Carpal Tunnel Syndrome (CTS)NCT07707089
Evaluation of AI-Mouse Use in Patients With Hand and Wrist Conditions
A study testing AI-Assisted Computer Input System and Conventional Computer Mouse in people with Carpal Tunnel Syndrome (CTS) and Wounds and Injuries, Hands, run by Nazarbayev University.
Trial summary
People with hand and wrist conditions, such as carpal tunnel syndrome or hand injuries, often experience pain and discomfort when using a computer mouse. This study will evaluate a new artificial intelligence (AI)-assisted computer input system ("AI-mouse") designed to reduce the amount of hand movement needed during… Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Carpal Tunnel Syndrome (CTS), Wounds and Injuries, Hands, Wounds and Injuries, Wrists
- What is being tested?
- AI-Assisted Computer Input System and Conventional Computer Mouse
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 15 participants
- Where
- No sites listed yet
- Study dates
- Jul 2026to Oct 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults aged 18-65 years
- Diagnosis of a hand or wrist condition, including carpal tunnel syndrome or hand/wrist injury.
- Receiving care at the Hand Surgery Department of the National Scientific Center of Traumatology and Orthopedics.
- Medically stable and assessed by a study physician as able to safely perform light computer-based hand movements.
- Able to understand the study procedures and provide written informed consent.
- Normal or corrected-to-normal vision sufficient to complete computer-based tasks.
Who cannot join
- Severe pain or acute symptoms that may be aggravated by computer task performance.
- Postoperative restrictions limiting hand or wrist movement.
- Severe motor impairment preventing completion of the study tasks.
- Cognitive or neurological disorders that interfere with understanding study procedures or task performance.
- Uncorrected visual impairment that interferes with computer use.
- Any medical condition that, in the opinion of the study physician, would make participation unsafe.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
People with hand and wrist conditions, such as carpal tunnel syndrome or hand injuries, often experience pain and discomfort when using a computer mouse. This study will evaluate a new artificial intelligence (AI)-assisted computer input system ("AI-mouse") designed to reduce the amount of hand movement needed during computer tasks. Participants will complete short computer-based tasks using both a conventional mouse and the AI-assisted system while researchers measure task performance, muscle activity using surface electromyography (EMG), and participants' ratings of pain, physical strain, and usability. The study aims to determine whether the AI-assisted system can reduce physical effort and muscle load while maintaining effective computer interaction. Findings may help improve accessible computer technologies and support the development of ergonomic tools for people with hand and wrist impairments.
- Conditions
- Carpal Tunnel Syndrome (CTS), Wounds and Injuries, Hands, Wounds and Injuries, Wrists, Hand Injuries, Wrist Injuries
- Being tested
- AI-Assisted Computer Input System, Conventional Computer Mouse
- Medical subject headings
- Carpal Tunnel Syndrome, Wounds and Injuries, Hand Injuries, Wrist Injuries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AI-Assisted Computer Input SystemDevice
A non-invasive computer input system that uses artificial intelligence to predict the user's intended on-screen action. Instead of relying primarily on continuous cursor movement and mouse clicking, the system presents predicted actions that participants can preview, accept, or discard using minimal keyboard input. The intervention is designed to reduce repetitive hand movements during computer interaction while preserving user control. Participants complete standardized computer tasks using the system during a single study session lasting less than four minutes.
Conventional Computer MouseDevice
A standard computer mouse used for conventional point-and-click interaction. Participants complete the same standardized computer tasks as in the experimental condition, allowing direct comparison of task performance, upper-limb muscle activity measured by surface electromyography (EMG), and participant-reported pain, physical strain, and usability.
| Study group | Role | What they receive |
|---|---|---|
| Conventional Mouse | Active comparator | Participants perform standardized computer pointing tasks using a conventional computer mouse. Performance (task completion time, error rate, throughput), surface electromyography (EMG) of upper-limb muscles, and participant-reported outcomes (pain, physical strain, and usability) are assessed during task completion. Receives: Device: Conventional Computer Mouse |
| AI-Mouse (Preview-Accept-Discard [PAD] System) | Experimental | Participants perform the same standardized computer tasks using the AI-Mouse, a predictive human-computer interaction system based on the Preview-Accept-Discard (PAD) paradigm. The system generates AI-assisted action suggestions that can be accepted or discarded using minimal keyboard input, reducing cursor movement. Performance, surface electromyography (EMG), and participant-reported outcomes (pain, physical strain, and usability) are assessed during task completion. Receives: Device: AI-Assisted Computer Input System |
What is being measured
The primary outcome is the main question the study is designed to answer.
APDF90 surface electromyography (sEMG) amplitude
90th percentile amplitude probability distribution function (APDF90) of the processed sEMG envelope recorded from selected upper-limb muscles during standardized computer tasks.
Measured: Baseline (during each intervention condition on Day 1)
Muscular rest time
Percentage of task duration during which the processed sEMG envelope remained below the predefined muscular-rest threshold of 2 µV.
Measured: Baseline (during each intervention condition on Day 1)
Secondary outcomes (5)
Integrated squared dynamic acceleration
Cumulative dynamic movement workload measured by tri-axial accelerometry and expressed as integrated squared dynamic acceleration (mG²·s).
Measured: Baseline (during each intervention condition on Day 1)
90th percentile dynamic acceleration
Peak dynamic movement intensity measured by tri-axial accelerometry and expressed as the 90th percentile of dynamic acceleration (mG).
Measured: Baseline (during each intervention condition on Day 1)
Task completion time
Time required to complete the standardized computer task using the conventional mouse and the AI-assisted computer input system.
Measured: Baseline (during each intervention condition on Day 1)
Error rate
Percentage of incorrect target selections during the standardized computer task
Measured: Baseline (during each intervention condition on Day 1)
Self-reported pain
Participant-reported hand and wrist pain after completing each intervention condition, assessed using a numeric rating scale
Measured: Immediately after each intervention condition on Day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Jul 2026
- Study startJul 2026 (estimated)
- Primary completionSep 2026 (estimated)
- Study completionOct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Carpal Tunnel Syndrome (CTS)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 15 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Nazarbayev University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07707089
- Sponsor's protocol ID
- 1220/02042026
- Status last verified
- Jul 2026
- First submitted
- 30 Jun 2026
- Last updated
- 16 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of AI-Mouse Use in Patients With Hand and Wrist Conditions
- ClinicalTrials.gov ID
- NCT07707089
- Acronym / sponsor ID
- 1220/02042026
- Conditions
- Carpal Tunnel Syndrome (CTS), Wounds and Injuries, Hands, Wounds and Injuries, Wrists, Hand Injuries, Wrist Injuries
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 15 participants (estimated)
- Lead sponsor
- Nazarbayev UniversityUniversity, hospital or other
- Study start
- Jul 2026 (estimated)
- Primary completion
- Sep 2026 (estimated)
- Study completion
- Oct 2026 (estimated)
- First posted
- 16 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
People with hand and wrist conditions, such as carpal tunnel syndrome or hand injuries, often experience pain and discomfort when using a computer mouse. This study will evaluate a new artificial intelligence (AI)-assisted computer input system ("AI-mouse") designed to reduce the amount of hand movement needed during computer tasks. Participants will complete short computer-based tasks using both a conventional mouse and the AI-assisted system while researchers measure task performance, muscle activity using surface electromyography (EMG), and participants' ratings of pain, physical strain, and usability. The study aims to determine whether the AI-assisted system can reduce physical effort and muscle load while maintaining effective computer interaction. Findings may help improve accessible computer technologies and support the development of ergonomic tools for people with hand and wrist impairments.
Study design
- Primary purpose
- Supportive care
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Conventional Mouse | Active comparator | Device: Conventional Computer MouseParticipants perform standardized computer pointing tasks using a conventional computer mouse. Performance (task completion time, error rate, throughput), surface electromyography (EMG) of upper-limb muscles, and participant-reported outcomes (pain, physical strain, and usability) are assessed during task completion. |
| AI-Mouse (Preview-Accept-Discard [PAD] System) | Experimental | Device: AI-Assisted Computer Input SystemParticipants perform the same standardized computer tasks using the AI-Mouse, a predictive human-computer interaction system based on the Preview-Accept-Discard (PAD) paradigm. The system generates AI-assisted action suggestions that can be accepted or discarded using minimal keyboard input, reducing cursor movement. Performance, surface electromyography (EMG), and participant-reported outcomes (pain, physical strain, and usability) are assessed during task completion. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Adults aged 18-65 years
- Diagnosis of a hand or wrist condition, including carpal tunnel syndrome or hand/wrist injury.
- Receiving care at the Hand Surgery Department of the National Scientific Center of Traumatology and Orthopedics.
- Medically stable and assessed by a study physician as able to safely perform light computer-based hand movements.
- Able to understand the study procedures and provide written informed consent.
Key exclusion criteria (6 listed)
- Severe pain or acute symptoms that may be aggravated by computer task performance.
- Postoperative restrictions limiting hand or wrist movement.
- Severe motor impairment preventing completion of the study tasks.
- Cognitive or neurological disorders that interfere with understanding study procedures or task performance.
- Uncorrected visual impairment that interferes with computer use.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| AI-Assisted Computer Input SystemA non-invasive computer input system that uses artificial intelligence to predict the user's intended on-screen action. Instead of relying primarily on continuous cursor movement and mouse clicking, the system presents predicted actions that participants can preview, accept, or discard using minimal keyboard input. The intervention is designed to reduce repetitive hand movements during computer interaction while preserving user control. Participants complete standardized computer tasks using the system during a single study session lasting less than four minutes. | Device | AI-Mouse (Preview-Accept-Discard [PAD] System) |
| Conventional Computer MouseA standard computer mouse used for conventional point-and-click interaction. Participants complete the same standardized computer tasks as in the experimental condition, allowing direct comparison of task performance, upper-limb muscle activity measured by surface electromyography (EMG), and participant-reported pain, physical strain, and usability. | Device | Conventional Mouse |
Primary outcome
APDF90 surface electromyography (sEMG) amplitude
Time frame: Baseline (during each intervention condition on Day 1)
90th percentile amplitude probability distribution function (APDF90) of the processed sEMG envelope recorded from selected upper-limb muscles during standardized computer tasks.
Muscular rest time
Time frame: Baseline (during each intervention condition on Day 1)
Percentage of task duration during which the processed sEMG envelope remained below the predefined muscular-rest threshold of 2 µV.
5 secondary outcomes
Integrated squared dynamic acceleration
Time frame: Baseline (during each intervention condition on Day 1)
90th percentile dynamic acceleration
Time frame: Baseline (during each intervention condition on Day 1)
Task completion time
Time frame: Baseline (during each intervention condition on Day 1)
Error rate
Time frame: Baseline (during each intervention condition on Day 1)
Self-reported pain
Time frame: Immediately after each intervention condition on Day 1
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing AI-Assisted Computer Input System and Conventional Computer Mouse in people with Carpal Tunnel Syndrome (CTS) and Wounds and Injuries, Hands, run by Nazarbayev University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 16 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Jose Berengueres, PhD (+7 778 358 18 26, jose.berengueres@nu.edu.kz), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
APDF90 surface electromyography (sEMG) amplitude (time frame: Baseline (during each intervention condition on Day 1)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jul 2026.