Wound HealingNCT07874789
Effect of Curcumin Topical Spray on Wound Healing After Tooth Extraction
A study testing Curcumin Topical Spray and Chlorhexidine Topical Spray in people with Wound Healing and Alveolitis of Jaw, run by Istanbul University at 1 site in Turkey (Türkiye).
Trial summary
This randomized, single-blind, controlled clinical trial aims to evaluate the effects of a topical curcumin spray on post-extraction wound healing and postoperative symptoms in adults undergoing first molar extraction. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Wound Healing, Alveolitis of Jaw, Tooth Extraction
- What is being tested?
- Curcumin Topical Spray and Chlorhexidine Topical Spray
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 54 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 29 Sep 2026to 25 Jan 2027
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy individuals aged 18-40 years with ASA physical status I.
- Patients scheduled for extraction of a mandibular first molar.
- Individuals who voluntarily agree to participate and provide written informed consent.
- Individuals without chronic systemic disease and who do not use regular medication.
- Patients with no oral health condition that would contraindicate the surgical procedure.
Who cannot join
- Pregnant or breastfeeding individuals.
- Patients with systemic diseases or immunosuppression.
- Individuals with a history of previous surgery or trauma in the same region.
- Individuals with a known allergy or hypersensitivity to turmeric (curcumin), chlorhexidine spray, or any component of the study products.
- Individuals who smoke or consume alcohol.
- Individuals who regularly use medications, particularly anti-inflammatory or anticoagulant drugs.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Istanbul University Faculty of Dentistry, Department of Oral and Maxillofacial Surgery
Istanbul, Istanbul, 34452
Ece Duru, Dentist, +905314066610, duru.ece@ogr.iu.edu.tr
About this study
Official title: Evaluation of the Effect of Curcumin Topical Spray on Post-Extraction Wound Healing and Postoperative Symptoms
This randomized, single-blind, controlled clinical trial aims to evaluate the effects of a topical curcumin spray on post-extraction wound healing and postoperative symptoms in adults undergoing first molar extraction. Participants will be randomly assigned to one of three groups: curcumin topical spray, 0.12% chlorhexidine topical spray, or standard postoperative care without a topical spray. The interventions will be applied twice daily for 7 days. Postoperative pain will be assessed using a visual analog scale, while wound healing will be evaluated using the Landry, Turnbull, and Howley Healing Index. Wound dimensions will also be recorded during follow-up. In addition, salivary levels of inflammatory biomarkers, including interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α), and prostaglandin E2 (PGE2), will be analyzed to assess the local inflammatory response during the postoperative healing period.The study aims to compare the clinical effects of topical curcumin with chlorhexidine and standard postoperative care during the early healing period after tooth extraction.
Read the detailed description
This study is designed as a randomized, single-blind, three-arm controlled clinical trial to evaluate the effect of a curcumin-containing topical spray on early wound healing and postoperative symptoms following first molar extraction in adults aged 18-40 years.
Eligible participants requiring first molar extraction will undergo minimally traumatic tooth extraction without primary suturing. Following extraction, participants will be randomly allocated to one of three study groups. Participants in the curcumin group will use a Curcuma longa-containing topical spray, administered as two sprays to the extraction site twice daily for 7 days. Participants in the chlorhexidine group will use a 0.12% chlorhexidine topical spray according to the same administration schedule. Participants in the control group will receive standard postoperative care without the use of an additional topical spray.
All participants will receive standardized postoperative instructions. Clinical follow-up will be performed during the early postoperative healing period. Postoperative pain will be assessed using a 0-10 visual analog scale (VAS) on postoperative days 1, 3, 5, and 7. Soft-tissue wound healing will be evaluated using the Landry, Turnbull, and Howley Healing Index on postoperative days 7 and 14. Wound dimensions will be measured in the buccolingual and mesiodistal directions during follow-up.
In addition to clinical assessments, salivary inflammatory biomarkers, including interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and prostaglandin E2 (PGE2), will be analyzed to evaluate the local inflammatory response associated with postoperative healing.
The study will compare clinical healing, postoperative pain, wound dimensions, mouth opening, and inflammatory biomarker levels among the curcumin, chlorhexidine, and control groups. The aim is to determine whether topical curcumin influences early post-extraction wound healing and postoperative inflammatory symptoms compared with chlorhexidine and standard postoperative care.
- Conditions
- Wound Healing, Alveolitis of Jaw, Tooth Extraction, Curcumin
- Being tested
- Curcumin Topical Spray, Chlorhexidine Topical Spray
- Keywords
- curcumin, Curcuma longa, Tooth extraction, Wound healing, Postoperative Pain, Chlorhexidine, Oral Wound Healing, Inflammation, Salivary Biomarkers, PGE2, IL-1β, TNF-α
- Medical subject headings
- Dry Socket, Pain, Postoperative, Inflammation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Curcumin Topical SprayDietary supplement
A commercially available Curcuma longa-containing topical spray (Minerelax®) will be applied directly to the extraction site as two sprays twice daily for 7 days following tooth extraction, in addition to standardized postoperative care.
Chlorhexidine Topical SprayDrug
Also called Chlorhexidine 0.12% Topical Spray
0.12% chlorhexidine topical spray administered to the extraction site as two sprays twice daily for 7 days.
| Study group | Role | What they receive |
|---|---|---|
| Curcumin Topical Spray | Experimental | Participants will receive a Curcuma longa-containing topical spray applied to the extraction site as two sprays twice daily for 7 days, in addition to standard postoperative care. Receives: Dietary Supplement: Curcumin Topical Spray |
| Chlorhexidine Topical Spray | Active comparator | Participants will receive a 0.12% chlorhexidine topical spray applied to the extraction site as two sprays twice daily for 7 days, in addition to standard postoperative care. Receives: Drug: Chlorhexidine Topical Spray |
| Standard Postoperative Care | No intervention | Participants will receive standard postoperative care following tooth extraction without the use of an additional topical spray. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Extraction Socket Healing Assessed Using the Landry, Turnbull and Howley Healing Index
Extraction socket healing will be assessed using the Landry, Turnbull and Howley Healing Index, ranging from 1 (very poor healing) to 5 (excellent healing). Higher scores indicate better wound healing. Scores will be compared among the curcumin spray, chlorhexidine spray, and standard postoperative care groups.
Measured: postoperative 7. and 14. days
Secondary outcomes (5)
Postoperative Pain Intensity
Pain intensity at the extraction site will be assessed using a visual analog scale ranging from 0 (no pain) to 10 (worst imaginable pain). Higher scores indicate greater pain intensity. Assessments will be performed by telephone on days 1, 3, and 5 and at the clinical visit on day 7. Scores will be compared among the three study groups.
Measured: Postoperative days 1, 3, 5, and 7.
Change in Extraction Socket Wound Size
Wound size will be assessed by directly measuring the distance between predefined anatomical landmarks at the extraction site. Measurements on postoperative days 7 and 14 will be compared with the initial measurement obtained on day 0 and among the three study groups. A reduction in the measured distance indicates wound closure.
Measured: Day 0 following extraction and postoperative days 7 and 14.
Change in Salivary Interleukin-1 Beta Concentration
Salivary interleukin-1 beta (IL-1 beta) concentrations will be measured using a commercial enzyme-linked immunosorbent assay (ELISA). Concentrations on postoperative days 2 and 7 and changes from the pre-extraction baseline will be compared among the three study groups to assess the local inflammatory response.
Measured: Before extraction (day 0) and postoperative days 2 and 7.
Change in Salivary Tumor Necrosis Factor Alpha Concentration
Salivary tumor necrosis factor alpha (TNF-alpha) concentrations will be measured using a commercial enzyme-linked immunosorbent assay (ELISA). Concentrations on postoperative days 2 and 7 and changes from the pre-extraction baseline will be compared among the three study groups to assess the local inflammatory response.
Measured: Before extraction (day 0) and postoperative days 2 and 7.
Change in Salivary Prostaglandin E2 Concentration
Salivary prostaglandin E2 (PGE2) concentrations will be measured using a commercial enzyme-linked immunosorbent assay (ELISA). Concentrations on postoperative days 2 and 7 and changes from the pre-extraction baseline will be compared among the three study groups to assess the local inflammatory response.
Measured: Before extraction (day 0) and postoperative days 2 and 7.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Oct 2026
- Study start29 Sep 2026 (estimated)
- Primary completion30 Nov 2026 (estimated)
- Study completion25 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (9)Papers the sponsor has linked to this study.
- Other trials for Wound HealingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Eligible participants will be randomly allocated in a 1:1:1 ratio to three parallel intervention groups: curcumin topical spray, 0.12% chlorhexidine topical spray, or standard postoperative care. Each participant will receive only the intervention assigned to their group throughout the study period
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 54 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Istanbul University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ece Duru, Istanbul University
- Investigators
- Metin Berk Kasapoglu, associate professor, Principal investigator, Istanbul University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07874789
- Sponsor's protocol ID
- 2025//82
- Status last verified
- Oct 2026
- First submitted
- 8 Oct 2026
- Last updated
- 15 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared because a formal data-sharing plan and infrastructure have not been established for this study.
Publications
Dei Cas M, Ghidoni R. Dietary Curcumin: Correlation between Bioavailability and Health Potential. Nutrients. 2019 Sep 8;11(9):2147. doi: 10.3390/nu11092147.
PubMed 31500361Amaliya A, Ramadhanti R, Hadikrishna I, Maulina T. The Effectiveness of 0.2% Chlorhexidine Gel on Early Wound Healing after Tooth Extraction: A Randomized Controlled Trial. Eur J Dent. 2022 Jul;16(3):688-694. doi: 10.1055/s-0041-1739544. Epub 2022 Jan 11.
PubMed 35016228Broers DLM, Dubois L, de Lange J, Su N, de Jongh A. Reasons for Tooth Removal in Adults: A Systematic Review. Int Dent J. 2022 Feb;72(1):52-57. doi: 10.1016/j.identj.2021.01.011. Epub 2021 Feb 26.
PubMed 33648772Sahebkar A, Henrotin Y. Analgesic Efficacy and Safety of Curcuminoids in Clinical Practice: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Pain Med. 2016 Jun;17(6):1192-202. doi: 10.1093/pm/pnv024. Epub 2015 Dec 14.
PubMed 26814259Seyedzadeh MH, Safari Z, Zare A, Gholizadeh Navashenaq J, Razavi SA, Kardar GA, Khorramizadeh MR. Study of curcumin immunomodulatory effects on reactive astrocyte cell function. Int Immunopharmacol. 2014 Sep;22(1):230-5. doi: 10.1016/j.intimp.2014.06.035. Epub 2014 Jul 3.
PubMed 24998635Anthwal A, Thakur BK, Rawat MS, Rawat DS, Tyagi AK, Aggarwal BB. Synthesis, characterization and in vitro anticancer activity of C-5 curcumin analogues with potential to inhibit TNF-alpha-induced NF-kappaB activation. Biomed Res Int. 2014;2014:524161. doi: 10.1155/2014/524161. Epub 2014 Jul 24.
PubMed 25157362Esatbeyoglu T, Huebbe P, Ernst IM, Chin D, Wagner AE, Rimbach G. Curcumin--from molecule to biological function. Angew Chem Int Ed Engl. 2012 May 29;51(22):5308-32. doi: 10.1002/anie.201107724. Epub 2012 May 4.
PubMed 22566109McCoy LC, Wehler CJ, Rich SE, Garcia RI, Miller DR, Jones JA. Adverse events associated with chlorhexidine use: results from the Department of Veterans Affairs Dental Diabetes Study. J Am Dent Assoc. 2008 Feb;139(2):178-83. doi: 10.14219/jada.archive.2008.0134.
PubMed 18245686Yin Y, Shuai F, Liu X, Zhao Y, Han X, Zhao H. Biomaterials and therapeutic strategies designed for tooth extraction socket healing. Biomaterials. 2025 May;316:122975. doi: 10.1016/j.biomaterials.2024.122975. Epub 2024 Nov 29.
PubMed 39626339