Post Operative PainNCT07855549
Comparative Study Between Erector Spinae Plane Block Versus Combined Pectoralis and Serratus Interfascial Plane Blocks for Post-operative Analgesia After Thoracic Surgery.
A study testing Erector spinae plane block and Combined pectoralis and serratus anterior plane blocks in people with Post Operative Pain and Thoracic Surgery, run by Minia University at 1 site in Egypt.
Trial summary
The aim of this study is to evaluate the effect of combined pectoralis II and serratus interfascial plane blocks in comparison with erector spinae plane block on post-operative analgesia after thoracic surgeries. Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Post Operative Pain, Thoracic Surgery
- What is being tested?
- Erector spinae plane block and Combined pectoralis and serratus anterior plane blocks
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 66 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Apr 2025to Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Body mass index (BMI) from 20 - 35 kg/m2.
- ASA physical status I\&II .
Who cannot join
- Patients with signs of active infection or infection at the site of block placement.
- Refusal of consent.
- History of any motor or sensory deficits as peripheral neuropathy
- History of stroke with residual muscle weakness
- multiple sclerosis
- pre-existing sensory loss as diabetic neuropathy, spinal cord injury
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- spine abnormalities as kypholordosis.
- Hypersensitivity or allergy to the drugs used for block.
- Patients with coagulopathy or on anticoagulant therapy.
- Extended incision not covered by the block (posterior or medial extended incision).
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Randomized Controlled Double Blinded Comparative Study Between Erector Spinae Plane Block Versus Combined Pectoralis and Serratus Interfascial Plane Blocks for Post-operative Analgesia After Thoracic Surgery.
The aim of this study is to evaluate the effect of combined pectoralis II and serratus interfascial plane blocks in comparison with erector spinae plane block on post-operative analgesia after thoracic surgeries.
- Conditions
- Post Operative Pain, Thoracic Surgery
- Being tested
- Erector spinae plane block, Combined pectoralis and serratus anterior plane blocks
- Keywords
- Nerve block in thoracic surgery
- Medical subject headings
- Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Erector spinae plane blockProcedure or surgery
Also called ESPB
Patients will be positioned in the lateral position, The thoracic vertebrae spinous process convenient to level of incision (T5-T7:the level which covers thoracic area) will be identified and the transducer will be placed approximately to 2-3 cm lateral to midline ,The needle tip will be advanced until it is located in the interfascial plane deep to the erector spinae muscle group and superior to the transverse process. Once in position, 30 ml bupivacaine 0.25% will be injected under ultrasound guidance. Correct needle-tip position will be confirmed by the presence of linear spread between the transverse process and the presence of linear spread between the transverse process and the erector spinae muscle group.
Combined pectoralis and serratus anterior plane blocksProcedure or surgery
Also called PECS &SAPB
Serratus anterior plane block will be performed with the patient in the supine position , The probe will be placed in a sagittal position, the mid-axillary region of the thoracic cage. The needle will be advanced with an in-plane technique and 20 ml bupivacaine 0.25% will be injected .
PECS block will be performed at the same position. The ultrasound probe will be placed obliquely over the lateral third of the clavicle. the needle will be advanced, in the same plane as the probe, from the medial to lateral direction ,10 ml 0.25% bupivacaine will be injected. Then the needle will be advanced to the fascial plane between the pectoralis minor and serratus anterior muscles, at which point an additional 10 ml 0.25% bupivacaine will be administered.
| Study group | Role | What they receive |
|---|---|---|
| Erector spinae group | Active comparator | Sonar guided interfacial plane block deep to erector spinae muscle that targets dorsal and central Rami of spinal nerves Receives: Procedure: Erector spinae plane block |
| Combined pectoralis and serratus anterior group | Active comparator | Sonar guided interfacial plane blocks firstly pectoralis plane block that targets lateral and medial pectoral nerves then serratus anterior plane block that targets lateral branches of intercostal nerves Receives: Procedure: Combined pectoralis and serratus anterior plane blocks |
| Controlled group | No intervention | This group doesn't receive any nerve block |
What is being measured
The primary outcome is the main question the study is designed to answer.
First analgesic request
The time of first request to analgesia by patient post operative
Measured: 24 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Oct 2026
- Study start1 Apr 2025
- Primary completionNov 2026 (estimated)
- Study completionNov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Post Operative PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 66 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Minia University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Aya Sedeek Mostafa, Minia University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07855549
- Sponsor's protocol ID
- thoracic surgery analgesia
- Status last verified
- Nov 2025
- First submitted
- 28 Sep 2026
- Last updated
- 8 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Not decided yet
Study at a glance
From the registry record, last updated by the sponsor on 8 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Randomized Controlled Double Blinded Comparative Study Between Erector Spinae Plane Block Versus Combined Pectoralis and Serratus Interfascial Plane Blocks for Post-operative Analgesia After Thoracic Surgery.
- ClinicalTrials.gov ID
- NCT07855549
- Acronym / sponsor ID
- thoracic surgery analgesia
- Conditions
- Post Operative Pain, Thoracic Surgery
- Keywords
- Nerve block in thoracic surgery
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 66 participants (estimated)
- Lead sponsor
- Minia UniversityUniversity, hospital or other
- Study start
- 1 Apr 2025 (actual)
- Primary completion
- Nov 2026 (estimated)
- Study completion
- Nov 2026 (estimated)
- First posted
- 2 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to evaluate the effect of combined pectoralis II and serratus interfascial plane blocks in comparison with erector spinae plane block on post-operative analgesia after thoracic surgeries.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Erector spinae group | Active comparator | Procedure: Erector spinae plane blockSonar guided interfacial plane block deep to erector spinae muscle that targets dorsal and central Rami of spinal nerves |
| Combined pectoralis and serratus anterior group | Active comparator | Procedure: Combined pectoralis and serratus anterior plane blocksSonar guided interfacial plane blocks firstly pectoralis plane block that targets lateral and medial pectoral nerves then serratus anterior plane block that targets lateral branches of intercostal nerves |
| Controlled group | No intervention | –This group doesn't receive any nerve block |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Body mass index (BMI) from 20 - 35 kg/m2.
- ASA physical status I\&II .
Key exclusion criteria (10 listed)
- Patients with signs of active infection or infection at the site of block placement.
- Refusal of consent.
- History of any motor or sensory deficits as peripheral neuropathy
- History of stroke with residual muscle weakness
- multiple sclerosis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Erector spinae plane blockAlso: ESPBPatients will be positioned in the lateral position, The thoracic vertebrae spinous process convenient to level of incision (T5-T7:the level which covers thoracic area) will be identified and the transducer will be placed approximately to 2-3 cm lateral to midline ,The needle tip will be advanced until it is located in the interfascial plane deep to the erector spinae muscle group and superior to the transverse process. Once in position, 30 ml bupivacaine 0.25% will be injected under ultrasound guidance. Correct needle-tip position will be confirmed by the presence of linear spread between the transverse process and the presence of linear spread between the transverse process and the erector spinae muscle group. | Procedure or surgery | Erector spinae group |
| Combined pectoralis and serratus anterior plane blocksAlso: PECS &SAPBSerratus anterior plane block will be performed with the patient in the supine position , The probe will be placed in a sagittal position, the mid-axillary region of the thoracic cage. The needle will be advanced with an in-plane technique and 20 ml bupivacaine 0.25% will be injected . PECS block will be performed at the same position. The ultrasound probe will be placed obliquely over the lateral third of the clavicle. the needle will be advanced, in the same plane as the probe, from the medial to lateral direction ,10 ml 0.25% bupivacaine will be injected. Then the needle will be advanced to the fascial plane between the pectoralis minor and serratus anterior muscles, at which point an additional 10 ml 0.25% bupivacaine will be administered. | Procedure or surgery | Combined pectoralis and serratus anterior group |
Primary outcome
First analgesic request
Time frame: 24 hours
The time of first request to analgesia by patient post operative
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Oct 2026.
- Individual participant dataSharing planned: Undecided. Not decided yet
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Erector spinae plane block and Combined pectoralis and serratus anterior plane blocks in people with Post Operative Pain and Thoracic Surgery, run by Minia University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 8 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
First analgesic request (time frame: 24 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Oct 2026.