Carpal Tunnel Syndrome (CTS)CTSNCT07779096
Effect of Neural Mobilization on Carpal Tunnel Syndrome
A study testing Neuromobilization in people with Carpal Tunnel Syndrome (CTS), run by Cairo University at 1 site in Egypt.
Trial summary
The study group (G1) consisted of 15 patients treated by neural mobilization techniques targeting the median nerve, in addition to a selected physical therapy program including transcutaneous electrical nerve stimulation (TENS), therapeutic ultrasound, and strengthening exercises for the wrist and hand muscles. Read more about this study
- Who is it for?
- Ages 45 to 55 years, women only
- Conditions the study is for
- Carpal Tunnel Syndrome (CTS)
- What is being tested?
- Neuromobilization
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jan 2023to 25 Oct 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 45 to 55 years
- Women only
- No healthy volunteers
- Adult
Who may be able to join
- Female patients diagnosed with carpal tunnel syndrome (CTS) confirmed by electrophysiological nerve conduction study Age range: 45-55years Unilateral or bilateral CTS (mild to moderate severity) Symptom duration of at least 3 months (chronic cases) No previous surgical intervention for CTS Willing to participate and sign informed consent
Who cannot join
- Severe CTS requiring surgical intervention Previous wrist surgery or fracture history Cervical radiculopathy or thoracic outlet syndrome (double crush syndrome)
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Neural Mobilization on Selective Sonographic Parameters and Functional Outcome in Patients With Carpal Tunnel Syndrome
The study group (G1) consisted of 15 patients treated by neural mobilization techniques targeting the median nerve, in addition to a selected physical therapy program including transcutaneous electrical nerve stimulation (TENS), therapeutic ultrasound, and strengthening exercises for the wrist and hand muscles. The control group (G2) consisted of 15 patients treated only by the same selected physical therapy program as in G1, without neural mobilization.
All outcome variables (median nerve cross-sectional area, flattening ratio, and flexor retinaculum bowing measured by diagnostic ultrasound; hand grip strength measured by handheld dynamometer; and symptom severity and functional status measured by the Boston Carpal Tunnel Questionnaire) were assessed pre-treatment and after 6 weeks of intervention, for comparison within and between groups.
Read the detailed description
The study group (G1) consisted of 15 patients treated by neural mobilization techniques targeting the median nerve, in addition to a selected physical therapy program including transcutaneous electrical nerve stimulation (TENS), therapeutic ultrasound, and strengthening exercises for the wrist and hand muscles. The control group (G2) consisted of 15 patients treated only by the same selected physical therapy program as in G1, without neural mobilization.
All outcome variables (median nerve cross-sectional area, flattening ratio, and flexor retinaculum bowing measured by diagnostic ultrasound; hand grip strength measured by handheld dynamometer; and symptom severity and functional status measured by the Boston Carpal Tunnel Questionnaire) were assessed pre-treatment and after 6 weeks of intervention, for comparison within and between groups.
- Conditions
- Carpal Tunnel Syndrome (CTS)
- Being tested
- Neuromobilization
- Keywords
- Carpal tunnel syndrome, Neural mobilization, Diagnostic ultrasound, Median nerve, Handheld dynamometer, Boston Carpal Tunnel Questionnaire
- Medical subject headings
- Carpal Tunnel Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
NeuromobilizationOther
Neuromobilization (also called Neural Mobilization or Neurodynamic Techniques) is a conservative physiotherapy intervention that aims to restore the normal mechanical movement of the median nerve through the carpal tunnel and surrounding tissues.
| Study group | Role | What they receive |
|---|---|---|
| Study group (G1) | Experimental | Neural mobilization Transcutaneous electrical nerve stimulation (TENS) Therapeutic ultrasound Stretching / strengthening exercises Receives: Other: Neuromobilization |
| control group (G2) | Active comparator | Transcutaneous electrical nerve stimulation (TENS) Therapeutic ultrasound Stretching / strengthening exercises Receives: Other: Neuromobilization |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in pain intensity measured by the Visual Analogue Scale (VAS)
Pain intensity was assessed using the 0-10 cm Visual Analogue Scale (0 = no pain, 10 = worst imaginable pain). Higher scores indicate greater pain.
Measured: Baseline and after 6 weeks of treatment
Secondary outcomes (6)
Change in symptom severity measured by the Symptom Severity Scale (SSS) of the Boston Carpal Tunnel Questionnaire (BCTQ)
Symptom severity was assessed using the SSS of the BCTQ (11 items, each scored 1-5; higher mean score indicates more severe symptoms).
Measured: Baseline and after 6 weeks of treatment
Change in functional status measured by the Functional Status Scale (FSS) of the Boston Carpal Tunnel Questionnaire (BCTQ)
Functional status was assessed using the FSS of the BCTQ (8 items, each scored 1-5; higher mean score indicates greater functional impairment).
Measured: Baseline and after 6 weeks of treatment
Change in hand grip strength measured by a handheld dynamometer
Maximum hand grip strength was measured using a handheld dynamometer (in kg).
Measured: Baseline and after 6 weeks of treatment
Change in median nerve cross-sectional area (CSA) measured by diagnostic ultrasound
CSA of the median nerve at the carpal tunnel inlet was measured by diagnostic ultrasonography (in mm²).
Measured: Baseline and after 6 weeks of treatment
Change in median nerve flattening ratio measured by diagnostic ultrasound
The flattening ratio of the median nerve was measured by diagnostic ultrasonography.
Measured: Baseline and after 6 weeks of treatment
Change in flexor retinaculum (palmar) bowing measured by diagnostic ultrasound
Palmar bowing of the flexor retinaculum was measured by diagnostic ultrasonography (in mm).
Measured: Baseline and after 6 weeks of treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Aug 2026
- Study start1 Jan 2023
- Primary completion30 Jun 2025
- Study completion25 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Carpal Tunnel Syndrome (CTS)Studies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Trevena Elia Eskander, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07779096
- Sponsor's protocol ID
- CTS
- Acronym
- CTS
- Status last verified
- Aug 2026
- First submitted
- 15 Mar 2026
- Last updated
- 21 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Neural Mobilization on Selective Sonographic Parameters and Functional Outcome in Patients With Carpal Tunnel Syndrome
- ClinicalTrials.gov ID
- NCT07779096
- Acronym / sponsor ID
- CTS / CTS
- Conditions
- Carpal Tunnel Syndrome (CTS)
- Keywords
- Carpal tunnel syndrome, Neural mobilization, Diagnostic ultrasound, Median nerve, Handheld dynamometer, Boston Carpal Tunnel Questionnaire
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Jan 2023 (actual)
- Primary completion
- 30 Jun 2025 (actual)
- Study completion
- 25 Oct 2025 (actual)
- First posted
- 21 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study group (G1) consisted of 15 patients treated by neural mobilization techniques targeting the median nerve, in addition to a selected physical therapy program including transcutaneous electrical nerve stimulation (TENS), therapeutic ultrasound, and strengthening exercises for the wrist and hand muscles. The control group (G2) consisted of 15 patients treated only by the same selected physical therapy program as in G1, without neural mobilization.
All outcome variables (median nerve cross-sectional area, flattening ratio, and flexor retinaculum bowing measured by diagnostic ultrasound; hand grip strength measured by handheld dynamometer; and symptom severity and functional status measured by the Boston Carpal Tunnel Questionnaire) were assessed pre-treatment and after 6 weeks of intervention, for comparison within and between groups.
Detailed description
The study group (G1) consisted of 15 patients treated by neural mobilization techniques targeting the median nerve, in addition to a selected physical therapy program including transcutaneous electrical nerve stimulation (TENS), therapeutic ultrasound, and strengthening exercises for the wrist and hand muscles. The control group (G2) consisted of 15 patients treated only by the same selected physical therapy program as in G1, without neural mobilization.
All outcome variables (median nerve cross-sectional area, flattening ratio, and flexor retinaculum bowing measured by diagnostic ultrasound; hand grip strength measured by handheld dynamometer; and symptom severity and functional status measured by the Boston Carpal Tunnel Questionnaire) were assessed pre-treatment and after 6 weeks of intervention, for comparison within and between groups.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Study group (G1) | Experimental | Other: NeuromobilizationNeural mobilization Transcutaneous electrical nerve stimulation (TENS) Therapeutic ultrasound Stretching / strengthening exercises |
| control group (G2) | Active comparator | Other: NeuromobilizationTranscutaneous electrical nerve stimulation (TENS) Therapeutic ultrasound Stretching / strengthening exercises |
Who may qualify
- Ages
- 45 to 55 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Female patients diagnosed with carpal tunnel syndrome (CTS) confirmed by electrophysiological nerve conduction study Age range: 45-55years Unilateral or bilateral CTS (mild to moderate severity) Symptom duration of at least 3 months (chronic cases) No previous surgical intervention for CTS Willing to participate and sign informed consent
Key exclusion criteria (1 listed)
- Severe CTS requiring surgical intervention Previous wrist surgery or fracture history Cervical radiculopathy or thoracic outlet syndrome (double crush syndrome)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| NeuromobilizationNeuromobilization (also called Neural Mobilization or Neurodynamic Techniques) is a conservative physiotherapy intervention that aims to restore the normal mechanical movement of the median nerve through the carpal tunnel and surrounding tissues. | Other | Study group (G1), control group (G2) |
Primary outcome
Change in pain intensity measured by the Visual Analogue Scale (VAS)
Time frame: Baseline and after 6 weeks of treatment
Pain intensity was assessed using the 0-10 cm Visual Analogue Scale (0 = no pain, 10 = worst imaginable pain). Higher scores indicate greater pain.
6 secondary outcomes
Change in symptom severity measured by the Symptom Severity Scale (SSS) of the Boston Carpal Tunnel Questionnaire (BCTQ)
Time frame: Baseline and after 6 weeks of treatment
Change in functional status measured by the Functional Status Scale (FSS) of the Boston Carpal Tunnel Questionnaire (BCTQ)
Time frame: Baseline and after 6 weeks of treatment
Change in hand grip strength measured by a handheld dynamometer
Time frame: Baseline and after 6 weeks of treatment
Change in median nerve cross-sectional area (CSA) measured by diagnostic ultrasound
Time frame: Baseline and after 6 weeks of treatment
Change in median nerve flattening ratio measured by diagnostic ultrasound
Time frame: Baseline and after 6 weeks of treatment
Change in flexor retinaculum (palmar) bowing measured by diagnostic ultrasound
Time frame: Baseline and after 6 weeks of treatment
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Aug 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Neuromobilization in people with Carpal Tunnel Syndrome (CTS), run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 21 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in pain intensity measured by the Visual Analogue Scale (VAS) (time frame: Baseline and after 6 weeks of treatment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Aug 2026.