survival to hospital discharge
Measured: From meeting full eligibility criteria until the date/time of death or hospital discharge, assessed up to 180 days
Secondary outcomes (5)
Low flow time
Measured: time from onset of arrest to time of ECPR flow, or time of death
ICU length of stay
Measured: From the date/time of ICU admission until the date/time of ICU discharge/death, assessed up to 180 days
Mechanical ventilation days
Measured: From date/time of mechanical ventilation commencement until date/time of liberation from mechanical ventilation assessed up to 180 days
ECMO complications
Measured: From the date/time of commencement of ECMO support until 1 week following the date/time of cessation of ECMO support
Rates of organ and tissue donation in non-survivors
Measured: In the 48hours following date/time of death
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Jul 2026
- Study start1 Jan 2025
- Primary completionOct 2026 (estimated)
- Study completionOct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Out of Hospital Cardiac ArrestStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Retrospective
- Enrolment
- 250 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Australian and New Zealand Intensive Care Research Centre
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07679737
- Sponsor's protocol ID
- ANZIC-RC/SR001
- Acronym
- CHEER4TTE
- Status last verified
- Jun 2026
- First submitted
- 9 Jun 2026
- Last updated
- 1 Jul 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 1 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The CPR, Pre-hospital ECPR and Early Reperfusion Study: A Target Trial Emulation (CHEER4TTE)
- ClinicalTrials.gov ID
- NCT07679737
- Acronym / sponsor ID
- CHEER4TTE / ANZIC-RC/SR001
- Keywords
- ECMO, ECPR, Extracorporeal membrane oxygenation, ECMO CPR, at the scene, scene based, OHCA
- Study type
- Observational
- Recruitment status
- Active, not recruiting
- Enrolment
- 250 participants (estimated)
- Lead sponsor
- Australian and New Zealand Intensive Care Research CentreUniversity, hospital or other
- Study start
- 1 Jan 2025 (actual)
- Primary completion
- Oct 2026 (estimated)
- Study completion
- Oct 2026 (estimated)
- First posted
- 1 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
CHEER4TTE is a target trial emulation, designed to simulate a randomised controlled trial by utilising data from pre-existing data sources. The aim is to determine whether prehospital ECPR for refractory out-of-hospital cardiac arrest improves the rate of survival to hospital discharge when compared to conventional cardiac arrest care.
Study design
- Observational model
- Other
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Prehospital Extracorporeal Cardiopulmonary Resuscitation (ECPR) Strategy | – | Other: Extracorporeal cardiopulmonary resuscitationPatients with refractory OHCA treated with scene-based, pre-hospital ECPR (Intervention) will be identified within two studies testing feasibility of prehospital ECPR for refractory OHCA in the metropolitan regions of Melbourne and Sydney. All intra-arrest and post-arrest care follow guidelines based on the Australian and New Zealand Council of Resuscitation recommendations supplemented by the Victorian ECMO Service (VECMOS) guidelines within Victoria and Agency for Clinical Innovation ECMO Clinical Practice Guidelines in NSW. |
| Conventional Cardiac Arrest Strategy | – | –Patients with refractory OHCA treated with conventional cardiac arrest strategy (standard care) will be identified within NSW and Victorian Ambulance OHCA Registries. All intra-arrest and post-arrest care for patients in this group follow guidelines based on the Australian and New Zealand Council of Resuscitation recommendations. |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients with refractory out-of-hospital cardiac arrest in the metropolitan regions of Sydney and Melbourne.
Key inclusion criteria (5 listed)
- Witnessed cardiac arrest
- Bystander CPR
- Refractory cardiac arrest (failure to achieve sustained ROSC >20 minutes)
- Initial cardiac rhythm VF, VT or PEA
- Within the hours of prehospital ECPR service operation
Key exclusion criteria (9 listed)
- Initial cardiac rhythm asystole
- ROSC with sustained recovery
- Unable to reach the patient and commence cannulation within 45 minutes of onset of arrest
- Evidence of/suspected end-stage disease:
- severe disability impairing activities of daily living
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Extracorporeal cardiopulmonary resuscitationAlso: Extracorporeal Cardiopulmonary Resuscitation (ECPR), Prehospital ECPR, Scene based ECPRThe Intervention being evaluated is the initiation of extracorporeal cardiopulmonary resuscitation (ECPR) at the scene, in addition to conventional cardiac arrest care. | Other | Prehospital Extracorporeal Cardiopulmonary Resuscitation (ECPR) Strategy |
Primary outcome
Survival to hospital discharge
Time frame: From meeting full eligibility criteria until the date/time of death or hospital discharge, assessed up to 180 days
5 secondary outcomes
Low flow time
Time frame: time from onset of arrest to time of ECPR flow, or time of death
ICU length of stay
Time frame: From the date/time of ICU admission until the date/time of ICU discharge/death, assessed up to 180 days
Mechanical ventilation days
Time frame: From date/time of mechanical ventilation commencement until date/time of liberation from mechanical ventilation assessed up to 180 days
ECMO complications
Time frame: From the date/time of commencement of ECMO support until 1 week following the date/time of cessation of ECMO support
Rates of organ and tissue donation in non-survivors
Time frame: In the 48hours following date/time of death
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Jul 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Out of Hospital Cardiac Arrest and Extracorporeal Cardiopulmonary Resuscitation, run by Australian and New Zealand Intensive Care Research Centre at 1 site in Australia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 1 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Australia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Survival to hospital discharge (time frame: From meeting full eligibility criteria until the date/time of death or hospital discharge, assessed up to 180 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Jul 2026; AzTrials last refreshed its copy on 6 Nov 2026.