Muscle Fatigue Caused by Repetitive Muscle ExerciseNCT07808814
Portable Low-Level Laser Therapy for Recovery After a Quadriceps-Dominant Fatiguing Task in Recreational Runners
A study testing LLLT in people with Muscle Fatigue Caused by Repetitive Muscle Exercise, run by Chia Nan University of Pharmacy ＆ Science at 1 site in Taiwan.
Trial summary
This randomized, sham-controlled, two-period crossover study evaluated the effects of portable 808-nm low-level laser therapy (LLLT) on acute recovery and running biomechanics following a quadriceps-dominant fatiguing task in recreational runners. Read more about this study
- Who is it for?
- Ages 18 to 40 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Muscle Fatigue Caused by Repetitive Muscle Exercise
- What is being tested?
- LLLT
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 20 participants
- Where
- 1 siteTaiwan
- Study dates
- 17 Feb 2025to 19 Jun 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male recreational runners aged 18-40 years.
- Recreational running status determined using the World Masters Athletics (WMA) age-graded performance score, with an age-graded score below 60%.
- Previous experience with treadmill running.
- Rearfoot-strike running pattern.
- No running-related lower-limb injury during the preceding 6 months
Who cannot join
- WMA age-graded performance score of 60% or higher.
- Non-rearfoot-strike running pattern.
- Leg-length discrepancy greater than 3 cm.
- Use of an orthosis, brace, or other lower-limb medical device that could influence running gait.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Portable Low-Level Laser Therapy on Running Kinematics in Recreational Runners With Quadriceps Fatigue
This randomized, sham-controlled, two-period crossover study evaluated the effects of portable 808-nm low-level laser therapy (LLLT) on acute recovery and running biomechanics following a quadriceps-dominant fatiguing task in recreational runners. Twenty male recreational runners completed both active LLLT and sham conditions, separated by a 2-week washout period. After the fatiguing task, participants received 10 minutes of bilateral quadriceps LLLT or sham treatment, followed by treadmill running at the same fixed self-selected speed. Quadriceps soreness, heart rate, running spatiotemporal parameters, and kinematic responses were assessed using a verbal numerical rating scale, heart-rate monitoring, two-dimensional video analysis, and inertial measurement units.
Read the detailed description
Each participant completed two experimental visits in randomized order, with one active LLLT condition and one sham condition separated by a 2-week washout period. At each visit, participants completed a 5-minute treadmill warm-up followed by a 3-minute pre-fatigue running trial at a fixed self-selected running speed. They then performed a repeated stand-sit-stand task designed to produce quadriceps-dominant lower-limb fatigue.
Immediately after the fatiguing task, participants received either active portable 808-nm LLLT or sham treatment for 10 minutes over the bilateral rectus femoris, vastus lateralis, and vastus medialis muscles. A 3-minute post-intervention treadmill running trial was then performed at the same running speed used before the fatiguing task.
Quadriceps soreness was assessed using a 0-10 verbal numerical rating scale. Heart rate was monitored using a chest-strap heart-rate monitor. Running spatiotemporal and kinematic variables were assessed using high-frame-rate two-dimensional video analysis and three inertial measurement units positioned over the bilateral distal tibiae and sacral region.
- Being tested
- LLLT, Sham
- Keywords
- Running Biomechanics, Inertial Measurement Units, Low-Level Laser Therapy, Photobiomodulation Therapy, Recreational Runners
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
LLLTDevice
Portable 808-nm low-level laser therapy applied bilaterally to the rectus femoris, vastus lateralis, and vastus medialis for 10 minutes.
ShamDevice
Sham device applied to the same bilateral quadriceps sites for 10 minutes, matching the LLLT condition in device appearance, placement, duration, and fixation.
| Study group | Role | What they receive |
|---|---|---|
| LLLT-Sham Sequence | Experimental | Participants received LLLT during the first experimental period and sham during the second experimental period, with a 2-week washout period between visits. Receives: Device: LLLT; Device: Sham |
| Sham-LLLT Sequence | Experimental | Participants received sham during the first experimental period and LLLT during the second experimental period, with a 2-week washout period between visits. Receives: Device: LLLT; Device: Sham |
What is being measured
The primary outcome is the main question the study is designed to answer.
Quadriceps Soreness
Quadriceps soreness was assessed using a 0-10 verbal numerical rating scale (VNRS), where 0 indicated no soreness and 10 indicated the worst imaginable soreness. Decimal responses were permitted.
Measured: Immediately after the 10-minute intervention and before the post-intervention running trial.
Distal-Tibial Acceleration at Initial Contact
Resultant distal-tibial acceleration was measured using bilateral inertial measurement units and expressed in meters per second squared (m/s²). Values from 10 consecutive steps were averaged for each limb, and the left- and right-limb means were subsequently averaged.
Measured: At initial contact during the post-intervention treadmill running trial; events were identified within the 60-120-second analysis interval.
Distal-Tibial Angular Velocity at Initial Contact
Resultant distal-tibial angular velocity was measured using bilateral inertial measurement units and expressed in degrees per second (°/s). Values from 10 consecutive steps were averaged for each limb, and the left- and right-limb means were subsequently averaged.
Measured: At initial contact during the post-intervention treadmill running trial; events were identified within the 60-120-second analysis interval.
Distal-Tibial Angular Velocity at Toe-Off
Resultant distal-tibial angular velocity was measured using bilateral inertial measurement units and expressed in degrees per second (°/s). Values from 10 consecutive steps were averaged for each limb, and the left- and right-limb means were subsequently averaged.
Measured: At toe-off during the post-intervention treadmill running trial; events were identified within the 60-120-second analysis interval.
Distal-Tibial Acceleration at Toe-Off
Resultant distal-tibial acceleration was measured using bilateral inertial measurement units and expressed in meters per second squared (m/s²). Values from 10 consecutive steps were averaged for each limb, and the left- and right-limb means were subsequently averaged.
Measured: At toe-off during the post-intervention treadmill running trial; events were identified within the 60-120-second analysis interval.
Step Width During Running
Step width was measured from posterior-view two-dimensional video analysis and expressed in centimeters. Ten consecutive steps were analyzed and averaged for each participant and condition.
Measured: During the 3-minute post-intervention treadmill running trial; 10 consecutive steps were analyzed from 60 to 120 seconds after the start of running.
Sacral Acceleration at Initial Contact
Resultant sacral acceleration was measured using an inertial measurement unit positioned over the S2 region and expressed in meters per second squared (m/s²). Values from 10 consecutive steps were averaged for each participant and condition.
Measured: At initial contact during the post-intervention treadmill running trial; events were identified within the 60-120-second analysis interval.
Sacral Acceleration at Toe-Off
Resultant sacral acceleration was measured using an inertial measurement unit positioned over the S2 region and expressed in meters per second squared (m/s²). Values from 10 consecutive steps were averaged for each participant and condition.
Measured: At toe-off during the post-intervention treadmill running trial; events were identified within the 60-120-second analysis interval.
Sacral Angular Velocity at Initial Contact
Resultant sacral angular velocity was measured using an inertial measurement unit positioned over the S2 region and expressed in degrees per second (°/s). Values from 10 consecutive steps were averaged for each participant and condition.
Measured: At initial contact during the post-intervention treadmill running trial; events were identified within the 60-120-second analysis interval.
Sacral Angular Velocity at Toe-Off
Resultant sacral angular velocity was measured using an inertial measurement unit positioned over the S2 region and expressed in degrees per second (°/s). Values from 10 consecutive steps were averaged for each participant and condition.
Measured: At toe-off during the post-intervention treadmill running trial; events were identified within the 60-120-second analysis interval.
Secondary outcomes (5)
Heart Rate at the End of the Intervention
Heart rate was recorded using a Polar H10 chest-strap heart-rate monitor and averaged over the final 10 seconds of the 10-minute intervention. Heart rate was expressed in beats per minute (beats/min).
Measured: During the final 10 seconds of the 10-minute intervention.
Sagittal Trunk Inclination Angle at Initial Contact
Sagittal trunk inclination angle was measured from lateral-view two-dimensional video analysis and expressed in degrees. Positive values indicated trunk flexion and negative values indicated trunk extension. Ten consecutive steps were analyzed and averaged for each participant and condition.
Measured: At initial contact during the post-intervention treadmill running trial; 10 consecutive steps were analyzed from 60 to 120 seconds after the start of running.
Sagittal Trunk Inclination Angle at Toe-Off
Sagittal trunk inclination angle was measured from lateral-view two-dimensional video analysis and expressed in degrees. Positive values indicated trunk flexion and negative values indicated trunk extension. Ten consecutive steps were analyzed and averaged for each participant and condition.
Measured: At toe-off during the post-intervention treadmill running trial; 10 consecutive steps were analyzed from 60 to 120 seconds after the start of running.
Knee-Flexion Angle at Initial Contact
Knee-flexion angle was measured from lateral-view two-dimensional video analysis and expressed in degrees. Smaller values represented a more extended knee position. Ten consecutive steps were analyzed and averaged for each participant and condition.
Measured: At initial contact during the post-intervention treadmill running trial; 10 consecutive steps were analyzed from 60 to 120 seconds after the start of running.
Knee-Flexion Angle at Toe-Off
Knee-flexion angle was measured from lateral-view two-dimensional video analysis and expressed in degrees. Smaller values represented a more extended knee position. Ten consecutive steps were analyzed and averaged for each participant and condition.
Measured: At toe-off during the post-intervention treadmill running trial; 10 consecutive steps were analyzed from 60 to 120 seconds after the start of running.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Sep 2026
- Study start17 Feb 2025
- Primary completion19 Jun 2025
- Study completion19 Jun 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for Muscle Fatigue Caused by Repetitive Muscle ExerciseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Randomized, two-period crossover design. Participants were assigned to one of two intervention sequences (LLLT followed by sham, or sham followed by LLLT), with a 2-week washout period between experimental visits.
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 20 participants (actual)
Sponsor and investigators
- Lead sponsor
- Chia Nan University of Pharmacy ＆ Science
- Sponsor type
- University, hospital or other
- Collaborators
- Lasinmed Medical Electronics Co., Ltd.
- Responsible party
- Principal investigator, Chen, Tsan-Yang, Chia Nan University of Pharmacy ＆ Science
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07808814
- Sponsor's protocol ID
- CNU_DSM_001
- Status last verified
- Sep 2026
- First submitted
- 2 Sep 2026
- Last updated
- 9 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be made publicly available because of participant privacy and ethical considerations. De-identified data may be available from the corresponding author upon reasonable request, subject to applicable ethical and institutional restrictions.
Publications
do Nascimento AP, de Oliveira GA, Bressanin JPB, Aguirra P, Ribeiro AS, Caldeira LFS, Casonatto J, Ferraresi C, Aguiar AF. Acute dose-response effect of photobiomodulation therapy on 5-km running performance in trained runners: a randomized, double-blind, placebo-controlled, crossover study. Lasers Med Sci. 2024 May 31;39(1):145. doi: 10.1007/s10103-024-04099-8.
PubMed 38819613De Marchi T, Leal Junior EC, Bortoli C, Tomazoni SS, Lopes-Martins RA, Salvador M. Low-level laser therapy (LLLT) in human progressive-intensity running: effects on exercise performance, skeletal muscle status, and oxidative stress. Lasers Med Sci. 2012 Jan;27(1):231-6. doi: 10.1007/s10103-011-0955-5. Epub 2011 Jul 8.
PubMed 21739259de Brito Vieira WH, Bezerra RM, Queiroz RA, Maciel NF, Parizotto NA, Ferraresi C. Use of low-level laser therapy (808 nm) to muscle fatigue resistance: a randomized double-blind crossover trial. Photomed Laser Surg. 2014 Dec;32(12):678-85. doi: 10.1089/pho.2014.3812.
PubMed 25496083Vanin AA, Verhagen E, Barboza SD, Costa LOP, Leal-Junior ECP. Photobiomodulation therapy for the improvement of muscular performance and reduction of muscular fatigue associated with exercise in healthy people: a systematic review and meta-analysis. Lasers Med Sci. 2018 Jan;33(1):181-214. doi: 10.1007/s10103-017-2368-6. Epub 2017 Oct 31.
PubMed 29090398Zandbergen MA, Marotta L, Bulthuis R, Buurke JH, Veltink PH, Reenalda J. Effects of level running-induced fatigue on running kinematics: A systematic review and meta-analysis. Gait Posture. 2023 Jan;99:60-75. doi: 10.1016/j.gaitpost.2022.09.089. Epub 2022 Oct 12.
PubMed 36332318
Study at a glance
From the registry record, last updated by the sponsor on 9 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Portable Low-Level Laser Therapy on Running Kinematics in Recreational Runners With Quadriceps Fatigue
- ClinicalTrials.gov ID
- NCT07808814
- Acronym / sponsor ID
- CNU_DSM_001
- Keywords
- Running Biomechanics, Inertial Measurement Units, Low-Level Laser Therapy, Photobiomodulation Therapy, Recreational Runners
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 20 participants (actual)
- Lead sponsor
- Chia Nan University of Pharmacy ＆ ScienceUniversity, hospital or other
- Collaborators
- Lasinmed Medical Electronics Co., Ltd.
- Study start
- 17 Feb 2025 (actual)
- Primary completion
- 19 Jun 2025 (actual)
- Study completion
- 19 Jun 2025 (actual)
- First posted
- 9 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized, sham-controlled, two-period crossover study evaluated the effects of portable 808-nm low-level laser therapy (LLLT) on acute recovery and running biomechanics following a quadriceps-dominant fatiguing task in recreational runners. Twenty male recreational runners completed both active LLLT and sham conditions, separated by a 2-week washout period. After the fatiguing task, participants received 10 minutes of bilateral quadriceps LLLT or sham treatment, followed by treadmill running at the same fixed self-selected speed. Quadriceps soreness, heart rate, running spatiotemporal parameters, and kinematic responses were assessed using a verbal numerical rating scale, heart-rate monitoring, two-dimensional video analysis, and inertial measurement units.
Detailed description
Each participant completed two experimental visits in randomized order, with one active LLLT condition and one sham condition separated by a 2-week washout period. At each visit, participants completed a 5-minute treadmill warm-up followed by a 3-minute pre-fatigue running trial at a fixed self-selected running speed. They then performed a repeated stand-sit-stand task designed to produce quadriceps-dominant lower-limb fatigue.
Immediately after the fatiguing task, participants received either active portable 808-nm LLLT or sham treatment for 10 minutes over the bilateral rectus femoris, vastus lateralis, and vastus medialis muscles. A 3-minute post-intervention treadmill running trial was then performed at the same running speed used before the fatiguing task.
Quadriceps soreness was assessed using a 0-10 verbal numerical rating scale. Heart rate was monitored using a chest-strap heart-rate monitor. Running spatiotemporal and kinematic variables were assessed using high-frame-rate two-dimensional video analysis and three inertial measurement units positioned over the bilateral distal tibiae and sacral region.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
- Model description
- Randomized, two-period crossover design. Participants were assigned to one of two intervention sequences (LLLT followed by sham, or sham followed by LLLT), with a 2-week washout period between experimental visits.
| Arm | Type | Receives |
|---|---|---|
| LLLT-Sham Sequence | Experimental | Device: LLLT, Device: ShamParticipants received LLLT during the first experimental period and sham during the second experimental period, with a 2-week washout period between visits. |
| Sham-LLLT Sequence | Experimental | Device: LLLT, Device: ShamParticipants received sham during the first experimental period and LLLT during the second experimental period, with a 2-week washout period between visits. |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Male recreational runners aged 18-40 years.
- Recreational running status determined using the World Masters Athletics (WMA) age-graded performance score, with an age-graded score below 60%.
- Previous experience with treadmill running.
- Rearfoot-strike running pattern.
- No running-related lower-limb injury during the preceding 6 months
Key exclusion criteria (4 listed)
- WMA age-graded performance score of 60% or higher.
- Non-rearfoot-strike running pattern.
- Leg-length discrepancy greater than 3 cm.
- Use of an orthosis, brace, or other lower-limb medical device that could influence running gait.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| LLLTPortable 808-nm low-level laser therapy applied bilaterally to the rectus femoris, vastus lateralis, and vastus medialis for 10 minutes. | Device | LLLT-Sham Sequence, Sham-LLLT Sequence |
| ShamSham device applied to the same bilateral quadriceps sites for 10 minutes, matching the LLLT condition in device appearance, placement, duration, and fixation. | Device | LLLT-Sham Sequence, Sham-LLLT Sequence |
Primary outcome
Quadriceps Soreness
Time frame: Immediately after the 10-minute intervention and before the post-intervention running trial.
Quadriceps soreness was assessed using a 0-10 verbal numerical rating scale (VNRS), where 0 indicated no soreness and 10 indicated the worst imaginable soreness. Decimal responses were permitted.
Distal-Tibial Acceleration at Initial Contact
Time frame: At initial contact during the post-intervention treadmill running trial; events were identified within the 60-120-second analysis interval.
Resultant distal-tibial acceleration was measured using bilateral inertial measurement units and expressed in meters per second squared (m/s²). Values from 10 consecutive steps were averaged for each limb, and the left- and right-limb means were subsequently averaged.
Distal-Tibial Angular Velocity at Initial Contact
Time frame: At initial contact during the post-intervention treadmill running trial; events were identified within the 60-120-second analysis interval.
Resultant distal-tibial angular velocity was measured using bilateral inertial measurement units and expressed in degrees per second (°/s). Values from 10 consecutive steps were averaged for each limb, and the left- and right-limb means were subsequently averaged.
Distal-Tibial Angular Velocity at Toe-Off
Time frame: At toe-off during the post-intervention treadmill running trial; events were identified within the 60-120-second analysis interval.
Resultant distal-tibial angular velocity was measured using bilateral inertial measurement units and expressed in degrees per second (°/s). Values from 10 consecutive steps were averaged for each limb, and the left- and right-limb means were subsequently averaged.
Distal-Tibial Acceleration at Toe-Off
Time frame: At toe-off during the post-intervention treadmill running trial; events were identified within the 60-120-second analysis interval.
Resultant distal-tibial acceleration was measured using bilateral inertial measurement units and expressed in meters per second squared (m/s²). Values from 10 consecutive steps were averaged for each limb, and the left- and right-limb means were subsequently averaged.
Step Width During Running
Time frame: During the 3-minute post-intervention treadmill running trial; 10 consecutive steps were analyzed from 60 to 120 seconds after the start of running.
Step width was measured from posterior-view two-dimensional video analysis and expressed in centimeters. Ten consecutive steps were analyzed and averaged for each participant and condition.
Sacral Acceleration at Initial Contact
Time frame: At initial contact during the post-intervention treadmill running trial; events were identified within the 60-120-second analysis interval.
Resultant sacral acceleration was measured using an inertial measurement unit positioned over the S2 region and expressed in meters per second squared (m/s²). Values from 10 consecutive steps were averaged for each participant and condition.
Sacral Acceleration at Toe-Off
Time frame: At toe-off during the post-intervention treadmill running trial; events were identified within the 60-120-second analysis interval.
Resultant sacral acceleration was measured using an inertial measurement unit positioned over the S2 region and expressed in meters per second squared (m/s²). Values from 10 consecutive steps were averaged for each participant and condition.
Sacral Angular Velocity at Initial Contact
Time frame: At initial contact during the post-intervention treadmill running trial; events were identified within the 60-120-second analysis interval.
Resultant sacral angular velocity was measured using an inertial measurement unit positioned over the S2 region and expressed in degrees per second (°/s). Values from 10 consecutive steps were averaged for each participant and condition.
Sacral Angular Velocity at Toe-Off
Time frame: At toe-off during the post-intervention treadmill running trial; events were identified within the 60-120-second analysis interval.
Resultant sacral angular velocity was measured using an inertial measurement unit positioned over the S2 region and expressed in degrees per second (°/s). Values from 10 consecutive steps were averaged for each participant and condition.
5 secondary outcomes
Heart Rate at the End of the Intervention
Time frame: During the final 10 seconds of the 10-minute intervention.
Sagittal Trunk Inclination Angle at Initial Contact
Time frame: At initial contact during the post-intervention treadmill running trial; 10 consecutive steps were analyzed from 60 to 120 seconds after the start of running.
Sagittal Trunk Inclination Angle at Toe-Off
Time frame: At toe-off during the post-intervention treadmill running trial; 10 consecutive steps were analyzed from 60 to 120 seconds after the start of running.
Knee-Flexion Angle at Initial Contact
Time frame: At initial contact during the post-intervention treadmill running trial; 10 consecutive steps were analyzed from 60 to 120 seconds after the start of running.
Knee-Flexion Angle at Toe-Off
Time frame: At toe-off during the post-intervention treadmill running trial; 10 consecutive steps were analyzed from 60 to 120 seconds after the start of running.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Sep 2026.
- Results publication: PubMed 38819613do Nascimento AP, de Oliveira GA, Bressanin JPB, Aguirra P, Ribeiro AS, Caldeira LFS, Casonatto J, Ferraresi C, Aguiar AF. Acute dose-response effect of photobiomodulation therapy on 5-km running performance in trained runners: a randomized, double-blind, placebo-controlled, crossover study. Lasers Med Sci. 2024 May 31;39(1):145. doi: 10.1007/s10103-024-04099-8.
- Results publication: PubMed 21739259De Marchi T, Leal Junior EC, Bortoli C, Tomazoni SS, Lopes-Martins RA, Salvador M. Low-level laser therapy (LLLT) in human progressive-intensity running: effects on exercise performance, skeletal muscle status, and oxidative stress. Lasers Med Sci. 2012 Jan;27(1):231-6. doi: 10.1007/s10103-011-0955-5. Epub 2011 Jul 8.
- Results publication: PubMed 25496083de Brito Vieira WH, Bezerra RM, Queiroz RA, Maciel NF, Parizotto NA, Ferraresi C. Use of low-level laser therapy (808 nm) to muscle fatigue resistance: a randomized double-blind crossover trial. Photomed Laser Surg. 2014 Dec;32(12):678-85. doi: 10.1089/pho.2014.3812.
- Results publication: PubMed 29090398Vanin AA, Verhagen E, Barboza SD, Costa LOP, Leal-Junior ECP. Photobiomodulation therapy for the improvement of muscular performance and reduction of muscular fatigue associated with exercise in healthy people: a systematic review and meta-analysis. Lasers Med Sci. 2018 Jan;33(1):181-214. doi: 10.1007/s10103-017-2368-6. Epub 2017 Oct 31.
- Results publication: PubMed 36332318Zandbergen MA, Marotta L, Bulthuis R, Buurke JH, Veltink PH, Reenalda J. Effects of level running-induced fatigue on running kinematics: A systematic review and meta-analysis. Gait Posture. 2023 Jan;99:60-75. doi: 10.1016/j.gaitpost.2022.09.089. Epub 2022 Oct 12.
- Individual participant dataSharing planned: No. Individual participant data will not be made publicly available because of participant privacy and ethical considerations. De-identified data may be available from the corresponding author upon reasonable request, subject to applicable ethical and institutional restrictions.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing LLLT in people with Muscle Fatigue Caused by Repetitive Muscle Exercise, run by Chia Nan University of Pharmacy ＆ Science at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 9 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Quadriceps Soreness (time frame: Immediately after the 10-minute intervention and before the post-intervention running trial.). The study lists 10 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07808814, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Sep 2026.