Clinical trials: Rapid Sequence Induction and Intubation
Airway Control, Anesthesia
Ketamine Versus Etomidate for Rapid Sequence Intubation
The purpose of this study is to compare the effectiveness and safety of ketamine and etomidate during rapid sequence intubation (RSI).
- Conditions
- Airway Control, Anesthesia, Intubation, Complication
- Trial name
- NCT01823328
- Testing
- Ketamine, Etomidate
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- Hennepin Healthcare Research Institute
Rapid Sequence Induction, Rapid Sequence Intubation
Rapid Sequence Intubation With Rocuronium in Elderly Patients
With the prolongation of life expectancy, the frequency of surgical intervention and anesthesia increases in elderly patients. The rapid Sequence Intubation(RSI) technique is preferred in patients with aspiration risk and who…
- Conditions
- Rapid Sequence Induction, Rapid Sequence Intubation, Rocuronium
- Trial name
- NCT05067829
- Testing
- Train of four(TOF)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Ankara City Hospital Bilkent
Rapid Sequence Intubation
Rapid Sequence Intubation and Hemodynamic Disorders in the Operating Room: a Prospective Multicenter Observational Study
There is a great heterogeneity in the practice of rapid sequence induction in the operating room in the world. There are no recent data assessing the rate of implementation of the latest French formalized expert recommendations…
- Trial name
- CoC (NCT06194058)
- Testing
- rapid sequence anesthetic induction
- Where
- 42 sites in France
- Volunteers
- 1,150 people
- Sponsor
- Nantes University Hospital
Rapid Sequence Induction Intubation
Effect of Cricoid Pressure on Macintosh, McGrath X-Blade and Glidescope Videolaryngoscopes in Rapid Sequence Induction Intubation
Non- Fasted patients need rapid sequence intubation. The investigators aimed to compare the intubation times of Macintosh , and McGrath X-Blade or Glidescope in these Ascenario.
- Trial name
- NCT02588157
- Testing
- Macintosh, Glidescope, McGrath MAC X-Blade
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Kocaeli University
Anesthesia
Comparison of Intubation Conditions During Rapid Sequence Induction Obtained With Modified Time Principal Induction With a Standard Intubation Dose of Rocuronium Versus Succinylcholine
The purpose of this study is to assess and compare conditions for tracheal intubation obtained with modified time principal induction with 0.6 mg/kg rocuronium and 1 mg/kg succinylcholine.
- Trial name
- NCT06029049
- Testing
- Modified Time Principle Induction (MTPI) with rocuronium, RSI succinylcholine
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- The University of Texas Health Science Center, Houston
Anesthesia Intubation Complication
Alfentanil and the Elimination of Sympathetic Responses to Tracheal Intubation During Rapid Sequence Induction of Anesthesia: A Probability-based Approach
Induction of anesthesia: After 3 minutes pre-oxygenation with 100% oxygen, a blinded dose alfentanil (0,10,20,30,40,50 or 60 µg/kg, followed by thiopental 4 mg/kg and rocuronium 0.6 mg/kg will be administered over 15 sec.
- Trial name
- NCT01518608
- Testing
- Alfentanil 0.5mg/ml (Rapifen , Janssen-Cilag)
- Where
- 2 sites in Norway
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Easy of Laryngoscopy Manipulation, Vocal Cord Position or Movement
Intubating Condition After Magnesium Pre-treatment
Magnesium had an inhibitory effect on neuromuscular transmission and caused a decrease in muscle fiber membrane excitability. It reduces the amount of acetylcholine that is released at the motor nerve terminal by decreasing the…
- Conditions
- Easy of Laryngoscopy Manipulation, Vocal Cord Position or Movement, Patient Reaction to Intubation and Cuff Inflation, Mean Arterial Pressure
- Trial name
- NCT01153256
- Testing
- magnesium sulphate, normal saline
- Where
- South Korea
- Volunteers
- 168 people
- Sponsor
- Seoul National University Bundang Hospital
Intra-tracheal Intubation
Assessment of Remifentanil for Rapid Sequence Induction and Intubation in Full Stomach Patient Compared to Muscle Relaxant
REMICrush is a French multicentric non inferiority simple blind randomized clinical trial that will compare the use of Remifentanil to muscle relaxant (reference treatment) for anesthetic rapid sequence intubation in terms of…
- Trial name
- REMICRUSH (NCT03960801)
- Testing
- Remifentanil group, neuromuscular blockade group
- Where
- 13 sites in France
- Volunteers
- 1,150 people
- Sponsor
- Nantes University Hospital
Apneic Oxygenation
A "Less-rapid" Sequence Anesthetic Induction/Intubation Sequence? Does Apneic Oxygenation by Means of an Oxygenating Laryngoscope Blade Prolong the "Duration of Apnea Without Desaturation" in Paralyzed Non-obese and Morbidly Obese Patients?
The study will test the efficacy of the Pentax AWSTM video laryngoscope (VLS) equipped with a P Blade (Figure 1) as the means to provide Apneic Oxygenation (AO) and prolong Duration of Apnea Without Desaturation (DAWD) in…
- Trial name
- NCT02943629
- Testing
- Apneic oxygenation: Eight minute, Without apneic oxygenation, Apneic oxygenation: five minutes
- Sponsor
- Vanderbilt University
Delayed Sequence Intubation, Rapid Sequence Induction and Intubation
Comparison of Peri-intubation Oxygenation Values and Complications in Patients Intubated With the Delayed Versus Rapid Sequence Intubation Protocols
This study compares two different methods of helping patients breathe by placing a tube in their airway (intubation) in an emergency setting.
- Conditions
- Delayed Sequence Intubation, Rapid Sequence Induction and Intubation, Intubation, Intubation Complications
- Trial name
- DSI vs RSI (NCT07380763)
- Testing
- Delayed Sequence Intubation, Rapid Sequence Intubation
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Intubation, Intratracheal, Laryngoscopes
The Clarus Video System and Direct Laryngoscope for Rapid Sequence Induction Intubation With Cricoid Pressure
During an emergency endotracheal intubation, rapid sequence induction intubation with cricoid pressure is frequently implemented to prevent aspiration pneumonia.
- Conditions
- Intubation, Intratracheal, Laryngoscopes, Anesthesia, General
- Trial name
- NCT03841890
- Testing
- the Clarus Video System as a video stylet, the Clarus Video System as a lightwand, direct laryngoscope
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Chang Gung Memorial Hospital
Tracheal Intubation, Rapid Sequence Induction and Intubation
Sequential Order of RSI on Tracheal Intubation
This clinical trial aims to understand the effect of the order of administration of Neuromuscular Blocking Agents (NMBAs) and sedatives on the success rate of intubation during Rapid Sequence Intubation (RSI) in the emergency…
- Trial name
- NCT07741578
- Testing
- Drug Sequence
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Zhongnan Hospital
Hypoxemia, Airway Management
Comparison of High-Flow Nasal Cannula and Tight Face Mask for Maintaining Oxygenation During Rapid Sequence Induction
This prospective randomized controlled trial aims to compare the effectiveness of High-Flow Nasal Cannula (HFNC) versus Tight Face Mask (TFM) in maintaining oxygenation during rapid sequence induction (RSI) for endotracheal…
- Conditions
- Hypoxemia, Airway Management, Endotracheal Intubation, Rapid Sequence Induction
- Trial name
- NCT07723430
- Testing
- High-Flow Nasal Cannula, Tight Face Mask
- Volunteers
- 290 people
- Sponsor
- Khyber Teaching Hospital
Respiratory Failure, Hypotension and Shock
Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure
The purpose of this study is to investigate whether protocolized vasopressor use for patients with normal blood pressure undergoing rapid sequence intubation improves hemodynamic parameters and mitigates adverse events.
- Conditions
- Respiratory Failure, Hypotension and Shock, Hypotension on Induction, Intubation Complication
- Trial name
- RAPID PRESS (NCT05355974)
- Testing
- Norepinephrine, Lactated Ringers, Intravenous, normal saline
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Wright State University
Intubation, Intratracheal, Rapid Sequence Induction and Intubation
Community Medical Center, Continuous Quality Improvement Project, Rapid Sequence Intubation
To assess the ongoing continuous quality improvement of rapid sequence intubation in our emergency department. Ongoing assessment will address standardization of the process and protocol driven measures that will improve the…
- Conditions
- Intubation, Intratracheal, Rapid Sequence Induction and Intubation, Checklist
- Trial name
- NCT05505799
- Testing
- Intubation Checklist, Standard Care
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Community Medical Center, Toms River, NJ
Hemodynamic Instability During Anesthesia, Induction Anesthesia
Low-dose Propofol Plus High-dose Alfentanil in Rapid Sequence Induction
This study compares four different anesthesia induction regimens to see which one provides the most stable blood pressure and heart rate during rapid sequence intubation.
- Conditions
- Hemodynamic Instability During Anesthesia, Induction Anesthesia, Intubation
- Trial name
- NCT07730918
- Testing
- propofol, alfentanil, Sufentanil
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Aoyang Hospital Affiliated to Jiangsu University
Trauma, Rapid Sequence Intubation
Prospective Study of Induction Medications Used in the Trauma RSI
To compare the outcomes of the use of propofol, etomidate, and ketamine as induction agents for adult trauma patients undergoing intubation within 24 hours of admission.
- Trial name
- ProTIM (NCT04291521)
- Testing
- Ketamine, Etomidate, Propofol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Southern California
Rapid Sequence Induction and Intubation, Rocuronium
Comparison of Standard rapi̇d Sequential Intubation Protocol With Rocuronium in Emergency Department
Airway management and advanced airway management are the issues that are applied every day in emergency services and that the emergency physician should know best.
- Trial name
- NCT05343702
- Testing
- priming with rocuronium
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Rapide Sequence Induction, Tracheal Intubation
Pain Assessment During Rapid Sequence Induction
Rapid sequence induction (RSI) is a standard anesthesia technique used in patients at risk of aspiration. Although tracheal intubation following RSI is a frequent and painful procedure, no study has yet evaluated nociception…
- Conditions
- Rapide Sequence Induction, Tracheal Intubation, Nociception, General Anesthesia
- Trial name
- NARSI (NCT07588165)
- Testing
- No Intervention: Observational Cohort
- Where
- Monaco
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Princesse Grace
Rapid Sequence Induction and Intubation
Intubation Conditions After RSI Using Rocuronium with Ephedrine Pretreatment
This trial will study if ephedrine pretreatment before low doses of rocuronium (0.6 or 0.8 mg/kg) would provide similar intubating conditions as with the high dose of 1.2 mg/kg in patients undergoing RSII.
- Trial name
- NCT05725031
- Testing
- Ephedrine, Rocuronium 0.6, Rocuronium 0.8
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University