Tooth ExtractionNCT07725029
Evaluation of Demineralized Dentin Matrix With and Without Injectable Platelet Rich Fibrin as Grafting Materials
A study testing Demineralized dentin matrix grafting material and Demineralized dentin matrix with injectable platelet rich fibrin in people with Tooth Extraction, run by Mansoura University at 1 site in Egypt.
Trial summary
Thirty two healthy patients will be selected from the outpatient clinic of the oral and maxillofacial surgery department, faculty of dentistry, Mansoura university, to be included in this study with non restorable teeth in the maxillary esthetic area. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Tooth Extraction
- What is being tested?
- Demineralized dentin matrix grafting material and Demineralized dentin matrix with injectable platelet rich fibrin
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 32 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jun 2025to 1 Jul 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Patient age ranged between 18-40 years old.
- Patients seeking to replace non-restorable tooth / teeth in maxillary esthetic zone (anterior \&premolars) by using immediate implant placement.
- Cooperative patients with high motivation and good oral hygiene.
- Intact socket wall after tooth extraction.
- Jumping gap more than 2mm.
- Favorable occlusion without presence of parafunctional habits, eg; bruxism and clenching.
- Sufficient inter-arch space to accommodate the future prothesis.
- Patients able to comply with the required recall visits.
Who cannot join
- Patients with known systemic diseases, which can affect normal bone formation or blood coagulation.
- Presence of signs of acute infection or pus formation.
- Pregnancy.
- Smoking.
- Patients on bisphosphonate drug.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Demineralized Dentin Matrix With and Without Injectable Platelet Rich Fibrin as Grafting Materials Around Immediate Dental Implants in the Maxillary Esthetic Zone
Thirty two healthy patients will be selected from the outpatient clinic of the oral and maxillofacial surgery department, faculty of dentistry, Mansoura university, to be included in this study with non restorable teeth in the maxillary esthetic area. After atraumatic teeth extraction, immediate implant placement will be done and buccal jumping gap will be filled by demineralized dentin matrix in study group and control one by demineralized dentin matrix mixed with in injectable platelet rich fibrin.
- Conditions
- Tooth Extraction
- Being tested
- Demineralized dentin matrix grafting material, Demineralized dentin matrix with injectable platelet rich fibrin
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Demineralized dentin matrix grafting materialOther
After atraumatic extraction, immediate implant placement will be performed and buccal jumping gap will be filled with demineralized dentin matrix
Demineralized dentin matrix with injectable platelet rich fibrinOther
After atraumatic extraction, immediate implant placement will be performed and buccal jumping gap will be filled with demineralized dentin matrix mixed with injectable platelet rich fibrin
| Study group | Role | What they receive |
|---|---|---|
| group 1 | Experimental | buccal jumping gap following immediate implant placement will be filled with demineralized dentin matrix for 16 cases Receives: Other: Demineralized dentin matrix grafting material |
| group 2 | Experimental | buccal jumping gap following immediate implant placement will be filled with demineralized dentin matrix mixed with injectable platelet rich fibrin for 16 cases Receives: Other: Demineralized dentin matrix with injectable platelet rich fibrin |
What is being measured
The primary outcome is the main question the study is designed to answer.
implant stability
implant stability will be measured using Osstell mentor device
Measured: 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Jul 2026
- Study start1 Jun 2025
- Primary completion1 Sep 2025
- Study completion1 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Tooth ExtractionStudies of the same condition, open and under way.
- More trials run by Mansoura UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 32 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mansoura University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Heba Elsheikh, Mansoura University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07725029
- Sponsor's protocol ID
- MS.25.05.28
- Status last verified
- Jul 2026
- First submitted
- 21 Jul 2026
- Last updated
- 24 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 24 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Demineralized Dentin Matrix With and Without Injectable Platelet Rich Fibrin as Grafting Materials Around Immediate Dental Implants in the Maxillary Esthetic Zone
- ClinicalTrials.gov ID
- NCT07725029
- Acronym / sponsor ID
- MS.25.05.28
- Conditions
- Tooth Extraction
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 32 participants (actual)
- Lead sponsor
- Mansoura UniversityUniversity, hospital or other
- Study start
- 1 Jun 2025 (actual)
- Primary completion
- 1 Sep 2025 (actual)
- Study completion
- 1 Jul 2026 (actual)
- First posted
- 24 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Thirty two healthy patients will be selected from the outpatient clinic of the oral and maxillofacial surgery department, faculty of dentistry, Mansoura university, to be included in this study with non restorable teeth in the maxillary esthetic area. After atraumatic teeth extraction, immediate implant placement will be done and buccal jumping gap will be filled by demineralized dentin matrix in study group and control one by demineralized dentin matrix mixed with in injectable platelet rich fibrin.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| group 1 | Experimental | Other: Demineralized dentin matrix grafting materialbuccal jumping gap following immediate implant placement will be filled with demineralized dentin matrix for 16 cases |
| group 2 | Experimental | Other: Demineralized dentin matrix with injectable platelet rich fibrinbuccal jumping gap following immediate implant placement will be filled with demineralized dentin matrix mixed with injectable platelet rich fibrin for 16 cases |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (8 listed)
- Patient age ranged between 18-40 years old.
- Patients seeking to replace non-restorable tooth / teeth in maxillary esthetic zone (anterior \&premolars) by using immediate implant placement.
- Cooperative patients with high motivation and good oral hygiene.
- Intact socket wall after tooth extraction.
- Jumping gap more than 2mm.
Key exclusion criteria (5 listed)
- Patients with known systemic diseases, which can affect normal bone formation or blood coagulation.
- Presence of signs of acute infection or pus formation.
- Pregnancy.
- Smoking.
- Patients on bisphosphonate drug.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Demineralized dentin matrix grafting materialAfter atraumatic extraction, immediate implant placement will be performed and buccal jumping gap will be filled with demineralized dentin matrix | Other | group 1 |
| Demineralized dentin matrix with injectable platelet rich fibrinAfter atraumatic extraction, immediate implant placement will be performed and buccal jumping gap will be filled with demineralized dentin matrix mixed with injectable platelet rich fibrin | Other | group 2 |
Primary outcome
implant stability
Time frame: 12 months
implant stability will be measured using Osstell mentor device
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Jul 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Demineralized dentin matrix grafting material and Demineralized dentin matrix with injectable platelet rich fibrin in people with Tooth Extraction, run by Mansoura University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
implant stability (time frame: 12 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Jul 2026.