Clinical trials: Oligospermia
Testicular Injury, Oligospermia
Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for Testicular Injury and Oligospermia
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord derived mesenchymal stem cells for the treatment of Testicular Injury and Oligospermia
- Trial name
- NCT05158114
- Testing
- AlloRx
- Where
- Antigua and Barbuda
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Infertility Unexplained, Oligospermia
Evaluation of Treatment With Coenzyme Q10 and L-Carnitine on Semen Parameters in Infertile Men With Idiopathic Oligoasthenoteratospermia
Evaluation of treatment with Coenzyme Q10 and L-Carnitine on Semen Parameters in Infertile men with Idiopathic Oligoasthenoteratospermia
- Trial name
- infertility (NCT06342856)
- Testing
- co enzyme Q10 , L- Carnitine
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Azoospermia, Nonobstructive, Cryptozoospermia
Maternal Inheritance of a Pathogenic MT-ND1 Mutation Causes Mitochondrial Dysfunction and Spermatogenic Failure in Men
Idiopathic non-obstructive azoospermia and cryptozoospermia are severe forms of male infertility in which sperm production is absent or extremely low and the cause is often unknown.
- Trial name
- MTND1-INA/C (NCT07691827)
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- The Third Affiliated Hospital of Guangzhou Medical University
Oligospermia, Teratospermia
Ramipril for the Treatment of Oligospermia
This is a randomized controlled trial to evaluate the effect of ramipril in stimulating and promoting sperm production in men with low sperm count.
- Conditions
- Oligospermia, Teratospermia, Asthenozoospermia, Male Infertility
- Trial name
- NCT01856361
- Testing
- Ramipril
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Infertility, Male, Oligozoospermia
The Role of Artery-Preserving Varicocelectomy in Subfertile Men With Severe Oligozoospermia.
A male factor is responsible for almost half the cases of subfertility. Varicocele is a major cause of impaired spermatogenesis and potentially a correctable cause.
- Conditions
- Infertility, Male, Oligozoospermia, Varicocelectomy
- Trial name
- NCT03344588
- Testing
- artery preserving varicocelectomy, artery ligation varicocelectomy
- Where
- Egypt
- Volunteers
- 330 people
- Sponsor
- Mansoura University
Infertility, Male, Infertility Unexplained
Using of Testes Shocker in Improving the Spermatogenesis and Sperms Activity
Infertility was reported in approximately 15% of all heterozygous couples, with male factor accounting for nearly half the cases.
- Conditions
- Infertility, Male, Infertility Unexplained, Infertility Due to Complete Spermatogenic Arrest, Oligospermia
- Trial name
- NCT05506722
- Testing
- Testes shocker
- Where
- Iraq
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Sub Fertility, Male, Fertility Disorders
Effects of a Fasting Mimicking Diet on Sperm Quality
This study investigates the effect of repetitive cycles of a Fasting Mimicking Diet (3x5 days in six months) on sperm quality in men
- Conditions
- Sub Fertility, Male, Fertility Disorders, Sperm Count, Low
- Trial name
- KiWu-B (NCT04908774)
- Testing
- Fasting Mimicking Diet
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- Charite University, Berlin, Germany
Obesity, Oligospermia
Aromatase Inhibitors in the Treatment of Male Infertility
Obesity is associated with an increase in blood levels of estrogen. Estrogen or "female hormone" is believed to have a negative effect on sperm production.
- Trial name
- NCT00440180
- Testing
- Anastrozole
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Infertility, Male
NAPO - Novel Approach for Oligospermia
This randomized controlled trial aims to assess whether treatment with denosumab can improve semen quality in infertile men selected by serum anti-mullerian hormone (AMH) as a positive predictive biomarker, and with severely…
- Trial name
- NAPO (NCT06300229)
- Testing
- Denosumab, sodium chloride
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Martin Blomberg Jensen
Oligozoospermia, Asthenozoospermia
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of STSP-0902 in Healthy Subjects
This is a Phase 1a, randomized, double-blind, placebo-controlled, single ascending dose (SAD) study to evaluate the safety, tolerability, pharmacokinetics (PK), and immunogenicity of STSP-0902.
- Trial name
- NCT06563713
- Testing
- STSP-0902 injection
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Staidson (Beijing) Biopharmaceuticals Co., Ltd
Oligospermia, Sperm Count, Low
Creatine and Ubiquinol for Sperm Quality
This randomized controlled double-blind parallel-group interventional trial explores the impact of 8-week creatine supplementation, with or without ubiquinol, on sperm quality biomarkers in normospermic and oligospermic men.
- Trial name
- CRESPAQ10 (NCT06202469)
- Testing
- Supplement 1, Supplement 2
- Where
- Serbia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Novi Sad, Faculty of Sport and Physical Education
Oligospermia
A Preliminary Study on Effect of Omega-3 on Human Sperm
The phospholipids of mammalian spermatozoa possess a distinctive fatty acid composition with high proportion of long chain polyunsaturated fatty acids.
- Trial name
- NCT00479960
- Testing
- commercially available omega-3 fatty acids supplementation
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Oligospermia, Azoospermia
Genetic Studies Spermatogenic Failure
The proposed study is designed to test the following hypotheses: 1. Mouse autosomal or X-linked genes which are exclusively expressed in mouse spermatogonia are also spermatogonia-specific in human. 2.
- Conditions
- Oligospermia, Azoospermia, Male Infertility
- Trial name
- NCT00548977
- Testing
- Drawing blood to study genetic polymorphism
- Where
- Taiwan
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Beta-hCG Positivity, Clinical Pregnancy
Evaluation of Assisted Reproductive Technology (ART) Outcomes in Couples With Nonobstructive Azoospermia, Cryptozoospermia, and Severe Oligozoospermia
This study aims to compare the In Vitro Fertilization (IVF/ICSI) outcomes of patients with a sperm concentration of <5 million/mL (severe oligozoospermia) and <1 million/mL (cryptozoospermia) to those diagnosed with…
- Conditions
- Beta-hCG Positivity, Clinical Pregnancy, Miscarriage, Multiple Pregnancy
- Trial name
- ART (NCT07897279)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duzce University
Cryptozoospermia
Varicocelectomy for Cryptozoospermic Men.
Patient Information leaflet on varicoceles surgery
- Trial name
- NCT07759713
- Testing
- Varicoceles ligation
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- Sohag University
Oligospermia
Identification and Characterization of the Methylation Abnormalities on Whole Genome Among Infertile Men
This study will analyse the sperm global methylation status of 62 infertile men before assisted reproductive techniques. Some of these patients (20%) present hypomethylation of H19 locus.
- Trial name
- METHYLHOMME (NCT01239186)
- Testing
- methylation analyses on spermatozoa from infertile men
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Oligoasthenoteratozoospermia, Male Infertility
Efficacy Comparison of Tamoxifen and Tamoxifen With Antioxidants on Semen Quality of Male With Idiopathic Infertility
Objective of the study is to compare the efficacy of tamoxifen alone \& tamoxifen with antioxidant on semen quality of infertile male with abnormal parameters (sperm count, motility, vitality, morphology) .Infertility is defines…
- Trial name
- NCT05200663
- Testing
- Tab Tamoxifen 10 mg, Tab Tamoxifen 10mg,Cap vitamin E 400mg
- Where
- Pakistan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Sharif Medical Research Center
Oligospermia, DNA Damage
Comparison of ICSI Outcomes in Cycles Using Testicular and Ejaculate Sperm From Couples With High SDF
In patients with oligospermia in the ejaculate or previous ICSI failures if it concurs with high DNA fragmentation, it has been hypothesized that the use of sperm obtained from the testicle would improve the clinical results…
- Conditions
- Oligospermia, DNA Damage, IVF, ICSI
- Trial name
- NCT04795440
- Testing
- Testicular biopsy
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Fundación IVI
Azoospermia or Severe Oligozoospermia
Detection of Microdeletions in the Azoospermia Factor (AZF) Regions in Infertile Male Patients
In this prospective study, we used Multiplex ligation-dependent probe amplification and next-generation sequencing technology to detect AZF microdeletion types accurately in selected genetic locus, and made correlation analysis…
- Trial name
- NCT03497728
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Microdissection Testicular Sperm Extraction
Timing of Oocyte Retrieval and Micro Testicular Sperm Extraction
This is a retrospective study to assess outcomes of micro-TESE performed 24 or 48 hours before oocyte retrieval and ICSI.
- Trial name
- NCT07268235
- Where
- Canada
- Volunteers
- 129 people
- Sponsor
- Clinique Ovo