Rotator Cuff TendinopathyeccentricNCT07727941
The Effect of Eccentric Isokinetic Exercise in Shoulder Tendinopathies
An observational study of Rotator Cuff Tendinopathy and Rehabilitation Exercise, run by Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization at 2 sites in Turkey (Türkiye).
Trial summary
To evaluate the effects of an eccentric isokinetic exercise program on shoulder pain, function, and ultrasonographic supraspinatus muscle architecture in patients with rotator cuff tendinopathy, and to compare outcomes with a standardized home exercise program. Read more about this study
- Who is it for?
- Ages 20 to 50 years
- Conditions the study is for
- Rotator Cuff Tendinopathy, Rehabilitation Exercise
- What is being tested?
- Exercise Group and Eccentric exercise
- Type of treatment
- Medical device
- How many people
- 50 participants
- Where
- 2 sitesTurkey (Türkiye)
- Study dates
- 21 Jul 2025to 21 Feb 2026
- How long will I take part?
- 3 Months
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 50 years
- All sexes
- No healthy volunteers
- Adult
Study population: Adult patients presenting to the Prof. Dr. Cemil Taşcıoğlu City Hospital Physical Therapy Outpatient Clinic with complaints of shoulder pain.
Who may be able to join
- Having a diagnosis of rotator cuff tendinopathy based on medical history, physical examination, and MRI findings
- Having full shoulder joint range of motion
- Absence of upper extremity deformity that would interfere with ultrasonographic measurement
- Having provided written informed consent
Who cannot join
- Adhesive capsulitis (stages 2-3)
- Radiographic evidence of calcific tendinitis or significant bursitis •Cervical radiculopathy Upper extremity or spinal deformities
- History of surgery involving the shoulder, cervical spine, or back
- Neurological or systemic disease (rheumatological, metabolic, etc.)
- Physical therapy for the shoulder, neck, or back region within the last 6 months
- Corticosteroid injection into the affected shoulder within the last 6 months
- Exposure to intensive repetitive shoulder movements in sports or occupational activities
- Use of medications that could affect exercise performance or metabolic response
Trial locations and contacts
2 sites in 1 country.
Turkey (Türkiye)2 sites
Prof. Dr. Cemil Taşcıoğlu City Hospital
Istanbul
Prof. Dr. Cemil Taşcıoğlu City Hospital
Istanbul, şişli, 34384
About this study
Official title: The Effect of Eccentric Isokinetic Exercise on Shoulder Function, Pain, and Muscle Architecture in Shoulder Tendinopathies
To evaluate the effects of an eccentric isokinetic exercise program on shoulder pain, function, and ultrasonographic supraspinatus muscle architecture in patients with rotator cuff tendinopathy, and to compare outcomes with a standardized home exercise program.
Read the detailed description
This study aims to evaluate the effects of eccentric isokinetic exercise on pain, shoulder function, and supraspinatus muscle architecture parameters in individuals diagnosed with rotator cuff tendinopathy. The study's primary hypothesis is that controlled eccentric isokinetic loading will induce measurable architectural adaptations in the supraspinatus muscle, in addition to clinical improvement.
- Conditions
- Rotator Cuff Tendinopathy, Rehabilitation Exercise
- Being tested
- Exercise Group, Eccentric exercise
- Keywords
- rotator cuff tendinopathy, eccentric exercise, muscle architecture, ultrasonography
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Exercise GroupOther
Eccentric isokinetic exercise in rotator cuff tendinopathy
Eccentric exerciseDevice
The isokinetic group performed eccentric exercises on the Humac Norm II device three times weekly for four weeks, in addition to a standardized shoulder exercise program.
| Study group | Role | What they receive |
|---|---|---|
| exercise group | active clinical isokinetic exercise Receives: Other: Exercise Group | |
| home exercise group | patients receive home erxercise program Receives: Device: Eccentric exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
To evaluate the effects of an eccentric isokinetic exercise program on shoulder compare outcomes
To evaluate the effects of an eccentric isokinetic exercise program on shoulder pain, function, and ultrasonographic supraspinatus muscle architecture in patients with rotator cuff tendinopathy, and to compare outcomes with a standardized pain was assessed using VAS. The VAS is an ordinal scale that rates pain from 0 to 10. Low scores indicate low pain, while high scores indicate severe pain.
Measured: 6 mounth
Western Ontario Rotator Cuff Index
It assesses the impact of shoulder pain on five key domains: physical symptoms, sports and recreation, work function, lifestyle, and emotional well-being. The questionnaire takes less than 10 minutes to complete, features 21 items, and is scored out of 2100 points, with higher scores indicating greater dysfunction.
Measured: 3 months
Ultrasonographic measurement
Supraspinatus muscle thickness was measured in millimeters using ultrasonography. High values indicate good function.
Measured: 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Jul 2026
- Study start21 Jul 2025
- Primary completion21 Oct 2025
- Study completion21 Feb 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Rotator Cuff TendinopathyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 50 participants (actual)
- Target duration
- 3 Months
Sponsor and investigators
- Lead sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Sevgi Atar, Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
- Investigators
- atar, Principal investigator, Prof Dr. Cemil Taşcıoğlu
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07727941
- Sponsor's protocol ID
- Prof. Dr. Cemil Tascioglu
- Acronym
- eccentric
- Status last verified
- Jun 2026
- First submitted
- 25 Jun 2026
- Last updated
- 27 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Eccentric Isokinetic Exercise on Shoulder Function, Pain, and Muscle Architecture in Shoulder Tendinopathies
- ClinicalTrials.gov ID
- NCT07727941
- Acronym / sponsor ID
- eccentric / Prof. Dr. Cemil Tascioglu
- Conditions
- Rotator Cuff Tendinopathy, Rehabilitation Exercise
- Keywords
- rotator cuff tendinopathy, eccentric exercise, muscle architecture, ultrasonography
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital OrganizationUniversity, hospital or other
- Study start
- 21 Jul 2025 (actual)
- Primary completion
- 21 Oct 2025 (actual)
- Study completion
- 21 Feb 2026 (actual)
- First posted
- 27 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To evaluate the effects of an eccentric isokinetic exercise program on shoulder pain, function, and ultrasonographic supraspinatus muscle architecture in patients with rotator cuff tendinopathy, and to compare outcomes with a standardized home exercise program.
Detailed description
This study aims to evaluate the effects of eccentric isokinetic exercise on pain, shoulder function, and supraspinatus muscle architecture parameters in individuals diagnosed with rotator cuff tendinopathy. The study's primary hypothesis is that controlled eccentric isokinetic loading will induce measurable architectural adaptations in the supraspinatus muscle, in addition to clinical improvement.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Target follow-up
- 3 Months
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| exercise group | – | Other: Exercise Groupactive clinical isokinetic exercise |
| home exercise group | – | Device: Eccentric exercisepatients receive home erxercise program |
Who may qualify
- Ages
- 20 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
- Study population
- Adult patients presenting to the Prof. Dr. Cemil Taşcıoğlu City Hospital Physical Therapy Outpatient Clinic with complaints of shoulder pain.
Key inclusion criteria (4 listed)
- Having a diagnosis of rotator cuff tendinopathy based on medical history, physical examination, and MRI findings
- Having full shoulder joint range of motion
- Absence of upper extremity deformity that would interfere with ultrasonographic measurement
- Having provided written informed consent
Key exclusion criteria (8 listed)
- Adhesive capsulitis (stages 2-3)
- Radiographic evidence of calcific tendinitis or significant bursitis •Cervical radiculopathy Upper extremity or spinal deformities
- History of surgery involving the shoulder, cervical spine, or back
- Neurological or systemic disease (rheumatological, metabolic, etc.)
- Physical therapy for the shoulder, neck, or back region within the last 6 months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Exercise GroupEccentric isokinetic exercise in rotator cuff tendinopathy | Other | exercise group |
| Eccentric exerciseThe isokinetic group performed eccentric exercises on the Humac Norm II device three times weekly for four weeks, in addition to a standardized shoulder exercise program. | Device | home exercise group |
Primary outcome
To evaluate the effects of an eccentric isokinetic exercise program on shoulder compare outcomes
Time frame: 6 mounth
To evaluate the effects of an eccentric isokinetic exercise program on shoulder pain, function, and ultrasonographic supraspinatus muscle architecture in patients with rotator cuff tendinopathy, and to compare outcomes with a standardized pain was assessed using VAS. The VAS is an ordinal scale that rates pain from 0 to 10. Low scores indicate low pain, while high scores indicate severe pain.
Western Ontario Rotator Cuff Index
Time frame: 3 months
It assesses the impact of shoulder pain on five key domains: physical symptoms, sports and recreation, work function, lifestyle, and emotional well-being. The questionnaire takes less than 10 minutes to complete, features 21 items, and is scored out of 2100 points, with higher scores indicating greater dysfunction.
Ultrasonographic measurement
Time frame: 3 months
Supraspinatus muscle thickness was measured in millimeters using ultrasonography. High values indicate good function.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Jul 2026.
Related trials for Rotator Cuff Tendinopathy
Recruiting
Effects of Cervicothoracic Mobilization in Patients With Supraspinatus Tendinitis
Rotator Cuff Tendonitis
Active, not recruitingObservational study
Natural History of Shoulder Pathology in Manual Wheelchair Users
Paraplegia, Spinal Cord Injuries
Active, not recruiting
Comparative Effects of Cyriax Approach With and Without Mobilization With Movement in Shoulder Restriction With Rotator Cuff Tendinopathy
Rotator Cuff Tendinopathy
Not yet recruiting
Comparison of High-Intensity and Conventional Physical Therapy in Musculoskeletal Disorders
Low Back Pain, Radicular Syndrome
Recruiting
Latissimus Dorsi Strengthening Exercises in Rotator Cuff Tendinopathy
Rotator Cuff Related Shoulder Pain, Rotator Cuff Tendinopathy
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
atar principal investigator
Prof Dr. Cemil Taşcıoğlu
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Rotator Cuff Tendinopathy and Rehabilitation Exercise, run by Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization at 2 sites in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
To evaluate the effects of an eccentric isokinetic exercise program on shoulder compare outcomes (time frame: 6 mounth). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Jul 2026.