Alveolar Bone LossNCT07812610
Mineralized Dentin Graft Versus Beta-Tricalcium Phosphate for Alveolar Ridge Preservation
A study testing Alveolar Ridge Preservation With Autogenous Mineralized Dentin Graft, Alveolar Ridge Preservation With Beta-Tricalcium Phosphate and Extraction Socket Healing Without Bone Graft in people with Alveolar Bone Loss, run by Soaad Tolba Mohammed Tolba Badawi at 1 site in Egypt.
Trial summary
The goal of this clinical trial was to compare three ways of helping the jawbone heal after removal of a tooth. The jawbone that supports a tooth is called the alveolar ridge. This bone can become narrower after a tooth is removed. Participants were randomly assigned to one of three groups. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Alveolar Bone Loss
- What is being tested?
- Alveolar Ridge Preservation With Autogenous Mineralized Dentin Graft, Alveolar Ridge Preservation With Beta-Tricalcium Phosphate and Extraction Socket Healing Without Bone Graft
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 22 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jan 2025to 1 Jan 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Aged 18 years or older.
- Clinical indication for extraction of a hopeless maxillary tooth.
- No evidence of acute infection at the intended extraction site.
- Willing and able to comply with the scheduled study visits and follow-up procedures.
- Provided written informed consent.
Who cannot join
- Systemic disorder known to impair bone metabolism.
- History of radiotherapy involving the head and neck region.
- Pregnancy or lactation.
- Advanced periodontal disease.
Trial locations and contacts
1 site in 1 country.
Egypt1 site
Faculty of Dentistry, Mansoura University
Al Mansurah, Aldakhlia, 35516
About this study
Official title: From Tooth to Bone: Can Mineralized Dentin Graft Be a Viable Alternative to Beta-Tricalcium Phosphate for Alveolar Ridge Preservation? A Randomized Controlled Trial
The goal of this clinical trial was to compare three ways of helping the jawbone heal after removal of a tooth. The jawbone that supports a tooth is called the alveolar ridge. This bone can become narrower after a tooth is removed.
Participants were randomly assigned to one of three groups. One group received no bone graft material. One group received mineralized dentin graft made from the participant's extracted tooth. One group received beta-tricalcium phosphate, which is a synthetic bone graft material.
Participants had cone-beam computed tomography, a three-dimensional dental X-ray, immediately after tooth removal and again after 6 months. During dental implant placement at 6 months, researchers collected a small bone sample to examine healing.
Read the detailed description
After tooth extraction, the alveolar ridge undergoes natural remodeling that can reduce its width and affect future dental implant placement. Alveolar ridge preservation aims to limit these dimensional changes. This randomized controlled clinical trial compared autogenous mineralized dentin graft, beta-tricalcium phosphate, and healing without bone graft material following extraction of hopeless maxillary teeth.
Participants were randomly assigned in a 1:1:1 ratio to three groups. The control group received no bone graft material. The mineralized dentin graft group received graft particles prepared from the participant's extracted tooth. The beta-tricalcium phosphate group received a synthetic bone graft material.
Alveolar ridge width was measured using cone-beam computed tomography immediately after extraction and at 6 months.
During delayed dental implant placement at 6 months, a small bone-core sample was collected from each study site.
- Conditions
- Alveolar Bone Loss
- Being tested
- Alveolar Ridge Preservation With Autogenous Mineralized Dentin Graft, Alveolar Ridge Preservation With Beta-Tricalcium Phosphate, Extraction Socket Healing Without Bone Graft
- Keywords
- Mineralized Dentin Graft, Autogenous Tooth-Derived Graft, Beta-Tricalcium Phosphate, Tooth Extraction, Cone-Beam Computed Tomography, Histomorphometry, Alveolar Ridge Preservation
- Medical subject headings
- Alveolar Bone Loss
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Alveolar Ridge Preservation With Autogenous Mineralized Dentin GraftProcedure or surgery
Following atraumatic tooth extraction, an autogenous mineralized dentin graft prepared chairside from the participant's extracted tooth is placed in the extraction socket.
Alveolar Ridge Preservation With Beta-Tricalcium PhosphateProcedure or surgery
Following atraumatic tooth extraction, beta-tricalcium phosphate granules are placed in the extraction socket.
Extraction Socket Healing Without Bone GraftProcedure or surgery
Following atraumatic tooth extraction, no bone graft material is placed in the extraction socket.
| Study group | Role | What they receive |
|---|---|---|
| Autogenous Mineralized Dentin Graft | Experimental | Following atraumatic tooth extraction, autogenous mineralized dentin graft prepared chairside from the participant's extracted tooth is placed in the extraction socket. Receives: Procedure: Alveolar Ridge Preservation With Autogenous Mineralized Dentin Graft |
| Beta-Tricalcium Phosphate | Active comparator | Following atraumatic tooth extraction, beta-tricalcium phosphate granules are placed in the extraction socket. Receives: Procedure: Alveolar Ridge Preservation With Beta-Tricalcium Phosphate |
| Control: No Bone Graft | Active comparator | Following atraumatic tooth extraction, no bone graft material is placed in the extraction socket. Receives: Procedure: Extraction Socket Healing Without Bone Graft |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Alveolar Bone Width From Baseline to 6 Months
Alveolar bone width was measured in millimeters using cone-beam computed tomography immediately after tooth extraction and at 6 months. Width was measured horizontally from the outer buccal cortical surface to the palatal cortical surface.
Measured: Baseline immediately after tooth extraction and 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Sep 2026
- Study start1 Jan 2025
- Primary completion1 Jan 2026
- Study completion1 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Alveolar Bone LossStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Three-arm, parallel-group randomized controlled trial in which extraction sites were allocated in a 1:1:1 ratio to healing without bone graft material, autogenous mineralized dentin graft, or beta-tricalcium phosphate.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 22 participants (actual)
Sponsor and investigators
- Lead sponsor
- Soaad Tolba Mohammed Tolba Badawi
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Soaad Tolba Mohammed Tolba Badawi, Mansoura University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07812610
- Sponsor's protocol ID
- R.26.08.135
- Status last verified
- Sep 2026
- First submitted
- 4 Sep 2026
- Last updated
- 17 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- From Tooth to Bone: Can Mineralized Dentin Graft Be a Viable Alternative to Beta-Tricalcium Phosphate for Alveolar Ridge Preservation? A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07812610
- Acronym / sponsor ID
- R.26.08.135
- Conditions
- Alveolar Bone Loss
- Keywords
- Mineralized Dentin Graft, Autogenous Tooth-Derived Graft, Beta-Tricalcium Phosphate, Tooth Extraction, Cone-Beam Computed Tomography, Histomorphometry, Alveolar Ridge Preservation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 22 participants (actual)
- Lead sponsor
- Soaad Tolba Mohammed Tolba BadawiUniversity, hospital or other
- Study start
- 1 Jan 2025 (actual)
- Primary completion
- 1 Jan 2026 (actual)
- Study completion
- 1 Jan 2026 (actual)
- First posted
- 10 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial was to compare three ways of helping the jawbone heal after removal of a tooth. The jawbone that supports a tooth is called the alveolar ridge. This bone can become narrower after a tooth is removed.
Participants were randomly assigned to one of three groups. One group received no bone graft material. One group received mineralized dentin graft made from the participant's extracted tooth. One group received beta-tricalcium phosphate, which is a synthetic bone graft material.
Participants had cone-beam computed tomography, a three-dimensional dental X-ray, immediately after tooth removal and again after 6 months. During dental implant placement at 6 months, researchers collected a small bone sample to examine healing.
Detailed description
After tooth extraction, the alveolar ridge undergoes natural remodeling that can reduce its width and affect future dental implant placement. Alveolar ridge preservation aims to limit these dimensional changes. This randomized controlled clinical trial compared autogenous mineralized dentin graft, beta-tricalcium phosphate, and healing without bone graft material following extraction of hopeless maxillary teeth.
Participants were randomly assigned in a 1:1:1 ratio to three groups. The control group received no bone graft material. The mineralized dentin graft group received graft particles prepared from the participant's extracted tooth. The beta-tricalcium phosphate group received a synthetic bone graft material.
Alveolar ridge width was measured using cone-beam computed tomography immediately after extraction and at 6 months.
During delayed dental implant placement at 6 months, a small bone-core sample was collected from each study site.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 3
- Model description
- Three-arm, parallel-group randomized controlled trial in which extraction sites were allocated in a 1:1:1 ratio to healing without bone graft material, autogenous mineralized dentin graft, or beta-tricalcium phosphate.
| Arm | Type | Receives |
|---|---|---|
| Autogenous Mineralized Dentin Graft | Experimental | Procedure: Alveolar Ridge Preservation With Autogenous Mineralized Dentin GraftFollowing atraumatic tooth extraction, autogenous mineralized dentin graft prepared chairside from the participant's extracted tooth is placed in the extraction socket. |
| Beta-Tricalcium Phosphate | Active comparator | Procedure: Alveolar Ridge Preservation With Beta-Tricalcium PhosphateFollowing atraumatic tooth extraction, beta-tricalcium phosphate granules are placed in the extraction socket. |
| Control: No Bone Graft | Active comparator | Procedure: Extraction Socket Healing Without Bone GraftFollowing atraumatic tooth extraction, no bone graft material is placed in the extraction socket. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Aged 18 years or older.
- Clinical indication for extraction of a hopeless maxillary tooth.
- No evidence of acute infection at the intended extraction site.
- Willing and able to comply with the scheduled study visits and follow-up procedures.
- Provided written informed consent.
Key exclusion criteria (4 listed)
- Systemic disorder known to impair bone metabolism.
- History of radiotherapy involving the head and neck region.
- Pregnancy or lactation.
- Advanced periodontal disease.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Alveolar Ridge Preservation With Autogenous Mineralized Dentin GraftFollowing atraumatic tooth extraction, an autogenous mineralized dentin graft prepared chairside from the participant's extracted tooth is placed in the extraction socket. | Procedure or surgery | Autogenous Mineralized Dentin Graft |
| Alveolar Ridge Preservation With Beta-Tricalcium PhosphateFollowing atraumatic tooth extraction, beta-tricalcium phosphate granules are placed in the extraction socket. | Procedure or surgery | Beta-Tricalcium Phosphate |
| Extraction Socket Healing Without Bone GraftFollowing atraumatic tooth extraction, no bone graft material is placed in the extraction socket. | Procedure or surgery | Control: No Bone Graft |
Primary outcome
Change in Alveolar Bone Width From Baseline to 6 Months
Time frame: Baseline immediately after tooth extraction and 6 months
Alveolar bone width was measured in millimeters using cone-beam computed tomography immediately after tooth extraction and at 6 months. Width was measured horizontally from the outer buccal cortical surface to the palatal cortical surface.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Sep 2026.
- Individual participant dataSharing planned: No
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Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth Loss, Alveolar Bone Regeneration Following Odontectomy
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Diagnostic Accuracy of Large Language Models for Peri-Implant Marginal Bone Loss on Panoramic Radiographs
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Alveolar Ridge Preservation With Autogenous Mineralized Dentin Graft, Alveolar Ridge Preservation With Beta-Tricalcium Phosphate and Extraction Socket Healing Without Bone Graft in people with Alveolar Bone Loss, run by Soaad Tolba Mohammed Tolba Badawi at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Alveolar Bone Width From Baseline to 6 Months (time frame: Baseline immediately after tooth extraction and 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Sep 2026.