Clinical trials: Out of Hospital Cardiac Arrest
Cardiac Arrest
Target-directed Management of Cerebral Oxygenation in Patients After Receiving ECPR
Neurological injury remains an important cause of morbidity and mortality in patients with ECPR. At present, the results of three prospective randomized controlled studies on ECPR are inconsistent, and it is inconclusive whether…
- Trial name
- TDMCO-ECPR (NCT06711016)
- Testing
- if rSO2 < 58%, if rSO2 58%-68%, rSO2>68%
- Where
- 2 sites in China
- Volunteers
- 654 people
- Sponsor
- Qilu Hospital of Shandong University
Non Shockable Out of Hospital Cardiac Arrest
Cyclosporine A in Cardiac Arrest
The investigators hypothesised that cyclosporine A administration at the onset of cardiopulmonary resuscitation, by inhibiting the mitochondrial permeability transition pore, could prevent the post cardiac arrest syndrome and…
- Trial name
- CYRUS (NCT01595958)
- Testing
- Cyclosporine A, cardio-pulmonary resuscitation
- Where
- France
- Volunteers
- 796 people
- Sponsor
- Hospices Civils de Lyon
Cardiac Arrest, Coma
Out-of-Hospital Intubation With Metal Single Use Laryngoscope Blades
New single use laryngoscope metal blades are available for intubation. This type of blade is safer than the reusable ones concerning the interhuman cross infection risk.
- Conditions
- Cardiac Arrest, Coma, Major Trauma, Respiratory Distress
- Trial name
- LAMETA (NCT00644722)
- Testing
- MacIntosh Green Lite (metal single use laryngoscope blades), MacIntosh Green Spec II (metal reusable laryngoscope blades)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Henri Mondor University Hospital
Cardiac Arrest
Prediction of Outcome in Out-of-Hospital Cardiac Arrest
In the course of prehospital respiratory and circulatory arrest, approximately 1000 persons are resuscitated by cardiopulmonary resuscitation in Upper Austria every year.
- Trial name
- PREDOHCA (NCT06030986)
- Testing
- ILCOR Utstein OHCA Core Outcome
- Where
- Austria
- Volunteers
- 10,000 people
- Sponsor
- Kepler University Hospital
Heart Arrest
Oxidative Stress and Cardiac Arrest
Cardiac arrest is a major health problem reaching 375000 cases in Europe each year. Only 5 to 31 % survive after an out of hospital cardiac arrest (OHCA). The main complication after OHCA is the anoxic encephalopathy.
- Trial name
- NCT00888966
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Institut d'Anesthesiologie des Alpes Maritimes
Out-of-Hospital Cardiac Arrest
Survival Study After Out-of-hospital Cardiac Arrest
The purpose of this study is to determine if dual dispatch of ambulance, fire fighters and/or police in out-of-hospital cardiac arrest (OHCA), can reduce the time to cardiopulmonary resuscitation (CPR) and defibrillation, thus…
- Trial name
- SAMS (NCT02184468)
- Testing
- Simultaneously dispatch of firefighters and/or police in case of OHCA
- Where
- Sweden
- Volunteers
- 6,000 people
- Sponsor
- Karolinska Institutet
Cardiac Arrest
Microcirculatory Perfusion in Patients With Coma After Out-of-hospital Cardiac Arrest
The hypothesis is: In patients after an out of hospital cardiac arrest, treated with therapeutic hypothermia (33°C) will be found significantly more microcirculatory abnormalities, compared to the same group of patients treated…
- Trial name
- NCT01850485
- Testing
- microcirculation by SDF and NIRS, in 33 and 36 degrees
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Frisius Medisch Centrum
Cardiac Arrest, Out-Of-Hospital Cardiac Arrest
Initial Double Sequential External Defibrillation in Out of Hospital Cardiac Arrest
Double Sequential External Defibrillation (DSED) represents an alternative treatment of refractory ventricular fibrillation (rVF) in out-of-hospital cardiac arrest (OHCA).
- Conditions
- Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation
- Trial name
- DUALDEFIB (NCT06672159)
- Testing
- Two defibrillators, One defibrillator
- Where
- Norway
- Volunteers
- 356 people
- Sponsor
- St. Olavs Hospital
Out-Of-Hospital Cardiac Arrest, Heart Arrest
The PulsePoint Study
This randomized controlled trial will evaluate whether use of the PulsePoint system increases bystander CPR or defibrillator use compared to standard dispatch procedures in patients who suffer non-traumatic, out-of-hospital…
- Conditions
- Out-Of-Hospital Cardiac Arrest, Heart Arrest, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT04806958
- Testing
- PulsePoint notification
- Where
- 2 sites in United States, Canada
- Volunteers
- 340 people
- Sponsor
- Dr. Steven Brooks
Cardiac Arrest, Heart Arrest
Rehabilitation for Survivors of Out-of-hospital Cardiac Arrest
This study is a parallel group multicentre investigator-initiated clinical randomised controlled superiority trial that will include a total of 214 survivors of OHCA.
- Conditions
- Cardiac Arrest, Heart Arrest, Cardiopulmonary Resuscitation, Return to Work
- Trial name
- NCT05173740
- Testing
- Individually tailored rehabilitation intervention, Usual care
- Where
- Denmark
- Volunteers
- 214 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Out-of-Hospital Cardiac Arrest
Early-onset Pneumonia After Out-of-hospital Cardiac Arrest
Early-onset pneumonia after out-of-hospital cardiac arrest is frequent. An association between early-onset pneumonia and an increase in morbidity has been reported in this population.
- Trial name
- PP-ACR (NCT03355885)
- Where
- France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Brest
Cardiac Arrest
The Haemodynamic Effects of Mechanical Standard and Active Chest Compression-decompression During Out-of-hospital CPR
The aim of this randomized out-of-hospital cardiopulmonary resuscitation study is to investigate haemodynamics generated by the standard mechanical external chest compression device (LUCAS™ 2) compared to a new version generating…
- Trial name
- NCT02479152
- Testing
- LUCAS2 AD
- Where
- Norway
- Volunteers
- 126 people
- Sponsor
- Physio-Control
Heart Arrest, Cardiac Arrest
Pre-arrival Instructions Effect on Bystander Cardiopulmonary Resuscitation (CPR).
The investigators hypothesized that pre-arrival instructions would increase the likelihood of bystanders performing Cardiopulmonary Resuscitation (CPR).
- Conditions
- Heart Arrest, Cardiac Arrest, Cardiopulmonary Arrest, Out of Hospital Cardiac Arrest
- Trial name
- NCT02007499
- Testing
- Pre-Arrival Instructions
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Medical College of Wisconsin
Post-Cardiac Arrest Syndrome, Post Cardiac Arrest Brain Injury
Cerebral Oximetry in Management of Post Cardiac Arrest
Resuscitation from a cardiac arrest is a common reason for admission to an intensive care unit (ICU). Because the brain is highly vulnerable to oxygen deprivation, severe brain damage often occurs during a cardiac arrest.
- Conditions
- Post-Cardiac Arrest Syndrome, Post Cardiac Arrest Brain Injury, Hypoxic-Ischemic Brain Injury
- Trial name
- COMPACT (NCT07829887)
- Testing
- Cerebral oximetry-guided treatment
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University of Calgary
Cardiac Arrest
Identification of Neurological Prognostic Markers of Cardiac Arrest Patients Alive on 3rd Day
The aim of the study is to identify prognostication predictors of 6-months neurological outcome in survivors at day 3 after cardiac arrest (CA) treated with therapeutic hypothermia (TH).
- Trial name
- NCT02888184
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Out-Of-Hospital Cardiac Arrest, Infarction, Myocardial
Post-ROSC Electrocardiogram After Cardiac arrEst
PEACE study retrospectively evaluate patients who suffered an out-hospital cardiac arrest (OHCA) and who underwent a coronary angiography, enrolled in the registry of the Province of Pavia (Italy), Ticino Region (Switzerland)…
- Trial name
- PEACE (NCT04096079)
- Volunteers
- 1,000 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Out of Hospital Cardiac Arrest Without ST-segment Elevation
Performance of Coronary CT Angiography to Rule Out Coronary Artery Disease After Out-of-hospital Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) has multiple etiologies. In the absence of ST-elevation myocardial infarction, percutaneous coronary intervention (PCI) is delayed.
- Trial name
- PERFECCT (NCT05961488)
- Testing
- Coronary Calcium Score and Coronary CT angiogram
- Where
- France
- Volunteers
- 200 people
- Sponsor
- CHU de Reims
Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation Sustained
Percutaneous Left Stellate Ganglion Block In Out-of-hospital Cardiac Arrest Due to Refractory VEntricular Arrhythmias (LIVE Study)
This is an observational, prospective study to verify the feasibility and practicability of percutaneous stellate ganglion block (PSGB) in patient suffering from a refractory out-of-hospital cardiac arrest (OHCA) due to a…
- Conditions
- Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation Sustained, Shockable Rhythm, Medical Etiology
- Trial name
- LIVE (NCT04168970)
- Testing
- PSGB
- Where
- 2 sites in Italy
- Volunteers
- 62 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Brain Injuries, Traumatic, Brain Injuries, Acute
Critical Hyperacute Assessment Research On Neurobiomarker Kinetics in Acute Brain Injury
Traumatic brain injury (TBI) and other conditions that reduce blood flow to the brain - such as cardiac arrest (CA) - are life-threatening medical emergencies.
- Conditions
- Brain Injuries, Traumatic, Brain Injuries, Acute, Hypoxia, Brain, Cardiac Arrest (CA)
- Trial name
- CHARON (NCT07782216)
- Where
- 4 sites in Hungary
- Volunteers
- 477 people
- Sponsor
- University of Pecs
Cardiac Arrest
Effects of Laryngeal Tube Ventilation on no Flow Time During Out of Hospital Cardiac Arrest
International recommendations stress on the importance of no flow time reduction in cardiac arrest management. In fact, no flow time is an independent factor of morbidity and mortality.
- Trial name
- FLOWERS (NCT01295749)
- Testing
- laryngeal tube ventilation and continuous chest compression
- Where
- 2 sites in France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Grenoble