Bone Defectssinus liftNCT07824037
Endoscopic-Assisted Versus Conventional Crestal Sinus Lift
A study testing Endoscopic-guided Sinus lift and non- endoscopic sinus lift in people with Bone Defects, run by Nahla Mahmoud Awad at 1 site in Egypt.
Trial summary
To compare Endoscopic-Assisted Versus Conventional Crestal Sinus Lift; bone grafting will be performed, followed by implant placement. Membrane perforation rates, surgical time, and bone density changes will be evaluated. Read more about this study
- Who is it for?
- Ages 21 years and older
- Conditions the study is for
- Bone Defects
- What is being tested?
- Endoscopic-guided Sinus lift and non- endoscopic sinus lift
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 24 participants
- Where
- 1 siteEgypt
- Study dates
- 25 May 2026to 31 Jul 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Loss of one or more maxillary posterior tooth, Patients age≥21 years, Bone height was 4-7 mm, sufficient inter-arch space and mesio-distal width.
Who cannot join
- Parafunctional habits, Drug or alcohol abuse, uncontrolled systemic diseases that contraindicate implant surgery, pregnant women, Smokers.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Clinical and Radiographic Evaluation of Endoscopic-Assisted Versus Conventional Crestal Sinus Lift: A Randomized Controlled Clinical Trial
To compare Endoscopic-Assisted Versus Conventional Crestal Sinus Lift; bone grafting will be performed, followed by implant placement. Membrane perforation rates, surgical time, and bone density changes will be evaluated.
Read the detailed description
Type of study design: A Randomized Clinical Trial Objective of the research: To compare Endoscopic-Assisted Versus Conventional Crestal Sinus Lift; bone grafting will be performed, followed by implant placement. Membrane perforation rates, surgical time, and bone density changes will be evaluated.
Steps of the research in short including the following:
- The inclusion and exclusion criteria for patient selection. Inclusion criteria: Loss of one or more maxillary posterior tooth, Patients age≥21 years, Bone height was 4-7 mm, sufficient inter-arch space and mesio-distal width.
Exclusion criteria Parafunctional habits, Drug or alcohol abuse, uncontrolled systemic diseases that contraindicate implant surgery, pregnant women, Smokers.
- Mention the source of the patients enrolled in the research All patients will be operated on and followed up at the Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University, Egypt.
- A written informed consent form will be signed from the patientis required.
- Description of the methodology. Radiographic assessment involved panoramic X-rays and cone-beam computed tomography (CBCT). CBCT analysis included evaluation of residual bone height, buccopalatal bone width, sinus pathology, bony septa, and precise measurement of Schneiderian membrane thickness at the planned implant sites Group 1(non-endoscopic-guided): Endoscopic evaluation was performed after complete osteotomy preparation and sinus membrane elevation using osteotomes.
Group 2 (Endoscopic-guided): Endoscopic evaluation was conducted after each drilling step, osteotome malleting, and bone graft placement to monitor sinus membrane integrity.
Sample size calculation.
- Randomization in case of RCT. Patients will be divided into two groups based on treatment type using block randomization of block size 4. An independent statistician will generate the random sequence using a computer-generated random number list method by (https://www.randomizer.org/).
- Number of visits \& follow up period. ( 4 visits)
Patients in both groups will be followed up at 24-hours, one, three, six, months postoperatively to assess this parameter:
- Membrane integrity intraoperative.
- Surgical intraoperative time.
- Radiographically, mean bone density will be measured (immediate post-operative and post 6 months CBCT)
- Conditions
- Bone Defects
- Being tested
- Endoscopic-guided Sinus lift, non- endoscopic sinus lift
- Keywords
- Maxillary sinus augmentation, Posterior maxillary implants, Sinus endoscopy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Endoscopic-guided Sinus liftProcedure or surgery
12 patients in Group 2 (Endoscopic-guided): Endoscopic evaluation was conducted after each drilling step, osteotome malleting, and bone graft placement to monitor sinus membrane integrity.
non- endoscopic sinus liftProcedure or surgery
12 patients in Group 1(non-endoscopic-guided): Endoscopic evaluation was performed after complete osteotomy preparation and sinus membrane elevation using osteotomes.
| Study group | Role | What they receive |
|---|---|---|
| Endoscopic-guided sinus lift | Experimental | Endoscopic-guided sinus lifting Receives: Procedure: Endoscopic-guided Sinus lift |
| non-endoscopic-guided sinus lift | Placebo comparator | conventional sinus lift Receives: Procedure: non- endoscopic sinus lift |
What is being measured
The primary outcome is the main question the study is designed to answer.
Membrane integrity intraoperative.
Membrane remains intact ( no perforation)
Measured: 24 hours
Secondary outcomes (1)
mean bone density
CBCT
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Sep 2026
- Study start25 May 2026
- Primary completion31 May 2028 (estimated)
- Study completion31 Jul 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Bone DefectsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 24 participants (actual)
Sponsor and investigators
- Lead sponsor
- Nahla Mahmoud Awad
- Sponsor type
- University, hospital or other
- Collaborators
- Cairo University
- Responsible party
- Sponsor-investigator, Nahla Mahmoud Awad, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07824037
- Sponsor's protocol ID
- 25526
- Acronym
- sinus lift
- Status last verified
- May 2026
- First submitted
- 11 Sep 2026
- Last updated
- 17 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical and Radiographic Evaluation of Endoscopic-Assisted Versus Conventional Crestal Sinus Lift: A Randomized Controlled Clinical Trial
- ClinicalTrials.gov ID
- NCT07824037
- Acronym / sponsor ID
- sinus lift / 25526
- Conditions
- Bone Defects
- Keywords
- Maxillary sinus augmentation, Posterior maxillary implants, Sinus endoscopy
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 24 participants (actual)
- Lead sponsor
- Nahla Mahmoud AwadUniversity, hospital or other
- Collaborators
- Cairo University
- Study start
- 25 May 2026 (actual)
- Primary completion
- 31 May 2028 (estimated)
- Study completion
- 31 Jul 2028 (estimated)
- First posted
- 17 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To compare Endoscopic-Assisted Versus Conventional Crestal Sinus Lift; bone grafting will be performed, followed by implant placement. Membrane perforation rates, surgical time, and bone density changes will be evaluated.
Detailed description
Type of study design: A Randomized Clinical Trial Objective of the research: To compare Endoscopic-Assisted Versus Conventional Crestal Sinus Lift; bone grafting will be performed, followed by implant placement. Membrane perforation rates, surgical time, and bone density changes will be evaluated.
Steps of the research in short including the following:
- The inclusion and exclusion criteria for patient selection. Inclusion criteria: Loss of one or more maxillary posterior tooth, Patients age≥21 years, Bone height was 4-7 mm, sufficient inter-arch space and mesio-distal width.
Exclusion criteria Parafunctional habits, Drug or alcohol abuse, uncontrolled systemic diseases that contraindicate implant surgery, pregnant women, Smokers.
- Mention the source of the patients enrolled in the research All patients will be operated on and followed up at the Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University, Egypt.
- A written informed consent form will be signed from the patientis required.
- Description of the methodology. Radiographic assessment involved panoramic X-rays and cone-beam computed tomography (CBCT). CBCT analysis included evaluation of residual bone height, buccopalatal bone width, sinus pathology, bony septa, and precise measurement of Schneiderian membrane thickness at the planned implant sites Group 1(non-endoscopic-guided): Endoscopic evaluation was performed after complete osteotomy preparation and sinus membrane elevation using osteotomes.
Group 2 (Endoscopic-guided): Endoscopic evaluation was conducted after each drilling step, osteotome malleting, and bone graft placement to monitor sinus membrane integrity.
Sample size calculation.
- Randomization in case of RCT. Patients will be divided into two groups based on treatment type using block randomization of block size 4. An independent statistician will generate the random sequence using a computer-generated random number list method by (https://www.randomizer.org/).
- Number of visits \& follow up period. ( 4 visits)
Patients in both groups will be followed up at 24-hours, one, three, six, months postoperatively to assess this parameter:
- Membrane integrity intraoperative.
- Surgical intraoperative time.
- Radiographically, mean bone density will be measured (immediate post-operative and post 6 months CBCT)
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Endoscopic-guided sinus lift | Experimental | Procedure: Endoscopic-guided Sinus liftEndoscopic-guided sinus lifting |
| non-endoscopic-guided sinus lift | Placebo comparator | Procedure: non- endoscopic sinus liftconventional sinus lift |
Who may qualify
- Ages
- 21 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Loss of one or more maxillary posterior tooth, Patients age≥21 years, Bone height was 4-7 mm, sufficient inter-arch space and mesio-distal width.
Key exclusion criteria (1 listed)
- Parafunctional habits, Drug or alcohol abuse, uncontrolled systemic diseases that contraindicate implant surgery, pregnant women, Smokers.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Endoscopic-guided Sinus lift12 patients in Group 2 (Endoscopic-guided): Endoscopic evaluation was conducted after each drilling step, osteotome malleting, and bone graft placement to monitor sinus membrane integrity. | Procedure or surgery | Endoscopic-guided sinus lift |
| non- endoscopic sinus lift12 patients in Group 1(non-endoscopic-guided): Endoscopic evaluation was performed after complete osteotomy preparation and sinus membrane elevation using osteotomes. | Procedure or surgery | non-endoscopic-guided sinus lift |
Primary outcome
Membrane integrity intraoperative.
Time frame: 24 hours
Membrane remains intact ( no perforation)
1 secondary outcome
mean bone density
Time frame: 6 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Endoscopic-guided Sinus lift and non- endoscopic sinus lift in people with Bone Defects, run by Nahla Mahmoud Awad at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 17 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Membrane integrity intraoperative. (time frame: 24 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Sep 2026.