Clinical trials: Vascular Aging
Aging, Oxidative Stress
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse
Prolonged periods of reduced activity are associated with decreased vascular function and muscle atrophy. Physical inactivity due to acute hospitalization is also associated with impaired recovery, hospital readmission, and…
- Conditions
- Aging, Oxidative Stress, Vascular Endothelium, Skeletal Muscle
- Trial name
- NCT04351113
- Testing
- MITO-AO, PB-125, Passive Leg Movement (PLM)
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Joel Trinity
Aging
The Eggs and actiVity in hEalth agiNg Pilot (EVEN-P) Trial in Older Persons
Two of the most effective lifestyle-based approaches to reduce the risk of adverse health events and enhance quality of life with aging are exercise and a healthy diet.
- Trial name
- EVEN-P (NCT04264013)
- Testing
- Exercise, Exercise plus diet (egg)
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Aging, Arterial Stiffness
Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study
This study investigates the effect of dietary inorganic nitrate supplementation on 1) large elastic artery stiffness and hemodynamics and 2) cerebrovascular function in middle-aged and older adults.
- Conditions
- Aging, Arterial Stiffness, Endothelial Dysfunction, Hypertension
- Trial name
- INCA (NCT03617302)
- Testing
- Experimental: Nitrate-containing
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce, PhD
Aging, Inflammation
Relationship Between Thoracic Aortic Structure Assessed B PET/CT Scan and Arterial Stiffness in Elderly Patients
The purpose of this study is to determine the relationship between thoracic aortic inflammation and arterial stiffness in elderly patients.
- Trial name
- FICTEP (NCT01963221)
- Testing
- fludeoxyglucose(18f), blood sample, cardiac and aortic magnetic resonance imaging
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Hypotension, Orthostatic
Orthostatic Hypotension in Rehabilitation Patients
The purpose of this study is to determine the prevalence and clinical course of orthostatic hypotension (OH) on a rehabilitation and nursing home unit during their inpatient stay and to initiate a standardized, interdisciplinary…
- Trial name
- NCT00117585
- Testing
- Treatment Phase 1, Treatment Phase 2, Treatment Phase 3
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- VA Office of Research and Development
Healthy Diet, Healthy Aging
Acute Effects of Added Sugar Intake on Cerebrovascular Function and Brain Integrity
This study will focus on acute effects of added sugars on brain health in a specific age group (30-64 years old). We will provide participants two meals (one meal containing 16 g of added sugars and the other containing 61 g of…
- Trial name
- NCT05408338
- Testing
- Low Added Sugar Meal, High Added Sugar Meal
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Stroke
Power Exercise for Stroke Recovery: The POWER Pilot Trial (POWER-P)
Weakness is one of the most common consequences of stroke. For the over 750,000 Canadians living with stroke, many daily activities like standing from a chair, walking and balance not only require strength but often efforts in…
- Trial name
- POWER-P (NCT06780995)
- Testing
- Power Exercise for Stroke Recovery (POWER), Strength Training Engaging Guidelines to Enhance Total Health (STRENGTH)
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- McMaster University
Stroke
Virtual Reality and Field Training to Enhance Community Walking After Stroke
While stroke survivors discharged from rehabilitation present with some recovery in mobility, their ability to ambulate in the community remains limited.
- Trial name
- NCT04559373
- Testing
- Virtual Reality and Field Training (VRFT)
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- McGill University
MCI, Alzheimer Disease
Cognitive Impairment in Ageing People
Mild cognitive impairment (MCI) and neurocognitive disorder such as Alzheimer's disease (AD) and Vascular dementia (VaD) have become common diseases in the elderly.
- Conditions
- MCI, Alzheimer Disease, VAD - Vascular Dementia, Cognitive Impairment
- Trial name
- NCT04360200
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Yamei Tang
Aging, Endothelial Dysfunction
Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging
The primary goal of this intervention is to determine the efficacy of acute mitochondrial-specific antioxidants to improve vascular endothelial function in middle-aged and older (≥45 y) adults who do no perform regular aerobic…
- Conditions
- Aging, Endothelial Dysfunction, Cardiovascular Function, Arterial Stiffness
- Trial name
- NCT05872139
- Testing
- Mitoquinone Mesylate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ball State University
Myocardial Infarction, Aging
Physical Activity Intervention in ELderly Patients With Myocardial INfarction
Elderly patients presenting with myocardial infarction (MI) are the highest risk population with the worst prognosis. No trial has ever been designed to optimize their outcome through a systematic improvement of their physical…
- Trial name
- PIpELINe (NCT04183465)
- Testing
- Health Education, Multi-domain lifestyle intervention
- Where
- 7 sites in Italy
- Volunteers
- 512 people
- Sponsor
- University Hospital of Ferrara
Alzheimer's Disease, Dementia With Lewy Bodies
Imaging of Brain Amyloid Plaques in the Aging Population
This is a prospective, open label, non-therapeutic, diagnostic imaging study. The purpose of this study is to utilize Pittsburgh Compound B positron emission imaging (PiB PET) to ascertain the relationship between change in…
- Conditions
- Alzheimer's Disease, Dementia With Lewy Bodies, Frontotemporal Dementia, Vascular Dementia
- Trial name
- NCT00950430
- Testing
- Pittsburgh Compound B (C-11 PiB), F-18 FDG, Tau (18-F-AV-1451)
- Where
- United States
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Multiple Myeloma, Amyloidosis
Cancer and Aging Resilience Evaluation in Older Adults With Hematologic Malignancies: The CARE-Heme Registry
The primary purpose of this protocol is to create a registry of older (≥50 years old) patients with Hematologic Malignancies. Our main objectives include: To understand the prevalence of frailty and geriatric impairments among…
- Conditions
- Multiple Myeloma, Amyloidosis, Plasma Cell Leukemia
- Trial name
- CARE-Heme (NCT05556928)
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- University of Alabama at Birmingham
Coronary Artery Disease
The Use of Aging Biomarkers to Predict Adverse Outcomes After Cardiac Surgery
Cardiac surgery associated acute kidney injury (CSA-AKI) has been recognized as the second most common cause of hospital acquired AKI.
- Trial name
- NCT02496234
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Sapere Bio
Coronary Artery Disease, Diabetes Mellitus, Type 2
PIPAF Platelets in the Pathogenesis of Ageing Associated Frailty
This is a prospective observational study aimed at testing the existence of an association between frailty, inflammatory status, and degree of platelet activation and reactivity in elderly subjects with type 2 diabetes or…
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Type 2, Alzheimer Disease
- Trial name
- PIPAF (NCT05798637)
- Testing
- Standard of care
- Where
- 2 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera di Perugia
Healthy, Stroke
Influence of Brain Oscillation-Dependent TMS on Motor Function
Background: When people have a stroke, they often have difficulty moving their arms and hands. Transcranial magnetic stimulation (TMS) can improve how well people with and without stroke can move their arms and hands.
- Conditions
- Healthy, Stroke, Normal Physiology, Aging
- Trial name
- NCT03288220
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Myocardial Infarction, Stroke
Women's Health Initiative Strong and Healthy Study
The WHISH trial applies state-of-the science behavioral principles and currently available technologies to deliver a physical activity intervention without face-to-face contact to ~25,000 older U.S. women expected to consent.
- Conditions
- Myocardial Infarction, Stroke, Cardiovascular Mortality, Hip Fractures
- Trial name
- WHISH (NCT02425345)
- Testing
- Physical Activity
- Volunteers
- 49,331 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Cardiovascular Disease, Coronary Heart Disease
Effects of Tart Cherry and Aroniaberry Supplementation on Endothelial Function and Cardiovascular Measures in Healthy Older Adults: Interactions With Genotype and Proteome
Background: Heart disease is the leading cause of death and disabilities in the United States. Diets high in fruits and vegetables may reduce the risk of heart disease.
- Conditions
- Cardiovascular Disease, Coronary Heart Disease, Aging
- Trial name
- NCT02379403
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Aging
Mitochondrial-targeted Antioxidant Supplementation for Improving Age-related Vascular Dysfunction in Humans
The majority of cardiovascular diseases (CVD) occur in men and women ≥60 years of age. Vascular dysfunction, including endothelial dysfunction, as assessed by reduced endothelium-dependent dilation (EDD), and stiffening of the…
- Trial name
- NCT04851288
- Testing
- MitoQ
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
TBI (Traumatic Brain Injury), Stroke
Cognitive Profile of Patients at the Sagol Center for Hyperbaric Medicine and Research
In the investigator's institute there is ongoing treatment of different patients with cognitive deficits using Hyperbaric oxygen therapy (HBOT).
- Conditions
- TBI (Traumatic Brain Injury), Stroke, Fibromyalgia, Aging
- Trial name
- NCT04287283
- Testing
- Hyperbaric Oxygen
- Where
- Israel
- Volunteers
- 2,500 people
- Sponsor
- Assaf-Harofeh Medical Center