FatigueNCT07855406
Effects of Physical and Cognitive Fatigue on Reaction Time and Depth Perception in Adolescents
A study testing Physical Fatigue Protocol, Cognitive Fatigue Protocol and Combined Fatigue Protocol in people with Fatigue and Reaction Time, run by AslanAhmetKaan at 1 site in Turkey (Türkiye).
Trial summary
This study investigates how physical fatigue, cognitive fatigue, and a combination of both affect reaction time and depth perception in adolescents. Sixty healthy adolescents will participate in four experimental conditions: a control condition, a physical fatigue condition, a cognitive fatigue condition, and a… Read more about this study
- Who is it for?
- Ages 14 to 18 yearsHealthy volunteers can take part
- Conditions the study is for
- Fatigue, Reaction Time, Depth Perception
- What is being tested?
- Physical Fatigue Protocol, Cognitive Fatigue Protocol and Combined Fatigue Protocol
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Apr 2026to 31 May 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 14 to 18 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- Adolescents aged 14 to 18 years.
- Male or female participants.
- Normal or corrected-to-normal vision.
- Ability to understand and follow study procedures.
- Written informed consent from both the participant and a parent/legal guardian.
Who cannot join
- History of neurological disorders.
- Visual disorders affecting depth perception.
- Orthopedic injuries or musculoskeletal conditions limiting physical activity.
- Any medical condition that would contraindicate participation in physical exercise.
- Failure to complete all experimental sessions.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Differential Effects of Physical, Cognitive, and Combined Fatigue on Reaction Time and Depth Perception in Adolescents
This study investigates how physical fatigue, cognitive fatigue, and a combination of both affect reaction time and depth perception in adolescents.
Sixty healthy adolescents will participate in four experimental conditions: a control condition, a physical fatigue condition, a cognitive fatigue condition, and a combined fatigue condition. Physical fatigue will be induced using a modified shuttle run protocol, while cognitive fatigue will be induced using computerized Stroop and mental arithmetic tasks.
Read more
Reaction time will be assessed using the BlazePod system, and depth perception will be evaluated using the Titmus Fly Stereotest before and after each condition. Heart rate, perceived exertion, and mental fatigue will also be measured to verify the effectiveness of the fatigue protocols.
The findings may improve understanding of how different types of fatigue influence perceptual and motor performance in adolescents and may contribute to the development of safer and more effective training and sport participation strategies.
Read the detailed description
Fatigue is a multifactorial phenomenon that can impair cognitive, perceptual, and motor performance. While the independent effects of physical fatigue and cognitive fatigue have been widely investigated, limited evidence exists regarding their comparative and combined effects on reaction time and depth perception during adolescence. Because perceptual and motor functions play a critical role in sports performance, injury prevention, and daily activities, understanding the effects of different fatigue states in adolescents is of practical and scientific importance.
The purpose of this study is to examine the differential effects of physical fatigue, cognitive fatigue, and combined fatigue on reaction time and depth perception in healthy adolescents. A within-subject crossover design will be employed, in which each participant completes four experimental conditions: control, physical fatigue, cognitive fatigue, and combined fatigue. Physical fatigue will be induced using a modified 20-meter shuttle run protocol. Cognitive fatigue will be induced through computerized Stroop and mental arithmetic tasks designed to impose sustained demands on attention, inhibitory control, working memory, and information processing. The combined fatigue condition will include both physical and cognitive fatigue protocols within the same session.
Reaction time will be measured using the BlazePod wireless light-based system, and depth perception will be assessed using the Titmus Fly Stereotest. Measurements will be obtained immediately before and after each experimental condition. Heart rate, rating of perceived exertion, and mental fatigue scores will be collected as manipulation checks to confirm the effectiveness of the fatigue protocols.
The results of this study are expected to improve understanding of the mechanisms through which different types of fatigue influence perceptual and motor performance in adolescents and may provide practical implications for youth sports training, performance monitoring, and injury prevention strategies.
- Conditions
- Fatigue, Reaction Time, Depth Perception
- Being tested
- Physical Fatigue Protocol, Cognitive Fatigue Protocol, Combined Fatigue Protocol, Control Condition
- Keywords
- fatigue, reaction time, depth perception, cognitive performance, psychomotor performance
- Medical subject headings
- Fatigue
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Physical Fatigue ProtocolBehavioural
A 16-minute modified 20-meter shuttle run protocol designed to induce physical fatigue through progressively increasing running intensity.
Cognitive Fatigue ProtocolBehavioural
A 16-minute computerized protocol consisting of Stroop and mental arithmetic tasks designed to induce cognitive fatigue.
Combined Fatigue ProtocolBehavioural
A protocol combining physical and cognitive fatigue tasks, including a modified shuttle run, Stroop task, and mental arithmetic task.
Control ConditionOther
Participants completed the testing procedures without exposure to any physical or cognitive fatigue protocol.
| Study group | Role | What they receive |
|---|---|---|
| Control Condition | Experimental | Participants completed the testing procedures without exposure to any physical or cognitive fatigue protocol. Reaction time and depth perception were assessed before and after the control condition. Receives: Other: Control Condition |
| Physical Fatigue Condition | Experimental | Participants completed a 16-minute modified 20-meter shuttle run protocol designed to induce physical fatigue. Reaction time and depth perception were assessed before and after the protocol. Receives: Behavioral: Physical Fatigue Protocol |
| Cognitive Fatigue Condition | Experimental | Participants completed a 16-minute cognitive fatigue protocol consisting of an 8-minute Stroop task and an 8-minute mental arithmetic task. Reaction time and depth perception were assessed before and after the protocol. Receives: Behavioral: Cognitive Fatigue Protocol |
| Combined Fatigue Condition | Experimental | Participants completed a combined fatigue protocol consisting of 8 minutes of a modified shuttle run followed by 4 minutes of a Stroop task and 4 minutes of a mental arithmetic task. Reaction time and depth perception were assessed before and after the protocol. Receives: Behavioral: Combined Fatigue Protocol |
What is being measured
The primary outcome is the main question the study is designed to answer.
Reaction Time
Reaction time will be assessed using the BlazePod wireless light-based system. Reaction time will be recorded in milliseconds as the latency between stimulus presentation and participant response. Two trials will be performed, and the best performance will be used for analysis.
Measured: Immediately before and immediately after each experimental condition.
Depth Perception
Depth perception will be assessed using the Titmus Fly Stereotest. Stereopsis will be expressed in arc seconds, with lower values indicating better depth perception performance. Two trials will be conducted at each measurement point, and the lowest value will be used for analysis.
Measured: Immediately before and immediately after each experimental condition.
Secondary outcomes (3)
Heart Rate
Heart rate will be measured before and after each experimental condition using photoplethysmography (PPG)-based smartwatches to verify the effectiveness of fatigue induction.
Measured: Immediately before and immediately after each experimental condition.
Rating of Perceived Exertion (RPE)
Perceived exertion will be assessed using the Borg CR-20 Scale before and after each experimental condition to evaluate subjective fatigue levels.
Measured: Perceived exertion will be assessed using the Borg CR-20 Scale before and after each experimental condition to evaluate subjective fatigue levels.
Mental Fatigue Scale Score
Mental fatigue will be assessed using the Mental Fatigue Scale (MFS), a 15-item self-report questionnaire measuring cognitive, emotional, and sensory aspects of fatigue.
Measured: Immediately before and immediately after each experimental condition.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Oct 2026
- Study start1 Apr 2026
- Primary completion21 May 2026
- Study completion31 May 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for FatigueStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- This study uses a counterbalanced within-subject crossover design. Each participant completes four experimental conditions (control, physical fatigue, cognitive fatigue, and combined fatigue) in a randomized counterbalanced order. A minimum 24-hour washout period is provided between sessions to minimize carryover effects. Reaction time and depth perception are assessed immediately before and after each condition, allowing each participant to serve as their own control.
- Masking
- None (open label)
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- AslanAhmetKaan
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ahmet Kaan Aslan, AslanAhmetKaan
- Investigators
- Ahmet Kaan ASLAN, PhD, Principal investigator, Gazi University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07855406
- Sponsor's protocol ID
- Kaaslan-1
- Status last verified
- Sep 2026
- First submitted
- 28 Sep 2026
- Last updated
- 2 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be made publicly available. Data contain information collected from adolescent participants, and sharing is restricted to protect participant confidentiality and privacy.
Study at a glance
From the registry record, last updated by the sponsor on 2 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Differential Effects of Physical, Cognitive, and Combined Fatigue on Reaction Time and Depth Perception in Adolescents
- ClinicalTrials.gov ID
- NCT07855406
- Acronym / sponsor ID
- Kaaslan-1
- Conditions
- Fatigue, Reaction Time, Depth Perception
- Keywords
- fatigue, reaction time, depth perception, cognitive performance, psychomotor performance
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- AslanAhmetKaanUniversity, hospital or other
- Study start
- 1 Apr 2026 (actual)
- Primary completion
- 21 May 2026 (actual)
- Study completion
- 31 May 2026 (actual)
- First posted
- 2 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study investigates how physical fatigue, cognitive fatigue, and a combination of both affect reaction time and depth perception in adolescents.
Sixty healthy adolescents will participate in four experimental conditions: a control condition, a physical fatigue condition, a cognitive fatigue condition, and a combined fatigue condition. Physical fatigue will be induced using a modified shuttle run protocol, while cognitive fatigue will be induced using computerized Stroop and mental arithmetic tasks.
Reaction time will be assessed using the BlazePod system, and depth perception will be evaluated using the Titmus Fly Stereotest before and after each condition. Heart rate, perceived exertion, and mental fatigue will also be measured to verify the effectiveness of the fatigue protocols.
The findings may improve understanding of how different types of fatigue influence perceptual and motor performance in adolescents and may contribute to the development of safer and more effective training and sport participation strategies.
Detailed description
Fatigue is a multifactorial phenomenon that can impair cognitive, perceptual, and motor performance. While the independent effects of physical fatigue and cognitive fatigue have been widely investigated, limited evidence exists regarding their comparative and combined effects on reaction time and depth perception during adolescence. Because perceptual and motor functions play a critical role in sports performance, injury prevention, and daily activities, understanding the effects of different fatigue states in adolescents is of practical and scientific importance.
The purpose of this study is to examine the differential effects of physical fatigue, cognitive fatigue, and combined fatigue on reaction time and depth perception in healthy adolescents. A within-subject crossover design will be employed, in which each participant completes four experimental conditions: control, physical fatigue, cognitive fatigue, and combined fatigue. Physical fatigue will be induced using a modified 20-meter shuttle run protocol. Cognitive fatigue will be induced through computerized Stroop and mental arithmetic tasks designed to impose sustained demands on attention, inhibitory control, working memory, and information processing. The combined fatigue condition will include both physical and cognitive fatigue protocols within the same session.
Reaction time will be measured using the BlazePod wireless light-based system, and depth perception will be assessed using the Titmus Fly Stereotest. Measurements will be obtained immediately before and after each experimental condition. Heart rate, rating of perceived exertion, and mental fatigue scores will be collected as manipulation checks to confirm the effectiveness of the fatigue protocols.
The results of this study are expected to improve understanding of the mechanisms through which different types of fatigue influence perceptual and motor performance in adolescents and may provide practical implications for youth sports training, performance monitoring, and injury prevention strategies.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 4
- Model description
- This study uses a counterbalanced within-subject crossover design. Each participant completes four experimental conditions (control, physical fatigue, cognitive fatigue, and combined fatigue) in a randomized counterbalanced order. A minimum 24-hour washout period is provided between sessions to minimize carryover effects. Reaction time and depth perception are assessed immediately before and after each condition, allowing each participant to serve as their own control.
| Arm | Type | Receives |
|---|---|---|
| Control Condition | Experimental | Other: Control ConditionParticipants completed the testing procedures without exposure to any physical or cognitive fatigue protocol. Reaction time and depth perception were assessed before and after the control condition. |
| Physical Fatigue Condition | Experimental | Behavioral: Physical Fatigue ProtocolParticipants completed a 16-minute modified 20-meter shuttle run protocol designed to induce physical fatigue. Reaction time and depth perception were assessed before and after the protocol. |
| Cognitive Fatigue Condition | Experimental | Behavioral: Cognitive Fatigue ProtocolParticipants completed a 16-minute cognitive fatigue protocol consisting of an 8-minute Stroop task and an 8-minute mental arithmetic task. Reaction time and depth perception were assessed before and after the protocol. |
| Combined Fatigue Condition | Experimental | Behavioral: Combined Fatigue ProtocolParticipants completed a combined fatigue protocol consisting of 8 minutes of a modified shuttle run followed by 4 minutes of a Stroop task and 4 minutes of a mental arithmetic task. Reaction time and depth perception were assessed before and after the protocol. |
Who may qualify
- Ages
- 14 to 18 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (5 listed)
- Adolescents aged 14 to 18 years.
- Male or female participants.
- Normal or corrected-to-normal vision.
- Ability to understand and follow study procedures.
- Written informed consent from both the participant and a parent/legal guardian.
Key exclusion criteria (5 listed)
- History of neurological disorders.
- Visual disorders affecting depth perception.
- Orthopedic injuries or musculoskeletal conditions limiting physical activity.
- Any medical condition that would contraindicate participation in physical exercise.
- Failure to complete all experimental sessions.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Physical Fatigue ProtocolA 16-minute modified 20-meter shuttle run protocol designed to induce physical fatigue through progressively increasing running intensity. | Behavioural | Physical Fatigue Condition |
| Cognitive Fatigue ProtocolA 16-minute computerized protocol consisting of Stroop and mental arithmetic tasks designed to induce cognitive fatigue. | Behavioural | Cognitive Fatigue Condition |
| Combined Fatigue ProtocolA protocol combining physical and cognitive fatigue tasks, including a modified shuttle run, Stroop task, and mental arithmetic task. | Behavioural | Combined Fatigue Condition |
| Control ConditionParticipants completed the testing procedures without exposure to any physical or cognitive fatigue protocol. | Other | Control Condition |
Primary outcome
Reaction Time
Time frame: Immediately before and immediately after each experimental condition.
Reaction time will be assessed using the BlazePod wireless light-based system. Reaction time will be recorded in milliseconds as the latency between stimulus presentation and participant response. Two trials will be performed, and the best performance will be used for analysis.
Depth Perception
Time frame: Immediately before and immediately after each experimental condition.
Depth perception will be assessed using the Titmus Fly Stereotest. Stereopsis will be expressed in arc seconds, with lower values indicating better depth perception performance. Two trials will be conducted at each measurement point, and the lowest value will be used for analysis.
3 secondary outcomes
Heart Rate
Time frame: Immediately before and immediately after each experimental condition.
Rating of Perceived Exertion (RPE)
Time frame: Perceived exertion will be assessed using the Borg CR-20 Scale before and after each experimental condition to evaluate subjective fatigue levels.
Mental Fatigue Scale Score
Time frame: Immediately before and immediately after each experimental condition.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Oct 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be made publicly available. Data contain information collected from adolescent participants, and sharing is restricted to protect participant confidentiality and privacy.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ahmet Kaan ASLAN, PhD principal investigator
Gazi University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Physical Fatigue Protocol, Cognitive Fatigue Protocol and Combined Fatigue Protocol in people with Fatigue and Reaction Time, run by AslanAhmetKaan at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Reaction Time (time frame: Immediately before and immediately after each experimental condition.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Oct 2026.