Intra Abdominal PressureMV and IAPNCT07687303
Relationship Between Mechanical Ventilator's Modes , Intra-Abdominal Pressure, Mechanical Power and Gastric Tube Tolerance Among Mechanically Ventilated Patients.
An observational study of Intra Abdominal Pressure and Mechanical Power, run by Heba.Attia@nur.dmu.edu.eg at 1 site in Egypt.
Trial summary
The study aims to: Explore the relationship between MV modes on the IA, MP and GT tolerance among mechanically ventilated patients. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Intra Abdominal Pressure, Mechanical Power
- How many people
- 90 participants
- Where
- 1 siteEgypt
- Study dates
- Aug 2026to Nov 2026
- How long will I take part?
- 3 Days
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Study population: A convenient sample
Who may be able to join
- adult patients requiring MV in ICU
Who cannot join
- patients with abdominal or chest trauma,
- patients with intra abdominal pathologies,
- patients who had received more than 10 units of red blood cells or more than 5 liters of intravenous liquids over the last 24 h,
- patients with sepsis or hepatic, or renal dysfunction,
- patients in positions other than supine, and
- body mass index (BMI) ≥ 30 kg/m2.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Alaa Mustafa assistant professor, assistant professor contact
Egypt1 site, 1 recruiting
- Recruiting
Faculty of Nursing, Damanhour University
Damanhūr
Reem Bassiony, chairperson of ethics committe, 045 3311679, admin.nur@nur.dmu.edu.eg
Heba attia, lecturer, 045 01274855242, heba.attia@nur.dmu.edu.eg
About this study
The study aims to:
Explore the relationship between MV modes on the IA, MP and GT tolerance among mechanically ventilated patients.
Read the detailed description
Modes of MVs by means of their differential effect on intra-thoracic pressure can have a significant influence on IAP. An ideal ventilation mode could optimize respiratory mechanics and may protect a variety of body systems functions. Among the many MV modes, SIMV, BIPAP and CPAP are the three most used modes
- Conditions
- Intra Abdominal Pressure, Mechanical Power
- Keywords
- mechanical ventilator modes, intraabdominal pressure
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| SIMV group | this group are attached with MV on SIMV mode | |
| CPAP group | this group are attached with MV on CPAP mode | |
| BiPAP group | this group are attached with MV on BiPAP mode |
What is being measured
The primary outcome is the main question the study is designed to answer.
intra-abdominal pressure "IAP"
IAP will be measured through foly catheter
Measured: day 1
mechanical power
it will be: MP (J/ min) =0.098×RR×Vt × [Peak Pressure-(DP/2)] measured through folly catheter
Measured: day 1
gastric tube tolerance
The GT tolerance will be presented as yes if the patient was on GT feeding, and no, if the patient had delayed gastric emptying and converted to gastric drain
Measured: day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Jul 2026
- Study startAug 2026 (estimated)
- Primary completionOct 2026 (estimated)
- Study completionNov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Intra Abdominal PressureStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 90 participants (estimated)
- Target duration
- 3 Days
Sponsor and investigators
- Lead sponsor
- Heba.Attia@nur.dmu.edu.eg
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Heba.Attia@nur.dmu.edu.eg, Damanhour University
- Investigators
- sahar youness youness, professor, Principal investigator, professor of emergency and critical nursing
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07687303
- Sponsor's protocol ID
- 125-c
- Acronym
- MV and IAP
- Status last verified
- Jul 2026
- First submitted
- 23 Jun 2026
- Last updated
- 7 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: ASD123456789
Publications
https://r.search.yahoo.com/_ylt=AwrFYna.5DpqRgIAKKRXNyoA;_ylu=Y29sbwNiZjEEcG9zAzEEdnRpZAMEc2VjA3Ny/RV=2/RE=1783454142/RO=10/RU=https%3a%2f%2fpmc.ncbi.nlm.nih.gov%2farticles%2fPMC3733186%2f/RK=2/RS=5S3GXdIx14M.h5tX6E6bTclSBZw-
Study at a glance
From the registry record, last updated by the sponsor on 7 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Relationship Between Mechanical Ventilator's Modes , Intra-Abdominal Pressure, Mechanical Power and Gastric Tube Tolerance Among Mechanically Ventilated Patients.
- ClinicalTrials.gov ID
- NCT07687303
- Acronym / sponsor ID
- MV and IAP / 125-c
- Conditions
- Intra Abdominal Pressure, Mechanical Power
- Keywords
- mechanical ventilator modes, intraabdominal pressure
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 90 participants (estimated)
- Lead sponsor
- Heba.Attia@nur.dmu.edu.egUniversity, hospital or other
- Study start
- Aug 2026 (estimated)
- Primary completion
- Oct 2026 (estimated)
- Study completion
- Nov 2026 (estimated)
- First posted
- 7 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study aims to:
Explore the relationship between MV modes on the IA, MP and GT tolerance among mechanically ventilated patients.
Detailed description
Modes of MVs by means of their differential effect on intra-thoracic pressure can have a significant influence on IAP. An ideal ventilation mode could optimize respiratory mechanics and may protect a variety of body systems functions. Among the many MV modes, SIMV, BIPAP and CPAP are the three most used modes
Study design
- Observational model
- Other
- Time perspective
- Prospective
- Target follow-up
- 3 Days
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| SIMV group | – | –this group are attached with MV on SIMV mode |
| CPAP group | – | –this group are attached with MV on CPAP mode |
| BiPAP group | – | –this group are attached with MV on BiPAP mode |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
- Study population
- A convenient sample
Key inclusion criteria (1 listed)
- adult patients requiring MV in ICU
Key exclusion criteria (6 listed)
- patients with abdominal or chest trauma,
- patients with intra abdominal pathologies,
- patients who had received more than 10 units of red blood cells or more than 5 liters of intravenous liquids over the last 24 h,
- patients with sepsis or hepatic, or renal dysfunction,
- patients in positions other than supine, and
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
intra-abdominal pressure "IAP"
Time frame: day 1
IAP will be measured through foly catheter
mechanical power
Time frame: day 1
it will be: MP (J/ min) =0.098×RR×Vt × [Peak Pressure-(DP/2)] measured through folly catheter
gastric tube tolerance
Time frame: day 1
The GT tolerance will be presented as yes if the patient was on GT feeding, and no, if the patient had delayed gastric emptying and converted to gastric drain
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Jul 2026.
- Backgroundhttps://r.search.yahoo.com/_ylt=AwrFYna.5DpqRgIAKKRXNyoA;_ylu=Y29sbwNiZjEEcG9zAzEEdnRpZAMEc2VjA3Ny/RV=2/RE=1783454142/RO=10/RU=https%3a%2f%2fpmc.ncbi.nlm.nih.gov%2farticles%2fPMC3733186%2f/RK=2/RS=5S3GXdIx14M.h5tX6E6bTclSBZw-
- Can Selection of Mechanical Ventilation Mode Prevent Increased Intra-Abdominal Pressure in Patients Admitted to the Intensive Care Unit?Link provided by the sponsor.
- Individual participant dataSharing planned: Yes. ASD123456789
Related trials for Intra Abdominal Pressure
Not yet recruiting
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Appendectomy, Laparoscopic, Intra Abdominal Pressure
Not yet recruiting
Intra-gastrointestinal Monitoring Device (PressureDOT®) and Centurion IAP Monitoring Device Comparison Study: Pivotal Study of Safety and Performance.
Intra Abdominal Pressure, Intra-Abdominal Hypertension
Not yet recruitingObservational study
Intra-abdominal Hypertension and Abdominal Compartment Syndrome in Patients After Pancreatic Procedures.
Intra Abdominal Pressure, Abdominal Compartment Syndrome
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Alaa Mustafa assistant professor, assistant professor contact
sahar youness youness, professor principal investigator
professor of emergency and critical nursing
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Intra Abdominal Pressure and Mechanical Power, run by Heba.Attia@nur.dmu.edu.eg at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 7 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact heba attia lecturer, lecturer (045 01274855242, heba.attia@nur.dmu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
intra-abdominal pressure "IAP" (time frame: day 1). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07687303, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jul 2026; AzTrials last refreshed its copy on 31 Oct 2026.