Alveolar Ridge PreservationNCT07771257
Polynucleotide-Hyaluronic Acid Gel With Xenograft for Alveolar Ridge Preservation
A study testing Polynucleotide-Hyaluronic Acid Gel With Xenograft and Xenograft With Collagen Membrane in people with Alveolar Ridge Preservation, run by Cairo University at 1 site in Egypt.
Trial summary
This randomized controlled clinical trial will evaluate the efficacy of polynucleotide-hyaluronic acid gel combined with xenograft and collagen membrane for alveolar ridge preservation following tooth extraction. Twenty participants will be randomly allocated into two parallel groups. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Alveolar Ridge Preservation
- What is being tested?
- Polynucleotide-Hyaluronic Acid Gel With Xenograft and Xenograft With Collagen Membrane
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteEgypt
- Study dates
- Sep 2026to Apr 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patients aged 18-60 years.
- Patients free from systemic diseases affecting wound healing or bone regeneration or contraindicating oral surgery.
- Non-smokers with good oral hygiene.
- Patients requiring tooth extraction in non-infected sockets due to endodontic failure, non-restorable caries, or trauma, and who will receive implant treatment.
- Class I extraction sockets with intact alveolar bone walls.
- Presence of teeth adjacent to the extraction site.
Who cannot join
- Use of drugs affecting wound healing.
- Heavy smokers (>10 cigarettes/day) or history of substance abuse.
- Pregnant or breastfeeding women.
- Previous grafting or surgical intervention in the study area.
- Uncontrolled and/or untreated periodontal disease (active periodontitis).
- Mentally or physically handicapped patients.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site
Faculty of Dentistry, Cairo University
Cairo, Cairo Governorate
Maryam Alabbas, BDS, +97366754440, maryam.alabbas@dentistry.cu.edu.eg
Maryam Alabbas, BDS
About this study
Official title: Evaluation of the Efficacy of Polynucleotide-Hyaluronic Acid Gel With Xenograft Compared to Xenograft Alone in Alveolar Ridge Preservation: A Randomized Clinical Trial
This randomized controlled clinical trial will evaluate the efficacy of polynucleotide-hyaluronic acid gel combined with xenograft and collagen membrane for alveolar ridge preservation following tooth extraction. Twenty participants will be randomly allocated into two parallel groups. The test group will receive xenograft mixed with polynucleotide-hyaluronic acid gel and covered with a collagen membrane, while the control group will receive xenograft with a collagen membrane alone. Clinical and CBCT assessments will be performed at baseline and during follow-up. After 6 months, ridge dimensional changes will be evaluated and core biopsies will be obtained at the time of implant placement for histological assessment.
- Conditions
- Alveolar Ridge Preservation
- Being tested
- Polynucleotide-Hyaluronic Acid Gel With Xenograft, Xenograft With Collagen Membrane
- Keywords
- Socket Preservation, Alveolar Ridge Preservation, Polynucleotide, Hyaluronic Acid, Xenograft, Collagen Membrane
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Polynucleotide-Hyaluronic Acid Gel With XenograftOther
Xenograft mixed with polynucleotide-hyaluronic acid gel and covered with a collagen membrane for alveolar ridge preservation after tooth extraction.
Xenograft With Collagen MembraneOther
Xenograft placed in the extraction socket and covered with a collagen membrane for alveolar ridge preservation after tooth extraction.
| Study group | Role | What they receive |
|---|---|---|
| Polynucleotide-Hyaluronic Acid Gel With Xenograft | Experimental | Alveolar ridge preservation using xenograft mixed with polynucleotide-hyaluronic acid gel and covered with a collagen membrane. Receives: Other: Polynucleotide-Hyaluronic Acid Gel With Xenograft |
| Xenograft Alone | Active comparator | Alveolar ridge preservation using xenograft covered with a collagen membrane. Receives: Other: Xenograft With Collagen Membrane |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Buccal Bone Plate Height
The height of the buccal bone plate will be measured using digital superimposition of Cone Beam Computed Tomography (CBCT) scans obtained at baseline and 6 months. Measurements will be recorded in millimeters
Measured: Baseline and 6 months
Secondary outcomes (4)
Change in Palatal Bone Plate Height
The height of the palatal bone plate will be measured using digital superimposition of Cone Beam Computed Tomography (CBCT) scans obtained at baseline and 6 months. Measurements will be recorded in millimeters.
Measured: Baseline and 6 months
Change in Horizontal Ridge Width
Horizontal ridge width will be measured using digital superimposition of Cone Beam Computed Tomography (CBCT) scans at 2 mm, 4 mm, and 6 mm below the most coronal aspect of the alveolar crest. Measurements will be compared between baseline and 6 months and recorded in millimeters.
Measured: Baseline and 6 months
Percentage of New Vital Bone Formation
The percentage of newly formed vital bone will be assessed histologically and histomorphometrically in core biopsy specimens obtained from the preserved site at the time of implant placement after 6 months.
Measured: 6 months
Percentage of Residual Graft Particles
The percentage of residual graft particles will be assessed histologically and histomorphometrically in core biopsy specimens obtained from the preserved site at the time of implant placement after 6 months.
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Aug 2026
- Study startSep 2026 (estimated)
- Primary completionApr 2027 (estimated)
- Study completionApr 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Alveolar Ridge PreservationStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Maryam Mohamed Ali radhi alabbas, Cairo University
- Investigators
- Maryam Alabbas, BDS, Principal investigator, Cairo UniversityManal Hosni, Study chair, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07771257
- Sponsor's protocol ID
- PER 631
- Status last verified
- Aug 2026
- First submitted
- 13 Aug 2026
- Last updated
- 18 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared outside the study research team in order to maintain participant confidentiality and data protection.
Study at a glance
From the registry record, last updated by the sponsor on 18 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Efficacy of Polynucleotide-Hyaluronic Acid Gel With Xenograft Compared to Xenograft Alone in Alveolar Ridge Preservation: A Randomized Clinical Trial
- ClinicalTrials.gov ID
- NCT07771257
- Acronym / sponsor ID
- PER 631
- Conditions
- Alveolar Ridge Preservation
- Keywords
- Socket Preservation, Alveolar Ridge Preservation, Polynucleotide, Hyaluronic Acid, Xenograft, Collagen Membrane
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- Sep 2026 (estimated)
- Primary completion
- Apr 2027 (estimated)
- Study completion
- Apr 2027 (estimated)
- First posted
- 18 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled clinical trial will evaluate the efficacy of polynucleotide-hyaluronic acid gel combined with xenograft and collagen membrane for alveolar ridge preservation following tooth extraction. Twenty participants will be randomly allocated into two parallel groups. The test group will receive xenograft mixed with polynucleotide-hyaluronic acid gel and covered with a collagen membrane, while the control group will receive xenograft with a collagen membrane alone. Clinical and CBCT assessments will be performed at baseline and during follow-up. After 6 months, ridge dimensional changes will be evaluated and core biopsies will be obtained at the time of implant placement for histological assessment.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Polynucleotide-Hyaluronic Acid Gel With Xenograft | Experimental | Other: Polynucleotide-Hyaluronic Acid Gel With XenograftAlveolar ridge preservation using xenograft mixed with polynucleotide-hyaluronic acid gel and covered with a collagen membrane. |
| Xenograft Alone | Active comparator | Other: Xenograft With Collagen MembraneAlveolar ridge preservation using xenograft covered with a collagen membrane. |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Patients aged 18-60 years.
- Patients free from systemic diseases affecting wound healing or bone regeneration or contraindicating oral surgery.
- Non-smokers with good oral hygiene.
- Patients requiring tooth extraction in non-infected sockets due to endodontic failure, non-restorable caries, or trauma, and who will receive implant treatment.
- Class I extraction sockets with intact alveolar bone walls.
Key exclusion criteria (6 listed)
- Use of drugs affecting wound healing.
- Heavy smokers (>10 cigarettes/day) or history of substance abuse.
- Pregnant or breastfeeding women.
- Previous grafting or surgical intervention in the study area.
- Uncontrolled and/or untreated periodontal disease (active periodontitis).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Polynucleotide-Hyaluronic Acid Gel With XenograftXenograft mixed with polynucleotide-hyaluronic acid gel and covered with a collagen membrane for alveolar ridge preservation after tooth extraction. | Other | Polynucleotide-Hyaluronic Acid Gel With Xenograft |
| Xenograft With Collagen MembraneXenograft placed in the extraction socket and covered with a collagen membrane for alveolar ridge preservation after tooth extraction. | Other | Xenograft Alone |
Primary outcome
Change in Buccal Bone Plate Height
Time frame: Baseline and 6 months
The height of the buccal bone plate will be measured using digital superimposition of Cone Beam Computed Tomography (CBCT) scans obtained at baseline and 6 months. Measurements will be recorded in millimeters
4 secondary outcomes
Change in Palatal Bone Plate Height
Time frame: Baseline and 6 months
Change in Horizontal Ridge Width
Time frame: Baseline and 6 months
Percentage of New Vital Bone Formation
Time frame: 6 months
Percentage of Residual Graft Particles
Time frame: 6 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Aug 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared outside the study research team in order to maintain participant confidentiality and data protection.
Related trials for Alveolar Ridge Preservation
Not yet recruiting
Effect of Ascorbic Acid-Loaded I-PRF With Partially Demineralized Dentin Graft on Alveolar Ridge Preservation
Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth Loss, Alveolar Bone Regeneration Following Odontectomy
Recruiting
Effect of Collagen Membrane on Ridge Preservation
Dehiscence, Tooth Extraction
Not yet recruitingPhase 1/2
Alveolar Ridge Preservation (ARP) Study Using Alloplastic Biomaterial and a Resorbable Synthetic Membrane. A Digital Workflow (CBCT/Scanner) Evaluates Hard and Soft Tissue Volumetric Changes at 4 Months, Validating Support for the Gingival Phenotype and Buccal Bone Plate.
Alveolar Ridge Augmentation, Bone Substitutes
RecruitingPhase 4
Biotivity A-C Membrane Socket Preservation Study
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Active, not recruiting
Vallomix Socket Preservation Study
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Maryam Alabbas, BDS principal investigator
Cairo University
Manal Hosni study chair
Cairo University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Polynucleotide-Hyaluronic Acid Gel With Xenograft and Xenograft With Collagen Membrane in people with Alveolar Ridge Preservation, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 18 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Maryam Alabbas, BDS (+97366754440, maryam.alabbas@dentistry.cu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Buccal Bone Plate Height (time frame: Baseline and 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Aug 2026.