AnxietyNCT07757971
2D:4D Ratio in Relation to Anxiety and Stress Among Anesthesiology Residents
An observational study of Anxiety and Stress, run by Ain Shams University at 1 site in Egypt.
Trial summary
Anesthesiologists are exposed to substantial occupational stress, making their psychological well-being essential for both personal health and optimal patient care. Early identification of mental health disorders among healthcare professionals is important for improving well-being and maintaining healthcare quality. Read more about this study
- Who is it for?
- Ages 20 to 35 years
- How many people
- 118 participants
- Where
- 1 siteEgypt
- Study dates
- 10 Sep 2026to 9 Oct 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 35 years
- All sexes
- No healthy volunteers
- Adult
Study population: Anesthesiology residents will be contacted to participate in the study
Who may be able to join
- Any anesthesiologists who voluntarily agreed to participate in the study.
- Age: 20-35 years
- Both genders
Who cannot join
- Incomplete questionnaires and/or irrelevant responses.
- Injuries to the 2nd or 4th digits,
- Unclear or inaccurate digit photocopy,
- If the participant is a twin
- Cumulative leave (e.g., maternity/sick leave) exceeding 6 months during the study period;
- Pre-existing diagnosis of psychiatric disorders prior to the study
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Association of Second-to-Fourth Digit Ratio (2D:4D) With Trait Anxiety and Occupational Stress Among Anesthesiology Residents: A Cross Sectional Observational Study
Anesthesiologists are exposed to substantial occupational stress, making their psychological well-being essential for both personal health and optimal patient care. Early identification of mental health disorders among healthcare professionals is important for improving well-being and maintaining healthcare quality.
Read the detailed description
Although anesthesia residency is associated with considerable psychological stress, residents differ in how they respond to these challenges. While some develop psychological distress, others continue to perform effectively despite the demanding environment. These individuals, often described as "resilient" or "stress resistant," demonstrate successful adaptation to stress. The mechanisms underlying these individual differences remain incompletely understood. As with many aspects of psychological functioning, responses to stress are influenced by the combined effects of genetic predisposition and environmental experiences throughout life.
Among the biological markers investigated in recent years, the second-to-fourth digit (2D:4D) ratio has attracted considerable scientific interest because of its reported associations with a wide range of physical, behavioral, and psychological traits.
- Keywords
- anxiety, stress
- Medical subject headings
- Anxiety Disorders
What is being measured
The primary outcome is the main question the study is designed to answer.
Anxiety score
Anxiety severity measured using the Penn State Worry Questionnaire (PSWQ). The PSWQ is a 16-item validated measure of the tendency toward excessive, uncontrollable worry, the cognitive hallmark of Generalized Anxiety Disorder. The association between anxiety score and digit measurement will be evaluated. Total scores range from 16 to 80, with higher scores indicating greater worry severity. A score ≥45 is commonly used as a clinical cutoff in research settings, with ≥60 strongly associated with Generalized Anxiety Disorder criteria.
Measured: Baseline (single assessment)
Secondary outcomes (1)
Demographic data
Personal information, habits and health status
Measured: Baseline (single assessment)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Aug 2026
- Study start10 Sep 2026
- Primary completion2 Oct 2026
- Study completion9 Oct 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AnxietyStudies of the same condition, open and under way.
- More trials run by Ain Shams UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Ecologic or community
- Time perspective
- Cross-sectional
- Enrolment
- 118 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ain Shams University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Raham Hasan Mostafa, MD, Ain Shams University
- Investigators
- Raham H Mostafa, MD, Principal investigator, Faculty of Medicine, Ain Shams university
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07757971
- Sponsor's protocol ID
- R 186/ 2026
- Status last verified
- Oct 2026
- First submitted
- 3 Aug 2026
- Last updated
- 13 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 13 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Association of Second-to-Fourth Digit Ratio (2D:4D) With Trait Anxiety and Occupational Stress Among Anesthesiology Residents: A Cross Sectional Observational Study
- ClinicalTrials.gov ID
- NCT07757971
- Acronym / sponsor ID
- R 186/ 2026
- Keywords
- anxiety, stress
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 118 participants (actual)
- Lead sponsor
- Ain Shams UniversityUniversity, hospital or other
- Study start
- 10 Sep 2026 (actual)
- Primary completion
- 2 Oct 2026 (actual)
- Study completion
- 9 Oct 2026 (actual)
- First posted
- 11 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Anesthesiologists are exposed to substantial occupational stress, making their psychological well-being essential for both personal health and optimal patient care. Early identification of mental health disorders among healthcare professionals is important for improving well-being and maintaining healthcare quality.
Detailed description
Although anesthesia residency is associated with considerable psychological stress, residents differ in how they respond to these challenges. While some develop psychological distress, others continue to perform effectively despite the demanding environment. These individuals, often described as "resilient" or "stress resistant," demonstrate successful adaptation to stress. The mechanisms underlying these individual differences remain incompletely understood. As with many aspects of psychological functioning, responses to stress are influenced by the combined effects of genetic predisposition and environmental experiences throughout life.
Among the biological markers investigated in recent years, the second-to-fourth digit (2D:4D) ratio has attracted considerable scientific interest because of its reported associations with a wide range of physical, behavioral, and psychological traits.
Study design
- Observational model
- Ecologic or community
- Time perspective
- Cross-sectional
Who may qualify
- Ages
- 20 to 35 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
- Study population
- Anesthesiology residents will be contacted to participate in the study
Key inclusion criteria (3 listed)
- Any anesthesiologists who voluntarily agreed to participate in the study.
- Age: 20-35 years
- Both genders
Key exclusion criteria (6 listed)
- Incomplete questionnaires and/or irrelevant responses.
- Injuries to the 2nd or 4th digits,
- Unclear or inaccurate digit photocopy,
- If the participant is a twin
- Cumulative leave (e.g., maternity/sick leave) exceeding 6 months during the study period;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Anxiety score
Time frame: Baseline (single assessment)
Anxiety severity measured using the Penn State Worry Questionnaire (PSWQ). The PSWQ is a 16-item validated measure of the tendency toward excessive, uncontrollable worry, the cognitive hallmark of Generalized Anxiety Disorder. The association between anxiety score and digit measurement will be evaluated. Total scores range from 16 to 80, with higher scores indicating greater worry severity. A score ≥45 is commonly used as a clinical cutoff in research settings, with ≥60 strongly associated with Generalized Anxiety Disorder criteria.
1 secondary outcome
Demographic data
Time frame: Baseline (single assessment)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Raham H Mostafa, MD principal investigator
Faculty of Medicine, Ain Shams university
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Anxiety and Stress, run by Ain Shams University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Anxiety score (time frame: Baseline (single assessment)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Oct 2026.