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SarcopeniaNCT07741786

PNF Versus Conventional Exercise in Older Women at Increased Risk of Sarcopenia

A study testing Conventional Exercise Program and Proprioceptive Neuromuscular Facilitation Exercises in people with Sarcopenia, run by Uşak University at 2 sites in Turkey (Türkiye).

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

Age-related declines in muscle strength and physical performance may impair balance, mobility, and independence in older adults. Exercise may help preserve these functions; however, thethe comparative benefits of PNF-based exercise versus conventional exercise remain unclear in older women who screen positive for… Read more about this study

Who is it for?
Ages 65 years and older, women only
Conditions the study is for
Sarcopenia
What is being tested?
Conventional Exercise Program and Proprioceptive Neuromuscular Facilitation Exercises
Could I receive a placebo?
No, everyone receives an active treatment
How many people
40 participants
Where
2 sitesTurkey (Türkiye)
Study dates
1 Aug 2022to 1 Aug 2023
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 65 years and older
  • Women only
  • No healthy volunteers
  • Older adult

Who may be able to join

  • Female sex.
  • Age 65 years or older.
  • SARC-F score of 4 or higher.
  • Ability to participate safely in the prescribed exercise programme.
  • Completion of the baseline assessment.
  • Written informed consent.

Who cannot join

  • Clinically significant musculoskeletal pain, new-onset gait disturbance, or another active condition requiring additional treatment.
  • Parkinson's disease, stroke, multiple sclerosis, vestibular disorders, vertigo, or other major neurological diseases that could affect balance, gait, mobility, or physical performance.
  • Severe musculoskeletal disorders.
  • Uncontrolled cardiovascular disease.
  • Any condition precluding safe participation in the exercise programme.
  • Participation in a regular exercise programme during the preceding six months.

Trial locations and contacts

2 sites in 1 country.

Turkey (Türkiye)2 sites
  • Facility Name: Uşak Training and Research Hospital

    Uşak, Uşak, 64100

  • Usak Training and Research Hospital, Physical Medicine and Rehabilitation Clinic

    Uşak

Other trials in Turkey (Türkiye)

About this study

Official title: Comparative Effects of Proprioceptive Neuromuscular Facilitation and Conventional Exercise on Balance, Mobility, and Fall-Related Outcomes in Older Older Women at Increased Risk of Sarcopenia

Age-related declines in muscle strength and physical performance may impair balance, mobility, and independence in older adults. Exercise may help preserve these functions; however, thethe comparative benefits of PNF-based exercise versus conventional exercise remain unclear in older women who screen positive for sarcopenia risk.

This randomized study compared a PNF-based exercise program with conventional exercise in community-dwelling women aged 65 years or older with SARC-F scores of 4 or higher. Although all participants screened positive for sarcopenia risk, none met the criteria for confirmed sarcopenia according to the revised European Working Group on Sarcopenia in Older People framework (EWGSOP2). Forty participants were randomly allocated to two groups, with 20 participants in each group. Thirty-four participants completed the study and were included in the analysis, with 17 participants in each group.

Read more

Both groups followed a 10-week exercise program comprising three sessions per week, with each session lasting approximately 45 minutes. The first three sessions were conducted at the clinic under physiotherapist supervision. The remaining sessions were performed independently at home, with adherence monitored through weekly telephone follow-up.

The conventional exercise program included lower-extremity strengthening, balance training, functional mobility exercises, sit-to-stand practice, gait exercises, and stretching. The PNF-based program incorporated diagonal and multiplanar movement patterns and task-oriented functional movements into conventional therapeutic exercises. Manual contacts, manual resistance, and hands-on facilitation were used only during the first three supervised sessions.

Participants were assessed at baseline and at one and three months after completion of the 10-week program. Outcomes included balance, functional mobility, walking capacity, lower-extremity functional strength, stair performance, falls efficacy, and depressive symptoms. Assessments included the Berg Balance Scale, Timed Up and Go Test, 6-Minute Walk Test, Five Times Sit-to-Stand Test, stair ascent and descent test, Tinetti Falls Efficacy Scale, and 15-item Geriatric Depression Scale.

Read the detailed description

Age-related declines in muscle strength and physical performance may contribute to impaired balance, mobility limitations, and reduced independence. A positive sarcopenia screening result does not establish a diagnosis of sarcopenia. This study focused on community-dwelling older women who screened positive for sarcopenia risk using the SARC-F questionnaire but did not meet EWGSOP2 criteria for confirmed sarcopenia.

The rationale for the study was to investigate whether incorporating proprioceptive neuromuscular facilitation (PNF) principles into a predominantly home-based exercise program provides additional functional benefits compared with conventional therapeutic exercise of comparable duration and frequency.

This prospective, single-center, two-arm randomized study was conducted at the outpatient Physical Medicine and Rehabilitation and Medical Ecology and Hydroclimatology Clinic of Uşak Training and Research Hospital, Uşak, Türkiye. Participants were women aged 65 years or older with SARC-F scores of 4 or higher who could safely participate in the prescribed exercise program. Participants were randomly allocated in a 1:1 ratio using a computer-generated random-number table.

Both groups followed a 10-week program consisting of three approximately 45-minute sessions per week. The first three sessions were supervised by a physiotherapist at the clinic to demonstrate the exercises, correct performance, and prepare participants for independent practice. Subsequent sessions were performed at home, with weekly telephone follow-up to monitor adherence and address participants' questions. Exercise intensity and progression were individualized according to functional capacity and clinical tolerance.

The PNF-based program incorporated diagonal and multiplanar movement patterns, coordinated neuromuscular activation, and task-oriented functional movements into conventional therapeutic exercises. Manual contacts, manual resistance, and hands-on facilitation were restricted to the first three supervised clinic sessions. Home sessions used PNF-derived movement patterns that participants could perform independently.

Participants and treating physiotherapists could not be blinded because of the nature of the interventions. Outcome assessments were performed by a physician who was not involved in delivering the exercise programs.

Assessments were conducted before the intervention and at one and three months after completion of the 10-week program to examine functional changes and their persistence beyond the intervention period. Outcomes covered balance, functional mobility, walking capacity, sit-to-stand and stair performance, falls efficacy, and depressive symptoms.

Forty participants were randomized, and 34 completed the study. Analyses included participants with complete data, without imputation of missing follow-up measurements. The trial was retrospectively registered, and between-group outcome analyses were interpreted as exploratory.

Conditions
Sarcopenia
Being tested
Conventional Exercise Program, Proprioceptive Neuromuscular Facilitation Exercises
Keywords
Sarcopenia, PNF exercises, Balance, Fear of falling, Resistance exercise
Medical subject headings
Sarcopenia

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Conventional Exercise ProgramBehavioural

    Participants received a conventional therapeutic exercise program including lower-extremity strengthening, balance training, functional mobility exercises, sit-to-stand practice, gait exercises, and stretching. The program comprised three sessions per week for 10 consecutive weeks, with each session lasting approximately 45 minutes. The first three sessions were conducted at the clinic under physiotherapist supervision. The remaining sessions were performed independently at home, with adherence monitored through weekly telephone follow-up. Exercise intensity and progression were individualized according to each participant's functional capacity and clinical tolerance.

  • Proprioceptive Neuromuscular Facilitation ExercisesBehavioural

    Also called PNF Exercises

    Participants received proprioceptive neuromuscular facilitation exercises program. The PNF intervention included diagonal movement patterns, proprioceptive stimulation, coordinated neuromuscular activation, manual resistance, and task-oriented functional movement patterns designed to improve postural control, balance, gait, and lower-extremity functional performance. The program was performed three days per week for 10 consecutive weeks, with each session lasting approximately 45 minutes.Manual contacts, manual resistance, and hands-on facilitation techniques were applied only during the first three supervised clinic sessions. The remaining sessions were performed independently at home using PNF-derived movement patterns taught at the clinic. Adherence was monitored through weekly telephone follow-up.

Study groups in NCT07741786
Study groupRoleWhat they receive
ARM 1 / Conventional Exercise GroupActive comparatorParticipants in this group received a conventional exercise program including lower-extremity strengthening, balance training, functional mobility exercises, sit-to-stand practice, gait exercises, and stretching. The program comprised three sessions per week for 10 consecutive weeks, with each session lasting approximately 45 minutes. The first three sessions were conducted at the clinic under physiotherapist supervision. The remaining sessions were performed independently at home, with adherence monitored through weekly telephone follow-up. Exercise intensity and progression were individualized according to each participant's functional capacity and clinical tolerance.
Receives: Behavioral: Conventional Exercise Program
PNF-Based Exercise ProgramExperimentalParticipants in this group received a proprioceptive neuromuscular facilitation (PNF)-based exercise program. The program emphasized diagonal and multiplanar movement patterns, coordinated neuromuscular activation, and task-oriented functional movements targeting postural control, balance, gait, and lower-extremity performance. The program comprised three sessions per week for 10 consecutive weeks, with each session lasting approximately 45 minutes. The first three sessions were conducted at the clinic under physiotherapist supervision. Manual contacts, manual resistance, and hands-on facilitation techniques were applied only during these supervised sessions. The remaining sessions were performed independently at home using PNF-derived movement patterns taught at the clinic. Adherence was monitored through weekly telephone follow-up. Progression was individualized according to functional improvement.
Receives: Behavioral: Proprioceptive Neuromuscular Facilitation Exercises

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Change in Berg Balance Scale score

    Balance function was assessed using the Berg Balance Scale. Scores were measured at baseline, at the first-month assessment, and at the third-month assessment after completion of the 10-week exercise programme. Changes over time and differences between the groups were analyzed.

    Measured: Baseline and 1 and 3 months after completion of the 10-week exercise programm

Secondary outcomes (6)
  1. Change in Tinetti Falls Efficacy Scale score

    Description: Fear of falling was assessed using the Tinetti Falls Efficacy Scale. Scores were measured at baseline, at the first-month assessment, and at the third-month assessment after completion of the 10-week exercise programme. Changes over time and differences between the groups were analyzed.

    Measured: Baseline, 1 month, and 3 months after completion of the 10-week exercise programme

  2. Change in Timed Up and Go Test performance

    Description: Functional mobility and dynamic balance were assessed using the Timed Up and Go Test. Completion time were measured at baseline, at the first-month assessment, and at the third-month assessment after completion of the 10-week exercise programme. Changes over time and differences between the groups were analyzed. Lower completion times indicated better functional mobility. Changes over time and differences between the groups were analyzed.

    Measured: Baseline and 1 and 3 months completion of the 10-week exercise programme

  3. Change in 6-Minute Walk Test distance

    Description: Walking capacity was assessed using the 6-Minute Walk Test. Walking distance, measured in meters, was recorded at baseline, at the first-month assessment, and at the third-month assessment after completion of the 10-week exercise programme. Greater distances indicated better walking capacity. Changes over time and differences between the groups were analyzed.

    Measured: recorded at baseline, at the first-month assessment, and at the third-month assessment after completion of the 10-week exercise programme.

  4. Change in Five Times Sit-to-Stand Test time

    Description: Lower-extremity functional performance was assessed using the Five Times Sit-to-Stand Test. Completion time, measured in seconds, was recorded at baseline, at the first-month assessment, and at the third-month assessment after t the third-month assessment after completion of the 10-week exercise programme. Lower completion times indicated better functional performance. Changes over time and differences between the groups were analyzed.

    Measured: Time Frame: Baseline, 1 month, and 3 months after initiation of the 10-week exercise programme.

  5. Change in stair ascent and descent test time

    Description: Functional stair performance was assessed using a stair ascent and descent test. Completion time, measured in seconds, was recorded at baseline, at the first-month assessment, and at the third-month assessment after the 10-week exercise programme. Lower completion times indicated better stair performance. Changes over time and differences between the groups were analyzed.

    Measured: Time Frame: Baseline, 1 month, and 3 months after the third-month of the 10-week exercise programme.

  6. Change in Geriatric Depression Scale score

    Description: Depressive symptoms were assessed using the Geriatric Depression Scale. Scores were measured at baseline, at the first-month assessment, and at the third-month assessmen the third-month assessment after completion of the 10-week exercise programme. Lower scores indicated fewer depressive symptoms. Changes over time and differences between the groups were analyzed.

    Measured: Baseline, 1 month, and 3 months after completion of the 10-week exercise programme

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted3 Aug 2026
  2. Study start1 Aug 2022
  3. Primary completion15 May 2023
  4. Study completion1 Aug 2023

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Model description
Forty participants were randomly allocated in a 1:1 ratio to two parallel groups using a computer-generated random-number table, with 20 participants assigned to a conventional exercise group and 20 to a PNF-based exercise group.
Masking
None (open label)
Enrolment
40 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07741786
Sponsor's protocol ID
135-135-09
Status last verified
Oct 2026
First submitted
28 Jul 2026
Last updated
6 Oct 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No: Individual participant data will not be shared because the ethics approval and informed consent documents did not include permission for external sharing of individual-level data. Aggregate study results may be made available from the corresponding investigator upon reasonable request, subject to institutional and ethical regulations.

Publications

  • • Pereira MP, Gonc¸alves M Proprioceptive Neuromuscular Facilitation Improves Balance and Knee Extensors Strength of Older Fallers. International Scholarly Research Network ISRN Rehabilitation. Volume 2012, Article ID 402612, 7 pages

Questions about this trial

What is this clinical trial studying?

A study testing Conventional Exercise Program and Proprioceptive Neuromuscular Facilitation Exercises in people with Sarcopenia, run by Uşak University at 2 sites in Turkey (Türkiye).

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 6 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 2 sites in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Change in Berg Balance Scale score (time frame: Baseline and 1 and 3 months after completion of the 10-week exercise programm). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07741786, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Oct 2026.

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