Stress and PerformanceNCT07829159
The Investigators Want to See if There is a Correlation Between Stress and the Microbiome for Pilots and Astronauts and if There is a Way to Optimize This Balance for Pilots so That They Can Maximize Aerodynamic Decision Making on the Flight Deck.
An observational study of Stress and Performance and Pilot Stress, run by University of Nebraska.
Trial summary
The investigators are going to test the bacteria growing in your intestine to see if it influences your ability to manage stress while flying an airplane. Read more about this study
- Who is it for?
- Ages 18 minutes to 25 yearsHealthy volunteers can take part
- Conditions the study is for
- Stress and Performance, Pilot Stress
- What is being tested?
- Flight simulator
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 20 participants
- Where
- No sites listed yet
- Study dates
- 1 Nov 2026to 31 Dec 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 minutes to 25 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Study population: Healthy licensed instrument rated pilots.
Who may be able to join
- Healthy instrument rated pilot
Who cannot join
- Mental illness, chronic inflammatory disease, gastrointestinal disease.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Role of the Microbiome in Regulating Stress Response in Pilots, a Means of Determining Optimal Diets for Fighter Pilots and Airline Pilots
The investigators are going to test the bacteria growing in your intestine to see if it influences your ability to manage stress while flying an airplane.
- Conditions
- Stress and Performance, Pilot Stress
- Being tested
- Flight simulator
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Flight simulatorBehavioural
Also called Aeronautical Simulation
Use of flight simulator
| Study group | Role | What they receive |
|---|---|---|
| Pilots | 18-25 year old aviation students Receives: Behavioral: Flight simulator |
What is being measured
The primary outcome is the main question the study is designed to answer.
Microbial activity relationship to stress tolerance.
Correlation of microbiome with stress tolerance in flight simulation.
Measured: 30 minute simulation
Microbial metabolic pathways
We will evaluate the correlation between microbial strains and their metabolic activity with the ability to handle stressful situations in a flight simulator.
Measured: 30 minute simulation.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Sep 2026
- Study start1 Nov 2026 (estimated)
- Primary completion30 Dec 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Stress and PerformanceStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Prospective
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Nebraska
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Alison Adams, University of Nebraska
- Investigators
- Alison Adams, MS, Principal investigator, UNO
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07829159
- Sponsor's protocol ID
- 0398-26-FB
- Status last verified
- Oct 2026
- First submitted
- 14 Sep 2026
- Last updated
- 29 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 29 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Role of the Microbiome in Regulating Stress Response in Pilots, a Means of Determining Optimal Diets for Fighter Pilots and Airline Pilots
- ClinicalTrials.gov ID
- NCT07829159
- Acronym / sponsor ID
- 0398-26-FB
- Conditions
- Stress and Performance, Pilot Stress
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- University of NebraskaUniversity, hospital or other
- Study start
- 1 Nov 2026 (estimated)
- Primary completion
- 30 Dec 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 18 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The investigators are going to test the bacteria growing in your intestine to see if it influences your ability to manage stress while flying an airplane.
Study design
- Observational model
- Case only
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Pilots | – | Behavioral: Flight simulator18-25 year old aviation students |
Who may qualify
- Ages
- 18 minutes to 25 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
- Study population
- Healthy licensed instrument rated pilots.
Key inclusion criteria (1 listed)
- Healthy instrument rated pilot
Key exclusion criteria (1 listed)
- Mental illness, chronic inflammatory disease, gastrointestinal disease.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Flight simulatorAlso: Aeronautical SimulationUse of flight simulator | Behavioural | Pilots |
Primary outcome
Microbial activity relationship to stress tolerance.
Time frame: 30 minute simulation
Correlation of microbiome with stress tolerance in flight simulation.
Microbial metabolic pathways
Time frame: 30 minute simulation.
We will evaluate the correlation between microbial strains and their metabolic activity with the ability to handle stressful situations in a flight simulator.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Oct 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Alison Adams, MS principal investigator
UNO
Questions about this trial
What is this clinical trial studying?
An observational study of Stress and Performance and Pilot Stress, run by University of Nebraska.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 29 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Alison Adams, MS (402-719-0787, alisonadams@unomaha.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Microbial activity relationship to stress tolerance. (time frame: 30 minute simulation). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Oct 2026; AzTrials last refreshed its copy on 30 Oct 2026.