Acute Kidney Injury Cardiac SurgeryNCT07727772
Vascular Aging and Acute Kidney Injury After Cardiac Surgery
An observational study of Acute Kidney Injury Cardiac Surgery and Postoperative Complications, run by Nanjing First Hospital, Nanjing Medical University at 1 site in China.
Trial summary
This prospective observational cohort study will enroll adult patients undergoing cardiac surgery at Nanjing First Hospital, Nanjing Medical University. The study will evaluate multidimensional vascular aging markers before surgery and assess their association with postoperative acute kidney injury within 7 days after… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Acute Kidney Injury Cardiac Surgery, Postoperative Complications, Vascular Aging
- What is being tested?
- Multidimensional Vascular Aging Assessment
- How many people
- 472 participants
- Where
- 1 siteChina
- Study dates
- 1 Jul 2026to 28 Dec 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: The study population will consist of adult patients undergoing cardiac surgery at Nanjing First Hospital, Nanjing Medical University. Eligible patients will receive perioperative vascular aging assessment and postoperative renal function monitoring according to the study protocol. Participants will be followed for postoperative acute kidney injury within 7 days after surgery.
Who may be able to join
- Adult patients aged 18 years or older.
- Patients scheduled to undergo cardiac surgery at Nanjing First Hospital, Nanjing Medical University.
- Patients who are able to provide written informed consent.
- Patients who are expected to undergo perioperative vascular aging assessment and postoperative renal function monitoring according to the study protocol.
Who cannot join
- Patients younger than 18 years.
- Patients with preoperative end-stage renal disease or maintenance dialysis.
- Patients who are unable to complete the study-specified vascular aging assessment.
- Patients who decline participation or withdraw informed consent.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site
Nanjing First Hospital, Nanjing Medical University
Nanjing, Jiangsu, 210006
Feifan Hu, +8615162614385, feifanhu0722@foxmail.com
About this study
Official title: Multidimensional Assessment of Vascular Aging and Its Association With Postoperative Acute Kidney Injury in Patients Undergoing Cardiac Surgery
This prospective observational cohort study will enroll adult patients undergoing cardiac surgery at Nanjing First Hospital, Nanjing Medical University. The study will evaluate multidimensional vascular aging markers before surgery and assess their association with postoperative acute kidney injury within 7 days after surgery. No intervention will be assigned by the study protocol, and all perioperative management will follow routine clinical practice.
Read the detailed description
Acute kidney injury is a common postoperative complication after cardiac surgery and is associated with adverse short-term and long-term outcomes. Vascular aging may reflect systemic vascular dysfunction, impaired vascular compliance, endothelial dysfunction, and reduced renal perfusion reserve, which may increase susceptibility to postoperative acute kidney injury.
This prospective observational cohort study will include adult patients scheduled to undergo cardiac surgery at Nanjing First Hospital, Nanjing Medical University. Perioperative vascular aging-related indicators will be collected according to the study protocol. These indicators may include noninvasive vascular assessments, hemodynamic measurements, and relevant clinical and laboratory variables. Postoperative renal function will be monitored after surgery, and acute kidney injury will be assessed within 7 days after surgery according to predefined diagnostic criteria.
The primary objective is to investigate the association between multidimensional vascular aging markers and the occurrence and severity of postoperative acute kidney injury. Secondary analyses may evaluate the relationships between vascular aging burden and postoperative clinical outcomes, including intensive care unit stay, hospital stay, and other postoperative complications when available. This is an observational study, and no treatment, surgical procedure, or perioperative management strategy will be assigned by the study protocol.
- Being tested
- Multidimensional Vascular Aging Assessment
- Keywords
- vascular aging, acute kidney injury, postoperative complications
- Medical subject headings
- Postoperative Complications, Acute Kidney Injury
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Multidimensional Vascular Aging AssessmentOther
Perioperative assessment of vascular aging-related indicators, including noninvasive vascular assessments, hemodynamic measurements, and relevant clinical and laboratory variables. The assessment is observational and will not determine the treatment, surgical procedure, or perioperative management assigned to participants.
| Study group | Role | What they receive |
|---|---|---|
| Cardiac Surgery Cohort | Adult patients undergoing cardiac surgery at Nanjing First Hospital who will receive perioperative vascular aging assessment and postoperative renal function monitoring according to the study protocol. No treatment or perioperative management strategy will be assigned by the study protocol. Receives: Other: Multidimensional Vascular Aging Assessment |
What is being measured
The primary outcome is the main question the study is designed to answer.
Incidence of Postoperative Acute Kidney Injury Within 7 Days After Surgery
Postoperative acute kidney injury will be assessed within 7 days after surgery according to predefined diagnostic criteria based on postoperative renal function changes. The outcome will be recorded as the occurrence of acute kidney injury during the postoperative 7-day period.
Measured: From the date of surgery to postoperative day 7
Secondary outcomes (1)
Severity of Postoperative Acute Kidney Injury
The severity of postoperative acute kidney injury will be classified according to predefined staging criteria during the postoperative 7-day period.
Measured: From the date of surgery to postoperative day 7
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Jul 2026
- Study start1 Jul 2026 (estimated)
- Primary completion21 Feb 2027 (estimated)
- Study completion28 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Acute Kidney Injury Cardiac SurgeryStudies of the same condition, open and under way.
- More trials run by Nanjing First Hospital, Nanjing Medical UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 472 participants (estimated)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07727772
- Sponsor's protocol ID
- KY20260625-09
- Status last verified
- Jul 2026
- First submitted
- 22 Jul 2026
- Last updated
- 27 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be publicly shared because the study involves clinical data from hospitalized patients and data sharing is restricted by institutional policies and participant privacy protection requirements. De-identified aggregate results may be made available in publications.
Study at a glance
From the registry record, last updated by the sponsor on 27 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Multidimensional Assessment of Vascular Aging and Its Association With Postoperative Acute Kidney Injury in Patients Undergoing Cardiac Surgery
- ClinicalTrials.gov ID
- NCT07727772
- Acronym / sponsor ID
- KY20260625-09
- Keywords
- vascular aging, acute kidney injury, postoperative complications
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 472 participants (estimated)
- Lead sponsor
- Nanjing First Hospital, Nanjing Medical UniversityUniversity, hospital or other
- Study start
- 1 Jul 2026 (estimated)
- Primary completion
- 21 Feb 2027 (estimated)
- Study completion
- 28 Dec 2027 (estimated)
- First posted
- 27 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective observational cohort study will enroll adult patients undergoing cardiac surgery at Nanjing First Hospital, Nanjing Medical University. The study will evaluate multidimensional vascular aging markers before surgery and assess their association with postoperative acute kidney injury within 7 days after surgery. No intervention will be assigned by the study protocol, and all perioperative management will follow routine clinical practice.
Detailed description
Acute kidney injury is a common postoperative complication after cardiac surgery and is associated with adverse short-term and long-term outcomes. Vascular aging may reflect systemic vascular dysfunction, impaired vascular compliance, endothelial dysfunction, and reduced renal perfusion reserve, which may increase susceptibility to postoperative acute kidney injury.
This prospective observational cohort study will include adult patients scheduled to undergo cardiac surgery at Nanjing First Hospital, Nanjing Medical University. Perioperative vascular aging-related indicators will be collected according to the study protocol. These indicators may include noninvasive vascular assessments, hemodynamic measurements, and relevant clinical and laboratory variables. Postoperative renal function will be monitored after surgery, and acute kidney injury will be assessed within 7 days after surgery according to predefined diagnostic criteria.
The primary objective is to investigate the association between multidimensional vascular aging markers and the occurrence and severity of postoperative acute kidney injury. Secondary analyses may evaluate the relationships between vascular aging burden and postoperative clinical outcomes, including intensive care unit stay, hospital stay, and other postoperative complications when available. This is an observational study, and no treatment, surgical procedure, or perioperative management strategy will be assigned by the study protocol.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Cardiac Surgery Cohort | – | Other: Multidimensional Vascular Aging AssessmentAdult patients undergoing cardiac surgery at Nanjing First Hospital who will receive perioperative vascular aging assessment and postoperative renal function monitoring according to the study protocol. No treatment or perioperative management strategy will be assigned by the study protocol. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- The study population will consist of adult patients undergoing cardiac surgery at Nanjing First Hospital, Nanjing Medical University. Eligible patients will receive perioperative vascular aging assessment and postoperative renal function monitoring according to the study protocol. Participants will be followed for postoperative acute kidney injury within 7 days after surgery.
Key inclusion criteria (4 listed)
- Adult patients aged 18 years or older.
- Patients scheduled to undergo cardiac surgery at Nanjing First Hospital, Nanjing Medical University.
- Patients who are able to provide written informed consent.
- Patients who are expected to undergo perioperative vascular aging assessment and postoperative renal function monitoring according to the study protocol.
Key exclusion criteria (4 listed)
- Patients younger than 18 years.
- Patients with preoperative end-stage renal disease or maintenance dialysis.
- Patients who are unable to complete the study-specified vascular aging assessment.
- Patients who decline participation or withdraw informed consent.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Multidimensional Vascular Aging AssessmentPerioperative assessment of vascular aging-related indicators, including noninvasive vascular assessments, hemodynamic measurements, and relevant clinical and laboratory variables. The assessment is observational and will not determine the treatment, surgical procedure, or perioperative management assigned to participants. | Other | Cardiac Surgery Cohort |
Primary outcome
Incidence of Postoperative Acute Kidney Injury Within 7 Days After Surgery
Time frame: From the date of surgery to postoperative day 7
Postoperative acute kidney injury will be assessed within 7 days after surgery according to predefined diagnostic criteria based on postoperative renal function changes. The outcome will be recorded as the occurrence of acute kidney injury during the postoperative 7-day period.
1 secondary outcome
Severity of Postoperative Acute Kidney Injury
Time frame: From the date of surgery to postoperative day 7
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Jul 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be publicly shared because the study involves clinical data from hospitalized patients and data sharing is restricted by institutional policies and participant privacy protection requirements. De-identified aggregate results may be made available in publications.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Acute Kidney Injury Cardiac Surgery and Postoperative Complications, run by Nanjing First Hospital, Nanjing Medical University at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 27 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact F Hu (+8615162614385, feifanhu0722@foxmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Incidence of Postoperative Acute Kidney Injury Within 7 Days After Surgery (time frame: From the date of surgery to postoperative day 7). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Jul 2026.