Exercise-Induced Muscle DamageCURACTIVENCT07785986
Curcumin Versus Ibuprofen for Exercise-Induced Muscle Damage in Physically Active Women
A study testing Curcumin and Ibuprofen in people with Exercise-Induced Muscle Damage and Delayed Onset Muscle Soreness (DOMS), run by University of Valladolid at 1 site in Spain.
Trial summary
xercise-induced muscle damage (EIMD) is a common consequence of unaccustomed or high-intensity exercise and is characterized by muscle soreness, impaired physical performance, inflammation, oxidative stress, and increased circulating biomarkers of muscle damage. Read more about this study
- Who is it for?
- Ages 18 to 30 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Exercise-Induced Muscle Damage, Delayed Onset Muscle Soreness (DOMS), Sports Recovery
- What is being tested?
- Curcumin and Ibuprofen
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 36 participants
- Where
- 1 siteSpain
- Study dates
- 22 Aug 2026to 9 Sep 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- Women only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy physically active women. Age within the predefined study range. Regular participation in physical activity for at least 6 months before enrollment.
- Ability to perform the eccentric exercise protocol. Written informed consent provided before participation.
Who cannot join
- Current musculoskeletal injury or pain affecting exercise performance. History of cardiovascular, metabolic, neurological, renal, hepatic, or inflammatory disease.
- Pregnancy or breastfeeding. Current use of anti-inflammatory drugs, antioxidant supplements, or other nutritional supplements that could interfere with study outcomes.
- Known allergy or intolerance to curcumin, turmeric, ibuprofen, or study ingredients.
- Smoking or excessive alcohol consumption. Participation in another clinical trial during the study period. Any condition considered by the investigators to compromise participant safety or protocol compliance.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparative Efficacy of Oral Curcumin Supplementation Versus Ibuprofen on Exercise-Induced Muscle Damage, Inflammation, Oxidative Stress, and Sports Performance in Physically Active Women: A Randomized Double-Blind Placebo-Controlled Trial
xercise-induced muscle damage (EIMD) is a common consequence of unaccustomed or high-intensity exercise and is characterized by muscle soreness, impaired physical performance, inflammation, oxidative stress, and increased circulating biomarkers of muscle damage. Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, are frequently used to alleviate these symptoms, although their repeated use may be associated with adverse effects. Curcumin, a natural polyphenol with antioxidant and anti-inflammatory properties, has emerged as a potential nutritional strategy to support post-exercise recovery.
This randomized, double-blind, placebo-controlled trial aims to compare the effects of oral curcumin supplementation and ibuprofen administration on exercise-induced muscle damage in physically active women. The study evaluates clinical outcomes, physical performance, biomarkers of muscle damage, inflammation, oxidative stress, and other health-related biomarkers to determine whether curcumin may represent a safe and effective nutritional alternative for promoting recovery after eccentric exercise.
Read the detailed description
Exercise-induced muscle damage (EIMD) following eccentric exercise is characterized by structural disruption of skeletal muscle fibers accompanied by transient inflammation, oxidative stress, delayed-onset muscle soreness, and impaired physical performance. Although these responses are considered part of the normal adaptive process, excessive muscle damage may delay recovery and impair subsequent training or competition.
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used by athletes to reduce post-exercise pain and inflammation. However, repeated NSAID use has been associated with gastrointestinal, renal, and cardiovascular adverse effects, highlighting the need for safe nutritional alternatives capable of supporting recovery without interfering with physiological adaptation.
Curcumin, the principal bioactive polyphenol derived from Curcuma longa, exhibits antioxidant, anti-inflammatory, and cytoprotective properties through modulation of multiple molecular pathways involved in redox homeostasis and inflammatory signaling. Experimental and clinical studies suggest that curcumin may attenuate exercise-induced muscle damage by reducing oxidative stress, inflammatory responses, and muscle soreness, although evidence remains inconsistent and direct comparisons with NSAIDs are scarce.
The objective of this randomized, double-blind, placebo-controlled trial is to compare the efficacy of oral curcumin supplementation with ibuprofen and placebo in physically active women following eccentric exercise. The study evaluates clinical recovery, physical performance, biomarkers of muscle damage, inflammatory and oxidative stress biomarkers, and additional health-related biomarkers in order to characterize the physiological effects of curcumin supplementation and determine its potential role as a nutritional strategy for exercise recovery.
- Conditions
- Exercise-Induced Muscle Damage, Delayed Onset Muscle Soreness (DOMS), Sports Recovery, Exercise-Induced Oxidative Stress, Exercise-Induced Inflammation
- Being tested
- Curcumin, Ibuprofen, Placebo
- Keywords
- Curcumin, Curcuma longa, Ibuprofen, Nutritional Supplementation, Eccentric Exercise, Exercise Recovery, Muscle Damage, Oxidative Stress, Inflammation, Sports Nutrition, Female Athletes, Physically Active Women, Randomized Controlled Trial, Delayed Onset Muscle Soreness (DOMS), Oxidative Stres
- Medical subject headings
- Inflammation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
CurcuminDietary supplement
Also called Curcuma longa
Participants received oral curcumin supplementation according to the study protocol before and after the eccentric exercise protocol. Curcumin was administered at the predefined dose and duration specified in the protocol. The intervention aimed to evaluate its effects on exercise-induced muscle damage, inflammation, oxidative stress, antioxidant defense, physical performance, and recovery in physically active women.
IbuprofenDrug
Participants received oral ibuprofen according to the study protocol before and after the eccentric exercise protocol. Ibuprofen was administered at the predefined dose and duration specified in the protocol and served as the active comparator for evaluating recovery following exercise-induced muscle damage.
PlaceboOther
Participants received placebo capsules identical in appearance, packaging, and administration schedule to the active interventions. The placebo contained inert ingredients and was administered according to the study protocol before and after the eccentric exercise protocol.
| Study group | Role | What they receive |
|---|---|---|
| Curcumin | Experimental | Participants received oral curcumin supplementation according to the study protocol before and following the eccentric exercise protocol. Clinical recovery, physical performance, muscle damage, inflammatory, oxidative stress, antioxidant defense, and other health-related biomarkers were evaluated during the recovery period. Receives: Dietary Supplement: Curcumin |
| Ibuprofen | Active comparator | articipants received oral ibuprofen according to the study protocol before and following the eccentric exercise protocol. Clinical recovery, physical performance, muscle damage, inflammatory, oxidative stress, antioxidant defense, and other health-related biomarkers were evaluated during the recovery period. Receives: Drug: Ibuprofen |
| Placebo | Placebo comparator | Participants received placebo capsules identical in appearance to the active interventions according to the study protocol before and following the eccentric exercise protocol. Clinical recovery, physical performance, muscle damage, inflammatory, oxidative stress, antioxidant defense, and other health-related biomarkers were evaluated during the recovery period. Receives: Other: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Exercise-induced muscle damage
Exercise-induced muscle damage assessed using clinical outcomes and biochemical biomarkers following eccentric exercise to compare the effects of oral curcumin supplementation, ibuprofen, and placebo in physically active women.
Measured: Baseline and during the 72-hour recovery period following eccentric exercise.
Secondary outcomes (13)
Creatine kinase (CK)
Changes in serum creatine kinase concentration as a biomarker of exercise-induced skeletal muscle damage following eccentric exercise.
Measured: Baseline and during the 48-hour recovery period following eccentric exercise.
Lactate dehydrogenase (LDH)
Changes in serum lactate dehydrogenase concentration as an indicator of muscle membrane disruption and tissue damage.
Measured: Baseline and during the 48-hour recovery period following eccentric exercise.
Aspartate aminotransferase (AST)
Changes in serum aspartate aminotransferase concentration as an indirect biomarker of exercise-induced muscle tissue damage.
Measured: Baseline and during the 48-hour recovery period following eccentric exercise.
Alanine aminotransferase (ALT)
Changes in serum alanine aminotransferase concentration following eccentric exercise.
Measured: Baseline and during the 48-hour recovery period following eccentric exercise.
Alkaline phosphatase (ALP)
Changes in serum alkaline phosphatase concentration following eccentric exercise.
Measured: Baseline and during the 48-hour recovery period following eccentric exercise.
Interleukin-6 (IL-6)
Changes in circulating interleukin-6 concentration as a biomarker of the inflammatory response to exercise-induced muscle damage.
Measured: Baseline and during the 48-hour recovery period following eccentric exercise.
C-reactive protein (CRP)
Changes in serum C-reactive protein concentration as a marker of systemic inflammation following eccentric exercise.
Measured: Baseline and during the 48-hour recovery period following eccentric exercise.
Malondialdehyde (MDA)
Changes in plasma malondialdehyde concentration as a biomarker of lipid peroxidation and oxidative stress.
Measured: Baseline and during the 48-hour recovery period following eccentric exercise.
Superoxide dismutase (SOD)
Changes in superoxide dismutase activity as an indicator of endogenous antioxidant defense.
Measured: Baseline and during the 48-hour recovery period following eccentric exercise.
Catalase (CAT)
Changes in catalase activity as a marker of antioxidant defense following eccentric exercise.
Measured: Baseline and during the 48-hour recovery period following eccentric exercise.
Delayed-onset muscle soreness (DOMS)
Changes in perceived muscle soreness assessed using a validated visual analogue scale following eccentric exercise.
Measured: Baseline and during the 48-hour recovery period following eccentric exercise.
Countermovement jump (CMJ)
Changes in countermovement jump performance as a measure of lower-limb neuromuscular function and exercise recovery.
Measured: Baseline and during the 48-hour recovery period following eccentric exercise.
Thigh circumference
Changes in thigh circumference as an indirect indicator of exercise-induced muscle swelling.
Measured: Baseline and during the 48-hour recovery period following eccentric exercise.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Aug 2026
- Study start22 Aug 2026
- Primary completion9 Sep 2026
- Study completion9 Sep 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Exercise-Induced Muscle DamageStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants were randomly assigned to one of three parallel groups receiving oral curcumin supplementation, ibuprofen, or placebo. Following supplementation, all participants performed a standardized eccentric exercise protocol. Clinical outcomes, physical performance, biomarkers of muscle damage, inflammation, oxidative stress, antioxidant defense, and other health-related biomarkers were evaluated during the recovery period.
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 36 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Valladolid
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Diego Fernández Lázaro, University of Valladolid
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07785986
- Sponsor's protocol ID
- DFL-CURC-2025-01
- Acronym
- CURACTIVE
- Status last verified
- Sep 2026
- First submitted
- 20 Aug 2026
- Last updated
- 23 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: ndividual participant data that underlie the results reported in publications arising from this study (after de-identification) will be made available upon reasonable request to the corresponding investigator. Data will be shared with researchers who provide a methodologically sound proposal and whose proposed use of the data has been approved by the study investigators and complies with applicable ethical and institutional regulations.
Study at a glance
From the registry record, last updated by the sponsor on 23 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Efficacy of Oral Curcumin Supplementation Versus Ibuprofen on Exercise-Induced Muscle Damage, Inflammation, Oxidative Stress, and Sports Performance in Physically Active Women: A Randomized Double-Blind Placebo-Controlled Trial
- ClinicalTrials.gov ID
- NCT07785986
- Acronym / sponsor ID
- CURACTIVE / DFL-CURC-2025-01
- Conditions
- Exercise-Induced Muscle Damage, Delayed Onset Muscle Soreness (DOMS), Sports Recovery, Exercise-Induced Oxidative Stress, Exercise-Induced Inflammation
- Keywords
- Curcumin, Curcuma longa, Ibuprofen, Nutritional Supplementation, Eccentric Exercise, Exercise Recovery, Muscle Damage, Oxidative Stress
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 36 participants (actual)
- Lead sponsor
- University of ValladolidUniversity, hospital or other
- Study start
- 22 Aug 2026 (actual)
- Primary completion
- 9 Sep 2026 (actual)
- Study completion
- 9 Sep 2026 (actual)
- First posted
- 25 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
xercise-induced muscle damage (EIMD) is a common consequence of unaccustomed or high-intensity exercise and is characterized by muscle soreness, impaired physical performance, inflammation, oxidative stress, and increased circulating biomarkers of muscle damage. Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, are frequently used to alleviate these symptoms, although their repeated use may be associated with adverse effects. Curcumin, a natural polyphenol with antioxidant and anti-inflammatory properties, has emerged as a potential nutritional strategy to support post-exercise recovery.
This randomized, double-blind, placebo-controlled trial aims to compare the effects of oral curcumin supplementation and ibuprofen administration on exercise-induced muscle damage in physically active women. The study evaluates clinical outcomes, physical performance, biomarkers of muscle damage, inflammation, oxidative stress, and other health-related biomarkers to determine whether curcumin may represent a safe and effective nutritional alternative for promoting recovery after eccentric exercise.
Detailed description
Exercise-induced muscle damage (EIMD) following eccentric exercise is characterized by structural disruption of skeletal muscle fibers accompanied by transient inflammation, oxidative stress, delayed-onset muscle soreness, and impaired physical performance. Although these responses are considered part of the normal adaptive process, excessive muscle damage may delay recovery and impair subsequent training or competition.
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used by athletes to reduce post-exercise pain and inflammation. However, repeated NSAID use has been associated with gastrointestinal, renal, and cardiovascular adverse effects, highlighting the need for safe nutritional alternatives capable of supporting recovery without interfering with physiological adaptation.
Curcumin, the principal bioactive polyphenol derived from Curcuma longa, exhibits antioxidant, anti-inflammatory, and cytoprotective properties through modulation of multiple molecular pathways involved in redox homeostasis and inflammatory signaling. Experimental and clinical studies suggest that curcumin may attenuate exercise-induced muscle damage by reducing oxidative stress, inflammatory responses, and muscle soreness, although evidence remains inconsistent and direct comparisons with NSAIDs are scarce.
The objective of this randomized, double-blind, placebo-controlled trial is to compare the efficacy of oral curcumin supplementation with ibuprofen and placebo in physically active women following eccentric exercise. The study evaluates clinical recovery, physical performance, biomarkers of muscle damage, inflammatory and oxidative stress biomarkers, and additional health-related biomarkers in order to characterize the physiological effects of curcumin supplementation and determine its potential role as a nutritional strategy for exercise recovery.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 3
- Model description
- Participants were randomly assigned to one of three parallel groups receiving oral curcumin supplementation, ibuprofen, or placebo. Following supplementation, all participants performed a standardized eccentric exercise protocol. Clinical outcomes, physical performance, biomarkers of muscle damage, inflammation, oxidative stress, antioxidant defense, and other health-related biomarkers were evaluated during the recovery period.
| Arm | Type | Receives |
|---|---|---|
| Curcumin | Experimental | Dietary Supplement: CurcuminParticipants received oral curcumin supplementation according to the study protocol before and following the eccentric exercise protocol. Clinical recovery, physical performance, muscle damage, inflammatory, oxidative stress, antioxidant defense, and other health-related biomarkers were evaluated during the recovery period. |
| Ibuprofen | Active comparator | Drug: Ibuprofenarticipants received oral ibuprofen according to the study protocol before and following the eccentric exercise protocol. Clinical recovery, physical performance, muscle damage, inflammatory, oxidative stress, antioxidant defense, and other health-related biomarkers were evaluated during the recovery period. |
| Placebo | Placebo comparator | Other: PlaceboParticipants received placebo capsules identical in appearance to the active interventions according to the study protocol before and following the eccentric exercise protocol. Clinical recovery, physical performance, muscle damage, inflammatory, oxidative stress, antioxidant defense, and other health-related biomarkers were evaluated during the recovery period. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Healthy physically active women. Age within the predefined study range. Regular participation in physical activity for at least 6 months before enrollment.
- Ability to perform the eccentric exercise protocol. Written informed consent provided before participation.
Key exclusion criteria (4 listed)
- Current musculoskeletal injury or pain affecting exercise performance. History of cardiovascular, metabolic, neurological, renal, hepatic, or inflammatory disease.
- Pregnancy or breastfeeding. Current use of anti-inflammatory drugs, antioxidant supplements, or other nutritional supplements that could interfere with study outcomes.
- Known allergy or intolerance to curcumin, turmeric, ibuprofen, or study ingredients.
- Smoking or excessive alcohol consumption. Participation in another clinical trial during the study period. Any condition considered by the investigators to compromise participant safety or protocol compliance.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| CurcuminAlso: Curcuma longaParticipants received oral curcumin supplementation according to the study protocol before and after the eccentric exercise protocol. Curcumin was administered at the predefined dose and duration specified in the protocol. The intervention aimed to evaluate its effects on exercise-induced muscle damage, inflammation, oxidative stress, antioxidant defense, physical performance, and recovery in physically active women. | Dietary supplement | Curcumin |
| IbuprofenParticipants received oral ibuprofen according to the study protocol before and after the eccentric exercise protocol. Ibuprofen was administered at the predefined dose and duration specified in the protocol and served as the active comparator for evaluating recovery following exercise-induced muscle damage. | Drug | Ibuprofen |
| PlaceboParticipants received placebo capsules identical in appearance, packaging, and administration schedule to the active interventions. The placebo contained inert ingredients and was administered according to the study protocol before and after the eccentric exercise protocol. | Other | Placebo |
Primary outcome
Exercise-induced muscle damage
Time frame: Baseline and during the 72-hour recovery period following eccentric exercise.
Exercise-induced muscle damage assessed using clinical outcomes and biochemical biomarkers following eccentric exercise to compare the effects of oral curcumin supplementation, ibuprofen, and placebo in physically active women.
13 secondary outcomes
Creatine kinase (CK)
Time frame: Baseline and during the 48-hour recovery period following eccentric exercise.
Lactate dehydrogenase (LDH)
Time frame: Baseline and during the 48-hour recovery period following eccentric exercise.
Aspartate aminotransferase (AST)
Time frame: Baseline and during the 48-hour recovery period following eccentric exercise.
Alanine aminotransferase (ALT)
Time frame: Baseline and during the 48-hour recovery period following eccentric exercise.
Alkaline phosphatase (ALP)
Time frame: Baseline and during the 48-hour recovery period following eccentric exercise.
Interleukin-6 (IL-6)
Time frame: Baseline and during the 48-hour recovery period following eccentric exercise.
C-reactive protein (CRP)
Time frame: Baseline and during the 48-hour recovery period following eccentric exercise.
Malondialdehyde (MDA)
Time frame: Baseline and during the 48-hour recovery period following eccentric exercise.
Superoxide dismutase (SOD)
Time frame: Baseline and during the 48-hour recovery period following eccentric exercise.
Catalase (CAT)
Time frame: Baseline and during the 48-hour recovery period following eccentric exercise.
Delayed-onset muscle soreness (DOMS)
Time frame: Baseline and during the 48-hour recovery period following eccentric exercise.
Countermovement jump (CMJ)
Time frame: Baseline and during the 48-hour recovery period following eccentric exercise.
Thigh circumference
Time frame: Baseline and during the 48-hour recovery period following eccentric exercise.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Sep 2026.
- Individual participant dataSharing planned: Yes. ndividual participant data that underlie the results reported in publications arising from this study (after de-identification) will be made available upon reasonable request to the corresponding investigator. Data will be shared with researchers who provide a methodologically sound proposal and whose proposed use of the data has been approved by the study investigators and complies with applicable ethical and institutional regulations.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Curcumin and Ibuprofen in people with Exercise-Induced Muscle Damage and Delayed Onset Muscle Soreness (DOMS), run by University of Valladolid at 1 site in Spain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 23 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Exercise-induced muscle damage (time frame: Baseline and during the 72-hour recovery period following eccentric exercise.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Sep 2026.