Peripheral Venous CatheterizationNCT07683611
Short-Axis Versus Long-Axis Ultrasound-Guided Peripheral IV Cannulation in Adults
A study testing Short-Axis Out-of-Plane Ultrasound-Guided Cannulation and Long-Axis In-Plane Ultrasound-Guided Cannulation in people with Peripheral Venous Catheterization, run by Lady Reading Hospital, Pakistan at 1 site in Pakistan.
Trial summary
This randomized study compared two ultrasound-guided techniques for placing a peripheral intravenous cannula in adults aged 20 to 60 years who required intravenous access. Participants were assigned equally to either the short-axis out-of-plane approach or the long-axis in-plane approach. Read more about this study
- Who is it for?
- Ages 20 to 60 years
- Conditions the study is for
- Peripheral Venous Catheterization
- What is being tested?
- Short-Axis Out-of-Plane Ultrasound-Guided Cannulation and Long-Axis In-Plane Ultrasound-Guided Cannulation
- Type of treatment
- Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 222 participants
- Where
- 1 sitePakistan
- Study dates
- 7 Nov 2023to 7 May 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Men and women aged 20 to 60 years
- Required peripheral intravenous access
Who cannot join
- Body mass index of 30 kg/m² or greater
- Infection at the intended cannulation site
- Upper-limb deformity
- Previous venous thrombosis
- Refusal to participate
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Medical Teaching Institution-Lady Reading Hospital
Peshawar, Khyber Pakhtunkhwa
About this study
Official title: Comparison of Short-Axis Versus Long-Axis Approach for Ultrasound-Guided Peripheral Intravenous Cannulation: A Randomized Controlled Trial
This randomized study compared two ultrasound-guided techniques for placing a peripheral intravenous cannula in adults aged 20 to 60 years who required intravenous access. Participants were assigned equally to either the short-axis out-of-plane approach or the long-axis in-plane approach. The study evaluated whether the techniques differed in successful cannulation. It also compared cannulation time, number of attempts, and immediate complications, including arterial puncture, extravasation, and haematoma.
Read the detailed description
This single-centre, parallel-group randomized controlled trial was conducted in the Department of Anaesthesiology at Medical Teaching Institution-Lady Reading Hospital, Peshawar, Pakistan.
A total of 222 eligible adults requiring peripheral intravenous access were enrolled through consecutive sampling. Participants were randomized in a 1:1 ratio using a computer-generated sequence. In the short-axis group, the ultrasound probe was positioned perpendicular to the target vein to obtain a transverse image, and the needle was advanced using an out-of-plane technique. In the long-axis group, the probe was positioned parallel to the vein to obtain a longitudinal image, and the needle was advanced in plane while maintaining visualization of the needle tip. Experienced anaesthesiologists performed all procedures.
Cannulation was considered successful when the catheter advanced without resistance, blood returned freely into the hub, and saline could be flushed without local swelling. The primary outcome was successful peripheral intravenous cannulation. Secondary outcomes included cannulation time, number of attempts, and immediate complications comprising arterial puncture, extravasation, and haematoma. No delayed follow-up outcomes were assessed.
- Conditions
- Peripheral Venous Catheterization
- Being tested
- Short-Axis Out-of-Plane Ultrasound-Guided Cannulation, Long-Axis In-Plane Ultrasound-Guided Cannulation
- Keywords
- Ultrasound-Guided Peripheral Intravenous Cannulation, Short-Axis Out-of-Plane Approach, Long-Axis In-Plane Approach, Peripheral Intravenous Access, Interventional Ultrasonography
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Short-Axis Out-of-Plane Ultrasound-Guided CannulationProcedure or surgery
The ultrasound probe was positioned perpendicular to the target vein to obtain a transverse image. A peripheral intravenous cannula was inserted by advancing the needle using the out-of-plane technique under real-time ultrasound guidance.
Long-Axis In-Plane Ultrasound-Guided CannulationProcedure or surgery
The ultrasound probe was positioned parallel to the target vein to obtain a longitudinal image. A peripheral intravenous cannula was inserted by advancing the needle in plane while maintaining visualization of the needle tip under real-time ultrasound guidance.
| Study group | Role | What they receive |
|---|---|---|
| Short-Axis Out-of-Plane Approach | Experimental | Participants underwent ultrasound-guided peripheral intravenous cannulation with the probe positioned perpendicular to the target vein to obtain a transverse image. The needle was advanced using an out-of-plane technique. Receives: Procedure: Short-Axis Out-of-Plane Ultrasound-Guided Cannulation |
| Long-Axis In-Plane Approach | Active comparator | Participants underwent ultrasound-guided peripheral intravenous cannulation with the probe positioned parallel to the target vein to obtain a longitudinal image. The needle was advanced in plane while maintaining visualization of the needle tip. Receives: Procedure: Long-Axis In-Plane Ultrasound-Guided Cannulation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Successful Peripheral Intravenous Cannulation
Cannulation was considered successful when the catheter advanced without resistance, blood returned freely into the hub, and saline could be flushed without local swelling. The outcome was recorded as successful or unsuccessful.
Measured: Immediately following the assigned cannulation procedure
Secondary outcomes (1)
Cannulation Time
Time required to achieve successful peripheral intravenous cannulation, measured in seconds.
Measured: uring the assigned cannulation procedure
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Jul 2026
- Study start7 Nov 2023
- Primary completion7 May 2024
- Study completion7 May 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Peripheral Venous CatheterizationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants were randomly assigned in a 1:1 ratio to one of two parallel groups. One group received ultrasound-guided peripheral intravenous cannulation using the short-axis out-of-plane approach, while the other received the long-axis in-plane approach. Each group included 111 participants.
- Masking
- None (open label)
- Enrolment
- 222 participants (actual)
Sponsor and investigators
- Lead sponsor
- Lady Reading Hospital, Pakistan
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Mohib Ullah Khan, Lady Reading Hospital, Pakistan
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07683611
- Sponsor's protocol ID
- 962/LRH/MTI
- Status last verified
- Jun 2026
- First submitted
- 28 Jun 2026
- Last updated
- 6 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 6 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Short-Axis Versus Long-Axis Approach for Ultrasound-Guided Peripheral Intravenous Cannulation: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07683611
- Acronym / sponsor ID
- 962/LRH/MTI
- Conditions
- Peripheral Venous Catheterization
- Keywords
- Ultrasound-Guided Peripheral Intravenous Cannulation, Short-Axis Out-of-Plane Approach, Long-Axis In-Plane Approach, Peripheral Intravenous Access, Interventional Ultrasonography
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 222 participants (actual)
- Lead sponsor
- Lady Reading Hospital, PakistanOther government
- Study start
- 7 Nov 2023 (actual)
- Primary completion
- 7 May 2024 (actual)
- Study completion
- 7 May 2024 (actual)
- First posted
- 6 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized study compared two ultrasound-guided techniques for placing a peripheral intravenous cannula in adults aged 20 to 60 years who required intravenous access. Participants were assigned equally to either the short-axis out-of-plane approach or the long-axis in-plane approach. The study evaluated whether the techniques differed in successful cannulation. It also compared cannulation time, number of attempts, and immediate complications, including arterial puncture, extravasation, and haematoma.
Detailed description
This single-centre, parallel-group randomized controlled trial was conducted in the Department of Anaesthesiology at Medical Teaching Institution-Lady Reading Hospital, Peshawar, Pakistan.
A total of 222 eligible adults requiring peripheral intravenous access were enrolled through consecutive sampling. Participants were randomized in a 1:1 ratio using a computer-generated sequence. In the short-axis group, the ultrasound probe was positioned perpendicular to the target vein to obtain a transverse image, and the needle was advanced using an out-of-plane technique. In the long-axis group, the probe was positioned parallel to the vein to obtain a longitudinal image, and the needle was advanced in plane while maintaining visualization of the needle tip. Experienced anaesthesiologists performed all procedures.
Cannulation was considered successful when the catheter advanced without resistance, blood returned freely into the hub, and saline could be flushed without local swelling. The primary outcome was successful peripheral intravenous cannulation. Secondary outcomes included cannulation time, number of attempts, and immediate complications comprising arterial puncture, extravasation, and haematoma. No delayed follow-up outcomes were assessed.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants were randomly assigned in a 1:1 ratio to one of two parallel groups. One group received ultrasound-guided peripheral intravenous cannulation using the short-axis out-of-plane approach, while the other received the long-axis in-plane approach. Each group included 111 participants.
| Arm | Type | Receives |
|---|---|---|
| Short-Axis Out-of-Plane Approach | Experimental | Procedure: Short-Axis Out-of-Plane Ultrasound-Guided CannulationParticipants underwent ultrasound-guided peripheral intravenous cannulation with the probe positioned perpendicular to the target vein to obtain a transverse image. The needle was advanced using an out-of-plane technique. |
| Long-Axis In-Plane Approach | Active comparator | Procedure: Long-Axis In-Plane Ultrasound-Guided CannulationParticipants underwent ultrasound-guided peripheral intravenous cannulation with the probe positioned parallel to the target vein to obtain a longitudinal image. The needle was advanced in plane while maintaining visualization of the needle tip. |
Who may qualify
- Ages
- 20 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Men and women aged 20 to 60 years
- Required peripheral intravenous access
Key exclusion criteria (5 listed)
- Body mass index of 30 kg/m² or greater
- Infection at the intended cannulation site
- Upper-limb deformity
- Previous venous thrombosis
- Refusal to participate
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Short-Axis Out-of-Plane Ultrasound-Guided CannulationThe ultrasound probe was positioned perpendicular to the target vein to obtain a transverse image. A peripheral intravenous cannula was inserted by advancing the needle using the out-of-plane technique under real-time ultrasound guidance. | Procedure or surgery | Short-Axis Out-of-Plane Approach |
| Long-Axis In-Plane Ultrasound-Guided CannulationThe ultrasound probe was positioned parallel to the target vein to obtain a longitudinal image. A peripheral intravenous cannula was inserted by advancing the needle in plane while maintaining visualization of the needle tip under real-time ultrasound guidance. | Procedure or surgery | Long-Axis In-Plane Approach |
Primary outcome
Successful Peripheral Intravenous Cannulation
Time frame: Immediately following the assigned cannulation procedure
Cannulation was considered successful when the catheter advanced without resistance, blood returned freely into the hub, and saline could be flushed without local swelling. The outcome was recorded as successful or unsuccessful.
1 secondary outcome
Cannulation Time
Time frame: uring the assigned cannulation procedure
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Jul 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Short-Axis Out-of-Plane Ultrasound-Guided Cannulation and Long-Axis In-Plane Ultrasound-Guided Cannulation in people with Peripheral Venous Catheterization, run by Lady Reading Hospital, Pakistan at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Successful Peripheral Intravenous Cannulation (time frame: Immediately following the assigned cannulation procedure). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Jul 2026; AzTrials last refreshed its copy on 6 Nov 2026.