Morning SicknessNCT07688629
Multidimensional Assessment of Nausea in Pregnancy
A study testing Fresh Quince Consumption and P6 Acupressure in people with Morning Sickness and Vomiting During Pregnancy, run by Antalya Bilim University at 1 site in Turkey (Türkiye).
Trial summary
Nausea and vomiting during pregnancy are common, affecting a large proportion of women (approximately 50-75%). This symptom usually begins in the first trimester and is mostly mild or moderate; however, in some cases, it impairs quality of life, reduces nutritional intake, leads to emotional distress, and, rarely, can… Read more about this study
- Who is it for?
- Ages 18 to 35 years, women only
- Conditions the study is for
- Morning Sickness, Vomiting During Pregnancy
- What is being tested?
- Fresh Quince Consumption and P6 Acupressure
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 246 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 30 Nov 2025to 19 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- Women only
- No healthy volunteers
- Adult
Who may be able to join
- Pregnant women aged 18-35 years
- Gestational age between 6 and 14 weeks
- Singleton pregnancy
- Mild to moderate nausea and vomiting of pregnancy as assessed by the PUQE-24 scale
- Nausea and vomiting not requiring hospitalization or pharmacological treatment
- No known gastrointestinal disease
- Ability to understand study procedures and provide informed consent
- Willingness to participate and comply with study procedures
Who cannot join
- Severe nausea and vomiting requiring hospitalization
- Nausea and vomiting requiring pharmacological treatment
- Multiple pregnancy
- Threatened miscarriage
- Known gastrointestinal disease
- Withdrawal of consent at any stage of the study
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Antalya Bilim Üniversitesi
Antalya, Muratpaşa, 00007
About this study
Official title: Multidimensional Assessment of Nausea in Pregnancy: A Three-Arm Randomized Controlled Study on the Effects of Quince and Acupressure
Nausea and vomiting during pregnancy are common, affecting a large proportion of women (approximately 50-75%). This symptom usually begins in the first trimester and is mostly mild or moderate; however, in some cases, it impairs quality of life, reduces nutritional intake, leads to emotional distress, and, rarely, can develop into serious conditions such as hyperemesis gravidarum.
Pharmacological approaches can be effective, especially in severe cases; however, the fear of drug-related side effects among many pregnant women and physicians is a limiting factor in drug use. Therefore, the role of complementary and non-pharmacological approaches is gaining importance, particularly in pregnant women with mild to moderate nausea. On the other hand, acupressure (especially P6/Neiguan point stimulation) is a non-invasive complementary practice whose effect in reducing nausea and vomiting during pregnancy is debated. Meta-analyses report that acupressure can significantly reduce nausea symptoms in pregnancy. However, there is a need for clearer results in the literature due to methodological differences, variability in effect sizes, and low quality scores of some studies.
Read more
Quince (Cydonia oblonga), on the other hand, is not as researched an option as acupressure in the literature for managing nausea in pregnancy. In a study comparing quince syrup with vitamin B6 in the literature, quince was found to be a more effective application than vitamin B6. Quince may theoretically have the potential to reduce nausea due to its positive effects on gastrointestinal motility, its stomach-soothing properties, and its antioxidant compound content. However, randomized controlled trials proving this effect in terms of safety and efficacy during pregnancy are limited.
Nausea during pregnancy not only causes physical discomfort but also reduces quality of life, negatively affects self-care behaviors, and can increase perceived stress levels. Therefore, nausea management should aim not only at symptom reduction but also at supporting the holistic well-being of the pregnant woman. In this context, psychosocial indicators such as the Quality of Life in Pregnancy Scale, Self-Care Ability Scale, and Perceived Prenatal Stress Scale are important in revealing not only the physiological but also the psychological and behavioral effects of complementary practices.
Therefore, examining the effects of quince and acupressure applications on not only the severity of nausea but also on quality of life, self-care ability, and perceived stress levels in pregnant women with mild to moderate nausea will fill the gap in the literature and contribute to the identification of evidence-based, safe, and applicable complementary approaches in the management of nausea in pregnancy.
- Conditions
- Morning Sickness, Vomiting During Pregnancy
- Being tested
- Fresh Quince Consumption, P6 Acupressure
- Keywords
- vomiting, prengnancy, morning sickness, Quince, Acupressure p6
- Medical subject headings
- Morning Sickness, Vomiting
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Fresh Quince ConsumptionOther
Also called P6 Acupressure Group, Control Group
Participants assigned to the quince group will consume approximately 25-42 g of fresh quince daily for 7 consecutive days. The amount was determined based on phenolic content equivalence to quince syrup used in a previous randomized clinical trial. Participants will receive standardized instructions regarding preparation, portion size, timing of consumption, and daily recording of intake. All participants will also receive standard dietary recommendations for the management of nausea and vomiting during pregnancy.
P6 AcupressureOther
Participants assigned to the acupressure group will perform P6 (Neiguan) acupressure on both wrists three times daily for 5 minutes per session over a 7-day intervention period. The P6 point is located on the inner aspect of the wrist, approximately three finger widths proximal to the wrist crease between the tendons of the palmaris longus and flexor carpi radialis muscles. Participants will receive face-to-face training and demonstration by the research team. Standard dietary recommendations for nausea and vomiting during pregnancy will also be provided.
| Study group | Role | What they receive |
|---|---|---|
| Quince Group | Experimental | Participants will consume approximately 25-42 g of fresh quince daily for 7 consecutive days in addition to receiving standard dietary recommendations for nausea and vomiting during pregnancy. Receives: Other: Fresh Quince Consumption |
| P6 Acupressure Group | Experimental | Participants will perform P6 (Neiguan) acupressure on both wrists three times daily for 5 minutes per session over 7 consecutive days in addition to receiving standard dietary recommendations. Receives: Other: P6 Acupressure |
| Control Group | No intervention | Participants will receive standard dietary recommendations for nausea and vomiting during pregnancy and routine prenatal care. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pregnancy-Unique Quantification of Emesis and Nausea (PUQE-24) Score
Assessment of the severity of nausea and vomiting during pregnancy using the Pregnancy-Unique Quantification of Emesis and Nausea (PUQE-24) scale. Higher scores indicate more severe symptoms.
PUQE-24 Assessment Scale:
Lowest Score (0 - 3): Mild nausea and vomiting. Moderate Score (4 - 6): Moderate nausea and vomiting. Highest Score (7 - 15): Severe nausea and vomiting.
Measured: Baseline (Day 0), Daily During Intervention (Days 1-7), and Follow-up (Days 8-14)
Secondary outcomes (1)
Prenatal Perceived Stress Scale Score
Assessment of perceived prenatal stress using the Prenatal Perceived Stress Scale. Higher scores indicate greater perceived stress.
PUQE-24 Assessment Scale:
Lowest Score (0 - 3): Mild nausea and vomiting. Moderate Score (4 - 6): Moderate nausea and vomiting. Highest Score (7 - 15): Severe nausea and vomiting.
Measured: Baseline (Day 0) and End of Intervention (Day 7)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Jul 2026
- Study start30 Nov 2025
- Primary completion19 Jun 2026
- Study completion19 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Morning SicknessStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This is a single-blind, randomized, parallel-group controlled trial. Eligible pregnant women with mild to moderate nausea and vomiting of pregnancy will be randomly allocated in a 1:1:1 ratio to a quince intervention group, a P6 acupressure group, or a control group receiving standard dietary recommendations. Interventions will be administered for 7 days, followed by a 7-day follow-up period. Outcome measures will be collected longitudinally, and participants will remain in their assigned study arm throughout the trial.
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 246 participants (actual)
Sponsor and investigators
- Lead sponsor
- Antalya Bilim University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07688629
- Sponsor's protocol ID
- ABU-00007
- Status last verified
- Jul 2026
- First submitted
- 19 Jun 2026
- Last updated
- 7 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared to protect participant privacy and confidentiality.
Publications
1. Matthews A, Haas DM, O'Mathúna DP, Dowswell T. Interventions for nausea and vomiting in early pregnancy. Cochrane Database of Systematic Reviews. 2015;(9):CD007575. 2. Herrell HE. Nausea and vomiting of pregnancy. American Family Physician. 2014;89(12):965-970. 3. Jafari-Dehkordi E, Hashem-Dabaghian F, Aliasl F, et al. Comparison of quince with vitamin B6 for treatment of nausea and vomiting in pregnancy: a randomized clinical trial. Journal of Obstetrics and Gynaecology. 2017;37(8):1048-1052. 4. Gong J, Gu D, Wang H, Zhang F, Shen W, Yan H, Xie J. Effect of acupressure in nausea and vomiting treatment during pregnancy: A meta-analysis. Explore. 2024;20(1):17-26. 5. Soltani H, Forouhari S. Effect of P6 acupressure on nausea and vomiting in pregnancy: A systematic review and meta-analysis. Journal of Integrative Medicine. 2023;21(2):121-131.
Study at a glance
From the registry record, last updated by the sponsor on 7 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Multidimensional Assessment of Nausea in Pregnancy: A Three-Arm Randomized Controlled Study on the Effects of Quince and Acupressure
- ClinicalTrials.gov ID
- NCT07688629
- Acronym / sponsor ID
- ABU-00007
- Conditions
- Morning Sickness, Vomiting During Pregnancy
- Keywords
- vomiting, prengnancy, morning sickness, Quince, Acupressure p6
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 246 participants (actual)
- Lead sponsor
- Antalya Bilim UniversityUniversity, hospital or other
- Study start
- 30 Nov 2025 (actual)
- Primary completion
- 19 Jun 2026 (actual)
- Study completion
- 19 Jun 2026 (actual)
- First posted
- 7 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Nausea and vomiting during pregnancy are common, affecting a large proportion of women (approximately 50-75%). This symptom usually begins in the first trimester and is mostly mild or moderate; however, in some cases, it impairs quality of life, reduces nutritional intake, leads to emotional distress, and, rarely, can develop into serious conditions such as hyperemesis gravidarum.
Pharmacological approaches can be effective, especially in severe cases; however, the fear of drug-related side effects among many pregnant women and physicians is a limiting factor in drug use. Therefore, the role of complementary and non-pharmacological approaches is gaining importance, particularly in pregnant women with mild to moderate nausea. On the other hand, acupressure (especially P6/Neiguan point stimulation) is a non-invasive complementary practice whose effect in reducing nausea and vomiting during pregnancy is debated. Meta-analyses report that acupressure can significantly reduce nausea symptoms in pregnancy. However, there is a need for clearer results in the literature due to methodological differences, variability in effect sizes, and low quality scores of some studies.
Quince (Cydonia oblonga), on the other hand, is not as researched an option as acupressure in the literature for managing nausea in pregnancy. In a study comparing quince syrup with vitamin B6 in the literature, quince was found to be a more effective application than vitamin B6. Quince may theoretically have the potential to reduce nausea due to its positive effects on gastrointestinal motility, its stomach-soothing properties, and its antioxidant compound content. However, randomized controlled trials proving this effect in terms of safety and efficacy during pregnancy are limited.
Nausea during pregnancy not only causes physical discomfort but also reduces quality of life, negatively affects self-care behaviors, and can increase perceived stress levels. Therefore, nausea management should aim not only at symptom reduction but also at supporting the holistic well-being of the pregnant woman. In this context, psychosocial indicators such as the Quality of Life in Pregnancy Scale, Self-Care Ability Scale, and Perceived Prenatal Stress Scale are important in revealing not only the physiological but also the psychological and behavioral effects of complementary practices.
Therefore, examining the effects of quince and acupressure applications on not only the severity of nausea but also on quality of life, self-care ability, and perceived stress levels in pregnant women with mild to moderate nausea will fill the gap in the literature and contribute to the identification of evidence-based, safe, and applicable complementary approaches in the management of nausea in pregnancy.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (investigator, outcomes assessor)
- Number of arms
- 3
- Model description
- This is a single-blind, randomized, parallel-group controlled trial. Eligible pregnant women with mild to moderate nausea and vomiting of pregnancy will be randomly allocated in a 1:1:1 ratio to a quince intervention group, a P6 acupressure group, or a control group receiving standard dietary recommendations. Interventions will be administered for 7 days, followed by a 7-day follow-up period. Outcome measures will be collected longitudinally, and participants will remain in their assigned study arm throughout the trial.
| Arm | Type | Receives |
|---|---|---|
| Quince Group | Experimental | Other: Fresh Quince ConsumptionParticipants will consume approximately 25-42 g of fresh quince daily for 7 consecutive days in addition to receiving standard dietary recommendations for nausea and vomiting during pregnancy. |
| P6 Acupressure Group | Experimental | Other: P6 AcupressureParticipants will perform P6 (Neiguan) acupressure on both wrists three times daily for 5 minutes per session over 7 consecutive days in addition to receiving standard dietary recommendations. |
| Control Group | No intervention | –Participants will receive standard dietary recommendations for nausea and vomiting during pregnancy and routine prenatal care. |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (8 listed)
- Pregnant women aged 18-35 years
- Gestational age between 6 and 14 weeks
- Singleton pregnancy
- Mild to moderate nausea and vomiting of pregnancy as assessed by the PUQE-24 scale
- Nausea and vomiting not requiring hospitalization or pharmacological treatment
Key exclusion criteria (6 listed)
- Severe nausea and vomiting requiring hospitalization
- Nausea and vomiting requiring pharmacological treatment
- Multiple pregnancy
- Threatened miscarriage
- Known gastrointestinal disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Fresh Quince ConsumptionAlso: P6 Acupressure Group, Control GroupParticipants assigned to the quince group will consume approximately 25-42 g of fresh quince daily for 7 consecutive days. The amount was determined based on phenolic content equivalence to quince syrup used in a previous randomized clinical trial. Participants will receive standardized instructions regarding preparation, portion size, timing of consumption, and daily recording of intake. All participants will also receive standard dietary recommendations for the management of nausea and vomiting during pregnancy. | Other | Quince Group |
| P6 AcupressureParticipants assigned to the acupressure group will perform P6 (Neiguan) acupressure on both wrists three times daily for 5 minutes per session over a 7-day intervention period. The P6 point is located on the inner aspect of the wrist, approximately three finger widths proximal to the wrist crease between the tendons of the palmaris longus and flexor carpi radialis muscles. Participants will receive face-to-face training and demonstration by the research team. Standard dietary recommendations for nausea and vomiting during pregnancy will also be provided. | Other | P6 Acupressure Group |
Primary outcome
Pregnancy-Unique Quantification of Emesis and Nausea (PUQE-24) Score
Time frame: Baseline (Day 0), Daily During Intervention (Days 1-7), and Follow-up (Days 8-14)
Assessment of the severity of nausea and vomiting during pregnancy using the Pregnancy-Unique Quantification of Emesis and Nausea (PUQE-24) scale. Higher scores indicate more severe symptoms. PUQE-24 Assessment Scale: Lowest Score (0 - 3): Mild nausea and vomiting. Moderate Score (4 - 6): Moderate nausea and vomiting. Highest Score (7 - 15): Severe nausea and vomiting.
1 secondary outcome
Prenatal Perceived Stress Scale Score
Time frame: Baseline (Day 0) and End of Intervention (Day 7)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Jul 2026.
- Results publication1. Matthews A, Haas DM, O'Mathúna DP, Dowswell T. Interventions for nausea and vomiting in early pregnancy. Cochrane Database of Systematic Reviews. 2015;(9):CD007575. 2. Herrell HE. Nausea and vomiting of pregnancy. American Family Physician. 2014;89(12):965-970. 3. Jafari-Dehkordi E, Hashem-Dabaghian F, Aliasl F, et al. Comparison of quince with vitamin B6 for treatment of nausea and vomiting in pregnancy: a randomized clinical trial. Journal of Obstetrics and Gynaecology. 2017;37(8):1048-1052. 4. Gong J, Gu D, Wang H, Zhang F, Shen W, Yan H, Xie J. Effect of acupressure in nausea and vomiting treatment during pregnancy: A meta-analysis. Explore. 2024;20(1):17-26. 5. Soltani H, Forouhari S. Effect of P6 acupressure on nausea and vomiting in pregnancy: A systematic review and meta-analysis. Journal of Integrative Medicine. 2023;21(2):121-131.
- Individual participant dataSharing planned: No. Individual participant data will not be shared to protect participant privacy and confidentiality.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Fresh Quince Consumption and P6 Acupressure in people with Morning Sickness and Vomiting During Pregnancy, run by Antalya Bilim University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 7 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pregnancy-Unique Quantification of Emesis and Nausea (PUQE-24) Score (time frame: Baseline (Day 0), Daily During Intervention (Days 1-7), and Follow-up (Days 8-14)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07688629, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jul 2026; AzTrials last refreshed its copy on 6 Nov 2026.