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Athletic PerformanceTCP600-RESPNCT07710547

TCP-600 Supplementation and Performance Response in Professional Football Players

A study testing Taurine, Caffeine and Phosphatidylserine in people with Athletic Performance and Cognitive Fatigue, run by Vizja University in Warsaw at 3 sites in Poland.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

This 28-day randomised, placebo- and active-controlled trial investigated multidimensional responses to taurine-caffeine supplementation with or without phosphatidylserine in 65 male professional and highly trained football players. Read more about this study

Who is it for?
Ages 18 to 37 years, men onlyHealthy volunteers can take part
What is being tested?
Taurine, Caffeine and Phosphatidylserine
Type of treatment
Pill or oral medicine
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
65 participants
Where
3 sitesPoland
Study dates
7 Sep 2026to 8 Oct 2026
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 37 years
  • Men only
  • Healthy volunteers accepted
  • Adult

Who may be able to join

  • Male professional or highly trained football players aged 18-37 years.
  • Regular participation in structured football training and team activities.
  • Minimum of 5 years of structured football training experience.
  • Regular involvement in club training during the study period.
  • Medical clearance or no known contraindications to high-intensity exercise testing.
  • Ability to complete sprint, reaction-time, cognitive-fatigue, heart-rate-variability, wellness/readiness, and selected football-specific perceptual-cognitive assessments where available.
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  • Willingness to maintain usual diet and training habits during the study period.
  • Willingness to avoid additional ergogenic supplements outside the study protocol during the intervention.
  • Willingness to follow caffeine restrictions before testing sessions.
  • Written informed consent provided before participation.

Who cannot join

  • Current musculoskeletal injury or illness preventing full participation in training or testing.
  • Musculoskeletal injury within the previous 3 months that may affect sprint, football-specific performance, or perceptual-cognitive testing.
  • Cardiovascular, metabolic, neurological, psychiatric, or other chronic disease that may affect safety or study outcomes.
  • Diagnosed sleep disorder.
  • Use of medication affecting heart rate, autonomic nervous system function, sleep, cognition, or exercise performance.
  • Known hypersensitivity or intolerance to caffeine, taurine, phosphatidylserine, or any supplement ingredient.
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  • Regular use of ergogenic supplements that cannot be discontinued before and during the study period.
  • Smoking or regular use of nicotine products.
  • Participation in another interventional study during the same period.
  • Inability to comply with supplementation, monitoring, or testing procedures.
  • Failure to provide written informed consent.

Trial locations and contacts

3 sites in 1 country.

Poland3 sites
  • Professional Football Training Center

    Krakow

  • Professional Football Training Center

    Lodz, 01-043

  • Professional Football Training Center

    Warsaw, 01-043

Other trials in Poland

About this study

Official title: Multidimensional Responses to Taurine-Caffeine Supplementation With and Without Phosphatidylserine in Professional Football Players: A 28-Day Randomised, Placebo- and Active-Controlled Trial

This 28-day randomised, placebo- and active-controlled trial investigated multidimensional responses to taurine-caffeine supplementation with or without phosphatidylserine in 65 male professional and highly trained football players.

Participants were allocated to placebo (PLA), taurine 1500 mg/day plus caffeine 200 mg/day (TC), or the same combination supplemented with phosphatidylserine 600 mg/day (TCP-600). Assessments were conducted before and after the intervention and covered physical performance, cognitive function, cardiac autonomic modulation and football-specific perceptual-cognitive performance.

The primary outcome was the proportion of participants showing favourable responses in at least two of four predefined assessment domains. The principal treatment comparison was TCP-600 versus TC, with comparisons involving placebo providing additional information on the effects of supplementation.

Read the detailed description

This randomised, masked, placebo- and active-controlled trial examined physical, cognitive, autonomic and football-specific perceptual-cognitive responses to 28 days of supplementation in professional and highly trained male football players.

Participants were randomly allocated to placebo (PLA), taurine 1500 mg/day plus caffeine 200 mg/day (TC), or taurine 1500 mg/day plus caffeine 200 mg/day and phosphatidylserine 600 mg/day (TCP-600). Assessments were performed before supplementation and after the intervention.

The primary outcome was the proportion of multidimensional responders, defined as participants meeting favourable-response criteria in at least two of four assessment domains: physical performance, cognitive performance, autonomic/recovery-related response and football-specific perceptual-cognitive performance.

Secondary assessments included 30 m sprint performance, cognitive reaction time, cardiac autonomic modulation assessed using LnRMSSD, readiness to train, perceived fatigue, football-specific decision-making, response time and visual search behaviour. The study also monitored supplementation adherence and adverse events.

The principal treatment comparison was TCP-600 versus TC, allowing assessment of the additional effect of phosphatidylserine within a fixed taurine-caffeine supplementation regimen. Comparisons with placebo were also conducted.

Post-completion clarification (November 2026): The original registration included external validation of a previously developed responder prediction model, with AUROC as a secondary outcome. This analysis was not performed because a previously finalised prediction model suitable for independent validation was unavailable. The analysis therefore focuses on observed multidimensional response and treatment-group comparisons. The omission of the originally registered prediction-model validation analysis is disclosed as a deviation from the initial analysis plan.

Being tested
Placebo, Taurine, Caffeine, Phosphatidylserine
Keywords
Phosphatidylserine, Taurine, Caffeine, Football players, Soccer, Responder analysis, Heart rate variability, LnRMSSD, Reaction time, Mental fatigue, Sports nutrition, Individual responsiveness, Decision-making, Perceptual-cognitive performance, Recovery
Medical subject headings
Mental Fatigue

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • PlaceboOther

    Matching placebo capsules administered orally once daily for 28 consecutive days. The placebo was matched to the active supplements in appearance, number, packaging, and administration schedule.

  • TaurineDietary supplement

    Taurine 1500 mg/day administered orally once daily in capsules for 28 consecutive days.

  • CaffeineDietary supplement

    Anhydrous caffeine 200 mg/day administered orally once daily in capsules for 28 consecutive days.

  • PhosphatidylserineDietary supplement

    Phosphatidylserine 600 mg/day administered orally once daily in capsules for 28 consecutive days.

Study groups in NCT07710547
Study groupRoleWhat they receive
PlaceboPlacebo comparatorParticipants assigned to this arm will receive placebo capsules for 28 consecutive days. Placebo capsules will be matched to the active supplement in appearance, number, packaging, and administration schedule.
Receives: Other: Placebo
Taurine + CaffeineActive comparatorParticipants assigned to this arm will receive taurine 1500 mg/day and anhydrous caffeine 200 mg/day, administered orally once daily for 28 consecutive days. Matching placebo capsules will be used to maintain the same total number and appearance of capsules across study arms.
Receives: Dietary Supplement: Taurine; Dietary Supplement: Caffeine
Taurine + Caffeine + PhosphatidylserineExperimentalParticipants assigned to this arm will receive a multi-ingredient supplementation protocol containing taurine 1500 mg/day, anhydrous caffeine 200 mg/day, and phosphatidylserine 600 mg/day, administered orally once daily for 28 consecutive days. This intervention is referred to as the TCP-600 protocol.
Receives: Dietary Supplement: Taurine; Dietary Supplement: Caffeine; Dietary Supplement: Phosphatidylserine

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Proportion of Participants Classified as Multidimensional Responders After 28 Days

    Proportion of participants classified as multidimensional responders after 28 days of supplementation. A multidimensional responder will be defined as a participant meeting the predefined response criterion in at least two of four domains: physical performance/fatigue resistance, cognitive fatigue-related performance, recovery/readiness, and football-specific perceptual-cognitive performance. The outcome will be reported as the percentage of participants classified as multidimensional responders in each group.

    Unit of Measure: percentage of participants

    Measured: Baseline to post-intervention after 28 days of supplementation

Secondary outcomes (11)
  1. Change in 30 m Sprint Time

    Change in 30 m sprint performance from baseline to post-intervention testing. Sprint time will be measured using electronic timing gates. Participants will perform three maximal 30 m sprint trials separated by standardized recovery periods, and the best valid trial will be used for analysis.

    Measured: Baseline to post-intervention after 28 days of supplementation

  2. Change in Cognitive Fatigue Task Reaction Time

    Change in reaction time during the computerized cognitive fatigue task from baseline to post-intervention testing after 28 days of supplementation. Reaction time will be measured during the predefined cognitive task performed under cognitive load. The outcome will be reported as the mean change in reaction time from baseline to post-intervention testing. Lower values indicate faster cognitive responses.

    Unit of Measure: milliseconds

    Measured: Baseline to post-intervention after 28 days of supplementation

  3. Change in Perceived Mental Fatigue VAS Score

    Change in perceived mental fatigue from baseline to post-intervention testing after 28 days of supplementation. Perceived mental fatigue will be assessed using a 0-10 visual analogue scale, where 0 indicates no perceived mental fatigue and 10 indicates maximal perceived mental fatigue. The outcome will be reported as the mean change in score from baseline to post-intervention testing. Higher scores indicate greater perceived mental fatigue.

    Unit of Measure:

    points on a 0-10 scale

    Measured: Baseline to post-intervention after 28 days of supplementation.

  4. Change in Final 3-Day Mean LnRMSSD

    Change in heart rate variability from baseline monitoring to the final 3 days of supplementation. Heart rate variability will be expressed as the natural logarithm of the root mean square of successive RR interval differences. Morning HRV will be recorded under standardized resting conditions. The outcome will be reported as the mean change in final 3-day mean LnRMSSD compared with the baseline monitoring period.

    Unit of Measure: ln(ms)

    Measured: Baseline monitoring period to final 3 days of supplementation.

  5. Change in Readiness-to-Train Rating Scale Score

    Change in self-reported readiness to train from baseline monitoring to the final 3 days of supplementation. Readiness to train will be assessed using a single-item readiness-to-train rating scale scored from 1 to 10, where 1 indicates very poor readiness and 10 indicates excellent readiness. The outcome will be reported as the mean change in readiness-to-train score from the baseline monitoring period to the final 3-day supplementation period. Higher scores indicate greater perceived readiness to train.

    Unit of Measure: points on a 1-10 scale

    Measured: Baseline monitoring period to final 3 days of supplementation.

  6. Change in Hooper and Mackinnon Wellness Questionnaire Fatigue Item Score

    Change in self-reported fatigue from baseline monitoring to the final 3 days of supplementation. Fatigue will be assessed using the fatigue item of the Hooper and Mackinnon wellness questionnaire. The item is scored on a 1-7 scale. The outcome will be reported as the mean change in fatigue item score from the baseline monitoring period to the final 3-day supplementation period. Higher scores indicate greater perceived fatigue.

    Unit of Measure: points on a 1-7 scale

    Measured: Baseline monitoring period to final 3 days of supplementation.

  7. Area Under the Receiver Operating Characteristic Curve for the Predefined Responder Model

    Predictive performance of the predefined responder model in the independent validation cohort will be assessed using the area under the receiver operating characteristic curve. The model will compare predicted responder status with observed multidimensional responder status after 28 days of supplementation. Higher values indicate better discrimination.

    Unit of Measure: area under the curve Post-completion clarification (November 2026): The originally planned AUROC analysis was not performed because a previously finalised prediction model was not available for independent validation. No prediction model was developed using the present cohort as a substitute. This deviation from the original analysis plan will be disclosed in the study publication.

    Measured: Post-intervention after 28 days of supplementation.

  8. Number of Participants With Supplement-Related Adverse Events

    Number of participants reporting at least one supplement-related adverse event during the 28-day supplementation period. Participants will be asked to report gastrointestinal symptoms, sleep disturbances, headache, palpitations, nervousness, or any other unusual symptoms.

    Unit of Measure: participants

    Measured: During the 28-day supplementation period

  9. Change in Football-Specific Video Decision-Making Task Response Time

    Change in response time during the football-specific video decision-making task from baseline to post-intervention testing after 28 days of supplementation. Response time will be measured as the time from presentation of the decision prompt to participant response. The outcome will be reported as the mean change in response time from baseline to post-intervention testing. Lower values indicate faster football-specific decision-making.

    Unit of Measure: milliseconds

    Measured: Baseline to post-intervention after 28 days of supplementation.

  10. Change in Football-Specific Video Decision-Making Task Accuracy

    Change in football-specific decision-making accuracy from baseline to post-intervention testing after 28 days of supplementation. Decision-making accuracy will be assessed using a football-specific video decision-making task. Participants will view standardized football-specific scenarios and select the most appropriate tactical decision. The outcome will be reported as the mean change in the percentage of correct decisions from baseline to post-intervention testing. Higher values indicate better football-specific decision-making accuracy.

    Unit of Measure: percentage of correct decisions

    Measured: Baseline to post-intervention after 28 days of supplementation.

  11. Change in Eye-Tracking Time to First Fixation on the Optimal Tactical Option

    Change in visual search behavior from baseline to post-intervention testing after 28 days of supplementation. Visual search behavior will be assessed using eye-tracking during the football-specific video decision-making task. Time to first fixation will be defined as the time from scenario onset to the first fixation on the predefined optimal tactical option. The outcome will be reported as the mean change in time to first fixation from baseline to post-intervention testing. Lower values indicate faster visual orientation toward the optimal tactical option.

    Unit of Measure: milliseconds

    Measured: Baseline to post-intervention after 28 days of supplementation.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted17 Jul 2026
  2. Study start7 Sep 2026
  3. Primary completion8 Oct 2026
  4. Study completion8 Oct 2026

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Other
Allocation
Randomised
Intervention model
Parallel groups
Model description
Participants will be randomly assigned in a 1:1:1 ratio to placebo, taurine plus caffeine, or taurine plus caffeine plus phosphatidylserine 600 mg/day for 28 days. The study will use a randomized, double-blind, placebo- and active-controlled, parallel-group design. This validation cohort will be used to test and extend predefined multidimensional responder profiles in professional football players, with particular focus on identifying players most likely to benefit from the addition of phosphatidylserine to taurine-caffeine supplementation.
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
65 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07710547
Sponsor's protocol ID
VIZJA-TCP600-RESP-2026 (28)
Acronym
TCP600-RESP
Status last verified
Nov 2026
First submitted
4 Jul 2026
Last updated
4 Nov 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No: Individual participant data will not be publicly shared due to participant confidentiality and the small, potentially identifiable nature of the professional athlete sample. Aggregated results may be reported in publications. Selected anonymized analysis outputs may be made available from the corresponding author upon reasonable request, where ethically and legally appropriate.

Questions about this trial

What is this clinical trial studying?

A study testing Taurine, Caffeine and Phosphatidylserine in people with Athletic Performance and Cognitive Fatigue, run by Vizja University in Warsaw at 3 sites in Poland.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 10 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 4 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 3 sites in Poland. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Proportion of Participants Classified as Multidimensional Responders After 28 Days (time frame: Baseline to post-intervention after 28 days of supplementation). It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Nov 2026.

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