Clinical trials: Mechanical Power
ARDS (Moderate or Severe), Adult Patients
Role of Elastic Power in Acute Respiratory Distress Syndrome
Mechanical ventilation is essential for managing acute respiratory distress syndrome (ARDS), but it can also cause ventilator-induced lung injury (VILI) due to mechanical forces.
- Trial name
- NCT06878313
- Volunteers
- 20 people
- Sponsor
- Hospital El Cruce
ARDS, Driving Pressure
Effects of Different Driving Pressure on Lung Stress, Strain and Mechanical Power in Patients With Moderate to Severe ARDS
ARDS is the most common acute respiratory failure in the ICU and the mortality rate is still as high as 40%. Mechanical ventilation(MV) is the major supportive treatment for ARDS, but inappropriate ventilator setting could lead…
- Conditions
- ARDS, Driving Pressure, Strains, Mechanical Power
- Trial name
- NCT03616704
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Jianfeng Xie
Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
EIT-Guided Ventilator Settings in AHRF
This exploratory study aims to investigate the effect of Electrical Impedance Tomography (EIT)-guided ventilator settings on mechanical power in patients with acute hypoxemic respiratory failure (AHRF), including both ARDS and…
- Conditions
- Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS), Mechanical Power, Ventilator Induced Lung Injury
- Trial name
- NCT06936618
- Testing
- Electrical Impedance Tomography (EIT), Enlight 2100
- Where
- Thailand
- Volunteers
- 17 people
- Sponsor
- Mahidol University
Mechanical Ventilation, Intensive Care (ICU)
Effects of PERMISSive Lung-protective Ventilation on Outcome in Critically Ill Invasively Ventilated Patients
RATIONALE Lung-protective ventilation using a lower respiratory rate (RR) is an appealing strategy to reduce ventilation intensity, which may require permissive hypercapnia.
- Trial name
- PERMISS pilot (NCT07077174)
- Testing
- Permissive lung-protective ventilation, Conventional lung-protective ventilation
- Where
- 5 sites in Netherlands, Spain
- Volunteers
- 56 people
- Sponsor
- Reinier de Graaf Groep
Postoperative Pulmonary Dysfunction, Oxygenation Impairment
Mechanical Power Ventilation in RALP
Robot-assisted laparoscopic radical prostatectomy (RALP) requires steep Trendelenburg positioning and pneumoperitoneum, which adversely affect respiratory mechanics and may lead to impaired postoperative oxygenation.
- Conditions
- Postoperative Pulmonary Dysfunction, Oxygenation Impairment, Robot-Assisted Radical Prostatectomy
- Trial name
- NCT07534553
- Testing
- Mechanical Power-Targeted Ventilation, Standard Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Acute Respiratory Distress Syndrome (ARDS), s100b
A Study of the Determinants of Neurological Outcomes in Patients With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is characterized by pathological pulmonary edema caused by direct or indirect damage to the alveolar-capillary membrane.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), s100b, Mechanical Power, Ventilator Induced Lung Injury
- Trial name
- NEURDS (NCT07629973)
- Testing
- Blood test scores calculations
- Volunteers
- 150 people
- Sponsor
- University Hospital, Angers
Mechanical Ventilation, Mechanical Power
The Effect of Closed-Loop Versus Conventional Ventilation on Mechanical Power
Several studies suggest fully-automated ventilation to ventilate with a lower amount of MP in unselected ICU patients, patients after cardiac surgery, and patients with and without ARDS.
- Trial name
- INTELLiPOWER (NCT04827927)
- Testing
- Procedure: INTELLiVENT-ASV, Procedure: Conventional ventilation
- Where
- 3 sites in Netherlands
- Volunteers
- 96 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Neck Pain
Influence of Adding High Power Pain Threshold Ultrasound to Traditional Therapy on Axioappendicular Muscles Amplitude and Fatigue in Mechanical Neck Pain Randomized Clinical Trials
The purpose of this study will investigate the effect of adding high power pain threshold ultrasound to traditional therapy on axioappendicular muscles amplitude and fatigue in neck pain
- Trial name
- MNP (NCT05540093)
- Testing
- high power pain threshold ultrasound, traditional therapy
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Acute Respiratory Failure, Invasive Mechanical Ventilation
Assessment of Ventilation Parameters for Extubation Prediction in ICU
The study aims to research the values of mechanical power, driving pressure, and elastic power in predicting the duration of mechanical ventilation in critically ill patients undergoing invasive mechanical ventilation.
- Trial name
- NCT06531005
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ankara University
Mechanical Ventilation, Postoperative Pulmonary Complications (PPCs)
Flow-Controlled Ventilation to Improve Postoperative Pulmonary Outcome After Thoracic Surgery
In an international multicenter randomized clinical pilot trial, intraoperative flow-controlled ventilation (FCV) will be compared with volume-controlled ventilation (VCV) in patients scheduled for (open, video- or…
- Trial name
- PROFLOW-THORAC (NCT07623395)
- Testing
- Flow-Controlled Ventilation, Volume-Controlled Ventilation
- Where
- 7 sites in Austria, France and 2 more
- Volunteers
- 140 people
- Sponsor
- Cantonal Hospital of St. Gallen
Mechanical Ventilation, Mechanical Power
Investigation of the Optimum PEEP Mechanical Power Relationship
The aim of this study is to compare the effects of standard and optimum positive end expiratory pressures on mechanical power during laparoscopic surgeries.
- Conditions
- Mechanical Ventilation, Mechanical Power, Optimum PEEP, Laparoscopic Abdominal Surgery
- Trial name
- NCT06625099
- Testing
- Mechanical Ventilation (MV) with Low PEEP, Mechanical Ventilation (MV) with Optimum PEEP
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Kocaeli City Hospital
Acue Respiratory Distress Syndrome
Use of Extracorporeal CO2 Removal in Case of Moderate to Severe ARDS to Apply an Ultraprotective Mechanical Ventilation Strategy
The extracorporeal CO2 removal (ECCO2R) has been recently proposed in case of Acute Respiratory Distress Syndrome (ARDS) in order to reduce pulmonary injuries induced by the mechanical ventilation.
- Trial name
- ECCO2R (NCT04556578)
- Testing
- High-flow extracorporeal CO2 removal
- Where
- France
- Volunteers
- 2 people
- Sponsor
- University Hospital, Montpellier
Postoperative Respiratory Failure, Abdominal Surgery
Mechanical Power for Ventilatory Settings in Operating Room
Postoperative respiratory failure (PRF) is a dreaded complication that imposes a significant burden through unplanned admission to the ICU, post discharge disability and mortality.
- Conditions
- Postoperative Respiratory Failure, Abdominal Surgery, Postoperative Pulmonary Complications, Morality
- Trial name
- IMPROVEIII (NCT07620132)
- Testing
- Mechanical power-guided ventilatory strategy, Standard fixed ventilatory settings
- Volunteers
- 490 people
- Sponsor
- University Hospital, Montpellier
Upper Limb Deformities, Congenital
Customized Self-Controlled Power-Driven or Mechanical Orthoses for the Upper Limb - A Pilot Study
Patients with congenital or acquired upper limb structural abnormalities and peripheral nerve or brachial plexus palsies have significant loss of function.
- Trial name
- NCT04199975
- Testing
- Orthoses
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- Chinese University of Hong Kong
Postoperative Pulmonary Atelectasis, Pneumothorax
Cardiopulmonary Bypass on Mechanical Power and Postoperative Pulmonary Complications
During cardiopulmonary bypass (CPB), oxygenation of the patient on the pump can be left completely under pump control, or the lungs can be ventilated with low tidal volume to reduce atelectasis.
- Conditions
- Postoperative Pulmonary Atelectasis, Pneumothorax, Pneumonia, Ards
- Trial name
- NCT06292767
- Testing
- mechanical power calculation
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- TC Erciyes University
Respiratory Distress Syndrome (RDS)
Components of Mechanical Power on the Functional Lung in ARDS
Mechanical power (MP) is a composite variable that integrates static and dynamic respiratory parameters and has been associated with ventilator-induced lung injury (VILI).
- Trial name
- NCT07171632
- Testing
- monitoring of clinical and ventilatory variables
- Volunteers
- 184 people
- Sponsor
- Ramos Mejía Hospital
Acute Respiratory Failure, Respiratory Insufficiency
HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport
The HERMES Phase III study is an international, multicenter, prospective observational investigation designed to characterize the quality and safety of patient transport during advanced respiratory support.
- Conditions
- Acute Respiratory Failure, Respiratory Insufficiency, Respiratory Distress, Critical Illness
- Trial name
- HERMES (NCT07805603)
- Testing
- Advanced Respiratory Support During Patient Transport
- Where
- 4 sites in Colombia, Egypt and 2 more
- Volunteers
- 565 people
- Sponsor
- Medipol University
Mechanical Power
Use of 'Mechanical Power' as a Predictor of Increased Serum and Pulmonary Proinflammatory Cytokine Concentrations in Patients With Acute Hypoxemic Respiratory Failure: A Prospective Observational Study
The aim of this study is to report the proportion of patients with acute hypoxemic respiratory failyre (AHRF) undergoing mechanical ventilation who exceed 17 J/min of mechanical power (MP) and the difference in terms of…
- Trial name
- NCT06425354
- Testing
- Mechanical ventilation
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Roma La Sapienza
Ventilator-Induced Lung Injury, Acute Respiratory Distress Syndrome
Comparing Mechanical Power in Different Inspiratory Times
We aimed to compare mechanical power and energy values using geometric methods at varying inspiratory rise times.
- Trial name
- NCT06413472
- Testing
- Mechanical ventilator adjustment for PCV, Mechanical ventilator adjustment for VCV
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Mechanical Ventilation Complication
Cross-sectional, Observational, Prospective and Analytical Study:MECHANICAL POWER DAY (MPDay)
Recently the new concept of "mechanical power" has been proposed. It refers to the amount of energy per minute that is transferred to the lung by the ventilator.
- Trial name
- MPDay (NCT03936231)
- Testing
- NO Intervention
- Where
- Spain
- Volunteers
- 2,000 people
- Sponsor
- Hospital Universitario Marqués de Valdecilla