Carpal Tunnel Syndrome (CTS)NCT07743879
Comparative Efficacy of Therapeutic Ultrasound and Neurodynamic Techniques for Carpal Tunnel Syndrome
A study testing Neurodynamic Techniques in people with Carpal Tunnel Syndrome (CTS), run by IBB University at 1 site in Yemen.
Trial summary
This randomized controlled trial compares the efficacy of therapeutic ultrasound alone, neurodynamic techniques alone, and combined therapeutic ultrasound and neurodynamic techniques in patients with mild to moderate carpal tunnel syndrome. Read more about this study
- Who is it for?
- Ages 18 to 65 years, women only
- Conditions the study is for
- Carpal Tunnel Syndrome (CTS)
- What is being tested?
- Neurodynamic Techniques
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteYemen
- Study dates
- 25 Feb 2025to 26 Nov 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- Women only
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Clinical diagnosis of mild to moderate carpal tunnel syndrome confirmed by electrophysiological testing.
- Age between 18 and 65 years.
- Presence of symptoms (pain, numbness, tingling) for at least 3 months.
Who cannot join
- History of previous carpal tunnel release surgery or wrist trauma.
- Corticosteroid injection into the wrist within the past 3 months.
- Cervical radiculopathy, polyneuropathy, or other upper extremity neurological disorders.
- Pregnancy or lactation.
- Contraindications to therapeutic ultrasound (e.g., active infection, metallic implants in the treatment area, malignant tumors).
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparative Study Of Ultrasound and Neurodynamic Technique For Patients With Carpal Tunnel Syndrome in Mild And Moderate Stag
This randomized controlled trial compares the efficacy of therapeutic ultrasound alone, neurodynamic techniques alone, and combined therapeutic ultrasound and neurodynamic techniques in patients with mild to moderate carpal tunnel syndrome.
Read the detailed description
This three-arm parallel-group randomized controlled trial evaluated the comparative efficacy of therapeutic ultrasound (US), neurodynamic techniques (ND), and combined US plus ND in 60 participants with mild to moderate carpal tunnel syndrome over a 6-week intervention period. The primary outcomes measured were pain intensity via visual analog scale (VAS) and symptom severity and functional status using the Boston Carpal Tunnel Questionnaire (BCTQ). Secondary outcomes evaluated nerve conduction parameters including distal motor latency (DML), sensory latency (SL), and sensory nerve action potential (SNAP) amplitude.
- Conditions
- Carpal Tunnel Syndrome (CTS)
- Being tested
- Neurodynamic Techniques
- Keywords
- therapeutic ultrasound, neurodynamic techniques, nerve conduction study, conservative management
- Medical subject headings
- Carpal Tunnel Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Neurodynamic TechniquesOther
Median nerve neurodynamic mobilization (progressing from sliders to tensioners), 3 sets of 10 repetitions.
| Study group | Role | What they receive |
|---|---|---|
| Therapeutic Ultrasound Group | Experimental | Continuous therapeutic ultrasound applied to the volar wrist at 1.5 W/cm² for 8 to 10 minutes per session, 3 times per week for 6 weeks. Receives: Other: Neurodynamic Techniques |
| Neurodynamic Techniques Group | Experimental | Median nerve neurodynamic mobilization (progressing from sliders to tensioners), 3 sets of 10 repetitions, 3 times per week for 6 weeks. Receives: Other: Neurodynamic Techniques |
| Combined Therapy Group | Experimental | Combined application of therapeutic ultrasound followed by neurodynamic techniques in the same session, 3 times per week for 6 weeks. Receives: Other: Neurodynamic Techniques |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain Intensity
Measure Description: Measured using the unabbreviated Visual Analog Scale (VAS). This scale ranges from 0 to 10 cm, where 0 represents no pain and 10 represents the worst imaginable pain. Higher scores indicate a worse outcome (greater pain intensity).
Measured: Baseline and 6 weeks post-intervention
Symptom Severity
Measure Description: Assessed using the unabbreviated Boston Carpal Tunnel Questionnaire Symptom Severity Scale (BCTQ-SSS). The scale ranges from 1 to 5, with higher scores indicating a worse outcome (more severe symptoms).
Measured: Baseline and 6 weeks post-intervention
Functional Status
Measure Description: Assessed using Boston Carpal Tunnel Questionnaire Functional Status Scale (BCTQ-FSS). The scale ranges from 1 to 5, with higher scores indicating a worse outcome (greater functional disability/impairment).
Measured: Baseline and 6 weeks post-intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Aug 2026
- Study start25 Feb 2025
- Primary completion1 Nov 2025
- Study completion26 Nov 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Carpal Tunnel Syndrome (CTS)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- IBB University
- Sponsor type
- University, hospital or other
- Collaborators
- Al-Razi University
- Responsible party
- Principal investigator, Faisal Ahmed, IBB University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07743879
- Sponsor's protocol ID
- RU/03/FMHS/2025
- Status last verified
- Jul 2026
- First submitted
- 29 Jul 2026
- Last updated
- 4 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Not applicable as there is no current plan to share individual participant data publicly.
Study at a glance
From the registry record, last updated by the sponsor on 4 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Study Of Ultrasound and Neurodynamic Technique For Patients With Carpal Tunnel Syndrome in Mild And Moderate Stag
- ClinicalTrials.gov ID
- NCT07743879
- Acronym / sponsor ID
- RU/03/FMHS/2025
- Conditions
- Carpal Tunnel Syndrome (CTS)
- Keywords
- therapeutic ultrasound, neurodynamic techniques, nerve conduction study, conservative management
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- IBB UniversityUniversity, hospital or other
- Collaborators
- Al-Razi University
- Study start
- 25 Feb 2025 (actual)
- Primary completion
- 1 Nov 2025 (actual)
- Study completion
- 26 Nov 2025 (actual)
- First posted
- 4 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial compares the efficacy of therapeutic ultrasound alone, neurodynamic techniques alone, and combined therapeutic ultrasound and neurodynamic techniques in patients with mild to moderate carpal tunnel syndrome.
Detailed description
This three-arm parallel-group randomized controlled trial evaluated the comparative efficacy of therapeutic ultrasound (US), neurodynamic techniques (ND), and combined US plus ND in 60 participants with mild to moderate carpal tunnel syndrome over a 6-week intervention period. The primary outcomes measured were pain intensity via visual analog scale (VAS) and symptom severity and functional status using the Boston Carpal Tunnel Questionnaire (BCTQ). Secondary outcomes evaluated nerve conduction parameters including distal motor latency (DML), sensory latency (SL), and sensory nerve action potential (SNAP) amplitude.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Therapeutic Ultrasound Group | Experimental | Other: Neurodynamic TechniquesContinuous therapeutic ultrasound applied to the volar wrist at 1.5 W/cm² for 8 to 10 minutes per session, 3 times per week for 6 weeks. |
| Neurodynamic Techniques Group | Experimental | Other: Neurodynamic TechniquesMedian nerve neurodynamic mobilization (progressing from sliders to tensioners), 3 sets of 10 repetitions, 3 times per week for 6 weeks. |
| Combined Therapy Group | Experimental | Other: Neurodynamic TechniquesCombined application of therapeutic ultrasound followed by neurodynamic techniques in the same session, 3 times per week for 6 weeks. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Clinical diagnosis of mild to moderate carpal tunnel syndrome confirmed by electrophysiological testing.
- Age between 18 and 65 years.
- Presence of symptoms (pain, numbness, tingling) for at least 3 months.
Key exclusion criteria (5 listed)
- History of previous carpal tunnel release surgery or wrist trauma.
- Corticosteroid injection into the wrist within the past 3 months.
- Cervical radiculopathy, polyneuropathy, or other upper extremity neurological disorders.
- Pregnancy or lactation.
- Contraindications to therapeutic ultrasound (e.g., active infection, metallic implants in the treatment area, malignant tumors).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Neurodynamic TechniquesMedian nerve neurodynamic mobilization (progressing from sliders to tensioners), 3 sets of 10 repetitions. | Other | Combined Therapy Group, Neurodynamic Techniques Group, Therapeutic Ultrasound Group |
Primary outcome
Pain Intensity
Time frame: Baseline and 6 weeks post-intervention
Measure Description: Measured using the unabbreviated Visual Analog Scale (VAS). This scale ranges from 0 to 10 cm, where 0 represents no pain and 10 represents the worst imaginable pain. Higher scores indicate a worse outcome (greater pain intensity).
Symptom Severity
Time frame: Baseline and 6 weeks post-intervention
Measure Description: Assessed using the unabbreviated Boston Carpal Tunnel Questionnaire Symptom Severity Scale (BCTQ-SSS). The scale ranges from 1 to 5, with higher scores indicating a worse outcome (more severe symptoms).
Functional Status
Time frame: Baseline and 6 weeks post-intervention
Measure Description: Assessed using Boston Carpal Tunnel Questionnaire Functional Status Scale (BCTQ-FSS). The scale ranges from 1 to 5, with higher scores indicating a worse outcome (greater functional disability/impairment).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Aug 2026.
- Individual participant dataSharing planned: No. Not applicable as there is no current plan to share individual participant data publicly.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Neurodynamic Techniques in people with Carpal Tunnel Syndrome (CTS), run by IBB University at 1 site in Yemen.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Yemen. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain Intensity (time frame: Baseline and 6 weeks post-intervention). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Aug 2026.