Critical IllnessNCT07842562
Continuous Renal Replacement Therapy Circuit Lifespan in Intensive Care Patients
An observational study of Critical Illness and Acute Kidney Injury, run by Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
The goal of this retrospective observational study is to evaluate how long continuous renal replacement therapy (CRRT) circuits remain in use in adult intensive care unit patients and to describe how CRRT pressure measurements change over time. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Critical Illness, Acute Kidney Injury
- What is being tested?
- Archived CRRT Device Log Data
- How many people
- 162 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 20 Sep 2026to 21 Sep 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: The study population consists of adult intensive care unit (ICU) patients who underwent continuous renal replacement therapy (CRRT) using the Prismaflex platform. Archived device log files (LOX format) generated during routine clinical care were evaluated. The unit of analysis was the individual CRRT session rather than the patient, as device logs were structured at the treatment-session level and patient-level linkage was not consistently available. Eligible sessions had a minimum runtime of 1 hour and at least 60 valid, chronologically ordered pressure recordings.
Who may be able to join
- Archived CRRT treatment sessions performed in adult intensive care unit patients.
- CRRT sessions recorded on the Prismaflex platform and available as LOX device log files.
- Sessions with a circuit lifespan of at least 1 hour, defined as the time between the first and last valid pressure recording.
- Sessions containing sufficient time-stamped pressure data for analysis, including at least 60 valid pressure measurements.
- Sessions with available pressure recordings for the relevant variables, including transmembrane pressure, access pressure, filter pressure, effluent pressure, and/or return pressure.
- Sessions with adequate data integrity and chronologically interpretable pressure records.
Who cannot join
- CRRT sessions with a runtime of less than 1 hour.
- Sessions with missing pressure tables.
- Sessions with fewer than 60 pressure measurements.
- Sessions with missing or incomplete primary device records.
- Sessions with missing timestamps or pressure records that cannot be ordered chronologically.
- Sessions with inadequate pressure-data density for trajectory analysis.
- Sessions with major data-integrity problems that prevent reliable calculation of circuit lifespan or pressure-derived variables.
- Duplicate or otherwise unusable device-log records.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Dr. Abdurrahman Yurtaslan Ankara Oncology Hospital
Yenimahalle, Ankara, 06200
About this study
Official title: Evaluation of Continuous Renal Replacement Therapy Circuit Lifespan in Intensive Care Patients: A Retrospective Study
The goal of this retrospective observational study is to evaluate how long continuous renal replacement therapy (CRRT) circuits remain in use in adult intensive care unit patients and to describe how CRRT pressure measurements change over time. The main questions it aims to answer are:
Are higher maximum and mean transmembrane pressure (TMP) values associated with longer CRRT circuit lifespan? Do time-normalized pressure trajectories and cumulative TMP burden differ between circuits with different lifespans? Do access pressure patterns influence the relationship between pressure measurements and circuit lifespan? Researchers will analyze archived CRRT device log files, including access pressure, filter pressure, effluent pressure, return pressure, and TMP measurements. No additional procedures, interventions, or study visits will be required. No directly identifiable patient information will be included in the analytical dataset.
- Conditions
- Critical Illness, Acute Kidney Injury
- Being tested
- Archived CRRT Device Log Data
- Keywords
- Continuous Renal Replacement Therapy, Continuous Kidney Replacement Therapy, CRRT Circuit Lifespan, Transmembrane Pressure, Circuit Pressure Dynamics
- Medical subject headings
- Critical Illness, Acute Kidney Injury
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Archived CRRT Device Log DataOther
This observational study involves no assigned intervention, treatment, device use, or change in clinical care. The study analyzes archived pressure recordings from CRRT device log files generated during routine clinical care. The analyzed variables include access pressure, filter pressure, effluent pressure, return pressure, and transmembrane pressure. CRRT circuit lifespan is evaluated retrospectively according to the time between the first and last valid pressure recording. No additional procedures or study-related interventions are performed.
| Study group | Role | What they receive |
|---|---|---|
| CRRT Circuit Lifespan <12 Hours | CRRT sessions with a circuit lifespan of less than 12 hours, defined as the time between the first and last valid pressure recording in the device log. No intervention was assigned. Receives: Other: Archived CRRT Device Log Data | |
| CRRT Circuit Lifespan 12 to <24 Hours | CRRT sessions with a circuit lifespan of at least 12 hours but less than 24 hours, defined as the time between the first and last valid pressure recording in the device log. No intervention was assigned. Receives: Other: Archived CRRT Device Log Data | |
| CRRT Circuit Lifespan 24 to <48 Hours | CRRT sessions with a circuit lifespan of at least 24 hours but less than 48 hours, defined as the time between the first and last valid pressure recording in the device log. No intervention was assigned. Receives: Other: Archived CRRT Device Log Data | |
| CRRT Circuit Lifespan ≥48 Hours | CRRT sessions with a circuit lifespan of 48 hours or longer, defined as the time between the first and last valid pressure recording in the device log. No intervention was assigned. Receives: Other: Archived CRRT Device Log Data |
What is being measured
The primary outcome is the main question the study is designed to answer.
Maximum Transmembrane Pressure Across CRRT Circuit Lifespan Categories
To compare maximum transmembrane pressure values among CRRT sessions grouped by circuit lifespan: less than 12 hours, 12 to less than 24 hours, 24 to less than 48 hours, and 48 hours or longer.
Measured: From the first to the last valid pressure recording of each CRRT session
Secondary outcomes (1)
Initial 6-hour TMP slope
The initial 6-hour transmembrane pressure (TMP) slope will be calculated from the time-stamped TMP measurements obtained during the first 6 hours of each CRRT session. It will be expressed in mmHg per hour and will be evaluated as a secondary pressure-dynamics measure in relation to CRRT circuit lifespan and lifespan categories. Sessions without sufficient pressure data during the initial 6-hour period will be excluded from this specific analysis.
Measured: During the first 6 hours of each CRRT session
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Sep 2026
- Study start20 Sep 2026
- Primary completion20 Sep 2026
- Study completion21 Sep 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Critical IllnessStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 162 participants (actual)
Sponsor and investigators
- Lead sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Arif Timuroğlu, MD, Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07842562
- Sponsor's protocol ID
- 2026-09/218
- Status last verified
- Sep 2026
- First submitted
- 21 Sep 2026
- Last updated
- 25 Sep 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared with other researchers. This retrospective study uses archived CRRT device log files, and patient-level linkage was not consistently available. The analytical dataset does not include directly identifiable patient information; however, the underlying device logs and study dataset will not be made publicly available because of institutional data-protection requirements and the terms of the ethics approval. Aggregate results will be reported in the publication.
Study at a glance
From the registry record, last updated by the sponsor on 25 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Continuous Renal Replacement Therapy Circuit Lifespan in Intensive Care Patients: A Retrospective Study
- ClinicalTrials.gov ID
- NCT07842562
- Acronym / sponsor ID
- 2026-09/218
- Conditions
- Critical Illness, Acute Kidney Injury
- Keywords
- Continuous Renal Replacement Therapy, Continuous Kidney Replacement Therapy, CRRT Circuit Lifespan, Transmembrane Pressure, Circuit Pressure Dynamics
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 162 participants (actual)
- Lead sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research HospitalUniversity, hospital or other
- Study start
- 20 Sep 2026 (actual)
- Primary completion
- 20 Sep 2026 (actual)
- Study completion
- 21 Sep 2026 (actual)
- First posted
- 25 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this retrospective observational study is to evaluate how long continuous renal replacement therapy (CRRT) circuits remain in use in adult intensive care unit patients and to describe how CRRT pressure measurements change over time. The main questions it aims to answer are:
Are higher maximum and mean transmembrane pressure (TMP) values associated with longer CRRT circuit lifespan? Do time-normalized pressure trajectories and cumulative TMP burden differ between circuits with different lifespans? Do access pressure patterns influence the relationship between pressure measurements and circuit lifespan? Researchers will analyze archived CRRT device log files, including access pressure, filter pressure, effluent pressure, return pressure, and TMP measurements. No additional procedures, interventions, or study visits will be required. No directly identifiable patient information will be included in the analytical dataset.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| CRRT Circuit Lifespan <12 Hours | – | Other: Archived CRRT Device Log DataCRRT sessions with a circuit lifespan of less than 12 hours, defined as the time between the first and last valid pressure recording in the device log. No intervention was assigned. |
| CRRT Circuit Lifespan 12 to <24 Hours | – | Other: Archived CRRT Device Log DataCRRT sessions with a circuit lifespan of at least 12 hours but less than 24 hours, defined as the time between the first and last valid pressure recording in the device log. No intervention was assigned. |
| CRRT Circuit Lifespan 24 to <48 Hours | – | Other: Archived CRRT Device Log DataCRRT sessions with a circuit lifespan of at least 24 hours but less than 48 hours, defined as the time between the first and last valid pressure recording in the device log. No intervention was assigned. |
| CRRT Circuit Lifespan ≥48 Hours | – | Other: Archived CRRT Device Log DataCRRT sessions with a circuit lifespan of 48 hours or longer, defined as the time between the first and last valid pressure recording in the device log. No intervention was assigned. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- The study population consists of adult intensive care unit (ICU) patients who underwent continuous renal replacement therapy (CRRT) using the Prismaflex platform. Archived device log files (LOX format) generated during routine clinical care were evaluated. The unit of analysis was the individual CRRT session rather than the patient, as device logs were structured at the treatment-session level and patient-level linkage was not consistently available. Eligible sessions had a minimum runtime of 1 hour and at least 60 valid, chronologically ordered pressure recordings.
Key inclusion criteria (6 listed)
- Archived CRRT treatment sessions performed in adult intensive care unit patients.
- CRRT sessions recorded on the Prismaflex platform and available as LOX device log files.
- Sessions with a circuit lifespan of at least 1 hour, defined as the time between the first and last valid pressure recording.
- Sessions containing sufficient time-stamped pressure data for analysis, including at least 60 valid pressure measurements.
- Sessions with available pressure recordings for the relevant variables, including transmembrane pressure, access pressure, filter pressure, effluent pressure, and/or return pressure.
Key exclusion criteria (8 listed)
- CRRT sessions with a runtime of less than 1 hour.
- Sessions with missing pressure tables.
- Sessions with fewer than 60 pressure measurements.
- Sessions with missing or incomplete primary device records.
- Sessions with missing timestamps or pressure records that cannot be ordered chronologically.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Archived CRRT Device Log DataThis observational study involves no assigned intervention, treatment, device use, or change in clinical care. The study analyzes archived pressure recordings from CRRT device log files generated during routine clinical care. The analyzed variables include access pressure, filter pressure, effluent pressure, return pressure, and transmembrane pressure. CRRT circuit lifespan is evaluated retrospectively according to the time between the first and last valid pressure recording. No additional procedures or study-related interventions are performed. | Other | CRRT Circuit Lifespan 12 to <24 Hours, CRRT Circuit Lifespan 24 to <48 Hours, CRRT Circuit Lifespan <12 Hours, CRRT Circuit Lifespan ≥48 Hours |
Primary outcome
Maximum Transmembrane Pressure Across CRRT Circuit Lifespan Categories
Time frame: From the first to the last valid pressure recording of each CRRT session
To compare maximum transmembrane pressure values among CRRT sessions grouped by circuit lifespan: less than 12 hours, 12 to less than 24 hours, 24 to less than 48 hours, and 48 hours or longer.
1 secondary outcome
Initial 6-hour TMP slope
Time frame: During the first 6 hours of each CRRT session
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Sep 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared with other researchers. This retrospective study uses archived CRRT device log files, and patient-level linkage was not consistently available. The analytical dataset does not include directly identifiable patient information; however, the underlying device logs and study dataset will not be made publicly available because of institutional data-protection requirements and the terms of the ethics approval. Aggregate results will be reported in the publication.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Critical Illness and Acute Kidney Injury, run by Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Maximum Transmembrane Pressure Across CRRT Circuit Lifespan Categories (time frame: From the first to the last valid pressure recording of each CRRT session). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Sep 2026.