OligospermiaCoQ10 DHEANCT07771153
DHEA Plus Coenzyme Q10 Verus Coenzyme Q10 Alone on Sperm Concentration in Subfertile Male With Oligospermia.
A study testing Tablet DHEA and Coenzyme Q10 in people with Oligospermia, run by Mst.Sumyara Khatun at 1 site in Bangladesh.
Trial summary
The goal of the clinical trail is to learn weather DHEA plus Coenzyme Q10 works better to improve sperm concentration in subfertile male with oligospermia. We will also learn about the saftey of combination of drugs. Read more about this study
- Who is it for?
- Ages 20 to 50 years, men only
- Conditions the study is for
- Oligospermia
- What is being tested?
- Tablet DHEA and Coenzyme Q10
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 56 participants
- Where
- 1 siteBangladesh
- Study dates
- 1 Jul 2025to 30 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 50 years
- Men only
- No healthy volunteers
- Adult
Who may be able to join
- Age 20-50 years. Subfertile males with oligospermia (sperm concentration less than16 million/ml)
Who cannot join
- Severe oligospermia (less than 5million/ml) Any medical and endocrine disorders like hypertension, diabetes mellitus, hypothyroidism, hyperprolactinemia, renal or liver disease. Any abnormality on genital examination and scrotal sonogram. History of chemotherapy or radiotherapy, genital infection, genital surgery. Antioxidants supplmentation in the last 3 months Drug, alcohol or substance abuse, psycho-sexual abnormalities.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of DHEA Plus Coenzyme Q10 Combination Therapy Compared to Coenzyme Q10 Alone on Sperm Concentration in Subfertile Male With Oligospermia.
The goal of the clinical trail is to learn weather DHEA plus Coenzyme Q10 works better to improve sperm concentration in subfertile male with oligospermia. We will also learn about the saftey of combination of drugs.
The main question it aims to answer are:
Read more
Does taking DHEA plus Coenzyme Q10 improve sperm concentration compared to Coenzyme Q10 alone? Are there any side effects or saftey concerns with DHEA plus Coenzyme Q10?
Researcher will compare DHEA plus Coenzyme Q10 with Coenzyme Q10 to see weather cobination drugs works better in improving sperm count than Coenzyme Q10 alone.
Participant will randomly placed into two group:
Group A (Combination Group): Tablet DHEA 25 mg BD and tablet Coenzyme Q10 100mg BD for 3 months.
Group B (Alone Group): Tablet Coenzyme Q10 100mg BD for 3 months. All participants will follow up at the start and after 3 months of treatment for check up and test.
Read the detailed description
This Randomized controlled trial will be conducted in the Department of Reproductive Endocrinology \& Infertility, BMU from the day of approval. Ethical clearance will be obtained from the Institutional Review Board. The study population will be the subfertile men with oligospermia according to WHO Laboratory manual 6 th Edition in 2021, fulfilling the inclusion and exclusion criteria.
A baseline semen analysis for the evaluation of male infertility will be done. Infertility will be determined by clinical history. A baseline semen sample will be collected in the laboratory of Reproductive Endocrinology \& Infertility, BMU by masturbation in a sterile plastic container. The sperm parameter will be checked by Makler Counting Chamber. An aliquot (0.5 ml) of each well-mixed semen sample will be placed on the Makler counting chamber, and the coverslip will be applied. The spermatozoa will be allowed to sediment for 3 minutes. Recognizable spermatozoa will be counted in 10 squares with x20 objective of a light microscope and recorded as spermatozoa in millions/mL of semen.
A total of 52 patients will be included in the study according to the inclusion and exclusion criteria. Eligible men will be randomly allocated into either Group A or Group B. Group A will receive (DHEA 25mg and Coenzyme Q10 100mg) twice daily and Group B will receive (Coenzyme Q10 100mg) twice daily for 3 months. They will be informed not to take other medications that could affect spermatogenesis during the study period expect after counseling physician.
The side effects and the spontaneous pregnancies will also be recorded. There will be two hospital visits during the dosing period. During the initial visit after recruitment, the participants will be prescribed medicines by some designated prescribing form.
One week later, a telephone interview will be conducted to review for side effects and arrange an early appointment at the patient's request if needed. Patients will be advised for timed sexual intercourse and for urinary pregnancy test in case of missed period. After three months of intervention, a semen analysis and serum testosterone level will be performed.
- Conditions
- Oligospermia
- Being tested
- Tablet DHEA, Coenzyme Q10
- Keywords
- DHEA, Coenzyme Q10
- Medical subject headings
- Oligospermia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Tablet DHEADrug
DHEA 25mg twice daily and Coenzyme Q10 100mg twice daily for 3 months.
Coenzyme Q10Drug
Coenzyme Q10 100mg twice daily for 3 months.
| Study group | Role | What they receive |
|---|---|---|
| Experimental arm: DHEA and Coenzyme Q10 | Experimental | DHEA 25mg twice daily and Coenzyme Q10 100mg twice daily for 3 months. Receives: Drug: Tablet DHEA |
| Comparator arm: Coenzyme Q10 | Active comparator | Coenzyme Q10 100mg twice daily for 3 months. Receives: Drug: Coenzyme Q10 |
What is being measured
The primary outcome is the main question the study is designed to answer.
Sperm concentration
The number of sperm cells present in one milliliter of semen, measured by microscopic semen analysis according to WHO standards, after 30-60 min of liquifaction, at 37 degree celcius, avereged over two independent reading byt trained laboratory technicians blinded to tratmentt allocation.
Measured: 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Aug 2026
- Study start1 Jul 2025
- Primary completion30 Jun 2026
- Study completion30 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for OligospermiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 56 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mst.Sumyara Khatun
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Mst.Sumyara Khatun, Bangladesh Medical University
- Investigators
- Jemine Banu, MS, Study chair, Bangladesh Medical University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07771153
- Sponsor's protocol ID
- 5513
- Acronym
- CoQ10 DHEA
- Status last verified
- Aug 2026
- First submitted
- 13 Aug 2026
- Last updated
- 18 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Alahmar AT, Calogero AE, Sengupta P, Dutta S. Coenzyme Q10 Improves Sperm Parameters, Oxidative Stress Markers and Sperm DNA Fragmentation in Infertile Patients with Idiopathic Oligoasthenozoospermia. World J Mens Health. 2021 Apr;39(2):346-351. doi: 10.5534/wjmh.190145. Epub 2020 Jan 20.
PubMed 32009311Akhigbe TM, Fidelis FB, Adekunle AO, Ashonibare VJ, Akorede BA, Shuaibu MS, Hassan SA, Adegbola CA, Ashonibare PJ, Oladapo OM, Adeogun AE, Bamidele SG, Oyedokun PA, Mukolokota M, Kukoyi OS, Oladipo AA, Adelowo OE, Akangbe MD, Hughes JR, Ricken AM, Culty M, Avellar MCW, Akhigbe RE. Does coenzyme Q10 improve semen quality and circulating testosterone level? a systematic review and meta-analysis of randomized controlled trials. Front Pharmacol. 2025 Jan 3;15:1497930. doi: 10.3389/fphar.2024.1497930. eCollection 2024.
PubMed 39830337
Study at a glance
From the registry record, last updated by the sponsor on 18 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of DHEA Plus Coenzyme Q10 Combination Therapy Compared to Coenzyme Q10 Alone on Sperm Concentration in Subfertile Male With Oligospermia.
- ClinicalTrials.gov ID
- NCT07771153
- Acronym / sponsor ID
- CoQ10 DHEA / 5513
- Conditions
- Oligospermia
- Keywords
- DHEA, Coenzyme Q10
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 56 participants (actual)
- Lead sponsor
- Mst.Sumyara KhatunUniversity, hospital or other
- Study start
- 1 Jul 2025 (actual)
- Primary completion
- 30 Jun 2026 (actual)
- Study completion
- 30 Jun 2026 (actual)
- First posted
- 18 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of the clinical trail is to learn weather DHEA plus Coenzyme Q10 works better to improve sperm concentration in subfertile male with oligospermia. We will also learn about the saftey of combination of drugs.
The main question it aims to answer are:
Does taking DHEA plus Coenzyme Q10 improve sperm concentration compared to Coenzyme Q10 alone? Are there any side effects or saftey concerns with DHEA plus Coenzyme Q10?
Researcher will compare DHEA plus Coenzyme Q10 with Coenzyme Q10 to see weather cobination drugs works better in improving sperm count than Coenzyme Q10 alone.
Participant will randomly placed into two group:
Group A (Combination Group): Tablet DHEA 25 mg BD and tablet Coenzyme Q10 100mg BD for 3 months.
Group B (Alone Group): Tablet Coenzyme Q10 100mg BD for 3 months. All participants will follow up at the start and after 3 months of treatment for check up and test.
Detailed description
This Randomized controlled trial will be conducted in the Department of Reproductive Endocrinology \& Infertility, BMU from the day of approval. Ethical clearance will be obtained from the Institutional Review Board. The study population will be the subfertile men with oligospermia according to WHO Laboratory manual 6 th Edition in 2021, fulfilling the inclusion and exclusion criteria.
A baseline semen analysis for the evaluation of male infertility will be done. Infertility will be determined by clinical history. A baseline semen sample will be collected in the laboratory of Reproductive Endocrinology \& Infertility, BMU by masturbation in a sterile plastic container. The sperm parameter will be checked by Makler Counting Chamber. An aliquot (0.5 ml) of each well-mixed semen sample will be placed on the Makler counting chamber, and the coverslip will be applied. The spermatozoa will be allowed to sediment for 3 minutes. Recognizable spermatozoa will be counted in 10 squares with x20 objective of a light microscope and recorded as spermatozoa in millions/mL of semen.
A total of 52 patients will be included in the study according to the inclusion and exclusion criteria. Eligible men will be randomly allocated into either Group A or Group B. Group A will receive (DHEA 25mg and Coenzyme Q10 100mg) twice daily and Group B will receive (Coenzyme Q10 100mg) twice daily for 3 months. They will be informed not to take other medications that could affect spermatogenesis during the study period expect after counseling physician.
The side effects and the spontaneous pregnancies will also be recorded. There will be two hospital visits during the dosing period. During the initial visit after recruitment, the participants will be prescribed medicines by some designated prescribing form.
One week later, a telephone interview will be conducted to review for side effects and arrange an early appointment at the patient's request if needed. Patients will be advised for timed sexual intercourse and for urinary pregnancy test in case of missed period. After three months of intervention, a semen analysis and serum testosterone level will be performed.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Experimental arm: DHEA and Coenzyme Q10 | Experimental | Drug: Tablet DHEADHEA 25mg twice daily and Coenzyme Q10 100mg twice daily for 3 months. |
| Comparator arm: Coenzyme Q10 | Active comparator | Drug: Coenzyme Q10Coenzyme Q10 100mg twice daily for 3 months. |
Who may qualify
- Ages
- 20 to 50 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Age 20-50 years. Subfertile males with oligospermia (sperm concentration less than16 million/ml)
Key exclusion criteria (1 listed)
- Severe oligospermia (less than 5million/ml) Any medical and endocrine disorders like hypertension, diabetes mellitus, hypothyroidism, hyperprolactinemia, renal or liver disease. Any abnormality on genital examination and scrotal sonogram. History of chemotherapy or radiotherapy, genital infection, genital surgery. Antioxidants supplmentation in the last 3 months Drug, alcohol or substance abuse, psycho-sexual abnormalities.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Tablet DHEADHEA 25mg twice daily and Coenzyme Q10 100mg twice daily for 3 months. | Drug | Experimental arm: DHEA and Coenzyme Q10 |
| Coenzyme Q10Coenzyme Q10 100mg twice daily for 3 months. | Drug | Comparator arm: Coenzyme Q10 |
Primary outcome
Sperm concentration
Time frame: 3 months
The number of sperm cells present in one milliliter of semen, measured by microscopic semen analysis according to WHO standards, after 30-60 min of liquifaction, at 37 degree celcius, avereged over two independent reading byt trained laboratory technicians blinded to tratmentt allocation.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Aug 2026.
- Results publication: PubMed 32009311Alahmar AT, Calogero AE, Sengupta P, Dutta S. Coenzyme Q10 Improves Sperm Parameters, Oxidative Stress Markers and Sperm DNA Fragmentation in Infertile Patients with Idiopathic Oligoasthenozoospermia. World J Mens Health. 2021 Apr;39(2):346-351. doi: 10.5534/wjmh.190145. Epub 2020 Jan 20.
- Results publication: PubMed 39830337Akhigbe TM, Fidelis FB, Adekunle AO, Ashonibare VJ, Akorede BA, Shuaibu MS, Hassan SA, Adegbola CA, Ashonibare PJ, Oladapo OM, Adeogun AE, Bamidele SG, Oyedokun PA, Mukolokota M, Kukoyi OS, Oladipo AA, Adelowo OE, Akangbe MD, Hughes JR, Ricken AM, Culty M, Avellar MCW, Akhigbe RE. Does coenzyme Q10 improve semen quality and circulating testosterone level? a systematic review and meta-analysis of randomized controlled trials. Front Pharmacol. 2025 Jan 3;15:1497930. doi: 10.3389/fphar.2024.1497930. eCollection 2024.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jemine Banu, MS study chair
Bangladesh Medical University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Tablet DHEA and Coenzyme Q10 in people with Oligospermia, run by Mst.Sumyara Khatun at 1 site in Bangladesh.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 18 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Bangladesh. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Sperm concentration (time frame: 3 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07771153, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Aug 2026.