GonarthrosisNCT07867405
The Effect of Tail Fat Application on Joint Pain, Joint Stiffness, and Daily Living Activities in Patients With Gonarthrosis
A study testing Sheep Tail Fat and Standard medical treatment in people with Gonarthrosis, run by Inonu University at 2 sites in Turkey (Türkiye).
Trial summary
In recent years, experimental and clinical studies conducted on sheep tail fat, a natural and easily accessible resource, have shown that bioactive components found in sheep tail fat, such as palmitic acid, stearic acid, oleic acid, linoleic acid, and myristic acid, have anti-inflammatory and chondroprotective… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Gonarthrosis
- What is being tested?
- Sheep Tail Fat and Standard medical treatment
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 66 participants
- Where
- 2 sitesTurkey (Türkiye)
- Study dates
- 12 May 2026to 31 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients diagnosed with gonarthrosis by a physician.
- Patients with a VAS score above 4.
- Individuals who have experienced pain related to knee osteoarthritis for at least the last 3 months.
- Participants aged 18 years and older.
- Individuals without an allergy to sheep tail fat or other animal products.
- Individuals who can communicate in Turkish and understand written and verbal instructions.
- Individuals who can apply the sheep tail fat according to the instructions.
- Individuals who agree to participate in the study.
Who cannot join
- Individuals with severe physical disability or mental/psychological problems in the knee region.
- Individuals with intellectual or cognitive limitations.
- Individuals who have undergone knee surgery within the last year.
- Individuals with peripheral vascular disease.
- Individuals with infection, wound, cellulitis, or active skin disease in the knee region.
- Individuals who have experienced knee trauma or received an intra-articular steroid injection within the last six months.
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- Individuals diagnosed with secondary arthritis or inflammatory joint disease.
- Pregnant or breastfeeding women.
- Individuals with active bleeding disorders.
- Individuals with asthma and individuals with liver or kidney failure.
- Individuals with connective tissue diseases (e.g., lupus, systemic sclerosis).
- Individuals who have experienced a serious infection within the last three months or are immunosuppressed.
- Individuals with neurological diseases affecting knee stability.
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)2 sites, 2 recruiting
- Recruiting
Bitlis State Hospital
Bitlis
Veysi TÖR, 05063149754, vtor@beu.edu.tr
- Recruiting
Bitlis Tatvan State Hospital
Bitlis
veysi tör, 05063149754, vtor@beu.edu.tr
About this study
In recent years, experimental and clinical studies conducted on sheep tail fat, a natural and easily accessible resource, have shown that bioactive components found in sheep tail fat, such as palmitic acid, stearic acid, oleic acid, linoleic acid, and myristic acid, have anti-inflammatory and chondroprotective (cartilage-protective) properties. In addition, literature reviews have revealed that sheep tail fat alleviates joint pain and has a positive effect on joint stiffness. Sheep tail fat is known to be frequently used by patients with gonarthrosis (knee osteoarthritis) in Türkiye and many other countries as a traditional and complementary medicine method.
In this context, this study is designed as a randomized controlled experimental study to evaluate the effects of sheep tail fat application on pain, joint stiffness, and activities of daily living in patients with gonarthrosis. The study population consists of patients diagnosed with gonarthrosis who apply to the Physical Therapy and Rehabilitation outpatient clinics of two state hospitals located in Bitlis. According to the sample size calculation performed using G*Power 3.1.9.7 software, a total of 66 participants were determined and randomly assigned to the experimental and control groups. Participants in the experimental group will receive topical sheep tail fat application in addition to standard medical treatment, while the control group will continue to receive standard medical treatment only.
Read more
Data collection tools include the Patient Identification Form developed by the researcher, the Visual Analog Scale (VAS) for assessing pain intensity, and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for assessing pain, joint stiffness, and daily physical function. These scales will be administered at baseline and again after completion of the intervention period.
The double-boiler (bain-marie) method is used to obtain the sheep tail fat, and participants are provided with training on the application techniques. The required ethics committee approval and institutional permissions from the relevant healthcare institutions have been obtained, and written informed consent has been obtained from all participants. Hamdani sheep, one of the sheep breeds commonly raised and traditionally preferred in the region where the study is conducted, are used to obtain the sheep tail fat.
For the statistical analysis of the data, in addition to descriptive statistics, the paired-samples t-test or Wilcoxon signed-rank test will be used for within-group comparisons, while the independent-samples t-test or Mann-Whitney U test will be used for between-group comparisons. When the assumptions of parametric tests are not met, appropriate non-parametric methods will be preferred.
This study aims to contribute scientifically to clinical decision-making processes regarding traditional and complementary treatment approaches by evaluating, within an evidence-based framework, the effectiveness of a method traditionally used for the management of gonarthrosis symptoms in many countries. It also aims to support the standardization of traditional, complementary, and alternative medicine practices and to provide scientific evidence regarding a low-cost, natural, non-invasive, and accessible alternative treatment option. In addition, the findings are expected to guide the development of new strategies to improve functional well-being in patients with gonarthrosis.
- Conditions
- Gonarthrosis
- Being tested
- Sheep Tail Fat, Standard medical treatment
- Keywords
- gonarthrosis
- Medical subject headings
- Osteoarthritis, Knee
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Sheep Tail FatOther
Topical application of sheep tail fat to the knee once daily for two weeks, seven days per week, with each application lasting at least three hours.
Standard medical treatmentOther
Participants in the control group will receive standard medical treatment only.
| Study group | Role | What they receive |
|---|---|---|
| Experimental Group(Sheep Tail Fat + Standard Treatment) | Experimental | Participants in this group will receive topical sheep tail fat application in addition to standard medical treatment. Receives: Other: Sheep Tail Fat |
| Control Group(Standard Medical Treatment) | Active comparator | Participants in this group will receive standard medical treatment only. Receives: Other: Standard medical treatment |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain intensity measured by the Visual Analog Scale (VAS)
Pain intensity will be assessed using the Visual Analog Scale (VAS), ranging from 0 to 10, with higher scores indicating greater pain intensity.
Measured: Baseline and 2 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Oct 2026
- Study start12 May 2026
- Primary completion31 Jan 2027 (estimated)
- Study completion31 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for GonarthrosisStudies of the same condition, open and under way.
- More trials run by Inonu UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 66 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Inonu University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Medet Korkmaz, Inonu University
- Investigators
- Medet KORKMAZ, Study director, Inonu University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07867405
- Sponsor's protocol ID
- ınonu2
- Status last verified
- Oct 2026
- First submitted
- 29 Sep 2026
- Last updated
- 9 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 9 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Tail Fat Application on Joint Pain, Joint Stiffness, and Daily Living Activities in Patients With Gonarthrosis
- ClinicalTrials.gov ID
- NCT07867405
- Acronym / sponsor ID
- ınonu2
- Conditions
- Gonarthrosis
- Keywords
- gonarthrosis
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 66 participants (estimated)
- Lead sponsor
- Inonu UniversityUniversity, hospital or other
- Study start
- 12 May 2026 (actual)
- Primary completion
- 31 Jan 2027 (estimated)
- Study completion
- 31 Jan 2027 (estimated)
- First posted
- 9 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In recent years, experimental and clinical studies conducted on sheep tail fat, a natural and easily accessible resource, have shown that bioactive components found in sheep tail fat, such as palmitic acid, stearic acid, oleic acid, linoleic acid, and myristic acid, have anti-inflammatory and chondroprotective (cartilage-protective) properties. In addition, literature reviews have revealed that sheep tail fat alleviates joint pain and has a positive effect on joint stiffness. Sheep tail fat is known to be frequently used by patients with gonarthrosis (knee osteoarthritis) in Türkiye and many other countries as a traditional and complementary medicine method.
In this context, this study is designed as a randomized controlled experimental study to evaluate the effects of sheep tail fat application on pain, joint stiffness, and activities of daily living in patients with gonarthrosis. The study population consists of patients diagnosed with gonarthrosis who apply to the Physical Therapy and Rehabilitation outpatient clinics of two state hospitals located in Bitlis. According to the sample size calculation performed using G*Power 3.1.9.7 software, a total of 66 participants were determined and randomly assigned to the experimental and control groups. Participants in the experimental group will receive topical sheep tail fat application in addition to standard medical treatment, while the control group will continue to receive standard medical treatment only.
Data collection tools include the Patient Identification Form developed by the researcher, the Visual Analog Scale (VAS) for assessing pain intensity, and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for assessing pain, joint stiffness, and daily physical function. These scales will be administered at baseline and again after completion of the intervention period.
The double-boiler (bain-marie) method is used to obtain the sheep tail fat, and participants are provided with training on the application techniques. The required ethics committee approval and institutional permissions from the relevant healthcare institutions have been obtained, and written informed consent has been obtained from all participants. Hamdani sheep, one of the sheep breeds commonly raised and traditionally preferred in the region where the study is conducted, are used to obtain the sheep tail fat.
For the statistical analysis of the data, in addition to descriptive statistics, the paired-samples t-test or Wilcoxon signed-rank test will be used for within-group comparisons, while the independent-samples t-test or Mann-Whitney U test will be used for between-group comparisons. When the assumptions of parametric tests are not met, appropriate non-parametric methods will be preferred.
This study aims to contribute scientifically to clinical decision-making processes regarding traditional and complementary treatment approaches by evaluating, within an evidence-based framework, the effectiveness of a method traditionally used for the management of gonarthrosis symptoms in many countries. It also aims to support the standardization of traditional, complementary, and alternative medicine practices and to provide scientific evidence regarding a low-cost, natural, non-invasive, and accessible alternative treatment option. In addition, the findings are expected to guide the development of new strategies to improve functional well-being in patients with gonarthrosis.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Experimental Group(Sheep Tail Fat + Standard Treatment) | Experimental | Other: Sheep Tail FatParticipants in this group will receive topical sheep tail fat application in addition to standard medical treatment. |
| Control Group(Standard Medical Treatment) | Active comparator | Other: Standard medical treatmentParticipants in this group will receive standard medical treatment only. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Patients diagnosed with gonarthrosis by a physician.
- Patients with a VAS score above 4.
- Individuals who have experienced pain related to knee osteoarthritis for at least the last 3 months.
- Participants aged 18 years and older.
- Individuals without an allergy to sheep tail fat or other animal products.
Key exclusion criteria (13 listed)
- Individuals with severe physical disability or mental/psychological problems in the knee region.
- Individuals with intellectual or cognitive limitations.
- Individuals who have undergone knee surgery within the last year.
- Individuals with peripheral vascular disease.
- Individuals with infection, wound, cellulitis, or active skin disease in the knee region.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Sheep Tail FatTopical application of sheep tail fat to the knee once daily for two weeks, seven days per week, with each application lasting at least three hours. | Other | Experimental Group(Sheep Tail Fat + Standard Treatment) |
| Standard medical treatmentParticipants in the control group will receive standard medical treatment only. | Other | Control Group(Standard Medical Treatment) |
Primary outcome
Pain intensity measured by the Visual Analog Scale (VAS)
Time frame: Baseline and 2 weeks
Pain intensity will be assessed using the Visual Analog Scale (VAS), ranging from 0 to 10, with higher scores indicating greater pain intensity.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Medet KORKMAZ study director
Inonu University
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Sheep Tail Fat and Standard medical treatment in people with Gonarthrosis, run by Inonu University at 2 sites in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 9 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Medet KORKMAZ (05065027980, medet.korkmaz@inonu.edu.tr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain intensity measured by the Visual Analog Scale (VAS) (time frame: Baseline and 2 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Oct 2026.