Parkinson's Disease (PD)EBA-BNCT07835230
Boxing-Based Training to Improve Balance and Mobility in Parkinson's Disease
A study testing Boxing-Based Balance and Agility Training (EBA-B). and Mobility and Education (AC). in people with Parkinson's Disease (PD), run by University of Chile at 1 site in Chile.
Trial summary
The goal of this clinical trial is to learn if physical exercise that extensively and simultaneously challenges the brain's balance control network is effective in improving balance for people with mild to moderate Parkinson's disease. Read more about this study
- Who is it for?
- Ages 25 years and older
- Conditions the study is for
- Parkinson's Disease (PD)
- What is being tested?
- Boxing-Based Balance and Agility Training (EBA-B). and Mobility and Education (AC).
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 22 participants
- Where
- 1 siteChile
- Study dates
- 23 Nov 2022to 1 Mar 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 25 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age 25 years or older
- Confirmed diagnosis of idiopathic Parkinson's Disease by a specialist physician
- Parkinson's Disease severity stage between I and III on the Hoehn and Yahr scale
- Current use of stable doses of anti-parkinsonian medication
- Ability to stand upright without assistance
- Ability to walk independently at home for at least two minutes, with or without a walking aid
- Not currently participating in any other specialized exercise program (such as non-contact boxing, Tai Chi, tango, or aquatic therapy)
- Availability and means to attend in-person group sessions three times per week for eight weeks
Who cannot join
- Currently undergoing the process of Parkinson's Disease diagnostic confirmation
- Diagnosis of atypical parkinsonism
- Other neurological conditions besides Parkinson's Disease
- History of Deep Brain Stimulation (DBS) or other brain surgeries
- Severe bone or muscle problems that prevent safe exercise
- Uncontrolled heart or metabolic conditions that make exercise unsafe
- Severe respiratory conditions or current COVID-19 (SARS-COV2) infection
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Challenging Physical Exercise to Improve Balance: Effects of Multidomain Boxing-Based Training in People With Parkinson's Disease
The goal of this clinical trial is to learn if physical exercise that extensively and simultaneously challenges the brain's balance control network is effective in improving balance for people with mild to moderate Parkinson's disease.
The study aims to test a specific hypothesis: that a physically demanding, "multidomain" program-which trains multiple areas of balance at the same time-will produce significantly better results than simple exercises that only partially address the balance network.
Read more
To test this, researchers will use a specialized boxing-based program (EBA-B) as a model of challenging exercise. This will be compared to an active control group performing simple, low-intensity mobility movements in a chair.
The main questions it aims to answer are:
- Does exercise that simultaneously challenges multiple domains of balance (using boxing as a tool) produce superior global improvements compared to less demanding programs?
- Is this extensive neural challenge more effective at reducing motor symptoms and improving functional mobility?
Participants will:
- Complete an 8-week "challenging" phase involving 50-minute group boxing sessions (EBA-B) 3 times per week, designed to challenge speed, agility, and coordination.
- Complete an 8-week "simple exercise" phase involving 20-minute home-based mobility seated workout 5 times per week, along with weekly education talks.
- Undergo clinical evaluations and balance tests at the start, middle, and end of the study to measure changes in their mobility
Read the detailed description
Background and Rationale Balance control is a complex function managed by a distributed neural network within the central nervous system, where the basal ganglia serve as a central node operating in coordination with the cerebral cortex, brainstem, and cerebellum. This network spans multiple neurochemical systems, including dopaminergic, cholinergic, and serotonergic pathways. In Parkinson's Disease (PD), this multi-level system is compromised early on, leading to symptoms like axial rigidity and progressive postural instability.
Current standard treatments, such as Levodopa and Deep Brain Stimulation (DBS), often fail to address global balance dysfunction. While Levodopa may improve gait speed, it can paradoxically worsen postural sway and fails to significantly improve dynamic balance or dual-tasking. Therefore, there is a clinical need for interventions that target the balance network globally rather than in isolation.
Study Hypothesis The core hypothesis of this trial is that physical exercise that extensively and simultaneously challenges the distributed neural network of balance control is significantly more effective at improving multiple domains of balance in people with mild-to-moderate PD than simple exercise programs. Researchers propose that to achieve global improvement, the intervention must mimic the simultaneous demands of functional mobility in daily life. In this study, the Boxing-Based Balance and Agility Training (EBA-B) is utilized as a specific tool to operationalize this high-intensity, multidomain neural challenge.
Study Design This study is a randomized, crossover, controlled clinical trial. Participants are randomized into two groups (EF and EDU) which differ only in the order of the interventions received. The total study duration per participant is approximately 19 weeks, consisting of:
- Phase 1: 8 weeks of intervention (EBA-B or AC).
- Washout Period: 3 weeks of no study-related exercise to minimize carry-over effects.
- Phase 2: 8 weeks of the opposite intervention.
Intervention Protocols
- Boxing-Based Training (EBA-B): The EBA-B program combines functional exercise with non-contact boxing techniques.
- Structure: 24 sessions (50 minutes each, 3 times per week).
- Progression: Organized into a Learning Block (Weeks 1-4) for habit formation and technical acquisition, and an Integration Block (Weeks 5-8) where exercises increase in volume, complexity, and intensity.
- Session Layout: Each session includes a warm-up, three successive 12-minute work stations, and a cool-down. Stations focus on asymmetric postures, trunk mobility, coordination of punch sequences, and reaction to stimuli.
- Intensity: Monitored via heart rate (pulse oximetry) and Rated Perceived Exertion (RPE), with a planned progression from 40% to 75% of maximum heart rate.
- Active Control (AC): The AC intervention is designed to match the total weekly volume of 150 minutes but with lower physical demand.
- Education: Weekly 50-minute in-person talks regarding PD pathology and quality of life to maintain group socialization.
- Mobility: A 20-minute video workout of simple, seated (chair-based) mobility exercises to be performed at home 5 times per week.
Monitoring and Safety Clinical evaluations are performed in the "ON" medication state at three time points: Baseline (0M), Mid-point/Washout (2M), and Study Completion (4M). Participants are instructed to maintain stable medication and daily activity levels throughout the study. Adverse events, such as falls or musculoskeletal injuries, are recorded via participant diaries and direct reporting during sessions.
- Conditions
- Parkinson's Disease (PD)
- Being tested
- Boxing-Based Balance and Agility Training (EBA-B)., Mobility and Education (AC).
- Keywords
- Postural Balance, Boxing, Exercise Therapy, Gait, Neurological Rehabilitation, Mobility, Agility, Balance
- Medical subject headings
- Parkinson Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Boxing-Based Balance and Agility Training (EBA-B).Behavioural
This intervention is a specialized multidomain exercise program designed to extensively and simultaneously challenge the brain's balance control network.
- Frequency: 50-minute group sessions, 3 times per week for 8 weeks (24 sessions total).
- Structure: Organized into two 4-week blocks: a Learning Block for technical acquisition and an Integration Block where exercise complexity and volume increase.
- Session Layout: Includes a warm-up, three 12-minute work stations focusing on boxing techniques (punches and footwork), speed, and agility drills, followed by a cool-down.
- Intensity: Progressively increases from 40% to 75% of maximum heart rate, monitored via pulse oximetry.
Mobility and Education (AC).Behavioural
This active control intervention provides a partial challenge to the balance network through simpler movements and social interaction.
- Total Volume: 150 minutes per week, matching the EBA-B volume.
- Education Component: Weekly 50-minute in-person group sessions led by specialists, covering topics related to Parkinson's Disease and quality of life.
- Mobility Component: 20-minute home-based exercise sessions performed 5 times per week. These are simple, low-intensity mobility drills performed in a seated position (chair-based) following a video-recorded guide.
| Study group | Role | What they receive |
|---|---|---|
| Group EF: EBA-B followed by Active Control | Experimental | Participants in this arm first receive 8 weeks of the experimental boxing-based balance and agility training (EBA-B), followed by a 3-week washout period. Subsequently, they crossover to receive 8 weeks of the Active Control (AC) intervention, which consists of education sessions and home-based mobility exercises. Receives: Behavioral: Boxing-Based Balance and Agility Training (EBA-B).; Behavioral: Mobility and Education (AC). |
| Group EDU: Active Control followed by EBA-B | Experimental | Participants in this arm first receive 8 weeks of the Active Control (AC) intervention (education and home-based mobility exercises), followed by a 3-week washout period. Subsequently, they crossover to receive 8 weeks of the experimental boxing-based balance and agility training (EBA-B). Receives: Behavioral: Boxing-Based Balance and Agility Training (EBA-B).; Behavioral: Mobility and Education (AC). |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change from Baseline in Mini-Balance Evaluation Systems Test (MiniBESTest) Total Score
The MiniBESTest is a clinical rating scale used to assess four domains of balance: anticipatory postural adjustments, reactive postural control, sensory orientation, and dynamic balance. It consists of 14 items, each scored on an ordinal scale from 0 to 2. The total score ranges from 0 to 28 points, where 0 represents the greatest balance impairment and 28 represents typical, healthy balance performance.
Measured: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
Change from Baseline in Functional Gait Assessment (FGA) Total Score
The FGA is a clinical scale designed to assess postural stability during various walking tasks. It comprises 10 tasks, each rated from 0 to 3 points. The total score ranges from 0 to 30 points, where 0 indicates severe gait impairment and 30 indicates normal functional gait.
Measured: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
Secondary outcomes (8)
Change from Baseline in Movement Disorder Society - Unified Parkinson's Disease Rating Scale Part III (MDS-UPDRS III)
This scale measures the severity of motor symptoms in individuals with Parkinson's Disease. It involves a clinical examination of motor functions such as tremors, rigidity, and bradykinesia. The total score is the sum of all items; a higher score indicates greater motor symptom severity and a lower score indicates fewer symptoms.
Measured: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
Change from Baseline in Parkinson's Disease Questionnaire (PDQ-39) Summary Index and Individual Domain Scores
The PDQ-39 is a self-administered questionnaire used to evaluate the impact of Parkinson's Disease on health-related quality of life. It consists of 39 items covering 8 distinct dimensions:
- Mobility
- Activities of Daily Living (ADL)
- Emotional Well-being
- Stigma
- Social Support
- Cognition
- Communication
- Bodily Discomfort
Scores for each of the 8 domains and the overall Summary Index (SI) are calculated on a scale from 0 to 100, where 0 represents the best possible health status (no impact or limitations) and 100 represents the worst health-related quality of life. The study analyzed changes from baseline in the global summary index and in each dimension separately to detect domain-specific therapeutic effects.
Measured: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
Change from Baseline in Activities-specific Balance Confidence (ABC) Scale
This scale measures the participant's level of confidence in maintaining balance while performing 16 specific daily activities. Each activity is rated on a percentage scale from 0% (no confidence) to 100% (complete confidence). The final score is the average percentage of all items, where higher percentages indicate greater balance confidence.
Measured: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
Change from Baseline in First Step Range of Motion (ROM)
An objective mobility metric of Anticipatory Postural Adjustments (APA) obtained using APDM® Opal inertial sensors (placed on feet and lumbar region) during gait initiation[5][6]. Measured in degrees (°), where higher values indicate greater angular displacement of the ankle and improved APA magnitude.
Measured: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
Change from Baseline in Functional Gait Speed
An objective spatiotemporal gait metric captured via APDM® Opal inertial sensors during a 10-meter Walk Test in single task. Measured in meters per second (m/s), where higher values represent faster functional walking speed.
Measured: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
Change from Baseline in Instrumented Postural Sway Area
An objective postural stability metric captured via APDM® Opal inertial sensors (lumbar sensor) during dynamic and static balance tasks. Measured in centimeters squared (cm²), where lower values indicate reduced body sway and better postural control.
Measured: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
Change from Baseline in Postural Movement Smoothness (Jerk)
An objective metric quantifying the fluidity of postural control, captured via the lumbar APDM® Opal inertial sensor during balance tasks. Measured in meters squared per second to the fifth power (m²/s⁵), where lower values represent smoother movement and reduced postural instability.
Measured: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
Change from Baseline in Dual-Task Cost (DTC) During Timed Up and Go (TUG) Test
An objective mobility metric evaluating cognitive-motor interference during dynamic balance and gait. Participants performed the Timed Up and Go (TUG) test under single-task and dual-task (performing a concurrent cognitive task) conditions while wearing APDM® Opal inertial sensors. Dual-Task Cost is calculated as a percentage using the standard relative formula: [(Dual-Task TUG Duration - Single-Task TUG Duration) / Single-Task TUG Duration] × 100. Reported in percentage (%), where lower or negative values represent less motor performance degradation during dual-tasking (i.e., superior cognitive-motor integration).
Measured: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Sep 2026
- Study start23 Nov 2022
- Primary completion6 Dec 2023
- Study completion1 Mar 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Parkinson's Disease (PD)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 22 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Chile
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Pablo Burgos, University of Chile
- Investigators
- Pablo I Burgos, PhD, Study director, University of Chile
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07835230
- Sponsor's protocol ID
- CEISH-174-2022
- Acronym
- EBA-B
- Status last verified
- Sep 2026
- First submitted
- 11 Sep 2026
- Last updated
- 22 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: All the collected IPD.
Study at a glance
From the registry record, last updated by the sponsor on 22 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Challenging Physical Exercise to Improve Balance: Effects of Multidomain Boxing-Based Training in People With Parkinson's Disease
- ClinicalTrials.gov ID
- NCT07835230
- Acronym / sponsor ID
- EBA-B / CEISH-174-2022
- Conditions
- Parkinson's Disease (PD)
- Keywords
- Postural Balance, Boxing, Exercise Therapy, Gait, Neurological Rehabilitation, Mobility, Agility, Balance
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 22 participants (actual)
- Lead sponsor
- University of ChileUniversity, hospital or other
- Study start
- 23 Nov 2022 (actual)
- Primary completion
- 6 Dec 2023 (actual)
- Study completion
- 1 Mar 2024 (actual)
- First posted
- 22 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn if physical exercise that extensively and simultaneously challenges the brain's balance control network is effective in improving balance for people with mild to moderate Parkinson's disease.
The study aims to test a specific hypothesis: that a physically demanding, "multidomain" program-which trains multiple areas of balance at the same time-will produce significantly better results than simple exercises that only partially address the balance network.
To test this, researchers will use a specialized boxing-based program (EBA-B) as a model of challenging exercise. This will be compared to an active control group performing simple, low-intensity mobility movements in a chair.
The main questions it aims to answer are:
- Does exercise that simultaneously challenges multiple domains of balance (using boxing as a tool) produce superior global improvements compared to less demanding programs?
- Is this extensive neural challenge more effective at reducing motor symptoms and improving functional mobility?
Participants will:
- Complete an 8-week "challenging" phase involving 50-minute group boxing sessions (EBA-B) 3 times per week, designed to challenge speed, agility, and coordination.
- Complete an 8-week "simple exercise" phase involving 20-minute home-based mobility seated workout 5 times per week, along with weekly education talks.
- Undergo clinical evaluations and balance tests at the start, middle, and end of the study to measure changes in their mobility
Detailed description
Background and Rationale Balance control is a complex function managed by a distributed neural network within the central nervous system, where the basal ganglia serve as a central node operating in coordination with the cerebral cortex, brainstem, and cerebellum. This network spans multiple neurochemical systems, including dopaminergic, cholinergic, and serotonergic pathways. In Parkinson's Disease (PD), this multi-level system is compromised early on, leading to symptoms like axial rigidity and progressive postural instability.
Current standard treatments, such as Levodopa and Deep Brain Stimulation (DBS), often fail to address global balance dysfunction. While Levodopa may improve gait speed, it can paradoxically worsen postural sway and fails to significantly improve dynamic balance or dual-tasking. Therefore, there is a clinical need for interventions that target the balance network globally rather than in isolation.
Study Hypothesis The core hypothesis of this trial is that physical exercise that extensively and simultaneously challenges the distributed neural network of balance control is significantly more effective at improving multiple domains of balance in people with mild-to-moderate PD than simple exercise programs. Researchers propose that to achieve global improvement, the intervention must mimic the simultaneous demands of functional mobility in daily life. In this study, the Boxing-Based Balance and Agility Training (EBA-B) is utilized as a specific tool to operationalize this high-intensity, multidomain neural challenge.
Study Design This study is a randomized, crossover, controlled clinical trial. Participants are randomized into two groups (EF and EDU) which differ only in the order of the interventions received. The total study duration per participant is approximately 19 weeks, consisting of:
- Phase 1: 8 weeks of intervention (EBA-B or AC).
- Washout Period: 3 weeks of no study-related exercise to minimize carry-over effects.
- Phase 2: 8 weeks of the opposite intervention.
Intervention Protocols
- Boxing-Based Training (EBA-B): The EBA-B program combines functional exercise with non-contact boxing techniques.
- Structure: 24 sessions (50 minutes each, 3 times per week).
- Progression: Organized into a Learning Block (Weeks 1-4) for habit formation and technical acquisition, and an Integration Block (Weeks 5-8) where exercises increase in volume, complexity, and intensity.
- Session Layout: Each session includes a warm-up, three successive 12-minute work stations, and a cool-down. Stations focus on asymmetric postures, trunk mobility, coordination of punch sequences, and reaction to stimuli.
- Intensity: Monitored via heart rate (pulse oximetry) and Rated Perceived Exertion (RPE), with a planned progression from 40% to 75% of maximum heart rate.
- Active Control (AC): The AC intervention is designed to match the total weekly volume of 150 minutes but with lower physical demand.
- Education: Weekly 50-minute in-person talks regarding PD pathology and quality of life to maintain group socialization.
- Mobility: A 20-minute video workout of simple, seated (chair-based) mobility exercises to be performed at home 5 times per week.
Monitoring and Safety Clinical evaluations are performed in the "ON" medication state at three time points: Baseline (0M), Mid-point/Washout (2M), and Study Completion (4M). Participants are instructed to maintain stable medication and daily activity levels throughout the study. Adverse events, such as falls or musculoskeletal injuries, are recorded via participant diaries and direct reporting during sessions.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group EF: EBA-B followed by Active Control | Experimental | Behavioral: Boxing-Based Balance and Agility Training (EBA-B)., Behavioral: Mobility and Education (AC).Participants in this arm first receive 8 weeks of the experimental boxing-based balance and agility training (EBA-B), followed by a 3-week washout period. Subsequently, they crossover to receive 8 weeks of the Active Control (AC) intervention, which consists of education sessions and home-based mobility exercises. |
| Group EDU: Active Control followed by EBA-B | Experimental | Behavioral: Boxing-Based Balance and Agility Training (EBA-B)., Behavioral: Mobility and Education (AC).Participants in this arm first receive 8 weeks of the Active Control (AC) intervention (education and home-based mobility exercises), followed by a 3-week washout period. Subsequently, they crossover to receive 8 weeks of the experimental boxing-based balance and agility training (EBA-B). |
Who may qualify
- Ages
- 25 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Age 25 years or older
- Confirmed diagnosis of idiopathic Parkinson's Disease by a specialist physician
- Parkinson's Disease severity stage between I and III on the Hoehn and Yahr scale
- Current use of stable doses of anti-parkinsonian medication
- Ability to stand upright without assistance
Key exclusion criteria (7 listed)
- Currently undergoing the process of Parkinson's Disease diagnostic confirmation
- Diagnosis of atypical parkinsonism
- Other neurological conditions besides Parkinson's Disease
- History of Deep Brain Stimulation (DBS) or other brain surgeries
- Severe bone or muscle problems that prevent safe exercise
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Boxing-Based Balance and Agility Training (EBA-B).This intervention is a specialized multidomain exercise program designed to extensively and simultaneously challenge the brain's balance control network. * Frequency: 50-minute group sessions, 3 times per week for 8 weeks (24 sessions total). * Structure: Organized into two 4-week blocks: a Learning Block for technical acquisition and an Integration Block where exercise complexity and volume increase. * Session Layout: Includes a warm-up, three 12-minute work stations focusing on boxing techniques (punches and footwork), speed, and agility drills, followed by a cool-down. * Intensity: Progressively increases from 40% to 75% of maximum heart rate, monitored via pulse oximetry. | Behavioural | Group EDU: Active Control followed by EBA-B, Group EF: EBA-B followed by Active Control |
| Mobility and Education (AC).This active control intervention provides a partial challenge to the balance network through simpler movements and social interaction. * Total Volume: 150 minutes per week, matching the EBA-B volume. * Education Component: Weekly 50-minute in-person group sessions led by specialists, covering topics related to Parkinson's Disease and quality of life. * Mobility Component: 20-minute home-based exercise sessions performed 5 times per week. These are simple, low-intensity mobility drills performed in a seated position (chair-based) following a video-recorded guide. | Behavioural | Group EDU: Active Control followed by EBA-B, Group EF: EBA-B followed by Active Control |
Primary outcome
Change from Baseline in Mini-Balance Evaluation Systems Test (MiniBESTest) Total Score
Time frame: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
The MiniBESTest is a clinical rating scale used to assess four domains of balance: anticipatory postural adjustments, reactive postural control, sensory orientation, and dynamic balance. It consists of 14 items, each scored on an ordinal scale from 0 to 2. The total score ranges from 0 to 28 points, where 0 represents the greatest balance impairment and 28 represents typical, healthy balance performance.
Change from Baseline in Functional Gait Assessment (FGA) Total Score
Time frame: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
The FGA is a clinical scale designed to assess postural stability during various walking tasks. It comprises 10 tasks, each rated from 0 to 3 points. The total score ranges from 0 to 30 points, where 0 indicates severe gait impairment and 30 indicates normal functional gait.
8 secondary outcomes
Change from Baseline in Movement Disorder Society - Unified Parkinson's Disease Rating Scale Part III (MDS-UPDRS III)
Time frame: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
Change from Baseline in Parkinson's Disease Questionnaire (PDQ-39) Summary Index and Individual Domain Scores
Time frame: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
Change from Baseline in Activities-specific Balance Confidence (ABC) Scale
Time frame: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
Change from Baseline in First Step Range of Motion (ROM)
Time frame: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
Change from Baseline in Functional Gait Speed
Time frame: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
Change from Baseline in Instrumented Postural Sway Area
Time frame: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
Change from Baseline in Postural Movement Smoothness (Jerk)
Time frame: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
Change from Baseline in Dual-Task Cost (DTC) During Timed Up and Go (TUG) Test
Time frame: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Sep 2026.
- Individual participant dataSharing planned: Yes. All the collected IPD.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Pablo I Burgos, PhD study director
University of Chile
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Boxing-Based Balance and Agility Training (EBA-B). and Mobility and Education (AC). in people with Parkinson's Disease (PD), run by University of Chile at 1 site in Chile.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Chile. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change from Baseline in Mini-Balance Evaluation Systems Test (MiniBESTest) Total Score (time frame: Baseline, 8 weeks (end of Phase 1), and 19 weeks (end of Phase 2/Study Completion).). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Sep 2026.