UlcerNCT07789561
Functional Food Product
A study testing pomegranate peel powder 1.5 g, pomegranate peel powder 3 g and Whole wheat muffin in people with Ulcer and Blood Tests, run by University of Lahore at 1 site in Pakistan.
Trial summary
Background/Objective: This study evaluated the effects of pomegranate peel powder (PPP)-enriched muffins containing 1.5 g or 2.5 g PPP on H. pylori, inflammation, oxidative stress, and gastric ulcer healing in patients with gastric ulcers. Read more about this study
- Who is it for?
- Ages 40 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Ulcer, Blood Tests, Liver Function Tests
- What is being tested?
- pomegranate peel powder 1.5 g, pomegranate peel powder 3 g and Whole wheat muffin
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 88 participants
- Where
- 1 sitePakistan
- Study dates
- 15 Feb 2024to 7 May 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Both male and female patients aged 40-60 years with confirmed Helicobacter pylori infection, verified through stool antigen testing along with elevated pepsinogen I and II levels, were included in the study
Who cannot join
- pregnancy or lactation, history of gastric surgery, and current use of proton pump inhibitors. and use of medication
- -
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Gastroprotective Effects of Pomegranate (Punica Granatum L.) Peel Powder-Enriched Functional Food in Gastric Ulcer Management
Background/Objective: This study evaluated the effects of pomegranate peel powder (PPP)-enriched muffins containing 1.5 g or 2.5 g PPP on H. pylori, inflammation, oxidative stress, and gastric ulcer healing in patients with gastric ulcers.
Conclusion: PPP-enriched muffins showed potential as a functional dietary intervention for improving antioxidant and anti-inflammatory status and supporting gastric ulcer healing.
Read the detailed description
Background/Objective: This study investigated the therapeutic potential of pomegranate peel powder (PPP), a polyphenol- and antioxidant-rich ingredient, incorporated into whole-wheat muffins at doses of 1.5 g and 2.5 g for patients with gastric ulcers. The study assessed its potential effects on H. pylori infection, gastric inflammation, oxidative stress, and mucosal healing.
Conclusion: PPP-enriched muffins were evaluated as a functional dietary intervention with potential gastroprotective, antioxidant, and anti-inflammatory properties, supporting their possible role in dietary management of gastric ulcers.
- Conditions
- Ulcer, Blood Tests, Liver Function Tests
- Being tested
- pomegranate peel powder 1.5 g, pomegranate peel powder 3 g, Whole wheat muffin
- Keywords
- Punica granatum,, Gastric Ulcer, Helicobacter pylori, Functional Foods
- Medical subject headings
- Ulcer, Stomach Ulcer
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
pomegranate peel powder 1.5 gDietary supplement
Whole wheat muffin enriched with pomegranate peel powder (PPP=1.5 g) + conventional Therapy
pomegranate peel powder 3 gDietary supplement
Whole wheat muffin enriched with pomegranate peel powder (PPP=3g) + conventional Therapy
Whole wheat muffinDietary supplement
Whole wheat muffin
| Study group | Role | What they receive |
|---|---|---|
| T0: placebo | Placebo comparator | wheat muffin Receives: Dietary Supplement: Whole wheat muffin |
| T1= muffin with 1.5g ppp | Experimental | Whole wheat muffin enriched with pomegranate peel powder (PPP=1.5g) + conventional Therapy Receives: Dietary Supplement: pomegranate peel powder 1.5 g |
| T2= Muffin with 3g ppp | Experimental | Whole wheat muffin enriched with pomegranate peel powder (PPP=2.5g) + conventional Therapy Receives: Dietary Supplement: pomegranate peel powder 3 g |
What is being measured
The primary outcome is the main question the study is designed to answer.
Liver Enzymes
Measured: 9 weeks
Secondary outcomes (1)
H.phylori
Measured: 9 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Aug 2026
- Study start15 Feb 2024
- Primary completion5 May 2024
- Study completion7 May 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for UlcerStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 88 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Lahore
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07789561
- Sponsor's protocol ID
- REC-UOL-604/24
- Status last verified
- Feb 2024
- First submitted
- 24 Aug 2026
- Last updated
- 27 Aug 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Gastroprotective Effects of Pomegranate (Punica Granatum L.) Peel Powder-Enriched Functional Food in Gastric Ulcer Management
- ClinicalTrials.gov ID
- NCT07789561
- Acronym / sponsor ID
- REC-UOL-604/24
- Conditions
- Ulcer, Blood Tests, Liver Function Tests
- Keywords
- Punica granatum,, Gastric Ulcer, Helicobacter pylori, Functional Foods
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 88 participants (actual)
- Lead sponsor
- University of LahoreUniversity, hospital or other
- Study start
- 15 Feb 2024 (actual)
- Primary completion
- 5 May 2024 (actual)
- Study completion
- 7 May 2024 (actual)
- First posted
- 27 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Background/Objective: This study evaluated the effects of pomegranate peel powder (PPP)-enriched muffins containing 1.5 g or 2.5 g PPP on H. pylori, inflammation, oxidative stress, and gastric ulcer healing in patients with gastric ulcers.
Conclusion: PPP-enriched muffins showed potential as a functional dietary intervention for improving antioxidant and anti-inflammatory status and supporting gastric ulcer healing.
Detailed description
Background/Objective: This study investigated the therapeutic potential of pomegranate peel powder (PPP), a polyphenol- and antioxidant-rich ingredient, incorporated into whole-wheat muffins at doses of 1.5 g and 2.5 g for patients with gastric ulcers. The study assessed its potential effects on H. pylori infection, gastric inflammation, oxidative stress, and mucosal healing.
Conclusion: PPP-enriched muffins were evaluated as a functional dietary intervention with potential gastroprotective, antioxidant, and anti-inflammatory properties, supporting their possible role in dietary management of gastric ulcers.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| T0: placebo | Placebo comparator | Dietary Supplement: Whole wheat muffinwheat muffin |
| T1= muffin with 1.5g ppp | Experimental | Dietary Supplement: pomegranate peel powder 1.5 gWhole wheat muffin enriched with pomegranate peel powder (PPP=1.5g) + conventional Therapy |
| T2= Muffin with 3g ppp | Experimental | Dietary Supplement: pomegranate peel powder 3 gWhole wheat muffin enriched with pomegranate peel powder (PPP=2.5g) + conventional Therapy |
Who may qualify
- Ages
- 40 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Both male and female patients aged 40-60 years with confirmed Helicobacter pylori infection, verified through stool antigen testing along with elevated pepsinogen I and II levels, were included in the study
Key exclusion criteria (2 listed)
- pregnancy or lactation, history of gastric surgery, and current use of proton pump inhibitors. and use of medication
- -
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| pomegranate peel powder 1.5 gWhole wheat muffin enriched with pomegranate peel powder (PPP=1.5 g) + conventional Therapy | Dietary supplement | T1= muffin with 1.5g ppp |
| pomegranate peel powder 3 gWhole wheat muffin enriched with pomegranate peel powder (PPP=3g) + conventional Therapy | Dietary supplement | T2= Muffin with 3g ppp |
| Whole wheat muffinWhole wheat muffin | Dietary supplement | T0: placebo |
Primary outcome
Liver Enzymes
Time frame: 9 weeks
1 secondary outcome
H.phylori
Time frame: 9 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Aug 2026.
- Related InfoLink provided by the sponsor.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing pomegranate peel powder 1.5 g, pomegranate peel powder 3 g and Whole wheat muffin in people with Ulcer and Blood Tests, run by University of Lahore at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Liver Enzymes (time frame: 9 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Aug 2026.