Hashimoto ThyroiditisNCT07852026
Role of Total Thyroidectomy in Relieving Local Symptoms in Hashimoto's Thyroiditis
An observational study of Hashimoto Thyroiditis and Goiter, run by Assiut University at 1 site in Egypt.
Trial summary
This study aims to evaluate the role and effectiveness of total thyroidectomy in relieving compressive and local symptoms (such as dysphagia, dyspnea, and anterior neck pain/discomfort) in patients with Hashimoto's thyroiditis who fail to improve with conservative medical management. Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Hashimoto Thyroiditis, Goiter
- What is being tested?
- Total Thyroidectomy
- Type of treatment
- Surgery or procedure
- How many people
- 30 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Oct 2026to 1 Jun 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients diagnosed with Hashimoto's thyroiditis who suffer from persistent local compressive symptoms and undergo total thyroidectomy at the Department of Surgery, Assiut University Hospitals.
Who may be able to join
- Adults patients with confirmed Hashimoto's thyroiditis (elevated serum anti-thyroid peroxidase \anti-thyroglobulin antibodies, characteristic ultrasound findings and/or positive fine needle aspiration cytology)
- Biochemically euthyroid with normal thyroid function test.
- Presence of persistent local symptoms (neck pain, throat discomfort,neck tightness,chocking) for more than 6 months
- Patient fit and motivated to surgery.
Who cannot join
- Confirmed or high-suspicion thyroid malignancy (Bethesda V or IV on FNAC
- Previous thyroid or neck surgery
- Patient refusal to participate in the study
- Severe comorbidities precluding general anesthesia
- Active psychiatric illness
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site
Assiut University Hospitals
Asyut, Asyut Governorate, 71515
Ahmed Atef Muslim, Bachelor of Medicine and Surge, +201099626447, ahmed.atef.465.aa@gmail.com
About this study
Official title: The Role of Total Thyroidectomy in Relieving Chronic Local Symptoms Associated With Hashimoto's Thyroiditis: Prospective Cohort Study
This study aims to evaluate the role and effectiveness of total thyroidectomy in relieving compressive and local symptoms (such as dysphagia, dyspnea, and anterior neck pain/discomfort) in patients with Hashimoto's thyroiditis who fail to improve with conservative medical management.
Read the detailed description
Hashimoto's thyroiditis is a chronic autoimmune disease often presenting with goiter and local pressure symptoms. While levothyroxine replacement is standard for hypothyroidism, persistent compressive symptoms, cosmetic concerns, or suspicion of malignancy may necessitate surgical intervention.
This study investigates patients diagnosed with Hashimoto's thyroiditis presenting with significant local symptoms. Eligible patients undergoing total thyroidectomy will be evaluated preoperatively and postoperatively to assess symptom resolution, postoperative complication rates (such as hypocalcemia and recurrent laryngeal nerve injury), and overall patient satisfaction following surgery.
- Conditions
- Hashimoto Thyroiditis, Goiter
- Being tested
- Total Thyroidectomy
- Keywords
- Total Thyroidectomy, Hashimoto's Thyroiditis, Compressive Symptoms, Thyroid Surgery
- Medical subject headings
- Hashimoto Disease, Goiter
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Total ThyroidectomyProcedure or surgery
Surgical removal of the entire thyroid gland performed under general anesthesia for patients with Hashimoto's thyroiditis presenting with compressive or local neck symptoms.
What is being measured
The primary outcome is the main question the study is designed to answer.
Improvement or Relief of Local Compressive Symptoms
Assessment of changes in patient-reported compressive symptoms (such as dysphagia, dyspnea, and local neck discomfort or pressure) following total thyroidectomy compared to baseline status.
Measured: 6 months postoperatively
Secondary outcomes (1)
Incidence of Postoperative Complications
Rate of surgical complications including transient or permanent hypocalcemia, recurrent laryngeal nerve injury, and wound complications.
Measured: Up to 30 days postoperatively
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Oct 2026
- Study start1 Oct 2026 (estimated)
- Primary completion1 Oct 2027 (estimated)
- Study completion1 Jun 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hashimoto ThyroiditisStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ahmed Atef Muslim Hassan, Assiut University
- Investigators
- Ahmed Gamal Hamdan, Lecturer, Study director
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07852026
- Sponsor's protocol ID
- Hashimoto's Thyroiditis
- Status last verified
- Sep 2026
- First submitted
- 25 Sep 2026
- Last updated
- 1 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 1 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Role of Total Thyroidectomy in Relieving Chronic Local Symptoms Associated With Hashimoto's Thyroiditis: Prospective Cohort Study
- ClinicalTrials.gov ID
- NCT07852026
- Acronym / sponsor ID
- Hashimoto's Thyroiditis
- Conditions
- Hashimoto Thyroiditis, Goiter
- Keywords
- Total Thyroidectomy, Hashimoto's Thyroiditis, Compressive Symptoms, Thyroid Surgery
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 1 Oct 2026 (estimated)
- Primary completion
- 1 Oct 2027 (estimated)
- Study completion
- 1 Jun 2028 (estimated)
- First posted
- 1 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to evaluate the role and effectiveness of total thyroidectomy in relieving compressive and local symptoms (such as dysphagia, dyspnea, and anterior neck pain/discomfort) in patients with Hashimoto's thyroiditis who fail to improve with conservative medical management.
Detailed description
Hashimoto's thyroiditis is a chronic autoimmune disease often presenting with goiter and local pressure symptoms. While levothyroxine replacement is standard for hypothyroidism, persistent compressive symptoms, cosmetic concerns, or suspicion of malignancy may necessitate surgical intervention.
This study investigates patients diagnosed with Hashimoto's thyroiditis presenting with significant local symptoms. Eligible patients undergoing total thyroidectomy will be evaluated preoperatively and postoperatively to assess symptom resolution, postoperative complication rates (such as hypocalcemia and recurrent laryngeal nerve injury), and overall patient satisfaction following surgery.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients diagnosed with Hashimoto's thyroiditis who suffer from persistent local compressive symptoms and undergo total thyroidectomy at the Department of Surgery, Assiut University Hospitals.
Key inclusion criteria (4 listed)
- Adults patients with confirmed Hashimoto's thyroiditis (elevated serum anti-thyroid peroxidase \anti-thyroglobulin antibodies, characteristic ultrasound findings and/or positive fine needle aspiration cytology)
- Biochemically euthyroid with normal thyroid function test.
- Presence of persistent local symptoms (neck pain, throat discomfort,neck tightness,chocking) for more than 6 months
- Patient fit and motivated to surgery.
Key exclusion criteria (5 listed)
- Confirmed or high-suspicion thyroid malignancy (Bethesda V or IV on FNAC
- Previous thyroid or neck surgery
- Patient refusal to participate in the study
- Severe comorbidities precluding general anesthesia
- Active psychiatric illness
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Total ThyroidectomySurgical removal of the entire thyroid gland performed under general anesthesia for patients with Hashimoto's thyroiditis presenting with compressive or local neck symptoms. | Procedure or surgery | – |
Primary outcome
Improvement or Relief of Local Compressive Symptoms
Time frame: 6 months postoperatively
Assessment of changes in patient-reported compressive symptoms (such as dysphagia, dyspnea, and local neck discomfort or pressure) following total thyroidectomy compared to baseline status.
1 secondary outcome
Incidence of Postoperative Complications
Time frame: Up to 30 days postoperatively
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Ahmed Gamal Hamdan, Lecturer study director
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Hashimoto Thyroiditis and Goiter, run by Assiut University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 1 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ahmed Atef Muslim, Bachelor of Medicine and Surge (+201099626447, ahmed.atef.465.aa@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Improvement or Relief of Local Compressive Symptoms (time frame: 6 months postoperatively). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Oct 2026.