Tracheal IntubationNCT07741578
Sequential Order of RSI on Tracheal Intubation
A study testing Drug Sequence in people with Tracheal Intubation and Rapid Sequence Induction and Intubation, run by Zhongnan Hospital at 1 site in China.
Trial summary
This clinical trial aims to understand the effect of the order of administration of Neuromuscular Blocking Agents (NMBAs) and sedatives on the success rate of intubation during Rapid Sequence Intubation (RSI) in the emergency department. The main questions to be answered include: 1. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Tracheal Intubation, Rapid Sequence Induction and Intubation
- What is being tested?
- Drug Sequence
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 380 participants
- Where
- 1 siteChina
- Study dates
- 1 Jul 2025to 30 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- in ED/EICU required emergency intubation
- RSI required
Who cannot join
- Pregnancy
- do not intubation orders
- Declined participation
- Other trials
- Non-emergent cases
- Active CPR
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Impact of Sequential Order of Emergency Sedation and Neuromuscular Blocking Agent During Rapid Sequence Induction on Tracheal Intubation
This clinical trial aims to understand the effect of the order of administration of Neuromuscular Blocking Agents (NMBAs) and sedatives on the success rate of intubation during Rapid Sequence Intubation (RSI) in the emergency department. The main questions to be answered include:
- The impact of sequential drug administration order during rapid sequence induction (RSI) on first-pass intubation success rates.
- Time to successful intubation
- Hypoxia incidence (SpO₂ <90%)
- Risk of post-traumatic stress disorder (PTSD)
- Procedure-related complications
- Being tested
- Drug Sequence
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Drug SequenceProcedure or surgery
Control: Sedative ( Propofol ) →within 30s→ NMBA ( Rocuronium ) → Intubation → 5min → Measure vital signs → After treatment → Remove tracheal intubation→ Recall of intubation Intervention: NMBA ( Rocuronium ) →within 30s→ Sedative(Propofol) → Intubation → 5min → Measure vital signs → After treatment → Remove tracheal intubation→ Recall of intubation
| Study group | Role | What they receive |
|---|---|---|
| Sedative to NMBA | No intervention | Sedative(Propofol) →within 30s→ NMBA(Rocuronium) → Intubation |
| NMBA to Sedative | Experimental | NMBA(Rocuronium) →within 30s→ Sedative(Propofol) → Intubation Receives: Procedure: Drug Sequence |
What is being measured
The primary outcome is the main question the study is designed to answer.
First-pass success rate
Successful intubation on the first attempt, confirmed by any one of:
Direct visualization of the ETT passing through vocal cords Bilateral breath sounds on auscultation Fiberoptic bronchoscopic confirmation of tracheal placement Sustained end-tidal CO₂ waveform (EtCO₂ >15 mmHg for ≥3 breaths)
Measured: Perioperative
Secondary outcomes (5)
Time to intubation
from laryngoscopy start to confirmation (seconds)
Measured: Perioperative
Intubation recall
Measured: From drug injection to Remove the endotracheal tube
Changes in SBP
ΔSBP, :SBPₜ₀ - SBPₜ₁ ; (SBPₜ₀ - SBPₜ₁)/SBPₜ₀ × 100%
Measured: Perioperative
Changes in HR
ΔHR (absolute and percentage change):HRₜ₀ - HRₜ₁ ; (HRₜ₀ - HRₜ₁)/HRₜ₀ × 100%
Measured: Perioperative
Changes in SpO₂
ΔSpO₂ (absolute and percentage change):SpO₂ₜ₀ - SpO₂ₜ₂ₘᵢₙ ; (SpO₂ₜ₀ - SpO₂ₜ₂ₘᵢₙ)/SpO₂ₜ₀ × 100%
Measured: Perioperative
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Aug 2026
- Study start1 Jul 2025
- Primary completion1 Jun 2026
- Study completion30 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Tracheal IntubationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 380 participants (actual)
Sponsor and investigators
- Lead sponsor
- Zhongnan Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07741578
- Sponsor's protocol ID
- ZKL-KY-2024-008
- Other IDs
- ZKL-KY-2024-008
- Status last verified
- Jul 2026
- First submitted
- 23 Jul 2026
- Last updated
- 3 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Impact of Sequential Order of Emergency Sedation and Neuromuscular Blocking Agent During Rapid Sequence Induction on Tracheal Intubation
- ClinicalTrials.gov ID
- NCT07741578
- Acronym / sponsor ID
- ZKL-KY-2024-008
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 380 participants (actual)
- Lead sponsor
- Zhongnan HospitalUniversity, hospital or other
- Study start
- 1 Jul 2025 (actual)
- Primary completion
- 1 Jun 2026 (actual)
- Study completion
- 30 Jun 2026 (actual)
- First posted
- 3 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This clinical trial aims to understand the effect of the order of administration of Neuromuscular Blocking Agents (NMBAs) and sedatives on the success rate of intubation during Rapid Sequence Intubation (RSI) in the emergency department. The main questions to be answered include:
- The impact of sequential drug administration order during rapid sequence induction (RSI) on first-pass intubation success rates.
- Time to successful intubation
- Hypoxia incidence (SpO₂ <90%)
- Risk of post-traumatic stress disorder (PTSD)
- Procedure-related complications
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Sedative to NMBA | No intervention | –Sedative(Propofol) →within 30s→ NMBA(Rocuronium) → Intubation |
| NMBA to Sedative | Experimental | Procedure: Drug SequenceNMBA(Rocuronium) →within 30s→ Sedative(Propofol) → Intubation |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- in ED/EICU required emergency intubation
- RSI required
Key exclusion criteria (6 listed)
- Pregnancy
- do not intubation orders
- Declined participation
- Other trials
- Non-emergent cases
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Drug SequenceControl: Sedative ( Propofol ) →within 30s→ NMBA ( Rocuronium ) → Intubation → 5min → Measure vital signs → After treatment → Remove tracheal intubation→ Recall of intubation Intervention: NMBA ( Rocuronium ) →within 30s→ Sedative(Propofol) → Intubation → 5min → Measure vital signs → After treatment → Remove tracheal intubation→ Recall of intubation | Procedure or surgery | NMBA to Sedative |
Primary outcome
First-pass success rate
Time frame: Perioperative
Successful intubation on the first attempt, confirmed by any one of: Direct visualization of the ETT passing through vocal cords Bilateral breath sounds on auscultation Fiberoptic bronchoscopic confirmation of tracheal placement Sustained end-tidal CO₂ waveform (EtCO₂ >15 mmHg for ≥3 breaths)
5 secondary outcomes
Time to intubation
Time frame: Perioperative
Intubation recall
Time frame: From drug injection to Remove the endotracheal tube
Changes in SBP
Time frame: Perioperative
Changes in HR
Time frame: Perioperative
Changes in SpO₂
Time frame: Perioperative
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Aug 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Drug Sequence in people with Tracheal Intubation and Rapid Sequence Induction and Intubation, run by Zhongnan Hospital at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
First-pass success rate (time frame: Perioperative). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Aug 2026; AzTrials last refreshed its copy on 6 Nov 2026.