AcneNCT07752368
A Clinical Trial Examining the Efficacy of a Novel Acne Treatment Serum
A study testing Acne Treatment Serum in people with Acne and Acne Vulgaris, run by Parea INC dba Cool as a Cucumber at 1 site in United States.
Trial summary
This single-group, open-label clinical trial examines the efficacy of Cool as a Cucumber's Acne Treatment Serum in adults with acne-prone skin. The study will enroll 25 male and female participants between the ages of 24 and 47 who will use the serum for eight weeks, with assessments conducted virtually at Baseline… Read more about this study
- Who is it for?
- Ages 24 to 47 years
- Conditions the study is for
- Acne, Acne Vulgaris, Skin Health
- What is being tested?
- Acne Treatment Serum
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 25 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Jun 2023to 1 Aug 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 24 to 47 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Male or female between the ages of 24-47 (between 2-4 males, the remainder females)
- Actively has acne (non-inflamed and/or inflamed acne)
- Has previously used or is currently using exfoliating acids (AHAs / BHA) and is willing to stop this for the duration of the study
- Has not experienced sunburn on the face in the last month
- No open wounds, sores, or non-acne related lesions on the face
- Generally healthy - don't live with any uncontrolled chronic disease
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- Willing to apply SPF on a daily basis during the study and to use other sun protection on the face (i.e. a hat)
- Must be willing to avoid products with coconut oil and shea butter, and Ethylhexyl Palmitate for the duration of the study
- Must be willing to cut out whey protein and cow's milk from their diet for the duration of the study
- Must be willing to avoid biotin products or supplements for the duration of the study
- Must agree to avoid sun tanning, tanning beds, and self-tanning products for the duration of the study
Who cannot join
- Any pre-existing chronic conditions that would prevent participants from adhering to the protocol, including oncological and psychiatric disorders
- Anyone with known severe allergic reactions
- Women who are pregnant, breastfeeding or attempting to become pregnant
- Unwilling to follow the study protocol
- Smoker
- Anyone consuming products containing Tetrahydrocannabinol (THC)
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- Identifies as a person with sensitive skin
- Anyone currently on steroids or undergoing hormone replacement therapy
- Anyone using prescription medication relevant to the skin
- Undergoing any cosmetic procedures during the study including facials, Botox, dermal filler, laser, or chemical peel treatments
- Use of prescription drug (topical or oral) that is targeted at any sort of skin condition (e.g., retinoids, accutane)
- Anyone allergic to niacinamide or salicylic acid
- Anyone who regularly consumes biotin supplements and is unwilling to stop for the duration of the study
- Participants who stopped using birth control within the past 3 months
- Participants currently have a Copper IUD or are using one of the following birth control high in androgen and low in estrogen activity: Amethyst, Jolessa, Lessina, Levonest/Levora, Lutera, Nordette, Portia, Seasonale/Seasonique, Sronyx, Mirena IUD, Triphasil/Trivora, Cryselle, Lo-Ovral/Ovral, Low-Ogestrel/Ogestrel, Lo-Feminol, Ortho tricyclen Lo, Estrostep Fe, Loestrin, Microgestin, Apri, Mircette, Azurette, Caziant, Cyclessa, Desogen, Emoquette, Kariva, Linessa, Marvelon, NuvaRing, Depo-Provera, Reclipsen
Trial locations and contacts
1 site in 1 country.
About this study
This single-group, open-label clinical trial examines the efficacy of Cool as a Cucumber's Acne Treatment Serum in adults with acne-prone skin. The study will enroll 25 male and female participants between the ages of 24 and 47 who will use the serum for eight weeks, with assessments conducted virtually at Baseline, Week 4, and Week 8.
The primary objective is to evaluate the effects of the Acne Treatment Serum on facial acne using the Validated Acne Quality-of-Life Scale (Acne QoL) and expert-graded before-and-after photographs. Secondary objectives include evaluating changes in skin texture, uneven skin tone, hyperpigmentation, redness, sebum production, and fine lines and wrinkles via self-reported questionnaires.
- Conditions
- Acne, Acne Vulgaris, Skin Health
- Being tested
- Acne Treatment Serum
- Medical subject headings
- Acne Vulgaris
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Acne Treatment SerumDietary supplement
All enrolled participants receive the Cool as a Cucumber Acne Treatment Serum (30ml bottle, active ingredient: Salicylic Acid 0.5%) applied topically as directed.
| Study group | Role | What they receive |
|---|---|---|
| Acne Treatment Serum | Experimental | Not described Receives: Dietary Supplement: Acne Treatment Serum |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Facial Acne Symptoms
Mean change in perceived facial acne symptoms assessed via the Validated Acne Quality-of-Life Scale (Acne QoL) self-reported questionnaire
Measured: Baseline, Week 4, and Week 8
Change in Facial Acne Severity on Photographs
Expert skin grading by a dermatologist of before-and-after selfie photographs to assess visual changes in acne severity
Measured: Baseline, Week 4, and Week 8
Secondary outcomes (6)
Change in Skin Texture
Self-reported change in skin texture assessed via study-specific questionnaire
Measured: Baseline, Week 4, and Week 8
Change in Skin Tone
Self-reported change in uneven skin tone assessed via study-specific questionnaire
Measured: Baseline, Week 4, and Week 8
Change in Hyperpigmentation
Self-reported change in hyperpigmentation assessed via study-specific questionnaire
Measured: Baseline, Week 4, and Week 8
Change in Redness/Inflammation
Self-reported change in redness and inflammation assessed via study-specific questionnaire
Measured: Baseline, Week 4, and Week 8
Change in Sebum Production
Self-reported change in sebum production assessed via study-specific questionnaire
Measured: Baseline, Week 4, and Week 8
Change in Fine Lines and Wrinkles
Self-reported change in fine lines and wrinkles assessed via study-specific questionnaire
Measured: Baseline, Week 4, and Week 8
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Aug 2026
- Study start1 Jun 2023
- Primary completion1 Aug 2023
- Study completion1 Aug 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AcneStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 25 participants (actual)
Sponsor and investigators
- Lead sponsor
- Parea INC dba Cool as a Cucumber
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- Citruslabs
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07752368
- Sponsor's protocol ID
- 20332
- Status last verified
- Aug 2026
- First submitted
- 3 Aug 2026
- Last updated
- 7 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 7 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Clinical Trial Examining the Efficacy of a Novel Acne Treatment Serum
- ClinicalTrials.gov ID
- NCT07752368
- Acronym / sponsor ID
- 20332
- Conditions
- Acne, Acne Vulgaris, Skin Health
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 25 participants (actual)
- Lead sponsor
- Parea INC dba Cool as a CucumberIndustry (pharma, biotech, devices)
- Collaborators
- Citruslabs
- Study start
- 1 Jun 2023 (actual)
- Primary completion
- 1 Aug 2023 (actual)
- Study completion
- 1 Aug 2023 (actual)
- First posted
- 7 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This single-group, open-label clinical trial examines the efficacy of Cool as a Cucumber's Acne Treatment Serum in adults with acne-prone skin. The study will enroll 25 male and female participants between the ages of 24 and 47 who will use the serum for eight weeks, with assessments conducted virtually at Baseline, Week 4, and Week 8.
The primary objective is to evaluate the effects of the Acne Treatment Serum on facial acne using the Validated Acne Quality-of-Life Scale (Acne QoL) and expert-graded before-and-after photographs. Secondary objectives include evaluating changes in skin texture, uneven skin tone, hyperpigmentation, redness, sebum production, and fine lines and wrinkles via self-reported questionnaires.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Acne Treatment Serum | Experimental | Dietary Supplement: Acne Treatment Serum |
Who may qualify
- Ages
- 24 to 47 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (11 listed)
- Male or female between the ages of 24-47 (between 2-4 males, the remainder females)
- Actively has acne (non-inflamed and/or inflamed acne)
- Has previously used or is currently using exfoliating acids (AHAs / BHA) and is willing to stop this for the duration of the study
- Has not experienced sunburn on the face in the last month
- No open wounds, sores, or non-acne related lesions on the face
Key exclusion criteria (15 listed)
- Any pre-existing chronic conditions that would prevent participants from adhering to the protocol, including oncological and psychiatric disorders
- Anyone with known severe allergic reactions
- Women who are pregnant, breastfeeding or attempting to become pregnant
- Unwilling to follow the study protocol
- Smoker
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Acne Treatment SerumAll enrolled participants receive the Cool as a Cucumber Acne Treatment Serum (30ml bottle, active ingredient: Salicylic Acid 0.5%) applied topically as directed. | Dietary supplement | Acne Treatment Serum |
Primary outcome
Change in Facial Acne Symptoms
Time frame: Baseline, Week 4, and Week 8
Mean change in perceived facial acne symptoms assessed via the Validated Acne Quality-of-Life Scale (Acne QoL) self-reported questionnaire
Change in Facial Acne Severity on Photographs
Time frame: Baseline, Week 4, and Week 8
Expert skin grading by a dermatologist of before-and-after selfie photographs to assess visual changes in acne severity
6 secondary outcomes
Change in Skin Texture
Time frame: Baseline, Week 4, and Week 8
Change in Skin Tone
Time frame: Baseline, Week 4, and Week 8
Change in Hyperpigmentation
Time frame: Baseline, Week 4, and Week 8
Change in Redness/Inflammation
Time frame: Baseline, Week 4, and Week 8
Change in Sebum Production
Time frame: Baseline, Week 4, and Week 8
Change in Fine Lines and Wrinkles
Time frame: Baseline, Week 4, and Week 8
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Aug 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Acne Treatment Serum in people with Acne and Acne Vulgaris, run by Parea INC dba Cool as a Cucumber at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 11 inclusion and 15 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 7 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Facial Acne Symptoms (time frame: Baseline, Week 4, and Week 8). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Aug 2026.