Ischemic StrokeNCT07756775
Comparison Between Non-contrast Magnetic Resonance Angiography and Carotid Doppler in Cerebrovascular Stroke
An observational study of Ischemic Stroke and Transient Ischemic Attack, run by Sohag University at 1 site in Egypt.
Trial summary
This prospective observational study aims to compare the diagnostic performance of non-contrast magnetic resonance angiography (NC-MRA) and carotid Doppler ultrasonography in the evaluation of carotid artery disease among patients with ischemic cerebrovascular stroke or transient ischemic attack. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Ischemic Stroke, Transient Ischemic Attack, Carotid Artery Stenosis (Symptomatic and Asymptomatic)
- How many people
- 200 participants
- Where
- 1 siteEgypt
- Study dates
- 20 Jul 2026to 20 Mar 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients (≥18 years) presenting to Sohag University Hospital with a clinical diagnosis of ischemic stroke or transient ischemic attack (TIA) who are eligible for magnetic resonance imaging and carotid Doppler ultrasonography.
Who may be able to join
- Adults aged 18 years or older.
- Clinically diagnosed ischemic stroke or transient ischemic attack (TIA).
- Imaging performed within 7-14 days of symptom onset.
- Hemodynamically stable and suitable for magnetic resonance imaging (MRI).
- Able and willing to provide written informed consent.
Who cannot join
- Hemorrhagic stroke.
- Previous carotid artery stenting.
- Contraindications to MRI, including:
- Non-MRI-compatible pacemakers or other MRI-incompatible implants.
- Cochlear implants.
- MRI-incompatible metallic orthopedic implants.
- Severe claustrophobia.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Sohag University Hospital
Sohag, Sohag Governorate, 82524
Mohamed Saad Gad, +201112435154, mohsaadgad@gmail.com
About this study
This prospective observational study aims to compare the diagnostic performance of non-contrast magnetic resonance angiography (NC-MRA) and carotid Doppler ultrasonography in the evaluation of carotid artery disease among patients with ischemic cerebrovascular stroke or transient ischemic attack. A total of 200 adult patients presenting to Sohag University Hospital will undergo both imaging modalities. The study will assess the agreement between NC-MRA and carotid Doppler in detecting and grading carotid artery stenosis according to the NASCET criteria, with the goal of evaluating the clinical utility of each technique and optimizing imaging strategies for the assessment of cerebrovascular stroke.
- Conditions
- Ischemic Stroke, Transient Ischemic Attack, Carotid Artery Stenosis (Symptomatic and Asymptomatic)
- Medical subject headings
- Ischemic Stroke, Ischemic Attack, Transient, Carotid Stenosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Patients with Ischemic Stroke or Transient Ischemic Attack | Adult patients (≥18 years) with clinically diagnosed ischemic stroke or transient ischemic attack who undergo both carotid Doppler ultrasonography and non-contrast magnetic resonance angiography for evaluation of carotid artery disease. The findings of the two imaging modalities will be compared for the assessment of carotid artery stenosis and atherosclerotic plaque characteristics. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Internal Carotid Artery Stenosis Grade (according to NASCET criteria) assessed by Non-contrast Magnetic Resonance Angiography and Carotid Doppler ultrasonography.
Internal carotid artery stenosis grade in patients with ischemic stroke or transient ischemic attack determined according to the North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria using non-contrast magnetic resonance angiography and carotid Doppler ultrasonography. The stenosis grades obtained by the two imaging modalities will be compared.
Measured: At the baseline imaging visit (within 7-14 days of symptom onset).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Aug 2026
- Study start20 Jul 2026
- Primary completion28 Feb 2027 (estimated)
- Study completion20 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Ischemic StrokeStudies of the same condition, open and under way.
- More trials run by Sohag UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 200 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Sohag University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mohamed Saad Gad, Sohag University
- Investigators
- Mohamed Tharwat Mahmoud, Professor, Study chair, Sohag University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07756775
- Sponsor's protocol ID
- Soh-Med-26-7-35MS
- Status last verified
- Aug 2026
- First submitted
- 26 Jul 2026
- Last updated
- 11 Aug 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Wardlaw JM, Chappell FM, Best JJ, Wartolowska K, Berry E; NHS Research and Development Health Technology Assessment Carotid Stenosis Imaging Group. Non-invasive imaging compared with intra-arterial angiography in the diagnosis of symptomatic carotid stenosis: a meta-analysis. Lancet. 2006 May 6;367(9521):1503-12. doi: 10.1016/S0140-6736(06)68650-9.
PubMed 16679163
Study at a glance
From the registry record, last updated by the sponsor on 11 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison Between Non-contrast Magnetic Resonance Angiography and Carotid Doppler in Cerebrovascular Stroke
- ClinicalTrials.gov ID
- NCT07756775
- Acronym / sponsor ID
- Soh-Med-26-7-35MS
- Conditions
- Ischemic Stroke, Transient Ischemic Attack, Carotid Artery Stenosis (Symptomatic and Asymptomatic)
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 200 participants (estimated)
- Lead sponsor
- Sohag UniversityUniversity, hospital or other
- Study start
- 20 Jul 2026 (actual)
- Primary completion
- 28 Feb 2027 (estimated)
- Study completion
- 20 Mar 2027 (estimated)
- First posted
- 11 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective observational study aims to compare the diagnostic performance of non-contrast magnetic resonance angiography (NC-MRA) and carotid Doppler ultrasonography in the evaluation of carotid artery disease among patients with ischemic cerebrovascular stroke or transient ischemic attack. A total of 200 adult patients presenting to Sohag University Hospital will undergo both imaging modalities. The study will assess the agreement between NC-MRA and carotid Doppler in detecting and grading carotid artery stenosis according to the NASCET criteria, with the goal of evaluating the clinical utility of each technique and optimizing imaging strategies for the assessment of cerebrovascular stroke.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Patients with Ischemic Stroke or Transient Ischemic Attack | – | –Adult patients (≥18 years) with clinically diagnosed ischemic stroke or transient ischemic attack who undergo both carotid Doppler ultrasonography and non-contrast magnetic resonance angiography for evaluation of carotid artery disease. The findings of the two imaging modalities will be compared for the assessment of carotid artery stenosis and atherosclerotic plaque characteristics. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients (≥18 years) presenting to Sohag University Hospital with a clinical diagnosis of ischemic stroke or transient ischemic attack (TIA) who are eligible for magnetic resonance imaging and carotid Doppler ultrasonography.
Key inclusion criteria (5 listed)
- Adults aged 18 years or older.
- Clinically diagnosed ischemic stroke or transient ischemic attack (TIA).
- Imaging performed within 7-14 days of symptom onset.
- Hemodynamically stable and suitable for magnetic resonance imaging (MRI).
- Able and willing to provide written informed consent.
Key exclusion criteria (7 listed)
- Hemorrhagic stroke.
- Previous carotid artery stenting.
- Contraindications to MRI, including:
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Internal Carotid Artery Stenosis Grade (according to NASCET criteria) assessed by Non-contrast Magnetic Resonance Angiography and Carotid Doppler ultrasonography.
Time frame: At the baseline imaging visit (within 7-14 days of symptom onset).
Internal carotid artery stenosis grade in patients with ischemic stroke or transient ischemic attack determined according to the North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria using non-contrast magnetic resonance angiography and carotid Doppler ultrasonography. The stenosis grades obtained by the two imaging modalities will be compared.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Aug 2026.
- Background: PubMed 16679163Wardlaw JM, Chappell FM, Best JJ, Wartolowska K, Berry E; NHS Research and Development Health Technology Assessment Carotid Stenosis Imaging Group. Non-invasive imaging compared with intra-arterial angiography in the diagnosis of symptomatic carotid stenosis: a meta-analysis. Lancet. 2006 May 6;367(9521):1503-12. doi: 10.1016/S0140-6736(06)68650-9.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Mohamed Tharwat Mahmoud, Professor study chair
Sohag University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Ischemic Stroke and Transient Ischemic Attack, run by Sohag University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 11 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Mohamed Saad Gad (+201112435154, mohsaadgad@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Internal Carotid Artery Stenosis Grade (according to NASCET criteria) assessed by Non-contrast Magnetic Resonance Angiography and Carotid Doppler ultrasonography. (time frame: At the baseline imaging visit (within 7-14 days of symptom onset).). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07756775, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Aug 2026; AzTrials last refreshed its copy on 7 Nov 2026.