Tooth LossABG-IDIPNCT07705399
Evaluation of Autogenous Bone Graft on Immediate Dental Implant Osseointegration Using Piezosurgery
A study testing Immediate implant with autogenous bone graft and Immediate implant without bone graft in people with Tooth Loss and Partial Edentulism in the Maxilla or in the Mandible, run by Suez Canal University at 1 site in Egypt.
Trial summary
This clinical study aims to evaluate the clinical and radiographic outcomes of immediate dental implant placement in mandibular premolar sites. Patients requiring extraction of mandibular premolars will receive immediate implant placement, with or without autogenous bone grafting, according to the study protocol. Read more about this study
- Who is it for?
- Ages 25 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Tooth Loss, Partial Edentulism in the Maxilla or in the Mandible
- What is being tested?
- Immediate implant with autogenous bone graft and Immediate implant without bone graft
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteEgypt
- Study dates
- 17 May 2025to 20 Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 25 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Patients requiring extraction of mandibular premolars.
- Age ≥ 25 years.
- Adequate oral hygiene and motivated patients for implant treatment.
- Sufficient bone volume to allow immediate implant placement (with or without minor augmentation).
- Patients willing to participate and attend follow-up visits for at least 6 months.
- Systemically healthy patients (ASA I or II).
Who cannot join
- Uncontrolled systemic diseases (e.g., uncontrolled diabetes, immunocompromised patients).
- Heavy smokers (e.g., >10-15 cigarettes/day).
- Active periodontal or acute infection at the implant site.
- Poor oral hygiene or non-compliant patients.
- Pregnancy or lactation.
- History of radiotherapy in head and neck region.
- Severe bone deficiency not suitable for immediate implant placement.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Evaluation of Autogenous Bone Graft on Osseointegration of Immediate Dental Implant in Lower Premolars Area Using Piezosurgery
This clinical study aims to evaluate the clinical and radiographic outcomes of immediate dental implant placement in mandibular premolar sites. Patients requiring extraction of mandibular premolars will receive immediate implant placement, with or without autogenous bone grafting, according to the study protocol.
When indicated, autogenous bone graft will be harvested using piezosurgery during the implant procedure. Participants will be followed up clinically and radiographically to assess implant stability, marginal bone level changes, and peri-implant tissue conditions over a defined follow-up period. The results of this study may help determine the effectiveness and predictability of immediate implant placement in mandibular premolar regions.
Read the detailed description
This prospective clinical study is designed to evaluate the clinical and radiographic outcomes of immediate dental implant placement in mandibular premolar regions following tooth extraction. Patients indicated for extraction of mandibular premolars will be enrolled according to predefined inclusion and exclusion criteria.
Following atraumatic tooth extraction, immediate dental implant placement will be performed in the extraction socket. two group included, one without bone graft and the other group with autogenous bone graft from ramus . Autogenous bone grafting will be utilized according to the study protocol and will be harvested intraoperatively using piezosurgery to ensure precise and minimally traumatic bone collection.
Implant placement will be performed following standard surgical protocols. Primary implant stability will be assessed at the time of placement. Patients will receive postoperative care and instructions according to institutional guidelines.
Clinical and radiographic evaluations will be conducted during follow-up visits to assess implant stability, peri-implant soft tissue condition, and marginal bone level changes. Radiographic assessment will be performed using standardized imaging techniques.
The primary outcome measures will include implant stability and marginal bone level changes around the implant. Secondary outcome measures will include implant stability and marginal bone level changes around the implant . overall implant success rate.
The results of this study aim to provide evidence regarding the predictability and effectiveness of immediate implant placement in mandibular premolar sites, with particular emphasis on the role of autogenous bone graft harvested using piezosurgery.
- Being tested
- Immediate implant with autogenous bone graft, Immediate implant without bone graft
- Keywords
- Immediate implant placement, Dental implants, Mandibular premolars, Autogenous bone graft, Osseointegration, Implant stability, Marginal bone loss
- Medical subject headings
- Tooth Loss
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Immediate implant with autogenous bone graftProcedure or surgery
Immediate implant with autogenous bone graft using piezo surgery
Immediate implant without bone graftProcedure or surgery
Immediate implant without bone graft
| Study group | Role | What they receive |
|---|---|---|
| Immediate implant without bone graft | Active comparator | Immediate implant without bone graft Receives: Procedure: Immediate implant without bone graft |
| Immediate implant with graft | Experimental | Immediate implant with outogenous bone graft Receives: Procedure: Immediate implant with autogenous bone graft |
What is being measured
The primary outcome is the main question the study is designed to answer.
Osseointegration success rate (%)
Implant success will be evaluated based on the absence of mobility, pain, infection, and peri-implant radiolucency around the implant.
Measured: 6 months after implant placement.
Secondary outcomes (4)
Implant stability (ISQ)
Implant stability will be measured using resonance frequency analysis (ISQ values) at the time of implant placement and during follow-up.
Measured: At implant placement and 6 months after implant placement
Marginal bone loss (mm)
Marginal bone level changes around the implant will be assessed using standardized periapical radiographs. Measurements will be performed using Digora software
Measured: Baseline (at implant placement) and 4 months after implant placement
Implant survival rate (%)
Presence of implant in situ without mobility or failure at follow-up visit.
Measured: 6 months after implant placement
Postoperative complication (%)
Clinical assessment of pain, swelling, infection, and delayed healing after implant placement.
Measured: Up to 6 months after implant placement.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Jul 2026
- Study start17 May 2025
- Primary completion17 Jul 2026 (estimated)
- Study completion20 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Tooth LossStudies of the same condition, open and under way.
- More trials run by Suez Canal UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Suez Canal University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07705399
- Sponsor's protocol ID
- 2024/897
- Other IDs
- 2024/897
- Acronym
- ABG-IDIP
- Status last verified
- Jul 2026
- First submitted
- 27 Jun 2026
- Last updated
- 15 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Autogenous Bone Graft on Osseointegration of Immediate Dental Implant in Lower Premolars Area Using Piezosurgery
- ClinicalTrials.gov ID
- NCT07705399
- Acronym / sponsor ID
- ABG-IDIP / 2024/897
- Keywords
- Immediate implant placement, Dental implants, Mandibular premolars, Autogenous bone graft, Osseointegration, Implant stability, Marginal bone loss
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- Suez Canal UniversityUniversity, hospital or other
- Study start
- 17 May 2025 (actual)
- Primary completion
- 17 Jul 2026 (estimated)
- Study completion
- 20 Nov 2026 (estimated)
- First posted
- 15 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This clinical study aims to evaluate the clinical and radiographic outcomes of immediate dental implant placement in mandibular premolar sites. Patients requiring extraction of mandibular premolars will receive immediate implant placement, with or without autogenous bone grafting, according to the study protocol.
When indicated, autogenous bone graft will be harvested using piezosurgery during the implant procedure. Participants will be followed up clinically and radiographically to assess implant stability, marginal bone level changes, and peri-implant tissue conditions over a defined follow-up period. The results of this study may help determine the effectiveness and predictability of immediate implant placement in mandibular premolar regions.
Detailed description
This prospective clinical study is designed to evaluate the clinical and radiographic outcomes of immediate dental implant placement in mandibular premolar regions following tooth extraction. Patients indicated for extraction of mandibular premolars will be enrolled according to predefined inclusion and exclusion criteria.
Following atraumatic tooth extraction, immediate dental implant placement will be performed in the extraction socket. two group included, one without bone graft and the other group with autogenous bone graft from ramus . Autogenous bone grafting will be utilized according to the study protocol and will be harvested intraoperatively using piezosurgery to ensure precise and minimally traumatic bone collection.
Implant placement will be performed following standard surgical protocols. Primary implant stability will be assessed at the time of placement. Patients will receive postoperative care and instructions according to institutional guidelines.
Clinical and radiographic evaluations will be conducted during follow-up visits to assess implant stability, peri-implant soft tissue condition, and marginal bone level changes. Radiographic assessment will be performed using standardized imaging techniques.
The primary outcome measures will include implant stability and marginal bone level changes around the implant. Secondary outcome measures will include implant stability and marginal bone level changes around the implant . overall implant success rate.
The results of this study aim to provide evidence regarding the predictability and effectiveness of immediate implant placement in mandibular premolar sites, with particular emphasis on the role of autogenous bone graft harvested using piezosurgery.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Immediate implant without bone graft | Active comparator | Procedure: Immediate implant without bone graftImmediate implant without bone graft |
| Immediate implant with graft | Experimental | Procedure: Immediate implant with autogenous bone graftImmediate implant with outogenous bone graft |
Who may qualify
- Ages
- 25 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Patients requiring extraction of mandibular premolars.
- Age ≥ 25 years.
- Adequate oral hygiene and motivated patients for implant treatment.
- Sufficient bone volume to allow immediate implant placement (with or without minor augmentation).
- Patients willing to participate and attend follow-up visits for at least 6 months.
Key exclusion criteria (7 listed)
- Uncontrolled systemic diseases (e.g., uncontrolled diabetes, immunocompromised patients).
- Heavy smokers (e.g., >10-15 cigarettes/day).
- Active periodontal or acute infection at the implant site.
- Poor oral hygiene or non-compliant patients.
- Pregnancy or lactation.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Immediate implant with autogenous bone graftImmediate implant with autogenous bone graft using piezo surgery | Procedure or surgery | Immediate implant with graft |
| Immediate implant without bone graftImmediate implant without bone graft | Procedure or surgery | Immediate implant without bone graft |
Primary outcome
Osseointegration success rate (%)
Time frame: 6 months after implant placement.
Implant success will be evaluated based on the absence of mobility, pain, infection, and peri-implant radiolucency around the implant.
4 secondary outcomes
Implant stability (ISQ)
Time frame: At implant placement and 6 months after implant placement
Marginal bone loss (mm)
Time frame: Baseline (at implant placement) and 4 months after implant placement
Implant survival rate (%)
Time frame: 6 months after implant placement
Postoperative complication (%)
Time frame: Up to 6 months after implant placement.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Jul 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Immediate implant with autogenous bone graft and Immediate implant without bone graft in people with Tooth Loss and Partial Edentulism in the Maxilla or in the Mandible, run by Suez Canal University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 15 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Osseointegration success rate (%) (time frame: 6 months after implant placement.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Jul 2026.