Hemianopia HomonymousOPTONCT07830745
Effects of Optokinetic Stimulation Without a Reading Task in Patients With Hemianopic Alexia
A study testing Optokinetic stimulation without reading task and Optokinetic stimulation with reading task in people with Hemianopia Homonymous and Stroke, run by Clinique Les Trois Soleils at 1 site in France.
Trial summary
The goal of this clinical trial is to investigate whether optokinetic stimulation delivered without a reading task can improve reading performance in adults with post-stroke hemianopic alexia. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Hemianopia Homonymous, Stroke
- What is being tested?
- Optokinetic stimulation without reading task and Optokinetic stimulation with reading task
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteFrance
- Study dates
- Oct 2026to Jun 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Time since lesion > 1 month
- Diagnosis of homonymous hemianopia post-stroke without macular sparing
- Reading complaint and/or reading impairment
- Proficiency in reading French
- Agreed to give informed consent
- Afiliated with national health insurance
Who cannot join
- History of neurological or psychiatric disorders
- Visual impairment of peripheral origin (i.e., related to damage to the structures of the eye or the optic nerve)
- Uncorrected visual acuity deficit
- Reading disorder prior to the stroke (dyslexia)
- Instability of reading impairment
- Instability of homonymous hemianopia
- Major cognitive that would limit the ability of the patient to participate in the study (unilateral spatial neglect, simultanagnosia, comprehension disorder, oral expression disorder)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Clotilde Guillerot contact
France1 site
Clinique Les Trois Soleils
Boissise-le-Roi, Île-de-France Region, 77310
Catherine Maulny, +33164718000, c.maulny@les-trois-soleils.fr
Christophe Duret
About this study
The goal of this clinical trial is to investigate whether optokinetic stimulation delivered without a reading task can improve reading performance in adults with post-stroke hemianopic alexia. The main question it aims to answer is: does optokinetic stimulation without a reading task improve reading speed more than optokinetic stimulation with a reading task? Optokinetic stimlation with a reading task is considered the standard rehabilitation. These two conditions will be administered according to a randomized crossover design to determine wether the presence or absence of a reading task influences reading outcomes.
Participants will
- receive 4 weeks of optokinetic stimulation without a reading task and 4 weeks of optokinétic stimulation with a reading task, with the order of these two interventions determined by randomization,
- undergo assesments of reading performance, oculomotor behavior, visual field and rehabilitation tolerability before and after each intervention period,
- undergo a follow-up assesment 1 month after completion of the interventions.
Read the detailed description
Stroke can cause a visual field defect known as homonymous hemianopia (HH). When this visual field loss involves the macula, the central area of vision, it may result in reading difficulties known as hemianopic alexia (HA).
The literature reports improved reading performance in these patients after repeated induction of horizontal optokinetic nystagmus (i.e., an oculomotor reflex consisting of horizontal saccades). To induce this nystagmus, previous studies have used a reading task involving text scrolling from right to left.
However, this type of exercise, which relies on reading, is cognitively demanding and may lead to frustration due to reading difficulties, fatigue, and reduced motivation and potentially the impact of rehabilitation. Therefore, the use of a non-reading task could help overcome these limitations.
The present study aims to compare the efficacy of optokinetic stimulation with reading to optokinetic stimulation without reading in patients with HA.
- Conditions
- Hemianopia Homonymous, Stroke
- Being tested
- Optokinetic stimulation without reading task, Optokinetic stimulation with reading task
- Keywords
- Homonymous hemianopia, Reading rehabilitation, Hemianopic alexia, Optokinetic, Ocular mobility
- Medical subject headings
- Hemianopsia, Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Optokinetic stimulation without reading taskOther
Participants are exposed to a horizontally moving optokinetic visual stimulus on a computer screen for 40 minutes per session. The task consists of viewing random sequences of letters scrolling from right to left. The sessions are spread out over 4 weeks, with 3 or 4 sessions per week, to achieve 10 hours (15 sessions) of optokinetic rehabilitation.
Optokinetic stimulation with reading taskOther
Participants are exposed to a horizontally moving optokinetic visual stimulus on a computer screen for 40 minutes per session. The task consists of reading aloud sentences scrolling from right to left. The sessions are spread out over 4 weeks, with 3 or 4 sessions per week, to achieve 10 hours (15 sessions) of optokinetic rehabilitation. The scrolling speed ranges from 85 to 275 words per minute, depending on the participant's reading accuracy.
| Study group | Role | What they receive |
|---|---|---|
| Group A | Other | Patients receive 15 sessions of optokinetic rehabilitation with a reading task, followed by 15 sessions of optokinetic rehabilitation without an associated reading task.
The optokinetic rehabilitation sessions with reading are considered the standard of care, while optokinetic rehabilitation without an associated reading task is the experimental condition. Each patient undergoes both conditions sequentially and serves as their own control. Receives: Other: Optokinetic stimulation without reading task; Other: Optokinetic stimulation with reading task |
| Group B | Other | Patients receive 15 sessions of optokinetic rehabilitation without an associated reading task, followed by 15 sessions of optokinetic rehabilitation with a reading task.
The optokinetic rehabilitation sessions with reading are considered the standard of care, while optokinetic rehabilitation without an associated reading task is the experimental condition. Each patient undergoes both conditions sequentially and serves as their own control. Receives: Other: Optokinetic stimulation without reading task; Other: Optokinetic stimulation with reading task |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in reading speed on paper
Change in the number of correctly read words per minute, assessed using the International Reading Speed Texts (IReST). For each participant, the change in reading speed will be calculated separately for the optokinetic rehabilitation condition with a reading task and for the optokinetic rehabilitation condition without a reading task. The within-participant changes obtained after each 4-week period will be pooled across the two randomized sequences and compared between conditions. A higher reading speed indicates better reading performance.
Measured: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Secondary outcomes (11)
Change in reading accuracy on paper
Change in the number and type of errors (paralexias, omissions) assessed using the International Reading Speed Texts (IReST).
Measured: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in reading speed on screen
Change in the number of correctly read words per minute, assessed using a screen-based reading task
Measured: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in reading accuracy on screen
Change in the number and type of errors (paralexias, omissions), assessed during a screen-based reading task
Measured: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in subjective reading abilities
Change in the score on the Hemianopia Reading Questionnaire (HRQ)
Measured: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in ocular fixations during reading
Change in the number of fixations and in the mean fixation duration (in ms) during the screen-based reading task, assessed with an eyetracker
Measured: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in ocular saccades during reading
Change in the number and in the mean amplitude of saccades (in degrees) during the screen-based reading task, assessed with an eyetracker
Measured: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in optokinetic nystagmus
Change of saccade amplitude and frequency during optokinetic stimulation
Measured: Baseline and at the end of both rehabilitation: Week 0 and Week 8
Change in visual detection during standard perimetry
Change in visual sensitivity (in dB) at each tested visual field location on automated static perimetry (Humphrey or Octopus)
Measured: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in visual detection during screen-based perimetry
Change in number of correctly detected targets and mean reaction time (in ms) at each tested visual field location on screen-based perimetry
Measured: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Tolerability of rehabilitation
Score of fatigue, stress, and mood induced by the treatment, self-assessed using a numbered visual analogue scale
Measured: Before and after each rehabilitation session
Motivation for rehabilitation
Score obtained on the Situational Motivation Scale
Measured: End of each 4-week rehabilitation period: Week 4 and Week 8
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Sep 2026
- Study startOct 2026 (estimated)
- Primary completionJun 2027 (estimated)
- Study completionJun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Hemianopia HomonymousStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Clinique Les Trois Soleils
- Sponsor type
- University, hospital or other
- Collaborators
- Laboratoire Mémoire Cerveau et Cognition, Boulogne-Billancourt, France
- Responsible party
- Sponsor
- Investigators
- Christophe Duret, Principal investigator, Clinique Les Trois Soleils, Boissise-le-Roi, France
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07830745
- Sponsor's protocol ID
- 2026-A00195-46
- Other IDs
- 26.02108.000598
- Acronym
- OPTO
- Status last verified
- Sep 2026
- First submitted
- 15 Sep 2026
- Last updated
- 21 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Goodwin D. Homonymous hemianopia: challenges and solutions. Clin Ophthalmol. 2014 Sep 22;8:1919-27. doi: 10.2147/OPTH.S59452. eCollection 2014.
PubMed 25284978Schuett S, Heywood CA, Kentridge RW, Zihl J. Rehabilitation of hemianopic dyslexia: are words necessary for re-learning oculomotor control? Brain. 2008 Dec;131(Pt 12):3156-68. doi: 10.1093/brain/awn285. Epub 2008 Nov 3.
PubMed 18984602Zihl J. Eye movement patterns in hemianopic dyslexia. Brain. 1995 Aug;118 ( Pt 4):891-912. doi: 10.1093/brain/118.4.891.
PubMed 7655887Spitzyna GA, Wise RJ, McDonald SA, Plant GT, Kidd D, Crewes H, Leff AP. Optokinetic therapy improves text reading in patients with hemianopic alexia: a controlled trial. Neurology. 2007 May 29;68(22):1922-30. doi: 10.1212/01.wnl.0000264002.30134.2a.
PubMed 17536049
Study at a glance
From the registry record, last updated by the sponsor on 21 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Optokinetic Stimulation Without a Reading Task in Patients With Hemianopic Alexia
- ClinicalTrials.gov ID
- NCT07830745
- Acronym / sponsor ID
- OPTO / 2026-A00195-46
- Conditions
- Hemianopia Homonymous, Stroke
- Keywords
- Homonymous hemianopia, Reading rehabilitation, Hemianopic alexia, Optokinetic, Ocular mobility
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Clinique Les Trois SoleilsUniversity, hospital or other
- Collaborators
- Laboratoire Mémoire Cerveau et Cognition, Boulogne-Billancourt, France
- Study start
- Oct 2026 (estimated)
- Primary completion
- Jun 2027 (estimated)
- Study completion
- Jun 2027 (estimated)
- First posted
- 21 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to investigate whether optokinetic stimulation delivered without a reading task can improve reading performance in adults with post-stroke hemianopic alexia. The main question it aims to answer is: does optokinetic stimulation without a reading task improve reading speed more than optokinetic stimulation with a reading task? Optokinetic stimlation with a reading task is considered the standard rehabilitation. These two conditions will be administered according to a randomized crossover design to determine wether the presence or absence of a reading task influences reading outcomes.
Participants will
- receive 4 weeks of optokinetic stimulation without a reading task and 4 weeks of optokinétic stimulation with a reading task, with the order of these two interventions determined by randomization,
- undergo assesments of reading performance, oculomotor behavior, visual field and rehabilitation tolerability before and after each intervention period,
- undergo a follow-up assesment 1 month after completion of the interventions.
Detailed description
Stroke can cause a visual field defect known as homonymous hemianopia (HH). When this visual field loss involves the macula, the central area of vision, it may result in reading difficulties known as hemianopic alexia (HA).
The literature reports improved reading performance in these patients after repeated induction of horizontal optokinetic nystagmus (i.e., an oculomotor reflex consisting of horizontal saccades). To induce this nystagmus, previous studies have used a reading task involving text scrolling from right to left.
However, this type of exercise, which relies on reading, is cognitively demanding and may lead to frustration due to reading difficulties, fatigue, and reduced motivation and potentially the impact of rehabilitation. Therefore, the use of a non-reading task could help overcome these limitations.
The present study aims to compare the efficacy of optokinetic stimulation with reading to optokinetic stimulation without reading in patients with HA.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group A | Other | Other: Optokinetic stimulation without reading task, Other: Optokinetic stimulation with reading taskPatients receive 15 sessions of optokinetic rehabilitation with a reading task, followed by 15 sessions of optokinetic rehabilitation without an associated reading task. The optokinetic rehabilitation sessions with reading are considered the standard of care, while optokinetic rehabilitation without an associated reading task is the experimental condition. Each patient undergoes both conditions sequentially and serves as their own control. |
| Group B | Other | Other: Optokinetic stimulation without reading task, Other: Optokinetic stimulation with reading taskPatients receive 15 sessions of optokinetic rehabilitation without an associated reading task, followed by 15 sessions of optokinetic rehabilitation with a reading task. The optokinetic rehabilitation sessions with reading are considered the standard of care, while optokinetic rehabilitation without an associated reading task is the experimental condition. Each patient undergoes both conditions sequentially and serves as their own control. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Time since lesion > 1 month
- Diagnosis of homonymous hemianopia post-stroke without macular sparing
- Reading complaint and/or reading impairment
- Proficiency in reading French
- Agreed to give informed consent
Key exclusion criteria (7 listed)
- History of neurological or psychiatric disorders
- Visual impairment of peripheral origin (i.e., related to damage to the structures of the eye or the optic nerve)
- Uncorrected visual acuity deficit
- Reading disorder prior to the stroke (dyslexia)
- Instability of reading impairment
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Optokinetic stimulation without reading taskParticipants are exposed to a horizontally moving optokinetic visual stimulus on a computer screen for 40 minutes per session. The task consists of viewing random sequences of letters scrolling from right to left. The sessions are spread out over 4 weeks, with 3 or 4 sessions per week, to achieve 10 hours (15 sessions) of optokinetic rehabilitation. | Other | Group A, Group B |
| Optokinetic stimulation with reading taskParticipants are exposed to a horizontally moving optokinetic visual stimulus on a computer screen for 40 minutes per session. The task consists of reading aloud sentences scrolling from right to left. The sessions are spread out over 4 weeks, with 3 or 4 sessions per week, to achieve 10 hours (15 sessions) of optokinetic rehabilitation. The scrolling speed ranges from 85 to 275 words per minute, depending on the participant's reading accuracy. | Other | Group A, Group B |
Primary outcome
Change in reading speed on paper
Time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in the number of correctly read words per minute, assessed using the International Reading Speed Texts (IReST). For each participant, the change in reading speed will be calculated separately for the optokinetic rehabilitation condition with a reading task and for the optokinetic rehabilitation condition without a reading task. The within-participant changes obtained after each 4-week period will be pooled across the two randomized sequences and compared between conditions. A higher reading speed indicates better reading performance.
11 secondary outcomes
Change in reading accuracy on paper
Time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in reading speed on screen
Time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in reading accuracy on screen
Time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in subjective reading abilities
Time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in ocular fixations during reading
Time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in ocular saccades during reading
Time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in optokinetic nystagmus
Time frame: Baseline and at the end of both rehabilitation: Week 0 and Week 8
Change in visual detection during standard perimetry
Time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in visual detection during screen-based perimetry
Time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Tolerability of rehabilitation
Time frame: Before and after each rehabilitation session
Motivation for rehabilitation
Time frame: End of each 4-week rehabilitation period: Week 4 and Week 8
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Sep 2026.
- Background: PubMed 25284978Goodwin D. Homonymous hemianopia: challenges and solutions. Clin Ophthalmol. 2014 Sep 22;8:1919-27. doi: 10.2147/OPTH.S59452. eCollection 2014.
- Background: PubMed 18984602Schuett S, Heywood CA, Kentridge RW, Zihl J. Rehabilitation of hemianopic dyslexia: are words necessary for re-learning oculomotor control? Brain. 2008 Dec;131(Pt 12):3156-68. doi: 10.1093/brain/awn285. Epub 2008 Nov 3.
- Background: PubMed 7655887Zihl J. Eye movement patterns in hemianopic dyslexia. Brain. 1995 Aug;118 ( Pt 4):891-912. doi: 10.1093/brain/118.4.891.
- Background: PubMed 17536049Spitzyna GA, Wise RJ, McDonald SA, Plant GT, Kidd D, Crewes H, Leff AP. Optokinetic therapy improves text reading in patients with hemianopic alexia: a controlled trial. Neurology. 2007 May 29;68(22):1922-30. doi: 10.1212/01.wnl.0000264002.30134.2a.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Clotilde Guillerot contact
Christophe Duret principal investigator
Clinique Les Trois Soleils, Boissise-le-Roi, France
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Optokinetic stimulation without reading task and Optokinetic stimulation with reading task in people with Hemianopia Homonymous and Stroke, run by Clinique Les Trois Soleils at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 21 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Anne-Gaëlle Grosmaire (+33164715200, ag.grosmaire@les-trois-soleils.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in reading speed on paper (time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07830745, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Sep 2026.