Vaccine HesitancyVaxNurse-RCTNCT07859579
Development and Evaluation of a Digital Educational Intervention to Improve Vaccine Confidence and Communication Among Registered Nurses: Protocol for a Randomized Controlled Trial (VaxNurse-RCT).
A study testing Digital educational intervention in people with Vaccine Hesitancy and Vaccine Acceptance, run by Universite du Quebec en Outaouais at 1 site in Canada.
Trial summary
Nurses play an important role in providing vaccine information and supporting informed vaccination decisions. This study will evaluate a digital educational intervention designed for registered nurses in Quebec. Read more about this study
- Who is it for?
- Ages 18 to 62 yearsHealthy volunteers can take part
- Conditions the study is for
- Vaccine Hesitancy, Vaccine Acceptance
- What is being tested?
- Digital educational intervention
- Type of treatment
- Vaccines
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- 1 siteCanada
- Study dates
- 1 Jan 2027to 31 Dec 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 62 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Registered nurse authorized to practice in Quebec.
- Aged 18 years or older.
- Able to provide informed consent.
- Able to complete the study questionnaires in French or English and digital educational intervention in French.
Who cannot join
- Not currently authorized to practice as a registered nurse in Quebec.
- Unable to provide informed consent.
- Previous participation in the VaxNurse pilot study.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Canada1 site
Université du Québec en Outaouais
Saint-Jérôme, J7Z 0B7
Philippe Corsenac, Ph.D.
About this study
Nurses play an important role in providing vaccine information and supporting informed vaccination decisions.
This study will evaluate a digital educational intervention designed for registered nurses in Quebec. The intervention will provide education about vaccination, including immunology, epidemiology, vaccine communication, motivational interviewing, and responding to vaccine misinformation.
Read more
Registered nurses will be randomly assigned to either the intervention group or a control group. The study will examine whether the intervention improves vaccine confidence and vaccine communication compared with the control group.
Participants will complete questionnaires before and after the intervention, with follow-up assessments at 3 and 6 months. The study will assess vaccine hesitancy and changes in vaccine-related knowledge, communication skills, and vaccination recommendation practices.
The findings will help determine whether a digital educational intervention can support nurses in their vaccine-related communication and professional practice.
Read the detailed description
Vaccine hesitancy can influence vaccine acceptance and communication between healthcare professionals and the public. Registered nurses have an important role in vaccination, including providing information, addressing concerns, and recommending vaccination.
This study will evaluate a digital educational intervention designed to strengthen knowledge related to vaccines, confidence, and communication among registered nurses in Quebec. The intervention will complement existing immunization training of INSPQ. It will integrate content on immunology, epidemiology, motivational interviewing, vaccine communication, and responses to vaccine misinformation.
The study will use a randomized controlled design with two parallel groups. Participants will be randomly assigned to the digital educational intervention + immunization training of INSPQ or the control condition (the immunization training of INSPQ, only). The intervention will be evaluated using measurements collected before and after the intervention and during follow-up (3 months and 6 months).
The primary focus will be the effect of the intervention on vaccine hesitancy of nurses. Secondary aims will include vaccine recommendation practices, immunological and epidemiological knowledge, and vaccine communication competencies.
Questionnaires will also examine psychosocial determinants of vaccination attitudes and behaviors. The pilot phase preceding the randomized trial will support refinement of the intervention, questionnaires, study procedures, and measurement instruments.
The study aims to generate evidence on whether digital education can strengthen nurses' vaccine-related competencies and support their communication with patients and the public.
- Conditions
- Vaccine Hesitancy, Vaccine Acceptance
- Being tested
- Digital educational intervention
- Keywords
- vaccination, Registered nurses, vaccine communication, motivational onterviewing, digital education, vaccine misinformation, health promotion
- Medical subject headings
- Vaccination Hesitancy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Digital educational interventionOther
The VaxNurse digital educational intervention is designed for registered nurses. It includes educational content on immunology and epidemiology, motivational interviewing, vaccine communication, and strategies for responding to vaccine misinformation. The intervention aims to reduce vaccine hesitancy and strengthen knowledge related to vaccine, confidence, communication skills, and recommendation practices. It complements existing immunization training provided by the INSPQ.
| Study group | Role | What they receive |
|---|---|---|
| Digital educational intervention + immunization training of INSPQ | Experimental | Registered nurses assigned to this arm will receive the digital educational intervention in addition to the existing immunization training provided by the INSPQ. The digital intervention will include immunology, epidemiology, motivational interviewing, vaccine communication, and strategies for responding to vaccine misinformation. Receives: Other: Digital educational intervention |
| Control | Experimental | Registered nurses assigned to this arm will receive the existing immunization training provided by the INSPQ without the additional digital educational intervention. Receives: Other: Digital educational intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
the Vaccine Hesitancy Scale (VHS)
Vaccine hesitancy will be assessed using the Vaccine Hesitancy Scale (VHS). The total score ranges from 10 to 50, with higher scores indicating greater vaccine hesitancy. Change from baseline will be compared between the intervention and control groups across follow-up assessments.
Measured: Baseline (T0), immediately post-intervention (Ti), 3 months, and 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Oct 2026
- Study start1 Jan 2027 (estimated)
- Primary completion1 Jan 2027 (estimated)
- Study completion31 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Vaccine HesitancyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomized 1:1 to either the digital educational intervention + immunization training of INSPQ or the control condition (the immunization training of INSPQ only). They will followed for six months (T 3 months and T 6 months)
- Masking
- None (open label)
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Universite du Quebec en Outaouais
- Sponsor type
- University, hospital or other
- Collaborators
- Ministere de la Sante et des Services Sociaux, McGill University, Angers University, Université Victor Segalen Bordeaux 2, ordre des infirmières et des infirmiers du Québec
- Responsible party
- Principal investigator, Corsenac Philippe, Universite du Quebec en Outaouais
- Investigators
- Philippe Corsenac, Ph.D., Principal investigator, Université du Québec en Outaouais
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07859579
- Sponsor's protocol ID
- CDC-453
- Acronym
- VaxNurse-RCT
- Status last verified
- Sep 2026
- First submitted
- 30 Sep 2026
- Last updated
- 6 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Development and Evaluation of a Digital Educational Intervention to Improve Vaccine Confidence and Communication Among Registered Nurses: Protocol for a Randomized Controlled Trial (VaxNurse-RCT).
- ClinicalTrials.gov ID
- NCT07859579
- Acronym / sponsor ID
- VaxNurse-RCT / CDC-453
- Conditions
- Vaccine Hesitancy, Vaccine Acceptance
- Keywords
- vaccination, Registered nurses, vaccine communication, motivational onterviewing, digital education, vaccine misinformation, health promotion
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Universite du Quebec en OutaouaisUniversity, hospital or other
- Collaborators
- Ministere de la Sante et des Services Sociaux, McGill University, Angers University, Université Victor Segalen Bordeaux 2, ordre des infirmières et des infirmiers du Québec
- Study start
- 1 Jan 2027 (estimated)
- Primary completion
- 1 Jan 2027 (estimated)
- Study completion
- 31 Dec 2027 (estimated)
- First posted
- 6 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Nurses play an important role in providing vaccine information and supporting informed vaccination decisions.
This study will evaluate a digital educational intervention designed for registered nurses in Quebec. The intervention will provide education about vaccination, including immunology, epidemiology, vaccine communication, motivational interviewing, and responding to vaccine misinformation.
Registered nurses will be randomly assigned to either the intervention group or a control group. The study will examine whether the intervention improves vaccine confidence and vaccine communication compared with the control group.
Participants will complete questionnaires before and after the intervention, with follow-up assessments at 3 and 6 months. The study will assess vaccine hesitancy and changes in vaccine-related knowledge, communication skills, and vaccination recommendation practices.
The findings will help determine whether a digital educational intervention can support nurses in their vaccine-related communication and professional practice.
Detailed description
Vaccine hesitancy can influence vaccine acceptance and communication between healthcare professionals and the public. Registered nurses have an important role in vaccination, including providing information, addressing concerns, and recommending vaccination.
This study will evaluate a digital educational intervention designed to strengthen knowledge related to vaccines, confidence, and communication among registered nurses in Quebec. The intervention will complement existing immunization training of INSPQ. It will integrate content on immunology, epidemiology, motivational interviewing, vaccine communication, and responses to vaccine misinformation.
The study will use a randomized controlled design with two parallel groups. Participants will be randomly assigned to the digital educational intervention + immunization training of INSPQ or the control condition (the immunization training of INSPQ, only). The intervention will be evaluated using measurements collected before and after the intervention and during follow-up (3 months and 6 months).
The primary focus will be the effect of the intervention on vaccine hesitancy of nurses. Secondary aims will include vaccine recommendation practices, immunological and epidemiological knowledge, and vaccine communication competencies.
Questionnaires will also examine psychosocial determinants of vaccination attitudes and behaviors. The pilot phase preceding the randomized trial will support refinement of the intervention, questionnaires, study procedures, and measurement instruments.
The study aims to generate evidence on whether digital education can strengthen nurses' vaccine-related competencies and support their communication with patients and the public.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants will be randomized 1:1 to either the digital educational intervention + immunization training of INSPQ or the control condition (the immunization training of INSPQ only). They will followed for six months (T 3 months and T 6 months)
| Arm | Type | Receives |
|---|---|---|
| Digital educational intervention + immunization training of INSPQ | Experimental | Other: Digital educational interventionRegistered nurses assigned to this arm will receive the digital educational intervention in addition to the existing immunization training provided by the INSPQ. The digital intervention will include immunology, epidemiology, motivational interviewing, vaccine communication, and strategies for responding to vaccine misinformation. |
| Control | Experimental | Other: Digital educational interventionRegistered nurses assigned to this arm will receive the existing immunization training provided by the INSPQ without the additional digital educational intervention. |
Who may qualify
- Ages
- 18 to 62 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Registered nurse authorized to practice in Quebec.
- Aged 18 years or older.
- Able to provide informed consent.
- Able to complete the study questionnaires in French or English and digital educational intervention in French.
Key exclusion criteria (3 listed)
- Not currently authorized to practice as a registered nurse in Quebec.
- Unable to provide informed consent.
- Previous participation in the VaxNurse pilot study.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Digital educational interventionThe VaxNurse digital educational intervention is designed for registered nurses. It includes educational content on immunology and epidemiology, motivational interviewing, vaccine communication, and strategies for responding to vaccine misinformation. The intervention aims to reduce vaccine hesitancy and strengthen knowledge related to vaccine, confidence, communication skills, and recommendation practices. It complements existing immunization training provided by the INSPQ. | Other | Control, Digital educational intervention + immunization training of INSPQ |
Primary outcome
the Vaccine Hesitancy Scale (VHS)
Time frame: Baseline (T0), immediately post-intervention (Ti), 3 months, and 6 months
Vaccine hesitancy will be assessed using the Vaccine Hesitancy Scale (VHS). The total score ranges from 10 to 50, with higher scores indicating greater vaccine hesitancy. Change from baseline will be compared between the intervention and control groups across follow-up assessments.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Philippe Corsenac, Ph.D. principal investigator
Université du Québec en Outaouais
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Digital educational intervention in people with Vaccine Hesitancy and Vaccine Acceptance, run by Universite du Quebec en Outaouais at 1 site in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 6 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
the Vaccine Hesitancy Scale (VHS) (time frame: Baseline (T0), immediately post-intervention (Ti), 3 months, and 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Oct 2026.