Physiological ParametersNCT07722260
Effect of Implementing Cough Augmentation Techniques on Weaning Outcomes Among Critically Ill Patients
A study testing cough augmentation techniques in people with Physiological Parameters, run by Heba.Attia@nur.dmu.edu.eg at 1 site in Egypt.
Trial summary
The study aims to determine the effect of implementing cough augmentation techniques on weaning outcomes among critically ill patients Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Physiological Parameters
- What is being tested?
- cough augmentation techniques
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 88 participants
- Where
- 1 siteEgypt
- Study dates
- 8 Jul 2026to 10 Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- adult intubated patients
- both sex
Who cannot join
- patient with facial trauma
- patient with tracheostomy tube
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Faculty of Nursing, Damanhur University
Damanhūr
Reem Bassiony, chairperson of ethics committe, 045 3311679, admin.nur@nur.dmu.edu.eg
Heba attia, lecturer, 045 01274855242, heba.attia@nur.dmu.edu.eg
About this study
The study aims to determine the effect of implementing cough augmentation techniques on weaning outcomes among critically ill patients
Read the detailed description
Cough augmentation techniques are important interventions for critically ill patients who have impaired cough strength due to mechanical ventilation, neuromuscular weakness, sedation, or respiratory muscle dysfunction. These techniques, which include manual assisted cough, lung volume recruitment, and mechanical insufflation-exsufflation, enhance expiratory airflow and improve the clearance of airway secretions
- Conditions
- Physiological Parameters
- Being tested
- cough augmentation techniques
- Keywords
- cough augmentation, weaning outcomes
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
cough augmentation techniquesOther
the lung volume recruitment maneuver via MV was applied with assistant of the attended physician as follows: Use pressure-controlled ventilation and increase end-inspiratory volume (30 or 40 cm H2O for 30 to 40 seconds unless contraindicated) or inspiratory hold for 30 to 40 seconds to promote cough effectiveness. The patient serially inhales a volume of gas without exhalation until maximum insufflation capacity via the ventilator to facilitate breath-holding (if not contraindicated).
| Study group | Role | What they receive |
|---|---|---|
| Interventional group | Experimental | the experimental group receive the cough augmentation techniques Receives: Other: cough augmentation techniques |
| conventional group | No intervention | receive the routine care in the unit |
What is being measured
The primary outcome is the main question the study is designed to answer.
weaning success
measured through successful extubating
Measured: within 7 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Jul 2026
- Study start8 Jul 2026 (estimated)
- Primary completion8 Oct 2026 (estimated)
- Study completion10 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Physiological ParametersStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 88 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Heba.Attia@nur.dmu.edu.eg
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Heba.Attia@nur.dmu.edu.eg, Damanhour University
- Investigators
- sahar youness, professor, Principal investigator, professor of critical care and emergency nursing
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07722260
- Sponsor's protocol ID
- 55-d
- Status last verified
- Jul 2026
- First submitted
- 19 Jul 2026
- Last updated
- 23 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: 55-d
Publications
Chatwin M, Wakeman RH. Mechanical Insufflation-Exsufflation: Considerations for Improving Clinical Practice. J Clin Med. 2023 Mar 31;12(7):2626. doi: 10.3390/jcm12072626.
PubMed 37048708
Study at a glance
From the registry record, last updated by the sponsor on 23 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Implementing Cough Augmentation Techniques on Weaning Outcomes Among Critically Ill Patients
- ClinicalTrials.gov ID
- NCT07722260
- Acronym / sponsor ID
- 55-d
- Conditions
- Physiological Parameters
- Keywords
- cough augmentation, weaning outcomes
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 88 participants (estimated)
- Lead sponsor
- Heba.Attia@nur.dmu.edu.egUniversity, hospital or other
- Study start
- 8 Jul 2026 (estimated)
- Primary completion
- 8 Oct 2026 (estimated)
- Study completion
- 10 Nov 2026 (estimated)
- First posted
- 23 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study aims to determine the effect of implementing cough augmentation techniques on weaning outcomes among critically ill patients
Detailed description
Cough augmentation techniques are important interventions for critically ill patients who have impaired cough strength due to mechanical ventilation, neuromuscular weakness, sedation, or respiratory muscle dysfunction. These techniques, which include manual assisted cough, lung volume recruitment, and mechanical insufflation-exsufflation, enhance expiratory airflow and improve the clearance of airway secretions
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Interventional group | Experimental | Other: cough augmentation techniquesthe experimental group receive the cough augmentation techniques |
| conventional group | No intervention | –receive the routine care in the unit |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- adult intubated patients
- both sex
Key exclusion criteria (2 listed)
- patient with facial trauma
- patient with tracheostomy tube
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| cough augmentation techniquesthe lung volume recruitment maneuver via MV was applied with assistant of the attended physician as follows: Use pressure-controlled ventilation and increase end-inspiratory volume (30 or 40 cm H2O for 30 to 40 seconds unless contraindicated) or inspiratory hold for 30 to 40 seconds to promote cough effectiveness. The patient serially inhales a volume of gas without exhalation until maximum insufflation capacity via the ventilator to facilitate breath-holding (if not contraindicated). | Other | Interventional group |
Primary outcome
weaning success
Time frame: within 7 days
measured through successful extubating
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Jul 2026.
- Background: PubMed 37048708Chatwin M, Wakeman RH. Mechanical Insufflation-Exsufflation: Considerations for Improving Clinical Practice. J Clin Med. 2023 Mar 31;12(7):2626. doi: 10.3390/jcm12072626.
- Mechanical Insufflation-Exsufflation: Considerations for Improving Clinical PracticeLink provided by the sponsor.
- Individual participant dataSharing planned: Yes. 55-d
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
sahar youness, professor principal investigator
professor of critical care and emergency nursing
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing cough augmentation techniques in people with Physiological Parameters, run by Heba.Attia@nur.dmu.edu.eg at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 23 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Alaa Mustafa, assistant professor (0201097210526, alaa.mustafa@nur.dmu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
weaning success (time frame: within 7 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07722260, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jul 2026.