Healthy AthleteNCT07879001
Effect of CPAP on Recovery in High-Performance Endurance Athletes
A study testing Continuous Positive Airway Pressure (CPAP) and Physical Training in people with Healthy Athlete, run by Federal University of São Paulo at 1 site in Brazil.
Trial summary
This study evaluated the use of nocturnal continuous positive airway pressure (CPAP) as a potential recovery strategy in healthy male endurance runners without obstructive sleep apnea. Read more about this study
- Who is it for?
- Ages 20 to 45 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Healthy Athlete
- What is being tested?
- Continuous Positive Airway Pressure (CPAP) and Physical Training
- Type of treatment
- Medical device, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 12 participants
- Where
- 1 siteBrazil
- Study dates
- 2 Jan 2012to Jul 2015
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 45 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- High-performance athletes aged 20 to 45 years
- Runners for at least one year
- No respiratory problems
Who cannot join
- Respiratory conditions
- Presence of sleep apnea
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of the Use of CPAP in the Recovery of High-Performance Athletes
This study evaluated the use of nocturnal continuous positive airway pressure (CPAP) as a potential recovery strategy in healthy male endurance runners without obstructive sleep apnea. Participants completed periods of high-intensity/high-volume and low-intensity/low-volume physical training, first without CPAP and subsequently with nocturnal CPAP. Sleep, physiological, biochemical, psychological, and recovery-related measures were assessed during the study. Polysomnography, blood tests, questionnaires, actigraphy, sleep diaries, and heart rate monitoring were used to evaluate participants across the experimental periods. The objective was to investigate whether nocturnal CPAP was associated with changes in recovery-related measures during different physical training loads.
Read the detailed description
The objective of this interventional study was to investigate the use of nocturnal continuous positive airway pressure (CPAP) in the recovery of high-performance endurance runners during different physical training loads.
Male endurance runners aged 20 to 45 years were screened for participation. Initial assessments included polysomnography (PSG), otorhinolaryngological evaluation, electrocardiography (ECG), blood tests, cardiopulmonary exercise testing, and questionnaires assessing psychological and recovery-related variables.
Participants completed two sequential experimental stages. In the first stage, participants completed five days of high-intensity/high-volume training without nocturnal CPAP, followed by a two-day rest period and five days of low-intensity/low-volume training without CPAP. In the second stage, the training sequence was repeated, with participants using CPAP during sleep for the corresponding training periods. A two-day rest period separated the high- and low-intensity training periods.
At the end of each five-day training period, participants underwent polysomnography. The following morning, blood samples and questionnaire-based assessments were obtained. Actigraphy and sleep diaries were used during the study protocol, and heart rate was monitored during training.
The study used a single-group, fixed-sequence design in which participants underwent the non-CPAP conditions before the corresponding CPAP conditions.
- Conditions
- Healthy Athlete
- Being tested
- Continuous Positive Airway Pressure (CPAP), Physical Training
- Keywords
- CPAP, Endurance Athletes, Exercise Recovery, Physical Training, Sleep, Polysomnography
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Continuous Positive Airway Pressure (CPAP)Device
Also called CPAP
Participants used continuous positive airway pressure (CPAP) during sleep for five consecutive nights during each CPAP training condition.
Physical TrainingBehavioural
Participants completed five days of high-intensity/high-volume training followed by a two-day period without training and five days of low-intensity/low-volume training. This training sequence was completed first without nocturnal CPAP and subsequently with nocturnal CPAP.
| Study group | Role | What they receive |
|---|---|---|
| CPAP and Physical Training | Experimental | Participants completed a fixed-sequence training protocol consisting of high-intensity/high-volume and low-intensity/low-volume training periods. The training periods were first completed without nocturnal CPAP and subsequently repeated with nocturnal CPAP. Receives: Device: Continuous Positive Airway Pressure (CPAP); Behavioral: Physical Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
REM Sleep Latency
REM sleep latency was measured by overnight polysomnography at baseline and after each five-day training period, including high-intensity/high-volume and low-intensity/low-volume training conditions without and with nocturnal CPAP. REM sleep latency was measured in minutes.
Measured: 26 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Oct 2026
- Study start2 Jan 2012
- Primary completionOct 2013
- Study completionJul 2015
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy AthleteStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- All participants followed the same fixed-sequence protocol. They first completed high-intensity/high-volume and low-intensity/low-volume training periods without nocturnal CPAP and subsequently repeated the corresponding training periods with nocturnal CPAP. No randomization or parallel-group assignment was used.
- Masking
- None (open label)
- Enrolment
- 12 participants (actual)
Sponsor and investigators
- Lead sponsor
- Federal University of São Paulo
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Gilberto Pantiga Junior, Federal University of São Paulo
- Investigators
- Marco Túlio de Mello, Phd, Study chair, Federal University of São Paulo
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07879001
- Sponsor's protocol ID
- GPantiga
- Status last verified
- Sep 2026
- First submitted
- 14 Oct 2013
- Last updated
- 16 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of the Use of CPAP in the Recovery of High-Performance Athletes
- ClinicalTrials.gov ID
- NCT07879001
- Acronym / sponsor ID
- GPantiga
- Conditions
- Healthy Athlete
- Keywords
- CPAP, Endurance Athletes, Exercise Recovery, Physical Training, Sleep, Polysomnography
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 12 participants (actual)
- Lead sponsor
- Federal University of São PauloUniversity, hospital or other
- Study start
- 2 Jan 2012 (actual)
- Primary completion
- Oct 2013 (actual)
- Study completion
- Jul 2015 (actual)
- First posted
- 16 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study evaluated the use of nocturnal continuous positive airway pressure (CPAP) as a potential recovery strategy in healthy male endurance runners without obstructive sleep apnea. Participants completed periods of high-intensity/high-volume and low-intensity/low-volume physical training, first without CPAP and subsequently with nocturnal CPAP. Sleep, physiological, biochemical, psychological, and recovery-related measures were assessed during the study. Polysomnography, blood tests, questionnaires, actigraphy, sleep diaries, and heart rate monitoring were used to evaluate participants across the experimental periods. The objective was to investigate whether nocturnal CPAP was associated with changes in recovery-related measures during different physical training loads.
Detailed description
The objective of this interventional study was to investigate the use of nocturnal continuous positive airway pressure (CPAP) in the recovery of high-performance endurance runners during different physical training loads.
Male endurance runners aged 20 to 45 years were screened for participation. Initial assessments included polysomnography (PSG), otorhinolaryngological evaluation, electrocardiography (ECG), blood tests, cardiopulmonary exercise testing, and questionnaires assessing psychological and recovery-related variables.
Participants completed two sequential experimental stages. In the first stage, participants completed five days of high-intensity/high-volume training without nocturnal CPAP, followed by a two-day rest period and five days of low-intensity/low-volume training without CPAP. In the second stage, the training sequence was repeated, with participants using CPAP during sleep for the corresponding training periods. A two-day rest period separated the high- and low-intensity training periods.
At the end of each five-day training period, participants underwent polysomnography. The following morning, blood samples and questionnaire-based assessments were obtained. Actigraphy and sleep diaries were used during the study protocol, and heart rate was monitored during training.
The study used a single-group, fixed-sequence design in which participants underwent the non-CPAP conditions before the corresponding CPAP conditions.
Study design
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- All participants followed the same fixed-sequence protocol. They first completed high-intensity/high-volume and low-intensity/low-volume training periods without nocturnal CPAP and subsequently repeated the corresponding training periods with nocturnal CPAP. No randomization or parallel-group assignment was used.
| Arm | Type | Receives |
|---|---|---|
| CPAP and Physical Training | Experimental | Device: Continuous Positive Airway Pressure (CPAP), Behavioral: Physical TrainingParticipants completed a fixed-sequence training protocol consisting of high-intensity/high-volume and low-intensity/low-volume training periods. The training periods were first completed without nocturnal CPAP and subsequently repeated with nocturnal CPAP. |
Who may qualify
- Ages
- 20 to 45 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- High-performance athletes aged 20 to 45 years
- Runners for at least one year
- No respiratory problems
Key exclusion criteria (2 listed)
- Respiratory conditions
- Presence of sleep apnea
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Continuous Positive Airway Pressure (CPAP)Also: CPAPParticipants used continuous positive airway pressure (CPAP) during sleep for five consecutive nights during each CPAP training condition. | Device | CPAP and Physical Training |
| Physical TrainingParticipants completed five days of high-intensity/high-volume training followed by a two-day period without training and five days of low-intensity/low-volume training. This training sequence was completed first without nocturnal CPAP and subsequently with nocturnal CPAP. | Behavioural | CPAP and Physical Training |
Primary outcome
REM Sleep Latency
Time frame: 26 days
REM sleep latency was measured by overnight polysomnography at baseline and after each five-day training period, including high-intensity/high-volume and low-intensity/low-volume training conditions without and with nocturnal CPAP. REM sleep latency was measured in minutes.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Marco Túlio de Mello, Phd study chair
Federal University of São Paulo
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Continuous Positive Airway Pressure (CPAP) and Physical Training in people with Healthy Athlete, run by Federal University of São Paulo at 1 site in Brazil.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Brazil. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
REM Sleep Latency (time frame: 26 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Oct 2026.