StrokeNCT07724925
Comparative Effects of Task-Oriented Training and Hand-Arm Bimanual Intensive in Post-Stroke Patients
A study testing Task-Oriented Training and Hand-Arm Bimanual Intensive Therapy in people with Stroke, run by Riphah International University at 1 site in Pakistan.
Trial summary
Stroke is a rapidly developing clinical signs of focal (or global) disturbance of cerebral function, lasting more than 24 hours or leading to death, with no apparent cause other than a vascular origin. Read more about this study
- Who is it for?
- Ages 45 to 70 years
- Conditions the study is for
- Stroke
- What is being tested?
- Task-Oriented Training and Hand-Arm Bimanual Intensive Therapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 sitePakistan
- Study dates
- 1 Jun 2025to 2 Aug 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 45 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- • Age 45-70
- Gender (both male and female)
- Pre diagnosed First-time stroke patients (ischemic or hemorrhagic)
- Time since stroke: ≥3 months
- Mild to moderate upper limb impairment (ABILHAND Questionnaire: Less than 50% of items rated as "impossible.")
- Moderate functional independence in basic activities (Barthel Index score ≥ 60)
- Ability to follow commands (MMSE > 24 or equivalent cognitive screening)
Who cannot join
- • Severe spasticity (Modified Ashworth Scale score ≥ 3) or contractures
- Other neurological conditions (Alzheimer's disease, Parkinson and dementia)
- Unstable medical conditions (diabetes and hypertension) that may interfere with participation
- Participation in any other structured upper limb rehabilitation or experimental therapy within the past 3 months
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
DHQ Hospital Nankana Sahib
Nankana Sahib
Dr. Taimoor-ul-Hassan, +923134192781, Taimoorsaim786@gmail.com
About this study
Official title: Comparative Effects of Task-Oriented Training and Hand-Arm Bimanual Intensive Therapy on Gross and Fine Motor Skills of Upper Limb and Activities of Daily Living in Post-Stroke Patients
Stroke is a rapidly developing clinical signs of focal (or global) disturbance of cerebral function, lasting more than 24 hours or leading to death, with no apparent cause other than a vascular origin. Among various rehabilitation strategies, Task-oriented training of low to moderate intensity and Hand-Arm bimanual intensive therapy have shown their promising results in stroke rehabilitation. So, this study aims to determine the comparative effects of Task-oriented and Hand-Arm bimanual intensive therapy on Gross and Fine motor skills of Upper Limb and Activities of Daily Living in Post-Stroke Patients.
Read the detailed description
This randomized clinical trial will be conducted at District Headquarter Hospital Nankana Sahib on 30 stroke patients, randomly assigned to two groups through seal opaque method. Group A will receive task-oriented training and Group B will undergo hand-arm bimanual therapy over an 8-week period. Outcome measures will include Action Research Arm Test for gross movement of upper limb and fine motor functions will be assessed using the Nine Hole Peg Test, while the Barthel Index will be used for daily activity performance. Pre and post-intervention assessments will be used to analyze and compare the effects of interventions. Data will be analyzed using the SPSS version 25. Statistical significance will be set at p=0.05. The normality of data will be checked by Shapiro wilk test (p-value 0.05). Difference between groups will be analyzed through Independent sample t-test/Mann-Whitney Test within group comparison will be analyzed through Paired sample t-test/Wilcoxen Signed-Rank test depending upon the normality of data.
- Conditions
- Stroke
- Being tested
- Task-Oriented Training, Hand-Arm Bimanual Intensive Therapy
- Keywords
- Task-Oriented Training, Hand-Arm Bimanual Intensive Therapy, Gross and Fine Motor Skills, Activities of Daily Living
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Task-Oriented TrainingOther
Frequency: 3 session/week for 8 weeks Intensity: 5 reps/session Duration: 30 minutes, increasing to 45 minutes by the end of week 8
Exercises:
- Reaching
- Push-pull tasks
- Grasping
- Wiping tasks
- Weight-bearing on hands
- Lifting an object (2 sets×5 reps of each exercise) Gradually increasing duration and intensity each week.
Hand-Arm Bimanual Intensive TherapyOther
Frequency: 3 session/week for 8 weeks Intensity: 5 reps/session Duration:30 minutes, increasing to 45 minutes by the end of week 8
Exercises:
- Rolling a ball
- Opening containers
- Towel folding
- Lifting and placing objects
- Cutting with scissors
- Zipping and buttoning
- Peeling fruits (2 sets×5 reps of each exercise) Gradually increasing duration and intensity each week.
| Study group | Role | What they receive |
|---|---|---|
| GROUP A: TOT | Experimental | Frequency: 3 session/week for 8 weeks Intensity: 5 reps/session Duration: 30 minutes, increasing to 45 minutes by the end of week 8
Exercises:
* Reaching
* Push-pull tasks
* Grasping
* Wiping tasks
* Weight-bearing on hands
* Lifting an object (2 sets×5 reps of each exercise) Gradually increasing duration and intensity each week. Receives: Other: Task-Oriented Training |
| GROUP B: HABIT | Active comparator | Frequency: 3 session/week for 8 weeks Intensity: 5 reps/session Duration:30 minutes, increasing to 45 minutes by the end of week 8
Exercises:
* Rolling a ball
* Opening containers
* Towel folding
* Lifting and placing objects
* Cutting with scissors
* Zipping and buttoning
* Peeling fruits (2 sets×5 reps of each exercise) Gradually increasing duration and intensity each week. Receives: Other: Hand-Arm Bimanual Intensive Therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Gross Motor Skills
Action Research Arm Test
Measured: Baseline and post 8 weeks
Fine Motor Skills
Nine Hole Peg Test
Measured: Baseline and post 8 weeks
Activities of Daily Living
Barthel Index Scale
Measured: Baseline and post 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Jul 2026
- Study start1 Jun 2025
- Primary completion30 Jul 2026 (estimated)
- Study completion2 Aug 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- randomized clinical trial
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Aiza Yousaf, MS-OMPT, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07724925
- Sponsor's protocol ID
- REC/RCR & AHS/25/0238
- Status last verified
- Jul 2026
- First submitted
- 21 Jul 2026
- Last updated
- 24 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 24 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Effects of Task-Oriented Training and Hand-Arm Bimanual Intensive Therapy on Gross and Fine Motor Skills of Upper Limb and Activities of Daily Living in Post-Stroke Patients
- ClinicalTrials.gov ID
- NCT07724925
- Acronym / sponsor ID
- REC/RCR & AHS/25/0238
- Conditions
- Stroke
- Keywords
- Task-Oriented Training, Hand-Arm Bimanual Intensive Therapy, Gross and Fine Motor Skills, Activities of Daily Living
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 1 Jun 2025 (actual)
- Primary completion
- 30 Jul 2026 (estimated)
- Study completion
- 2 Aug 2026 (estimated)
- First posted
- 24 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Stroke is a rapidly developing clinical signs of focal (or global) disturbance of cerebral function, lasting more than 24 hours or leading to death, with no apparent cause other than a vascular origin. Among various rehabilitation strategies, Task-oriented training of low to moderate intensity and Hand-Arm bimanual intensive therapy have shown their promising results in stroke rehabilitation. So, this study aims to determine the comparative effects of Task-oriented and Hand-Arm bimanual intensive therapy on Gross and Fine motor skills of Upper Limb and Activities of Daily Living in Post-Stroke Patients.
Detailed description
This randomized clinical trial will be conducted at District Headquarter Hospital Nankana Sahib on 30 stroke patients, randomly assigned to two groups through seal opaque method. Group A will receive task-oriented training and Group B will undergo hand-arm bimanual therapy over an 8-week period. Outcome measures will include Action Research Arm Test for gross movement of upper limb and fine motor functions will be assessed using the Nine Hole Peg Test, while the Barthel Index will be used for daily activity performance. Pre and post-intervention assessments will be used to analyze and compare the effects of interventions. Data will be analyzed using the SPSS version 25. Statistical significance will be set at p=0.05. The normality of data will be checked by Shapiro wilk test (p-value 0.05). Difference between groups will be analyzed through Independent sample t-test/Mann-Whitney Test within group comparison will be analyzed through Paired sample t-test/Wilcoxen Signed-Rank test depending upon the normality of data.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- randomized clinical trial
| Arm | Type | Receives |
|---|---|---|
| GROUP A: TOT | Experimental | Other: Task-Oriented TrainingFrequency: 3 session/week for 8 weeks Intensity: 5 reps/session Duration: 30 minutes, increasing to 45 minutes by the end of week 8 Exercises: * Reaching * Push-pull tasks * Grasping * Wiping tasks * Weight-bearing on hands * Lifting an object (2 sets×5 reps of each exercise) Gradually increasing duration and intensity each week. |
| GROUP B: HABIT | Active comparator | Other: Hand-Arm Bimanual Intensive TherapyFrequency: 3 session/week for 8 weeks Intensity: 5 reps/session Duration:30 minutes, increasing to 45 minutes by the end of week 8 Exercises: * Rolling a ball * Opening containers * Towel folding * Lifting and placing objects * Cutting with scissors * Zipping and buttoning * Peeling fruits (2 sets×5 reps of each exercise) Gradually increasing duration and intensity each week. |
Who may qualify
- Ages
- 45 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- • Age 45-70
Key exclusion criteria (4 listed)
- • Severe spasticity (Modified Ashworth Scale score ≥ 3) or contractures
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Task-Oriented TrainingFrequency: 3 session/week for 8 weeks Intensity: 5 reps/session Duration: 30 minutes, increasing to 45 minutes by the end of week 8 Exercises: * Reaching * Push-pull tasks * Grasping * Wiping tasks * Weight-bearing on hands * Lifting an object (2 sets×5 reps of each exercise) Gradually increasing duration and intensity each week. | Other | GROUP A: TOT |
| Hand-Arm Bimanual Intensive TherapyFrequency: 3 session/week for 8 weeks Intensity: 5 reps/session Duration:30 minutes, increasing to 45 minutes by the end of week 8 Exercises: * Rolling a ball * Opening containers * Towel folding * Lifting and placing objects * Cutting with scissors * Zipping and buttoning * Peeling fruits (2 sets×5 reps of each exercise) Gradually increasing duration and intensity each week. | Other | GROUP B: HABIT |
Primary outcome
Gross Motor Skills
Time frame: Baseline and post 8 weeks
Action Research Arm Test
Fine Motor Skills
Time frame: Baseline and post 8 weeks
Nine Hole Peg Test
Activities of Daily Living
Time frame: Baseline and post 8 weeks
Barthel Index Scale
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Jul 2026.
- Individual participant dataSharing planned: No
Related trials for Stroke
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Safety and Efficacy of CG-BM1 in Ischemic Stroke
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Not yet recruitingPhase 3
Recombinant Human Prourokinase for Acute Ischemic Stroke in the Extended Window Selected by CT-Based Artificial Intelligence
Acute Ischemic Stroke
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Effects of Mirror Therapy and Motor Imagery on Upper Limb Motor Functions in Middle Cerebral Artery Stroke
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Rapid Local Ischemic Postconditioning on Stroke After Thrombectomy
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Not yet recruitingObservational study
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Aiza Yousaf, MS-OMPT principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Task-Oriented Training and Hand-Arm Bimanual Intensive Therapy in people with Stroke, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 24 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Imran Amjad, PhD (03324390125, imran.amjad@riphah.edu.pk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Gross Motor Skills (time frame: Baseline and post 8 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Jul 2026.