Cardiac Arrest (CA)VECTORSNCT07818785
The Variation in Electrode Configuration for Termination of Out-of-Hospital Rhythms That Are Shockable in Cardiac Arrest Trial
A study testing defibrillator electrode pads in people with Cardiac Arrest (CA), run by Oregon Health and Science University.
Trial summary
The purpose of this study is to compare the effectiveness of two defibrillator pad placements, one where pads are placed on the front of the chest and back (anterior-posterior [AP]) and one where the pads are placed on the front and side of the chest (anterior-lateral [AL]), for the treatment of cardiac arrest. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cardiac Arrest (CA)
- What is being tested?
- defibrillator electrode pads
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 1,500 participants
- Where
- No sites listed yet
- Study dates
- 1 Apr 2027to 31 Dec 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Emergency medical services (EMS)-treated non-traumatic out-of-hospital cardiac arrest
Who cannot join
- ROSC at EMS arrival (e.g., bystander AED shock with ROSC prior to EMS care) without rearrest during EMS care
- Known prisoners
- Known pregnant patients
- Known pediatric patients (treated under the pediatric algorithm, generally <15 years)
- Known preexisting do-not-resuscitate orders limiting care
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: The Variation in Electrode Configuration for Termination of Out-of-Hospital Rhythms That Are Shockable (VECTORS) Trial: A Pragmatic Trial of Anterior-Posterior Versus Anterior-Lateral Initial Defibrillator Pad Placement for Out-of-Hospital Cardiac Arrest
The purpose of this study is to compare the effectiveness of two defibrillator pad placements, one where pads are placed on the front of the chest and back (anterior-posterior [AP]) and one where the pads are placed on the front and side of the chest (anterior-lateral [AL]), for the treatment of cardiac arrest. Both pad placement locations are recommended for use by the American Heart Association (AHA) and International Liaison Committee on Resuscitation (ILCOR) and are used in standard treatment. The investigators are hoping to find out if one pad position is more effective than the other in the treatment of cardiac arrest.
- Conditions
- Cardiac Arrest (CA)
- Being tested
- defibrillator electrode pads
- Medical subject headings
- Heart Arrest
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
defibrillator electrode padsDevice
Application of defibrillator electrode pads to be used in cardiac arrest treatment
| Study group | Role | What they receive |
|---|---|---|
| Anterior-Posterior | Active comparator | Defibrillation pads placed initially in the anterior-posterior position. Receives: Device: defibrillator electrode pads |
| Anterior-Lateral | Active comparator | Defibrillation pads placed initially in the anterior-lateral position. Receives: Device: defibrillator electrode pads |
What is being measured
The primary outcome is the main question the study is designed to answer.
Post-Shock Return of Spontaneous Circulation (ROSC)
Any palpable pulse documented at any time after the first EMS shock
Measured: day 1
Secondary outcomes (7)
Time to first rhythm analysis
Time from EMS arrival on-scene for non-EMS witnessed arrests and first rhythm analysis by the defibrillator
Measured: day 1
Time to initial shock
Time from EMS arrival on-scene for non-EMS witnessed arrests and initial shock by EMS
Measured: day 1
Total EMS shocks
Total shocks given by EMS
Measured: day 1
Time to ROSC
Time to ROSC from initial shock with competing risks (e.g. termination of resuscitation, pad change, double sequential external defibrillation use)
Measured: day 1
Survival to hospital admission
Survival to hospital admission
Measured: day 1
Survival to hospital discharge
Survival to hospital discharge
Measured: through study completion, an average of 7 days
Survival to hospital discharge with favorable outcome
Survival to hospital discharge with a Cerebral Performance Category score of 1-2
Measured: through study completion, an average of 7 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Sep 2026
- Study start1 Apr 2027 (estimated)
- Primary completion30 Jun 2029 (estimated)
- Study completion31 Dec 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cardiac Arrest (CA)Studies of the same condition, open and under way.
- More trials run by Oregon Health and Science UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 1,500 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Oregon Health and Science University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Joshua Lupton, Oregon Health and Science University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07818785
- Sponsor's protocol ID
- STUDY00030326
- Other IDs
- 1033808
- Acronym
- VECTORS
- Status last verified
- Sep 2026
- First submitted
- 4 Sep 2026
- Last updated
- 14 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- Yes: A de-identified dataset will be shared with all data elements required for analysis.
Study at a glance
From the registry record, last updated by the sponsor on 14 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Variation in Electrode Configuration for Termination of Out-of-Hospital Rhythms That Are Shockable (VECTORS) Trial: A Pragmatic Trial of Anterior-Posterior Versus Anterior-Lateral Initial Defibrillator Pad Placement for Out-of-Hospital Cardiac Arrest
- ClinicalTrials.gov ID
- NCT07818785
- Acronym / sponsor ID
- VECTORS / STUDY00030326
- Conditions
- Cardiac Arrest (CA)
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 1,500 participants (estimated)
- Lead sponsor
- Oregon Health and Science UniversityUniversity, hospital or other
- Study start
- 1 Apr 2027 (estimated)
- Primary completion
- 30 Jun 2029 (estimated)
- Study completion
- 31 Dec 2029 (estimated)
- First posted
- 14 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to compare the effectiveness of two defibrillator pad placements, one where pads are placed on the front of the chest and back (anterior-posterior [AP]) and one where the pads are placed on the front and side of the chest (anterior-lateral [AL]), for the treatment of cardiac arrest. Both pad placement locations are recommended for use by the American Heart Association (AHA) and International Liaison Committee on Resuscitation (ILCOR) and are used in standard treatment. The investigators are hoping to find out if one pad position is more effective than the other in the treatment of cardiac arrest.
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Anterior-Posterior | Active comparator | Device: defibrillator electrode padsDefibrillation pads placed initially in the anterior-posterior position. |
| Anterior-Lateral | Active comparator | Device: defibrillator electrode padsDefibrillation pads placed initially in the anterior-lateral position. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Emergency medical services (EMS)-treated non-traumatic out-of-hospital cardiac arrest
Key exclusion criteria (5 listed)
- ROSC at EMS arrival (e.g., bystander AED shock with ROSC prior to EMS care) without rearrest during EMS care
- Known prisoners
- Known pregnant patients
- Known pediatric patients (treated under the pediatric algorithm, generally <15 years)
- Known preexisting do-not-resuscitate orders limiting care
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| defibrillator electrode padsApplication of defibrillator electrode pads to be used in cardiac arrest treatment | Device | Anterior-Lateral, Anterior-Posterior |
Primary outcome
Post-Shock Return of Spontaneous Circulation (ROSC)
Time frame: day 1
Any palpable pulse documented at any time after the first EMS shock
7 secondary outcomes
Time to first rhythm analysis
Time frame: day 1
Time to initial shock
Time frame: day 1
Total EMS shocks
Time frame: day 1
Time to ROSC
Time frame: day 1
Survival to hospital admission
Time frame: day 1
Survival to hospital discharge
Time frame: through study completion, an average of 7 days
Survival to hospital discharge with favorable outcome
Time frame: through study completion, an average of 7 days
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Sep 2026.
- Individual participant dataSharing planned: Yes. A de-identified dataset will be shared with all data elements required for analysis.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing defibrillator electrode pads in people with Cardiac Arrest (CA), run by Oregon Health and Science University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 14 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Joshua Lupton, MD, MPH (503-418-6706, lupton@ohsu.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Post-Shock Return of Spontaneous Circulation (ROSC) (time frame: day 1). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Sep 2026.